国际生物医学工程杂志最新文献

{"title":"Benign and malignant classification of renal occupancy lesions CT images using convolutional neural networks","authors":"Leilei Zhou, Zuoheng Zhang, Yu-Chen Chen, Jing Fu, X. Yin, Hong-Bing Jiang","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.05.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.05.008","url":null,"abstract":"Objective \u0000To investigate the feasibility and application value of the benign and malignant classificational methods of renal occupying CT images based on convolutional neural networks (CNN). \u0000 \u0000 \u0000Methods \u0000An image omics method that can automatically learn the image features and classify CT images was used. Firstly, the CNN model obtained by large-scale natural image training was used to migrate the characteristics of the renal occupancy lesions CT images, and then the fine-tuning of the full connection layer was used to realize the benign and malignant classification of the images. \u0000 \u0000 \u0000Results \u0000The evaluation indexes of the VGG19 model were lower than ResNet50 and Inception V3, and the training result showed obvious overfitting. The accuracy, sensitivity and negative prediction values of the Inception V3 model was 93.8%, 99.5% and 99.1%, respectively, which were higher than that of the ResNet50 model. \u0000 \u0000 \u0000Conclusions \u0000The benign and malignant classification of renal occupancy lesions CT images using CNN is a reasonable and feasible method, and the fine-tuned Inception V3 model has a better classification performance. \u0000 \u0000 \u0000Key words: \u0000Convolutional neural networks; Transfer learning; Renal occupancy lesions; CT images; Benign and malignant classification","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"417-422"},"PeriodicalIF":0.0,"publicationDate":"2018-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43513801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital design of internal device of electro-magnetism excitation positioning for electronic capsule","authors":"Zhongyu Luo, Xudong Guo, Ruihua Qin, Huihe Zhang","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.05.009","url":null,"abstract":"Objective \u0000To develop a digital signal processing method for magnetic positioning of electronic capsules according to the theory of multiple alternating magnetic field source electromagnetic positioning, so as to reduce the volume and power consumption of electronic capsules. \u0000 \u0000 \u0000Method \u0000Based on STM32 MCU, software algorithms such as fast digital filtering, peak detection and frequency detection were designed to replace the corresponding analog hardware circuits such as analog filtering, peak detection and comparison circuits. \u0000 \u0000 \u0000Results \u0000The experimental results showed that the average relative error of the peak detection and frequency detection of the digital signal processing system were 1.51% and 0.28%, respectively. The linear relationships of theoretical amplification factor and actual amplification factor of the programmable amplifier were basically consistent, and the average ratio difference was 4.51 dB. \u0000 \u0000 \u0000Conclusions \u0000The proposed digital signal processing system can replace some analog hardware circuits, providing a basis for reducing the size and power consumption of electronic capsules. \u0000 \u0000 \u0000Key words: \u0000Electronic capsules; Magnetic positioning; Frequency division incentive; Digital filtering; STM32","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"423-427"},"PeriodicalIF":0.0,"publicationDate":"2018-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44472449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanism of the combination of mechanical strain stimulation and icariin on inhibiting the differentiation of osteoclasts induced by fatigue load stimulation","authors":"Lili Liu, Xiong-Fei Luo, Si-Wen Liu, Na Zhao, Xizheng Zhang, Qiangsong Wang","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.05.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.05.003","url":null,"abstract":"Objective \u0000To investigate the effect and molecular mechanism of the combination of mechanical strain stimulation and icariin (ICA) on inhibiting the differentiation of osteoclasts induced by fatigue load stimulation. \u0000 \u0000 \u0000Methods \u0000The mouse mononuclear macrophage cell line RAW264.7 was cultured in vitro, and the blank control group was α-MEM complete medium. In the fatigue load group, RAW264.7 cells were treated with 5 000 μe mechanical stretch strain, and then cultured in an osteoclast culture medium that was an α-MEM complete medium containing 40 ng/ml macrophage colony-stimulating factor and 40 ng/ml osteoclast differentiation factor. In the mechanical stimulation + ICA group, RAW264.7 cells were treated as the same procedure in the fatigue load group, and then cultured in an α-MEM complete medium containing 1×10-5 mol/L ICA simultaneously with a 1000 μe tensile strain on the substrate. The activity of tartrate-resistant acid phosphatase (TRAP) was detected using a TRAP assay kit. The mRNA expression of the osteoclast marker genes, i.e. TRAP, cathepsin K(CTSK) and matrix metalloproteinase 9 (MMP-9) was detected by real-time RT-PCR. The nuclear translocation of nuclear factor kappa B (NF-κB) was analyzed by Western Blot. \u0000 \u0000 \u0000Results \u0000Compared with the fatigue load group, the combination of mechanical stimulation (1 000 μe substrate stretching) and ICA (1×10-5 mol/L) could significantly inhibit the activity of TRAP in osteoclasts (P<0.01) and reduce osteoclastosis. Moreover, that combination not only could down-regulate the mRNA expression of TRAP, CTSK and MMP-9 and the differences were statistically significant (all P<0.01), but also could inhibit the formation of osteoclasts by inhibiting the phosphorylation of P65, P50 and IκB-α in NF-κB signaling pathway. \u0000 \u0000 \u0000Conclusions \u0000The coupling of mechanical stimulation and ICA can effectively inhibit the osteoclast differentiation and the bone resorption induced by fatigue load, and the mechanism may involve regulating NF-κB signaling pathway. \u0000 \u0000 \u0000Key words: \u0000Mechanical strain stimulation; Icariin; Osteoclasts; Nuclear factor-kappa B","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"386-389"},"PeriodicalIF":0.0,"publicationDate":"2018-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49001955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-delivery of CpG and antigen using hyaluronic acid bioconjugates-decorated nanoparticles to promote maturation and activation of dendritic cells","authors":"M. Yan, Yijia Liu, Xianghui Zhu, F. Cao, Hai Wang","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.05.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.05.001","url":null,"abstract":"Objective \u0000To study the maturation and activation effects of hyaluronic acid (HA) modified polymer nanoparticles co-delivering adjuvants and antigens on mouse bone marrow dendritic cells (BMDCs). \u0000 \u0000 \u0000Methods \u0000HA-modified polylactic acid-glycolic acid copolymer (PLGA) and cationic lipid DOTAP were used as nanocarriers (DOTAP-PLGA) to co-deliver adjuvant CpG with model antigen ovalbumin (OVA). In the drug-loaded nanocarriers, CpG was covalently bound to the surface of HA, and OVA was physically blended into DOTAP-PLGA nanocarriers. The nanoparticles were characterized by transmission electron microscopy and dynamic light scattering. The in vitro release of CpG and OVA in the nanoparticles was investigated. The uptake and distribution of nanoparticles in mouse BMDCs were studied by flow cytometry and laser scanning confocal microscopy. The maturation and cytokine expression of mouse BMDCs were evaluated by flow cytometry and enzyme-linked immunosorbent assay, respectively. \u0000 \u0000 \u0000Results \u0000The CpG-HA-OVA-PLGA nanoparticles loading CpG and OVA were prepared. The average particle size was (305.1±2.2) nm and the polydispersity index was 0.203. A core-shell structure of the nanoparticles modified by HA was clearly observed by transmission electron microscopy. Cellular experiment results showed that CpG-HA-OVA-PLGA nanoparticles could be efficiently uptaken by mouse BMDCs, and promote lysosomal release of CpG and cytoplasmic delivery of antigen OVA. Compared with free OVA group and free OVA+CpG group, the CpG-HA-OVA-PLGA nanoparticles significantly up-regulated the expression of co-stimulatory molecules CD86 and CD40 (all P<0.01), major histocompatibility complex I (MHC-I) (P<0.01), and cytokine tumor necrosis factor-α (TNF-α) (P<0.01). \u0000 \u0000 \u0000Conclusions \u0000HA-modified CpG and OVA nanoparticle co-delivery vectors can effectively promote the maturation and activation of dendritic cells, which provides a basis for the development of novel vaccine vectors for the co-delivery of antigens and adjuvants. \u0000 \u0000 \u0000Key words: \u0000Nanoparticles; Co-delivery; CpG; Antigen; Dendritic cells","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"373-379"},"PeriodicalIF":0.0,"publicationDate":"2018-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48702303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress of application of dexmedetomidine in cancer treatment","authors":"Yajing Yuan, Li-Ming Xu, Hong Zhao","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.04.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.04.017","url":null,"abstract":"Cancer is a serious disease threatening human life and social development, and has become one of the most important medical and health problems in the world. As the changing of disease patterns change and the trending of aging population, the burden of cancer patients is increasing in China. In clinical practice, various anesthesia methods are indispensable to complete surgery, invasive examinations and other operations. Therefore, safe and effective narcotic analgesic for cancer patients is the key factor for successful completion of examination and treatment. Dexmedetomidine (Dex) is a novel α2-adrenergic receptor agonist. Comparing with traditional opioids, Dex is more effective and safer, and can provide sedation, anxiolytic and analgesia after administration. In this paper, the progress of the usage of Dex in cancer patients was summarized to guide clinical treatment programs. \u0000 \u0000 \u0000Key words: \u0000Dexmedetomidine; Application; Sedation; Analgesia; Anxiolysis","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"365-370"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45888797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of the biomechanics in the rotational manipulation treatment of cervical spondylotic radiculopathy","authors":"Yuan-dong Li, Ping Wang, Aifeng Liu, Jun-tao Zhang, Jin Su, Jiayu Li, Yong-Shao Chen","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.04.