Acupuncture and Herbal Medicine最新文献

{"title":"Exploring a novel class tryptophan hydroxylase 1 inhibitor derived from Sambucus williamsii Hance for the osteoporosis treatment","authors":"Yu-Xin Zhu, Zi-Ling Tang, Lu Lu, Zuo-cheng Qiu, Dabo Pan, Yang Yu, Hui-Hui Xiao, Man-Sau Wong","doi":"10.1097/hm9.0000000000000095","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000095","url":null,"abstract":"Gut-derived serotonin strongly inhibits bone formation by inhibiting osteoblast proliferation. Our previous study demonstrated that the lignan-rich fraction prepared from Sambucus willimasii Hance, a folk herbal medicine used to treat bone fractures and joint diseases in China, exerted bone-protective effects, and its actions were modulated by suppressing the synthesis of gut-derived serotonin via the inhibition of intestinal tryptophan hydroxylase 1 (TPH-1). However, there is no direct evidence for the action of lignans on TPH-1. This study aimed to verify the direct action of lignans on the TPH-1 and its influence on serotonin synthesis and bone properties. Molecular docking, surface plasmon resonance, TPH-1 protein activity, TPH-1 protein expression, mouse serum serotonin levels, and bone properties upon lignan treatment were determined. This is the first study to report that lignans are novel TPH-1 inhibitors and that these lignans could be potential agents for the management of serotonin-related diseases, including osteoporosis.","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"20 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139868956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of acupuncture in treating low back and pelvic girdle pain during pregnancy: A systematic review and meta-analysis of randomized controlled trials","authors":"Aolin Zhang, Junwei Li, Tao He, Hongliang Xie, Xuanting Mou, Tsz Ching Yeung, Siming Chen, Chi Chiu Wang, Xiaohui Fan, Lu Li","doi":"10.1097/hm9.0000000000000093","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000093","url":null,"abstract":"\u0000 \u0000 Low back and pelvic girdle pain (LBPGP) is common during pregnancy. Acupuncture is an effective and safe therapy for pain relief. However, further evidence is required to confirm the efficacy and safety of acupuncture in treating LBPGP during pregnancy.\u0000 \u0000 \u0000 \u0000 This study aimed to systematically review and investigate the clinical efficacy and safety of acupuncture for the treatment of pregnancy-related LBPGP.\u0000 \u0000 \u0000 \u0000 The PubMed, EMBASE, Cochrane Library, CNKI, VIP, and WanFang databases were searched from January 2000 to August 2023. Only the randomized controlled trials (RCTs) involving pregnant women between 16 and 34 weeks of gestation diagnosed with LBPGP were included in the study. A meta-analysis was conducted and pooled risk ratios (RRs) or mean differences (MDs) with 95% confidence intervals (CIs) were compared.\u0000 \u0000 \u0000 \u0000 Meta-analysis included 12 RCTs involving 1641 participants. Eleven trials compared acupuncture alone or acupuncture combined with standard care (SC), of which three trials also used nonpenetrating or placebo acupuncture as the control group. One trial compared acupuncture alone with nonpenetrating acupuncture. Compared with SC, acupuncture combined with SC group significantly decreased visual analog scale score (MD = −2.83, 95%CI = −3.41 to −2.26, P ＜ 0.00001), cesarean section rate (RR = 0.69, 95%CI = 0.49 to 0.97, P = 0.03), preterm birth rate (RR = 0.42, 95%CI = 0.27 to 0.65, P < 0.0001), labor duration (MD = −1.97, 95%CI = −2.73 to −1.20, P < 0.0001), and Oswestry disability index score (MD = −9.14, 95%CI = −15.68 to −2.42, P =0.008). In addition, acupuncture combined with SC significantly improved SF-PCS. No significant differences were observed in the spontaneous delivery rate, newborn weight, drowsiness, and SF-MSC between the two groups. Adverse events such as needle pain and needle bleeding were aggravated in both the SC and acupuncture treatment groups but none were associated with acupuncture during or after the treatment period.\u0000 \u0000 \u0000 \u0000 Meta-analysis showed that acupuncture combined with SC had better efficacy than SC alone and could be a potential therapy for LBPGP during pregnancy. The safety results imply that acupuncture caused few adverse reactions; however, more evidence is required for further confirmation.\u0000","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140492956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for ischemic stroke: Where are we now?","authors":"Weiming Zhu, Qingqing Jia, Alberto Cantidio Ferreira, Hailun Jiang, Jieying Zhang, Boxuan Li, Menglong Zhang, Bifang Zhuo, Yuanhao Lyu, Junjie Chen, Li Li, Guang Tian, Shizhe Deng, Zhihong Meng, Xuemin Shi","doi":"10.1097/hm9.0000000000000094","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000094","url":null,"abstract":"Acupuncture is an effective treatment for ischemic stroke (IS) and plays a key role in neurological rehabilitation after IS. Acupuncture can improve the clinical symptoms of various complications after IS, including motor dysfunction, swallowing disorders, speech disorders, cognitive impairment, depression, insomnia, and fatigue. However, the mechanisms underlying the effects of acupuncture in IS remain unclear. Available