世界病毒学杂志(英文版)最新文献

{"title":"Hepatic manifestations of coronavirus disease 2019 infection: Clinical and laboratory perspective.","authors":"Farina M Hanif, Zain Majid, Shoaib Ahmed, Nasir H Luck, Muhammed Mubarak","doi":"10.5501/wjv.v11.i6.453","DOIUrl":"10.5501/wjv.v11.i6.453","url":null,"abstract":"<p><p>The novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2, has become a global challenge of unprecedented nature since December 2019. Although most patients with COVID-19 exhibit mild clinical manifestations and upper respiratory tract involvement, in approximately 5%-10% of patients, the disease is severe and involves multiple organs, leading to multi-organ dysfunction and failure. The liver and gastrointestinal tract are also frequently involved in COVID-19. In the context of liver involvement in patients with COVID-19, many key aspects need to be addressed in both native and transplanted organs. This review focuses on the clinical presentations and laboratory abnormalities of liver function tests in patients with COVID-19 with no prior liver disease, patients with pre-existing liver diseases and liver transplant recipients. A brief overview of the history of COVID-19 and etiopathogenesis of the liver injury will also be described as a prelude to better understanding the above aspects.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"11 6","pages":"453-466"},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/2c/WJV-11-453.PMC9724207.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10364176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musculoskeletal complications in long COVID-19: A systematic review.","authors":"Raktim Swarnakar,&nbsp;Shoibam Jenifa,&nbsp;Sanjay Wadhwa","doi":"10.5501/wjv.v11.i6.485","DOIUrl":"https://doi.org/10.5501/wjv.v11.i6.485","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19) has crippled humanity since early 2020. Various sequelae of COVID-19 have been reported in different body systems. Musculoskeletal symptoms are widely reported during COVID-19 infection, but musculoskeletal complications in long COVID-19 are underreported. However, post-COVID-19 survivors have reported complaints of persisting or new-onset fatigue, myalgia, arthralgia, arthritis, muscle weakness, <i>etc</i> in clinical practice. The well-known detrimental effects of steroids on the musculoskeletal system coupled with their over-the-counter availability can also be anticipated since they were the cornerstone of life-saving management in this pandemic.</p><p><strong>Aim: </strong>To determine the musculoskeletal complications in long COVID.</p><p><strong>Methods: </strong>We performed a systematic review of 'systematic reviews and meta-analyses'.</p><p><strong>Results: </strong>Of the 63 articles screened, 24 articles were included. Two articles specifically discussed children and adolescents. One article discussed rehabilitation intervention. No article addressed rehabilitation of musculoskeletal issues in long COVID-19 in particular. Fatigue was the most common musculoskeletal complication.</p><p><strong>Conclusion: </strong>Fatigue is found to be very common along with myalgia and arthralgia. There were no studies on rehabilitation intervention in musculoskeletal complications specifically. Considering the lacuna in literature and the needs of the current situation, further studies are warranted to standardize effective rehabilitation interventions in musculoskeletal complications. More homogenous studies are needed. Studies on functional impairment due to musculoskeletal involvement are essential.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"11 6","pages":"485-495"},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/e8/WJV-11-485.PMC9724204.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10371651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19-induced liver injury in adult patients: A brief overview.","authors":"Martina Grando,&nbsp;Massimiliano Balbi,&nbsp;Marco Zeppieri","doi":"10.5501/wjv.v11.i6.443","DOIUrl":"https://doi.org/10.5501/wjv.v11.i6.443","url":null,"abstract":"<p><p>Coronavirus disease has spread worldwide since 2019, causing important pandemic issues and various social health problems to date. Little is known about the origin of this virus and the effects it has on extra-pulmonary organs. The different mechanisms of the virus and the influence it has on humans are still being studied, with hopes of finding a cure for the disease and the pathologies associated with the infection. Liver damage caused by coronavirus disease 2019 (COVID-19) is sometimes underestimated and has been of important clinical interest in the past few years. Hepatic dysfunctions can manifest in different forms which can sometimes be mild and without specific signs and symptoms or be severe with important clinical implications. There are several studies that have tried to explain the mechanism of entry (hepatotropism) of the virus into hepatocytes and the effects the virus has on this important organ. What clearly emerges from the current literature is that hepatic injury represents an important clinical aspect in the management of patients infected with COVID-19, especially in frail patients and those with comorbidities. The aim of our brief overview is to summarize the current literature regarding the forms of hepatic damage, complications, mechanisms of pathology, clinical features of liver injury, influence of comorbidities and clinical management in patients with COVID-19 infection.