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.04.016","url":null,"abstract":"Cervical spondylotic radiculopathy is a common and frequently-occurring disease in the clinical department of orthopedics. It has the highest incidence of cervical spondylosis and has been classified as a difficult disease by the World Health Organization. Cervical spondylotic radiculopathy mainly manifests as root symptoms and signs consistent with the diseased segment, and the symptoms of stiffness, pain and numbness, which seriously affect the physical and mental health and life quality of patients. In clinical practice, the symptoms of cervical spondylotic radiculopathy can be alleviated by physical therapy, acupuncture, etc. Therefore, searching for more effective treatments has become a hot topic of current researches. Manipulations have the advantages of simple operation, quickness, quick effect and high recognition degree, and can achieve therapeutic purpose by improving the dynamic and static balance of cervical spines, correcting joint dislocation and improving blood circulation. Among them, the curative effect of rotational manipulations is more remarkable. The researches on rotational manipulations by domestic and foreign scholars mainly focus on the in vitro and in vivo biomechanics of cervical spines, and the biomechanical researches on the rotational manipulation itself were different. At present, the mechanical research on the rotational manipulation is still in the development stage, and there is no clear conclusion on the similarities and differences of the mechanical parameters and their influence on the mechanical environment of the cervical spine. In this paper, the research progress of biomechanical properties of cervical spine rotational manipulation was summarized to provide a theoretical basis for the mechanism of the rotational manipulation treatment of cervical spondylotic radiculopathy. \u0000 \u0000 \u0000Key words: \u0000Rotational manipulations; Biomechanics; Cervical spondylotic radiculopathy","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"359-364"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43365631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of immunological checkpoints in esophageal cancer and their application","authors":"Wencheng Zhang","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.04.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.04.011","url":null,"abstract":"Tumor immune escape is one of the important reasons for tumor development. Immunological checkpoint molecules play a key role in tumor immune escape, and have attracted much attention in basic and clinical studies recently. Immune checkpoint molecules transmit inhibitory signal to anti-tumor immune cells and inhibit their activity through receptor/ligand interactions, thereby exerting anti-tumor function. Molecular expression of the immunological checkpoints of esophageal cancer is closely related to prognosis. At present, clinical trials of treating esophageal cancer using specific antibodies to block the immune checkpoint related signaling pathways are being widely carried out and show some initial effects. However, there are still some patients who are resistant to this treatment. As a result, it is urgent to find novel biomarkers that can accurately predict the therapeutic effects of anti-tumor immunotherapy for esophageal cancer. In this paper, the researches on esophageal cancer immunological checkpoints and its clinical application were reviewed from four aspects, including the immune checkpoint molecules and their antibodies, the relationship between the expression of esophageal cancer immunological checkpoints and the prognosis, the clinical trials of esophageal cancer immunotherapy and novel biomarkers for predicting the efficacy. It is expected to provide new ideas for further researches on the molecular mechanism of immune escape of esophageal cancer, immunotherapy of esophageal cancer and the combination of various treatments. \u0000 \u0000 \u0000Key words: \u0000Esophageal cancer; Immunological checkpoint molecule; Immunotherapy","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"331-335"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47375557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of lung tumor cells using RFP and Fluc dual-labeled system","authors":"Xin Gao, Bin Yang, Panjian Wei, Xiao-jue Wang, Hongtao Zhang","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.04.