空腹呼吸丙酮在糖尿病筛查中的应用

L. Jing, Qingyuan Li, Yukai Ai, Yuan Yuan, Meixiu Sun, Yingxin Li, Chuji Wang
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引用次数: 0

摘要

目的研究糖尿病患者和健康人空腹呼气中丙酮的浓度分布,探讨各项指标对空腹呼气丙酮浓度的影响,探讨空腹呼气丙酮各项指标在糖尿病筛查中的作用。方法采用基于腔衰荡光谱(CRDS)的实时在线呼吸丙酮分析仪,对265名健康人、39名1型糖尿病(T1D)患者和300名2型糖尿病(T2D)患者进行空腹呼气丙酮浓度测定。使用SPSS 19.0软件消除异常值,并对相应的性别、年龄、身高、体重、体重指数(BMI)和血糖浓度(BGL)进行相关统计分析。采用受试者工作特性(ROC)曲线评价空腹呼吸丙酮浓度对糖尿病的诊断价值。结果T1D患者平均空腹呼吸丙酮浓度为(2.24±1.43),但T2D诊断的准确性较低(无统计学意义)。关键词:糖尿病;呼吸丙酮;腔衰荡光谱学
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of fasting breath acetone in diabetes screening
Objective To study the concentration distribution of acetone in fasting exhaled breath in diabetic patients and healthy subjects, to explore the effect of individual indexes on the concentration of acetone in fasting exhaled breath, and to study the role of individual indexes of fasting exhaled breath acetone in diabetes screening. Methods The acetone concentration measurements of fasting exhaled breath were performed on 265 healthy subjects, 39 patients with type 1 diabetes (T1D), and 300 patients with type 2 diabetes (T2D) using real-time online respiratory acetone analyzer based on cavity ring-down spectroscopy (CRDS). SPSS 19.0 software was used to eliminate outliers, and relevant statistical analysis was carried out with the corresponding gender, age, height, body mass, body mass index (BMI) and blood glucose concentration (BGL). The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of fasting breath acetone concentration for diabetes diagnosing. Results The mean fasting breath acetone concentration in T1D patients was (2.24±1.43)×10-6 was significantly higher than (1.43±0.55)×10-6 in healthy subjects and (1.41±0.73)×10-6 in T2D patients, and the differences were statistically significant (all P 0.05). Conclusions The detection of fasting breath acetone concentration is meaningful for T1D diagnosing, but has a low accuracy for T2D diagnosing (no statistically significant). Key words: Diabetes; Breath acetone; Cavity ringdown spectroscopy
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