中华结核和呼吸杂志最新文献

{"title":"[A case report of delayed drug hypersensitivity reaction caused by inhalation and nasal spray of budesonide].","authors":"Q Y Xu, L S Li, Y Y Xu, K Guan","doi":"10.3760/cma.j.cn112147-20250403-00181","DOIUrl":"https://doi.org/10.3760/cma.j.cn112147-20250403-00181","url":null,"abstract":"<p><p>Inhaled and intranasal corticosteroids are widely used in the management of allergic respiratory diseases. Delayed drug hypersensitivity reactions to budesonide are a rare adverse drug reaction characterized by non-immunoglobulin E (IgE)-mediated clinical manifestations, including localized or systemic contact dermatitis, mucosal edema, and paradoxical worsening of pre-existing symptoms. However, such reactions are often underdiagnosed due to atypical presentations. Here, we reported a patient with bronchial asthma and allergic rhinitis who developed a fever accompanied by lip and nasal swelling 12 hours after using a budesonide/formoterol powder inhaler and a budesonide nasal spray. The diagnosis of budesonide-induced delayed hypersensitivity was confirmed through skin prick testing, intradermal testing, patch testing, and drug provocation testing. This case underscores the role of integrating multiple diagnostic modalities in evaluating suspected drug hypersensitivity reactions. Our findings highlighted the need for clinical vigilance regarding the potential sensitizing effects of inhaled/intranasal corticosteroids and offered valuable insights into the individualized diagnosis and management of patients with similar allergic profiles.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 9","pages":"848-852"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on mechanical properties of through-the-scope airway stents and complications caused by TTS airway stents in rabbits trachea].","authors":"Z Y Yang, Z Y Liu, Y Y Xing, J Zhang, X X Li, C G Wang, J Y Wei, D X Zeng, J H Jiang","doi":"10.3760/cma.j.cn112147-20250205-00060","DOIUrl":"https://doi.org/10.3760/cma.j.cn112147-20250205-00060","url":null,"abstract":"<p><p>The TTS(through-the-scope)airway stent is a novel self-expanding nitinol alloy metal stent. Its structure and method of implantation differ significantly from those of the traditional OTW(over-the-wire)stent. In this study, we compared the mechanical properties of the TTS and OTW stents, and both of which were implanted into the tracheas of rabbits to compare the differences in complications caused by these two types of stents. The results indicate that the radial force of the TTS stent is stronger than, or at least comparable to, that of the OTW stent, and that the TTS stent has superior axial compliance. Both TTS and OTW stent can trigger airway inflammatory responses, and the incidence of stent-related complications caused by TTS and OTW stents is similar. However, the degree of granulation tissue hyperplasia caused by TTS stent is less than that caused by the OTW stent.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 9","pages":"838-844"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cough frequency monitoring: current technologies and clinical research applications].","authors":"J X Xie, K F Lai","doi":"10.3760/cma.j.cn112147-20250313-00139","DOIUrl":"https://doi.org/10.3760/cma.j.cn112147-20250313-00139","url":null,"abstract":"<p><p>Cough is a common symptom of many respiratory diseases, and parameters such as frequency, intensity, type and duration play important roles in disease screening, diagnosis and prognosis. Among these, cough frequency is the most widely applied metric. In current clinical practice, cough severity is primarily assessed based on patients' subjective symptom descriptions in combination with semi-structured questionnaires. In spite of convenience, this paradigm is inherently limited by recall bias and poor quantifiability. This results in only moderate correlation with objective cough assessments. Over the past two decades, rapid developments in signal processing, mobile communication, speech recognition, and artificial intelligence have enabled the objective measurement of cough frequency in clinical research. Objective cough frequency monitoring is now widely regarded as the gold standard for assessing cough severity. This review summarizes the principles and technologies of objective cough frequency monitoring, and outlines the characteristics and clinical research applications of currently available monitoring devices.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 9","pages":"880-887"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case report of tracheobronchial Dieulafoy's disease].","authors":"X Z Liu, W He, Y L Liu, H Y Dai, Q B Li, S L Guo","doi":"10.3760/cma.j.cn112147-20250706-00381","DOIUrl":"https://doi.org/10.3760/cma.j.cn112147-20250706-00381","url":null,"abstract":"<p><p>Tracheobronchial Dieulafoy's disease (TBDD) is a rare bronchial artery vascular malformation, characterized clinically by sudden, recurrent, and life-threatening massive hemoptysis. This article reports the case of a 9-year-old female patient who presented with massive hemoptysis lasting two weeks. Following ineffective treatment at a local hospital, she was transferred to our institution. Bronchoscopy revealed a smooth, submucosal protrusion at the orifice of the right lower lobe basal segment. Digital subtraction angiography (DSA) revealed tortuous bronchial arteries near the lesion, indicating a caliber-persistent artery malformation. Following embolization with Onyx, the patient's hemoptysis resolved, and follow-up bronchoscopy confirmed the disappearance of the lesion.