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"11 6","pages":"443-452"},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/26/82/WJV-11-443.PMC9724208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10364173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible agent for COVID-19 treatment: Rifampicin.","authors":"Ozlem Celik Aydin, Sonay Aydın, Sureyya Barun","doi":"10.5501/wjv.v11.i5.391","DOIUrl":"10.5501/wjv.v11.i5.391","url":null,"abstract":"<p><p>Rifampicin is a promising drug for the treatment of coronavirus disease 2019 based on its antiviral properties and recent <i>in silico</i> studies. <i>In silico</i> studies can serve as a foundation for further studies.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"11 5","pages":"391-393"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/3f/WJV-11-391.PMC9523331.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40391950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality rate of COVID-19 infection in end stage kidney disease patients on maintenance hemodialysis: A systematic review and meta-analysis.","authors":"Ivan Cancarevic,&nbsp;Mahmoud Nassar,&nbsp;Ahmed Daoud,&nbsp;Hatem Ali,&nbsp;Nso Nso,&nbsp;Angelica Sanchez,&nbsp;Avish Parikh,&nbsp;Asma Ul Hosna,&nbsp;Bhavana Devanabanda,&nbsp;Nazakat Ahmed,&nbsp;Karim M Soliman","doi":"10.5501/wjv.v11.i5.352","DOIUrl":"https://doi.org/10.5501/wjv.v11.i5.352","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19) has been the most talked-about disease of the past few years. Patients with significant comorbidities have been at particular risk of adverse outcomes. This study looked at the outcomes and risk factors for adverse outcomes among patients on chronic hemodialysis for end-stage renal disease, a group of patients known to be particularly susceptible to infectious complications.</p><p><strong>Aim: </strong>To assess outcomes and risk factors for adverse outcomes of COVID-19 infection among patients on chronic hemodialysis.</p><p><strong>Methods: </strong>We searched PubMed/MEDLINE, EMBASE, <i>Reference Citation Analysis</i> (https://www.referencecitationanalysis.com/) and Web of Science databases for relevant terms and imported the results into the Covidence platform. From there, studies were assessed in two stages for relevance and quality, and data from studies that satisfied all the requirements were extracted into a spreadsheet. The data was then analyzed descriptively and statistically.</p><p><strong>Results: </strong>Of the 920 studies identified through the initial database search, only 17 were included in the final analysis. The studies included in the analysis were mostly carried out during the first wave. We found that COVID-19 incidence among patients on hemodialysis was significant, over 10% in some studies. Those who developed COVID-19 infection were most likely going to be hospitalized, and over 1 in 5 died from the infection. Intensive care unit admission rate was lower than the infection lethality rate. Biochemical abnormalities and dyspnea were generally reported to be associated with adverse outcomes.</p><p><strong>Conclusion: </strong>This systematic review confirms that patients on chronic hemodialysis are very high-risk individuals for COVID-19 infections, and a significant proportion was infected during the first wave. Their prognosis is overall much worse than in the general population, and every effort needs to be made to decrease their exposure.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"11 5","pages":"352-361"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/01/WJV-11-352.PMC9523330.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of COVID-19 with hepatic metabolic dysfunction.","authors":"Ramesh Kumar,&nbsp;Vijay Kumar,&nbsp;Rahul Arya,&nbsp;Utpal Anand,&nbsp;Rajeev Nayan Priyadarshi","doi":"10.5501/wjv.v11.i5.237","DOIUrl":"https://doi.org/10.5501/wjv.v11.i5.237","url":null,"abstract":"<p><p>The coronavirus disease 2019 (COVID-19) pandemic continues to be a global problem with over 438 million cases reported so far. Although it mostly affects the respiratory system, the involvement of extrapulmonary organs, including the liver, is not uncommon. Since the beginning of the pandemic, metabolic com-orbidities, such as obesity, diabetes, hypertension, and dyslipidemia, have been identified as poor prognostic indicators. Subsequent metabolic and lipidomic studies have identified several metabolic dysfunctions in patients with COVID-19. The metabolic alterations appear to be linked to the course of the disease and inflammatory reaction in