Acupuncture and Herbal Medicine最新文献

{"title":"Clinical Research Report on Traditional Chinese patent medicines and Traditional Chinese Classic Famous Prescriptions (2022)","authors":"Danlei Wang, Haiyin Hu, Yucong Ma, Dehui Peng, Junhua Zhang, Alice Josephine Fauci, Zhaochen Ji","doi":"10.1097/hm9.0000000000000122","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000122","url":null,"abstract":"\u0000 \u0000 To comprehensively summarize and analyze the basic situation and methodological quality of clinical randomized controlled trials (RCTs) of Chinese and English traditional Chinese patent medicines and traditional Chinese classic famous prescriptions published in 2022, to provide evidence and reasonable suggestions for the advancement of clinical research and the formulation of policies and guidelines.\u0000 \u0000 \u0000 \u0000 The Evidence Database System of clinical evidence-based evaluation of traditional Chinese medicine was searched, and data from China National Knowledge Infrastructure (CNKI), PubMed, and other databases were supplemented. The search duration was from January 1, 2022, to December 31, 2022. RCTs of traditional Chinese patent medicines and traditional Chinese classic famous prescriptions were included as the source of clinical evidence, and published information, sample size, intervention, control measures, treatment course, methodological quality and key link report were analyzed and evaluated.\u0000 \u0000 \u0000 \u0000 A total of 1,464 RCTs of traditional Chinese patent medicines were included, which included 667 types of traditional Chinese patent medicines; \"traditional Chinese patent medicines+Western medicine vs. Western medicine\" was the most widely used intervention and control setting, involving 417 RCTs(28.48%). A total of 245 RCTs of traditional Chinese classic famous prescriptions were included, including 55 types of traditional Chinese classic famous prescriptions. \"Decoction+ conventional treatment vs. conventional treatment\" was the most widely used intervention and control setting, with 87 RCTs (35.51%). Published RCTs on traditional Chinese patent medicines and traditional Chinese classic famous prescriptions were limited by the study design and implementation. Most “allocation concealment” and “blinding of patients and personnel” were rated as medium to high risk,There are insufficient reports on key research links such as experimental registration and ethical approval.\u0000 \u0000 \u0000 \u0000 The number of RCTs on traditional Chinese patent medicines has decreased in 2022, but there has been a slight improvement in the research quality and impact. There are relatively few studies on traditional Chinese classic famous prescriptions. Measures must be taken to improve clinical trial design, implementation, and reporting. Methodological experts should be invited to provide professional technical guidance on the trial design. In the research implementation process, attention should be paid to quality control, particularly the standardization of the randomized execution.\u0000","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"19 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141350817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Pharmacology and Bioinformatics Analysis identify potential therapeutic effects of Berberine on Colon Cancer complicated with Radiation Enteritis","authors":"Ziqiao Yan, Hongyang Yu, Liangliang Zhang, Zebin Liao, Xiangwei Ge, Yu-guo Wang, Peiyu Tian, Zhexin Ni, Yongqi Dou, Yue Gao","doi":"10.1097/hm9.0000000000000121","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000121","url":null,"abstract":"\u0000 \u0000 Patients with colon adenocarcinoma (COAD) who undergo radiation therapy develop radiation enteritis (RE). The predictive value of RE in COAD is yet to be established. Berberine, an active compound derived from the traditional Chinese medicinal plant, Coptis chinensis, has notable anti-inflammatory properties and offers protection to the intestinal mucosa. This study aimed to evaluate the possible therapeutic effect and mechanism of berberine as a treatment for COAD complicated with RE (COAD&RE).\u0000 \u0000 \u0000 \u0000 Relevant genetic features of diverse COAD&RE populations were analyzed using bioinformatics and the Cox proportional hazards regression model. The therapeutic targets of berberine were predicted using network pharmacology and molecular docking. In vivo and in vitro experiments were conducted to validate the core genes identified using molecular docking.