evidence suggests that acupuncture may exert neuroprotective effects through neuroplasticity (neurogenesis and synaptogenesis), angiogenesis, cell proliferation and apoptosis, and regulation of oxidative stress, inflammation, and immunity. Further studies should be conducted to improve the high-quality evidence-based system of acupuncture intervention for IS, by focusing on the clinical and basic research design, increasing the sample size, standardizing and quantifying the standards of acupuncture operations, using multidisciplinary techniques and methods to systematically explore the key targets of acupuncture intervention for IS, and reveal the efficacy and mechanism of acupuncture in the treatment of IS.","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140493349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress and key scientific problems of traditional Chinese moxibustion","authors":"Huan-Zhen Wu, Luyi Wu","doi":"10.1097/hm9.0000000000000091","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000091","url":null,"abstract":"","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139604270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture targeting the immune system to alleviate sepsis","authors":"Mengyue Fang, Yuye Lan, Man Li, Chennan Li, Bin Xu, Yan Ma, Ailing Chen, Xianghong Jing, Lingling Yu","doi":"10.1097/hm9.0000000000000092","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000092","url":null,"abstract":"Sepsis is a life-threatening inflammatory syndrome with high morbidity and mortality rates. However, options for sepsis are still limited to general treatment in intensive care units (ICUs), and effective therapies that improve sepsis survival are required. Immune disturbances play a vital role in the pathology of sepsis and are associated with protracted inflammation, susceptibility to infections, and death. Therefore, many investigators have focused on the potential benefits of immunomodulation therapy for sepsis. Electroacupuncture (EA) has been practiced in clinics for many years and has shown advantages in treating infectious diseases. Over the last few decades, our understanding of the efficacy and mechanisms of EA in sepsis has undergone considerable developments. We searched the literature regarding “CNKI, Wan Fang Data, VIP Database, PubMed, and Ingenta Connect” from 2010 to 2023, using the keywords \"sepsis,\" \"septic,\" and “electroacupuncture” and 336 sources were searched. Finally, we included 82 studies that targeted the immune system to determine EA’s anti-inflammatory and immunomodulatory effects on sepsis. In this review, we found that EA has clinical benefits in relieving septic inflammation, improving immune function, and attenuating related muti-organ injury through several mechanisms, such as activation of the cholinergic anti-inflammatory pathway (CAP), vagal-adrenal axis, inhibition of the nuclear factor Kappa-B (NF-κB) signaling pathway, signal transducers and activators of transcription (STAT) signaling pathway, and improvement of immune cell function. Therefore, EA may be a promising complementary therapy for sepsis treatment. We also expect these data will contribute to further studies on EA in sepsis.","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"29 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Effects of Volatile Oil from Chrysanthemum and Its Associated Mechanisms: A Review","authors":"Jing Zhang, Weiqiang Su, N. Filipczak, Ying Luo, Anping Wan, Yao He, Shijuan Yan, Xiang Li, Ming Yang","doi":"10.1097/hm9.0000000000000090","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000090","url":null,"abstract":"Volatile oil (VO) is the main chemical component of common plants in Chrysanthemum genus, and it possesses several beneficial pharmacological properties, including bacteriostatic, antioxidant, anti-tumor, anti-inflammatory, antipyretic, analgesic, anti-osteoporotic, antihypertensive, sedative, and hypnotic effects. To date, research on the effective components of Chrysanthemum extract has mainly focused on flavonoids, whereas limited data are available on the chemical constituents and underlying mechanisms of action of the VO components. In this review, the pharmacological activities and mechanisms of VO are comprehensively reviewed with the aim of providing a foundation for further development for medicinal, aromatherapy, and diet therapy applications.","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"11 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crocus sativus L. produces anti-inflammatory effects and regulates NLRP3–NF-κB pathway","authors":"Liang Yang, Huan hua Xu, Qian Hong, Nuo Xu, Yan Zhang, Rui Tao, Shuai Li, Zizheng Zhang, Jiahao Geng, Zihan Wang, Huizi Hu, Yan Dong, Zhaoyi Chu, Bin Zheng, Jinmiao Zhu, Ming Geng, Yue Gao","doi":"10.1097/hm9.0000000000000088","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000088","url":null,"abstract":"\u0000 \u0000 This study aimed to evaluate with local or systemic inflammatory models whether a petal or stamen extraction of the saffron crocus (C. sativus) confers anti-inflammatory effects, and explore the underlying mechanism.