the body. The liver is an important organ with high metabolic activity, and a significant proportion of COVID-19 patients have metabolic comorbidities; thus, this factor could play a key role in orchestrating systemic metabolic changes during infection. Evidence suggests that metabolic dysregulation in COVID-19 has both short- and long-term metabolic implications. Furthermore, COVID-19 has adverse associations with metabolic-associated fatty liver disease. Due to the ensuing effects on the renin-angiotensin-aldosterone system and ammonia metabolism, COVID-19 can have significant implications in patients with advanced chronic liver disease. A thorough understanding of COVID-19-associated metabolic dysfunction could lead to the identification of important plasma biomarkers and novel treatment targets. In this review, we discuss the current understanding of metabolic dysfunction in COVID-19, focusing on the liver and exploring the underlying mechanistic pathogenesis and clinical implications.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"11 5","pages":"237-251"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/6e/WJV-11-237.PMC9523326.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and hemolysis, elevated liver enzymes and thrombocytopenia syndrome in pregnant women - association or causation?","authors":"Prashant Nasa,&nbsp;Deven Juneja,&nbsp;Ravi Jain,&nbsp;Ruchi Nasa","doi":"10.5501/wjv.v11.i5.310","DOIUrl":"https://doi.org/10.5501/wjv.v11.i5.310","url":null,"abstract":"<p><p>Pregnant women are among the high-risk population for severe coronavirus disease 2019 (COVID-19) with unfavorable peripartum outcomes and increased incidence of preterm births. Hemolysis, the elevation of liver enzymes, and low platelet count (HELLP) syndrome and severe preeclampsia are among the leading causes of maternal mortality. Evidence supports a higher odd of pre-eclampsia in women with COVID-19, given overlapping pathophysiology. Involvement of angiotensin-converting enzyme 2 receptors by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for the entry to the host cells and its downregulation cause dysregulation of the renin-angiotensin-aldosterone system. The overexpression of Angiotensin II mediated <i>via</i> p38 Mitogen-Activated Protein Kinase pathways can cause vasoconstriction and uninhibited platelet aggregation, which may be another common link between COVID-19 and HELLP syndrome. On PubMed search from January 1, 2020, to July 30, 2022, we found 18 studies on of SARS-COV-2 infection with HELLP Syndrome. Most of these studies are case reports or series, did not perform histopathology analysis of the placenta, or measured biomarkers linked to pre-eclampsia/HELLP syndrome. Hence, the relationship between SARS-CoV-2 infection and HELLP syndrome is inconclusive in these studies. We intend to perform a mini-review of the published literature on HELLP syndrome and COVID-19 to test the hypothesis on association <i>vs</i> causation, and gaps in the current evidence and propose an area of future research.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"11 5","pages":"310-320"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/69/WJV-11-310.PMC9523323.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomophysiological relationships and clinical considerations of taste and smell loss in patients with COVID-19.","authors":"Maria Fernanda Rossi Vigliar,&nbsp;Karina Torres Pomini,&nbsp;Daniela Vieira Buchaim,&nbsp;Rogerio Leone Buchaim","doi":"10.5501/wjv.v11.i5.362","DOIUrl":"https://doi.org/10.5501/wjv.v11.i5.362","url":null,"abstract":"<p><strong>Background: </strong>There are numerous conflicting discussions about the outbreak of the new coronavirus 2019 (COVID-19).</p><p><strong>Aim: </strong>To present some anatomical and physiological considerations about two of the symptoms reported by patients: The loss or reduction of smell and taste.</p><p><strong>Methods: </strong>The loss or reduction of smell and taste is presented in a peculiar way, with some cases of persistence even after COVID-19. For this, it was searched in three databases, PubMed/MEDLINE, Web of Science, and Scopus, using the following keywords: \"Smell\", \"Taste\", \"Smell AND COVID-19\", \"Taste AND COVID-19\", with no publication time restriction, only in English with full text available, excluding also brief communications, letters to the editor, editorials, reviews, comments, and conference abstracts.</p><p><strong>Results: </strong>The search found 776 articles in the PubMed/MEDLINE database, 1018 in the Web of Science database, and 552 in the Scopus database, from which duplicates were removed (104 articles). Finally, 17 studies were selected for detailed analysis within the eligibility criteria, with titles and abstracts related to central nervous system lesions responsible for smell and taste. This review suggests that viral mechanisms of action may be related to lesions both at the local level and at the level of the central nervous system, lasting up to 3 to 4 wk. It is considered persistent if it exceeds this period, as reported in one case in this review. There are still few studies about the treatment, and among those addressed in this review, only two studies reported possible treatments and emphasized the scarcity of data, with the best option being treatments that do not cause harm, such as gustatory and olfactory physiotherapy.