\u0000 \u0000 \u0000 \u0000 RE has a certain impact on the prognosis of COAD and berberine may play an important role in the treatment of COAD&RE. In addition, we identified five core therapeutic targets of berberine by network pharmacology and molecular docking: CCND1, MYC, AR, LEP, and CYP19A1. In vivo experiments showed that berberine increased short-term survival rate, body weight, and intestinal epithelial cell recovery in mice after radiation. In an in vitro study, berberine promoted the proliferation of human intestinal epithelial cells and enhanced the radiosensitivity of HT29 cells after radiation, and the relative mRNA expression levels of CCND1 and MYC closely correlated with these effects.\u0000 \u0000 \u0000 \u0000 This study predicted the potential therapeutic effects of berberine on COAD&RE and verified the relevant mechanisms, which may provide insights and suggestions for the clinical treatment of COAD&RE.\u0000","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"9 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141354245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Hemerocallis citrina extracts ameliorate radiation-induced ferroptosis in LO2 cells through the Nrf2-xCT/GPX4 pathway","authors":"Zihao Zhu, Yan Wang, Zhengzheng Deng, Pengyuan Lei, Qi Liu, Jingjing Guo, Qiancheng Qing, Bo Huang","doi":"10.1097/hm9.0000000000000120","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000120","url":null,"abstract":"\u0000 \u0000 Radiotherapy, a primary approach in cancer treatment, damages normal cells while targeting cancer cells. Therefore, it is crucial to identify drugs with minimal side effects, high reliability, and radioprotective effects to develop novel radiotherapy strategies. Hemerocallis citrina extracts (HCE), which are derived from plants with medicinal and culinary applications, possess antioxidative and anticancer properties.\u0000 \u0000 \u0000 \u0000 In this study, we investigated the radioprotective effects of HCE on LO2 cells exposed to radiation to determine whether these effects were mediated through the nuclear factor erythroid 2-related factor 2-cystine–glutamate antiporter/glutathione peroxidase 4 pathway.\u0000 \u0000 \u0000 \u0000 Cell proliferation experiments demonstrated the radioprotective effect of HCE on LO2 cells. Western blot analysis revealed that HCE regulated B-cell lymphoma protein 2-associated X, Cleaved-caspase 3, and B-cell lymphoma protein 2, thereby inhibiting radiation-induced apoptosis, which was consistent with the flow cytometry results.\u0000 \u0000 \u0000 \u0000 Moreover, the detection of ferroptosis-related markers indicated that HCE alleviated radiation-induced ferroptosis in LO2 cells through the nuclear factor erythroid 2-related factor 2-cystine–glutamate antiporter/glutathione peroxidase 4 pathway. These findings provide a theoretical basis for the radioprotective effects of HCE on LO2 cells and offer new insights into the development of radioprotective drugs.\u0000 Graphical abstract: http://links.lww.com/AHM/A122.\u0000","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"33 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The King of Chinese Medicine——Glycyrrhiza glabra (Licorice): All-round Inquiry in its Chemical Composition, Pharmacodynamics, Traditional and Medicinal Value","authors":"Lingling Dang, Yajing Jin, Ye Yuan, Rui Shao, Yu Wang","doi":"10.1097/hm9.0000000000000103","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000103","url":null,"abstract":"Licorice, a perennial herb of Leguminosa, is one of the oldest and most widely used herbal medicines worldwide. Its distinct sweet flavor and rich medicinal value make it an integral component of traditional Chinese medicine (TCM) formulations, which continue to be widely employed. The main chemical constituents of licorice include triterpenoid saponins, flavonoids, and polysaccharides. Experimental and clinical studies have demonstrated that various extracts and pure compounds derived from licorice exhibit a wide range of pharmacological properties including anti-inflammatory, antioxidant, antimicrobial, antiviral, antitumor, immune-regulatory, and neuroprotective activities. The bioactive constituents of licorice offer therapeutic benefits for cardiovascular and cerebrovascular diseases, diabetes mellitus, and liver disorders. This comprehensive review discusses the primary chemical constituents of licorice and their pharmacological activities, describes in vivo and in vitro models employed for studying licorice, and its potential targets and mechanisms of action. Furthermore, we discuss the toxicological profile, side effects, dosage recommendations, and clinical applications of licorice. This review aims to establish a foundation for further research on the safe and effective utilization of licorice while facilitating an in-depth exploration of its properties and fostering the development of novel therapeutic agents.