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 9","pages":"860-862"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnosis and management of severe pneumonia secondary to acute respiratory distress syndrome and sepsis: a clinical mission for pulmonary and critical care medicine physicians].","authors":"L X Xie, Q Y Zhan, Z A Liang","doi":"10.3760/cma.j.cn112147-20250609-00308","DOIUrl":"https://doi.org/10.3760/cma.j.cn112147-20250609-00308","url":null,"abstract":"<p><p>Severe pneumonia is a common clinical respiratory disease that is frequently managed by physicians in the Department of Pulmonary and Critical Care Medicine (PCCM). The development of acute respiratory distress syndrome (ARDS) and sepsis are critical factors that contribute to the disease progression and a poor prognosis in severe pneumonia patients. As a key focus in the diagnosis and treatment of critical illnesses, the management of severe pneumonia leverages the strengths of the discipline for pulmonary and critical care physicians. Significant importance is placed on emphasizing early screening, timely diagnosis, and precise treatment, mastering critical care technologies, and improving the understanding and management of severe illnesses, for the advancement of the field.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 9","pages":"801-803"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Spontaneous remissive pulmonary sarcoidosis in a patient with a history of surgical resection of lung adenocarcinoma: a case report].","authors":"R X Chen, Y J Shi, Z Y Li, J Wang, C Shao, H Huang","doi":"10.3760/cma.j.cn112147-20250531-00294","DOIUrl":"https://doi.org/10.3760/cma.j.cn112147-20250531-00294","url":null,"abstract":"<p><p>Pulmonary patches with mediastinal lymphadenopathy could be showed in both lung cancer and sarcoidosis. There are certain similarities in their imaging manifestations, and histopathological examination is necessary for diagnosis. This article reports a case of a 62-year-old female patient who had a history of early-stage lung adenocarcinoma and underwent surgical treatment. She had been followed up regularly without signs of recurrence. More than three years after the surgery, she presented with a new solid pulmonary mass and mediastinal lymphadenopathy, without significant clinical symptoms. Lung cancer recurrence was clinically suspected. However, mediastinal lymph node biopsy guided by endobronchial ultrasound revealed nonnecrotizing epithelioid-cell granulomas. Given the patient's history of diabetes, the lack of significant respiratory manifestations, and no evidence of extrathoracic involvement of sarcoidosis, we decided to closely monitor the disease course after communicating with the patient. Follow-up CT scans after two months and four months showed spontaneous remission of the pulmonary lesion and mediastinal lymphadenopathy, which was diagnosed as spontaneous remission of sarcoidosis after the history of lung cancer.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 9","pages":"845-847"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Treatment of bronchopleural fistula after lung transplantation with platelet-rich plasma: a case report and literature review].","authors":"W J Yu, Z Q Su, J X Lin, W Q Xiao, L Y Lu, H Q Feng, C R Ju, S Y Li, X B Chen","doi":"10.3760/cma.j.cn112147-20240925-00566","DOIUrl":"10.3760/cma.j.cn112147-20240925-00566","url":null,"abstract":"<p><p>The bronchopleural fistula (BPF) is a serious complication following pulmonary surgery, characterized by an abnormal conduit connecting various levels of the bronchi to the pleural cavity. Natural healing of such a condition is notoriously difficult, and traditional therapeutic approaches exhibit significant limitations. In recent years, platelet-rich plasma (PRP) has shown remarkable efficacy in the treatment of chronic wounds. Consequently, we developed a protocol utilizing PRP for the management of BPF. This article presented a case study of a patient who was successfully treated for BPF using PRP therapy. We carefully observed their clinical data and conducted a comprehensive review of relevant literature. Literature searches were conducted using the keywords \"platelet rich plasma\" and \"bronchopleural fistula\" in CNKI, Wanfang Medical Network, and PubMed databases up to February 2024.Our literature review found three relevant articles; after careful assessment, two were kept due to their relevance, reporting on four cases in total. Combined with our current case, the cumulative number of documented cases for this condition was five. This extensive review showed that local injection of PRP via bronchoscopy was emerging as a safe and effective treatment modality worthy of further exploration for patients suffering from BPF.