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.04.001","url":null,"abstract":"Objective \u0000To establish a human lung cancer cell line that can stably express firefly luciferase (Fluc) and red fluorescent protein (RFP) gene so as to lay the foundation for the further establishment of a live-imaging lung cancer xenograft model in nude mice and therapeutic research. \u0000 \u0000 \u0000Methods \u0000The lentiviral vector pHBLV-Fluc-RFP containing luciferase and red fluorescent protein was constructed and then transfected into 293T cells for virus packaging. The complete virus was used to infect human lung cancer cell lines A549, H1975 and human B-cell lymphoma cell line K562. The stable cell lines were obtained by puromycin selection. Fluorescence microscopy and quantitative PCR were used to confirm the RFP and Fluc expression. \u0000 \u0000 \u0000Results \u0000The lentiviral vector pHBLV-Fluc-RFP was successfully constructed. Cancer cell line A549, H1975 and K562 stably expressing Fluc and RFP was obtained. The real-time quantitative PCR results showed that the relative expression of Fluc gene in the three stable infected cells was much higher than that in the corresponding wild-type cells, and the differences were statistically significant(all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The human lung cancer cell line A549, H1975 and human B-cell lymphoma cell line K562 with dual expression of RFP and Fluc were obtained, which provided a new model of fluorescent cells for in vivo imaging of immunodeficient mouse models such as nude mice. \u0000 \u0000 \u0000Key words: \u0000Red fluorescent protein; Firefly luciferase; Lentivirus; Lung cancer cell fluorescence model","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"281-285"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47288984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages and feasibility of intraperitoneal insulin delivery","authors":"Ting Xia, Gao Guanxin, Xiao Huilin, H. Zhang, Yang Tao, Yue-ting Li, Jian Zhong, Hongfan Sun","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.04.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.04.015","url":null,"abstract":"Under normal conditions, insulin secreted by the pancreas enters the liver through the portal vein, forming a difference in insulin concentration above the peripheral circulation. Subcutaneous administration of insulin forms a portal-peripheral concentration gradient of insulin above the liver, which is inconsistent with normal physiological conditions. Intraperitoneal insulin administration has been extensively investigated because that is closer to physiological state. In this paper, the pharmacokinetic and pharmacodynamic studies of insulin intraperitoneal administration were reviewed. Compared with the conventional subcutaneous delivery, intraperitoneal insulin administration can not only reduce the incidence of hypoglycemia, but also has the advantage of correcting abnormal lipid metabolism. This means that intraperitoneal administration of insulin has a positive effect on the prevention and treatment of diabetic complications. Therefore, it is necessary and feasible to develop a safe, low-cost, and easy-to-use percutaneous intraperitoneal insulin delivery device. \u0000 \u0000 \u0000Key words: \u0000Insulin; Intraperitoneal delivery; Lipid metabolism; Diabetes","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"354-358"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44825952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation technology of oyster hydroxyapatite porous material for bone repair","authors":"Q. Xue, Yongzhen Xing, Qiqing Zhang","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.04.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.04.003","url":null,"abstract":"Objective \u0000To verify the feasibility of applying hydrothermal synthesis for preparing oyster hydroxyapatite(HA) and to develop a preparation method of oyster HA porous material for bone repair. \u0000 \u0000 \u0000Methods \u0000Hydrothermal synthesis was applied for preparing oyster HA, and the reaction condition was 220 ℃ for 6 h. Then, the prepared oyster HA was used as the raw material for porous scaffold preparation by sponge-soaking and sintering, successively. The porosity and compressive strength of the scaffold were adjusted by controlling the soaking time and absorbed HA slurry of the sponges. \u0000 \u0000 \u0000Results \u0000Hydrothermal synthesis was an effective method for preparing oyster HA. When the volume of the sponge cube was 1 cm3, the material absorbed by one to three times sponge-soaking were 0.184 8 g, 0.318 1 g and 0.426 1 g, respectively, the corresponding porosity were 91.5%, 82.9% and 78.5%, and the compressive strength were 1.06 MPa, 3.99 MPa and 8.49 MPa. \u0000 \u0000 \u0000Conclusion \u0000The oyster shell powder can be effectively converted into HA under the hydrothermal reaction condition of 220 ℃ for 6 h. The preparation of HA porous bone repair material by sponge-soaking method can obtain ideal porosity and mechanical strength. However, in this preparation process, the number of sponge-soaking and the weight of the absorbed HA slurry should be exactly controlled in order to obtain desired properties. \u0000 \u0000 \u0000Key words: \u0000Oyster shell; Hydroxyapatite; Bone repair material; Porosity; Compressive strength","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"291-295"},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41791981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}