</p><p><strong>Conclusion: </strong>Given the scarcity of data, this review emphasizes the importance of prevention, through the correct use of personal protective equipment by health professionals and respect for local behavioral indications. It is also emphasized, through five studies, that there is a predominance of such symptoms in patients with COVID-19, which can be a tool to control dissemination, through the early isolation of patients until the results are ready.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"11 5","pages":"362-374"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/fd/WJV-11-362.PMC9523329.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of high dose vitamin C in management of hospitalised COVID-19 patients: A minireview.","authors":"Deven Juneja,&nbsp;Anish Gupta,&nbsp;Sahil Kataria,&nbsp;Omender Singh","doi":"10.5501/wjv.v11.i5.300","DOIUrl":"https://doi.org/10.5501/wjv.v11.i5.300","url":null,"abstract":"<p><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as one of the most dreadful viruses the mankind has witnessed. It has caused world-wide havoc and wrecked human life. In our quest to find therapeutic options to counter this threat, several drugs have been tried, with varying success. Certain agents like corticosteroids, some anti-virals and immunosuppressive drugs have been found useful in improving clinical outcomes. Vitamin C, a water-soluble vitamin with good safety profile, has been tried to reduce progression and im-prove outcomes of patients with coronavirus disease 2019 (COVID-19). Because of its anti-oxidant and immunomodulatory properties, the role of vitamin C has expanded well beyond the management of scurvy and it is increasingly been employed in the treatment of critically ill patients with sepsis, septic shock, acute pancreatitis and even cancer. However, in spite of many case series, observational studies and even randomised control trials, the role of vitamin C remains ambiguous. In this review, we will be discussing the scientific rationale and the current clinical evidence for using high dose vitamin C in the management of COVID-19 patients.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"11 5","pages":"300-309"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/6f/WJV-11-300.PMC9523318.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute kidney injury and electrolyte disorders in COVID-19.","authors":"Gabriel Martins Nogueira,&nbsp;Noel Lucas Oliveira Rodrigues Silva,&nbsp;Ana Flávia Moura,&nbsp;Marcelo Augusto Duarte Silveira,&nbsp;José A Moura-Neto","doi":"10.5501/wjv.v11.i5.283","DOIUrl":"https://doi.org/10.5501/wjv.v11.i5.283","url":null,"abstract":"<p><p>Acute kidney injury (AKI) and electrolyte disorders are important complications of hospitalized coronavirus disease 2019 (COVID-19) patients. AKI is thought to occur due to multiple pathophysiological mechanisms, such as multiple organ dysfunction (mainly cardiac and respiratory), direct viral entry in the renal tubules, and cytokine release syndrome. AKI is present in approximately one in every ten hospitalized COVID-19 patients. The incidence rates of AKI increase in patients who are admitted to the intensive care unit (ICU), with levels higher than 50%. Additionally, renal replacement therapy (RRT) is used in 7% of all AKI cases, but in nearly 20% of patients admitted to an ICU. COVID-19 patients with AKI are considered moderate-to-severe cases and are managed with multiple interdisciplinary conducts. AKI acts as a risk factor for mortality in severe acute respiratory syndrome coronavirus 2 infection, especially when RRT is needed. Electrolyte disorders are also common manifestations in hospitalized COVID-19 patients, mainly hyponatremia, hypokalemia, and hypocalcemia. Hyponatremia occurs due to a combination of syndrome of inappropriate secretion of antidiuretic hormone and gastrointestinal fluid loss from vomiting and diarrhea. When it comes to hypokalemia, its mechanism is not fully understood but may derive from hyperaldosteronism due to renin angiotensin aldosterone system overstimulation and gastrointestinal fluid loss as well. The clinical features of hypokalemia in COVID-19 are similar to those in other conditions. Hypocalcemia is the most common electrolyte disorder in COVID-19 and seems to occur because of vitamin D deficiency and parathyroid imbalance. It is also highly associated with longer hospital and ICU stay.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"11 5","pages":"283-292"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/1e/WJV-11-283.PMC9523327.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40392628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}