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 6","pages":"552-556"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Annual review of interventional pulmonology 2024].","authors":"Y S He, D F Chen, S Y Li","doi":"10.3760/cma.j.cn112147-20250218-00089","DOIUrl":"https://doi.org/10.3760/cma.j.cn112147-20250218-00089","url":null,"abstract":"<p><p>As an indispensable diagnostic and therapeutic pillar of respiratory medicine, interventional pulmonology has made transformative progress through technological convergence and precision innovation. Milestones in 2024 include robotic bronchoscopy systems, airway ablation techniques that redefine the management of peripheral lung cancer, and bronchoscopy-regenerative medicine synergy. Together, these advances are driving the field towards personalized intervention paradigms, enhancing both early disease detection and advanced therapeutic delivery in pulmonary medicine.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 6","pages":"573-577"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Bedaquiline susceptibility and molecular mutation characteristics of <i>Mycobacterium tuberculosis</i> in Guizhou Province].","authors":"M D Wang, F Q Xia, X J Cao, T T Ren, W Z Ou, X L Yang, W Qin, J Huang","doi":"10.3760/cma.j.cn112147-20250123-00050","DOIUrl":"https://doi.org/10.3760/cma.j.cn112147-20250123-00050","url":null,"abstract":"<p><p><b>Objective:</b> To detect the drug resistance of <i>Mycobacterium tuberculosis</i> (MTB) to the new drug bedaquiline (Bdq) and the mutations of drug resistance-related genes, and to analyze the correlation between drug resistance gene mutation types and drug resistance phenotypes. <b>Methods:</b> From January 2020 to December 2022, 521 strains of MTB identified by Guiyang Public Health Clinical Center were collected, including 253 drug-susceptible tuberculosis (DS-TB) strains and 268 multi-drug resistant tuberculosis (MDR-TB) strains. The conventional drug sensitivity of <i>Mycobacterium tuberculosis</i> and the minimum inhibitory concentration (MIC) of Bdq were detected by microplate method. At the same time, Sanger sequencing was used to identify the mutations of Bdq resistance-related genes <i>Rv0678</i>, <i>atpE</i> and <i>pepQ</i> in all strains, and the whole genome sequencing of Bdq-resistant strains was performed to analyze their drug resistance and molecular mutation characteristics. <b>Results:</b> The Bdq MIC of 521 clinical strains was mainly concentrated in the range of 0.016-0.12 mg/L. Bdq-resistant strains were only detected in MDR strains, with a drug resistance rate of 4.1% (11/268). Known Bdq resistance gene mutations were detected in 11 Bdq phenotype resistant strains, of which 10 were <i>Rv0678</i> gene mutations, 1 was <i>Rv0678</i> and <i>pepQ</i> gene mutations, and no <i>atpE</i> gene mutation was detected. There were 8 types of mutations in the <i>Rv0678</i> gene, including C151T (3/11), 19delG (2/11), G404A (1/11), T284C (1/11), C305T (1/11), G149A (1/11), T95C (1/11) and 201delG (1/11). Our survey found that only one of the 11 patients with Bdq resistance had a history of Bdq medication; moreover, the whole genome sequence analysis of Bdq-resistant strains found that 3 strains were clustered strains, suggesting that transmission is an important cause of Bdq resistance. <b>Conclusions:</b> Bdq had a strong antibacterial activity in the Guizhou region. Mutations in the <i>Rv0678</i> gene served as the primary determinant of Bdq resistance; and transmission played a significant role in the dissemination of Bdq-resistant strains. The findings highlight the need for Bdq resistance-associated genetic screening and transmission chain surveillance in the control of multidrug-resistant tuberculosis.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 6","pages":"519-526"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Severe pneumonia, intracranial infection, and reversible splenial lesion syndrome caused by <i>chlamydia psittacosis</i> infection].","authors":"Y H Li, Y X Zhao, P L Liu, Y Y Wang, C L Tian, Y J Dong, L J Zhang, G Chen","doi":"10.3760/cma.j.cn112147-20240809-00474","DOIUrl":"https://doi.org/10.3760/cma.j.cn112147-20240809-00474","url":null,"abstract":"<p><p>A patient with severe pneumonia, central nervous system infection, and reversible splenial lesion syndrome was described in this article. Metagenomic next-generation sequencing of bronchoalveolar lavage fluid and cerebrospinal fluid revealed <i>chlamydia</i> <i>psittacosis</i>. After treatment with minocycline, the patient was cured. His respiratory and neurological symptoms all disappeared.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 6","pages":"557-559"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}