\u0000 \u0000 \u0000 \u0000 Local and systemic inflammatory models were used to explore the anti-inflammatory effects of C. sativus. In vivo, a xylene-induced inflammation model or lipopolysaccharide (LPS)-induced inflammation model was used. C. sativus petal and stamen extracts were each administered to the mice in the xylene and LPS models by gavage for 14 days at doses of 0.1 and 0.4 g/kg, respectively. ELISA was used to measure the concentration of TNF-α and IL-1β in mouse serum. HE staining was used to observe pathological changes in the ear in the xylene-induced inflammation model and spleen in the LPS-induced inflammation model. The level of NLRP3 protein in the NF-κB pathway was evaluated with western blot assay. RAW264.7 cells were treated with LPS (5 μg/mL) and LPS + C. sativus (0.05, 0.1, and 0.2 mg/mL) for 24 h, and Cell Counting Kit-8 was used to measure the cell proliferation. The change of NLRP3 and NF-κB in protein level were evaluated with western blot.\u0000 \u0000 \u0000 \u0000 Petal and stamen extractions of C. sativus attenuated the anti-inflammatory effects in local or systemic inflammatory models, repaired the pathological changes in the ear in the xylene-induced inflammation model or spleen in the LPS-induced inflammation model, and decreased the concentration of TNF-α and IL-1β in mouse serum in the LPS-induced inflammation model. C. sativus downregulated the protein level of NLRP3 through the NF-κB pathway, and also downregulated LC-3 and beclin-1, in vivo and in vitro. After the addition of CCCP, the effects of C. sativus on the NLRP3–NF-κB pathway were weakened.\u0000 \u0000 \u0000 \u0000 \u0000 C. sativus produces anti-inflammatory effects and regulates the NLRP3-NF-κB pathway.\u0000","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":" 789","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139617605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of traditional, complementary and alternative medicine with modern biomedicine: The scientization, evidence, and challenges for integration of Traditional Chinese medicine","authors":"Zihao Zhang, Raorao Li, Yu Chen, Hui Yang, Martin Fitzgerald, Qiaochu Wang, Ziwen Xu, Nanxi Huang, Dajun Lu, Lu Luo","doi":"10.1097/hm9.0000000000000089","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000089","url":null,"abstract":"Traditional medicine has garnered significant global recognition, with an estimated 80% of the global population using it. Therefore, it is essential to fully understand the integration of traditional medicines into current healthcare systems. This review aims to provide a comprehensive overview of the standard process to modernize traditional medicine scientifically in the context of modern biomedicine, further termed here as “scientization.” Specifically, we aim to summarize the advancements made in understanding the efficacy, effectiveness, and underlying mechanisms of herbal medicine. We also examined the transition from experience-to evidence-based medicine during acupuncture. Furthermore, we explore the development of universal safety and quality control standards. Finally, we discuss international trade and export markets for Chinese medical products. The development and integration of traditional medicine have allowed it to further improve human health, resulting in a more comprehensive health solution for the global population.","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139617205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review of azadirachtin: physicochemical properties, bioactivities, production, and biosynthesis","authors":"Xinyao Su, Zhipeng Liang, Qiang Xue, Jia Liu, Xuemi Hao, Caixia Wang","doi":"10.1097/HM9.0000000000000086","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000086","url":null,"abstract":"Azadirachtin, a complex tetratriterpenoid limonin with potent insecticidal properties, is the most widely used biological pesticide worldwide. Its versatile pharmacological applications include the inhibition of tumor growth and anti-malarial, anti-bacterial, and anti-inflammatory properties. Azadirachtin plays a pivotal role in pest control and novel drug development. The primary source of azadirachtin is the neem tree (Azadirachta indica A. Juss), with an azadirachtin content ranging from 0.3% to 0.5%. Despite the market demand for botanical pesticides reaching approximately 100,000 tons per year, the annual neem production in China is only 1.14 tons. Although azadirachtin can be obtained through plant extraction or chemical synthesis, the quantity obtained does not meet the market demand in China. The sluggish pace of azadirachtin biosynthesis results from the limited availability of genetic information and the complexity of the synthetic pathway. Recent advancements in azadirachtin biosynthesis hold promise as an efficient collection method. In this study, we explored the physicochemical properties, biological activities, mechanisms of action, and acquisition methods of azadirachtin. We also delved into recent progress in azadirachtin biosynthesis and assessed potential future usage challenges. This study aims to establish a theoretical foundation for the scientific application and efficient synthesis of azadirachtin, offering valuable reference information to the industry.","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"33 5","pages":"256 - 270"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139189919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}