L. Jing, Qingyuan Li, Yukai Ai, Yuan Yuan, Meixiu Sun, Yingxin Li, Chuji Wang
{"title":"空腹呼吸丙酮在糖尿病筛查中的应用","authors":"L. Jing, Qingyuan Li, Yukai Ai, Yuan Yuan, Meixiu Sun, Yingxin Li, Chuji Wang","doi":"10.3760/CMA.J.ISSN.1673-4181.2018.06.003","DOIUrl":null,"url":null,"abstract":"Objective \nTo study the concentration distribution of acetone in fasting exhaled breath in diabetic patients and healthy subjects, to explore the effect of individual indexes on the concentration of acetone in fasting exhaled breath, and to study the role of individual indexes of fasting exhaled breath acetone in diabetes screening. \n \n \nMethods \nThe acetone concentration measurements of fasting exhaled breath were performed on 265 healthy subjects, 39 patients with type 1 diabetes (T1D), and 300 patients with type 2 diabetes (T2D) using real-time online respiratory acetone analyzer based on cavity ring-down spectroscopy (CRDS). SPSS 19.0 software was used to eliminate outliers, and relevant statistical analysis was carried out with the corresponding gender, age, height, body mass, body mass index (BMI) and blood glucose concentration (BGL). The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of fasting breath acetone concentration for diabetes diagnosing. \n \n \nResults \nThe mean fasting breath acetone concentration in T1D patients was (2.24±1.43)×10-6 was significantly higher than (1.43±0.55)×10-6 in healthy subjects and (1.41±0.73)×10-6 in T2D patients, and the differences were statistically significant (all P 0.05). \n \n \nConclusions \nThe detection of fasting breath acetone concentration is meaningful for T1D diagnosing, but has a low accuracy for T2D diagnosing (no statistically significant). \n \n \nKey words: \nDiabetes; Breath acetone; Cavity ringdown spectroscopy","PeriodicalId":61751,"journal":{"name":"国际生物医学工程杂志","volume":"41 1","pages":"475-481"},"PeriodicalIF":0.0000,"publicationDate":"2018-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application of fasting breath acetone in diabetes screening\",\"authors\":\"L. Jing, Qingyuan Li, Yukai Ai, Yuan Yuan, Meixiu Sun, Yingxin Li, Chuji Wang\",\"doi\":\"10.3760/CMA.J.ISSN.1673-4181.2018.06.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo study the concentration distribution of acetone in fasting exhaled breath in diabetic patients and healthy subjects, to explore the effect of individual indexes on the concentration of acetone in fasting exhaled breath, and to study the role of individual indexes of fasting exhaled breath acetone in diabetes screening. \\n \\n \\nMethods \\nThe acetone concentration measurements of fasting exhaled breath were performed on 265 healthy subjects, 39 patients with type 1 diabetes (T1D), and 300 patients with type 2 diabetes (T2D) using real-time online respiratory acetone analyzer based on cavity ring-down spectroscopy (CRDS). SPSS 19.0 software was used to eliminate outliers, and relevant statistical analysis was carried out with the corresponding gender, age, height, body mass, body mass index (BMI) and blood glucose concentration (BGL). The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of fasting breath acetone concentration for diabetes diagnosing. \\n \\n \\nResults \\nThe mean fasting breath acetone concentration in T1D patients was (2.24±1.43)×10-6 was significantly higher than (1.43±0.55)×10-6 in healthy subjects and (1.41±0.73)×10-6 in T2D patients, and the differences were statistically significant (all P 0.05). \\n \\n \\nConclusions \\nThe detection of fasting breath acetone concentration is meaningful for T1D diagnosing, but has a low accuracy for T2D diagnosing (no statistically significant). \\n \\n \\nKey words: \\nDiabetes; Breath acetone; Cavity ringdown spectroscopy\",\"PeriodicalId\":61751,\"journal\":{\"name\":\"国际生物医学工程杂志\",\"volume\":\"41 1\",\"pages\":\"475-481\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-12-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际生物医学工程杂志\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.06.003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际生物医学工程杂志","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-4181.2018.06.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Application of fasting breath acetone in diabetes screening
Objective
To study the concentration distribution of acetone in fasting exhaled breath in diabetic patients and healthy subjects, to explore the effect of individual indexes on the concentration of acetone in fasting exhaled breath, and to study the role of individual indexes of fasting exhaled breath acetone in diabetes screening.
Methods
The acetone concentration measurements of fasting exhaled breath were performed on 265 healthy subjects, 39 patients with type 1 diabetes (T1D), and 300 patients with type 2 diabetes (T2D) using real-time online respiratory acetone analyzer based on cavity ring-down spectroscopy (CRDS). SPSS 19.0 software was used to eliminate outliers, and relevant statistical analysis was carried out with the corresponding gender, age, height, body mass, body mass index (BMI) and blood glucose concentration (BGL). The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of fasting breath acetone concentration for diabetes diagnosing.
Results
The mean fasting breath acetone concentration in T1D patients was (2.24±1.43)×10-6 was significantly higher than (1.43±0.55)×10-6 in healthy subjects and (1.41±0.73)×10-6 in T2D patients, and the differences were statistically significant (all P 0.05).
Conclusions
The detection of fasting breath acetone concentration is meaningful for T1D diagnosing, but has a low accuracy for T2D diagnosing (no statistically significant).
Key words:
Diabetes; Breath acetone; Cavity ringdown spectroscopy