\u0000 Graphical abstract: http://links.lww.com/AHM/A102\u0000","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"159 14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celastrol promotes apoptosis of breast cancer MDA-MB-231 cells by targeting HSDL2","authors":"Li Liu, Yanqing Liu, Shujie Zhang, Junzhe Zhang, Yuqing Meng, Dandan Liu, Liwei Gu, Ying Zhang, Liting Xu, Ziyue Zhang, Minghong Zhao, Yinkwan Wong, Qixin Wang, Yongping Zhu, Jigang Wang","doi":"10.1097/hm9.0000000000000102","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000102","url":null,"abstract":"\u0000 \u0000 Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicinal herb, Tripterygium wilfordii. This study aimed to provide a scientific basis for the rational development and use of celastrol in breast cancer.\u0000 \u0000 \u0000 \u0000 A quantitative chemical biology approach was used to investigate the protein targets and molecular mechanisms of celastrol in breast cancer cells.\u0000 \u0000 \u0000 \u0000 Low-concentration celastrol exerted an anti-tumor effect by directly binding to hydroxysteroid dehydrogenase-like 2 (HSDL2) and inhibiting its expression. Moreover, the expression of the pro-apoptotic protein, BaX, increased, the level of the anti-apoptotic protein, Bcl-2, decreased, and the rate of apoptosis increased. After the transfection of cells with si-HSDL2, the apoptosis rate was similar to that observed after the administration of celastrol. However, apoptosis was reversed by the overexpression of HSDL2. Furthermore, our MS (Mass Spectrometry) data indicated a relationship between HSDL2 and the MAPK signaling pathway. We also found that the expression of HSDL2 was directly related to the degree of ERK phosphorylation.\u0000 \u0000 \u0000 \u0000 Celastrol may promote apoptosis by suppressing the HSDL2/ MAPK/ERK signaling pathway.\u0000","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"724 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140446429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence and Evidence-Based Research Will Promote the Development of Traditional Medicine","authors":"Xinran Liu, Tao Gong","doi":"10.1097/hm9.0000000000000100","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000100","url":null,"abstract":"","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"23 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139859149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence and Evidence-Based Research Will Promote the Development of Traditional Medicine","authors":"Xinran Liu, Tao Gong","doi":"10.1097/hm9.0000000000000100","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000100","url":null,"abstract":"","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"315 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139799255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring a novel class tryptophan hydroxylase 1 inhibitor derived from Sambucus williamsii Hance for the osteoporosis treatment","authors":"Yu-Xin Zhu, Zi-Ling Tang, Lu Lu, Zuo-cheng Qiu, Dabo Pan, Yang Yu, Hui-Hui Xiao, Man-Sau Wong","doi":"10.1097/hm9.0000000000000095","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000095","url":null,"abstract":"Gut-derived serotonin strongly inhibits bone formation by inhibiting osteoblast proliferation. Our previous study demonstrated that the lignan-rich fraction prepared from Sambucus willimasii Hance, a folk herbal medicine used to treat bone fractures and joint diseases in China, exerted bone-protective effects, and its actions were modulated by suppressing the synthesis of gut-derived serotonin via the inhibition of intestinal tryptophan hydroxylase 1 (TPH-1). However, there is no direct evidence for the action of lignans on TPH-1. This study aimed to verify the direct action of lignans on the TPH-1 and its influence on serotonin synthesis and bone properties. Molecular docking, surface plasmon resonance, TPH-1 protein activity, TPH-1 protein expression, mouse serum serotonin levels, and bone properties upon lignan treatment were determined. This is the first study to report that lignans are novel TPH-1 inhibitors and that these lignans could be potential agents for the management of serotonin-related diseases, including osteoporosis.","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"22 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel Cabazitaxel Liposomes Modified with Ginsenoside Rk1 for Cancer Targeted Therapy","authors":"Dandan Huang, Zhongjie Tang, Pu Xiao, Feiyan Gao, Chong Li","doi":"10.1097/hm9.0000000000000096","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000096","url":null,"abstract":"\u0000 \u0000 In this study, we aimed to enhance the anti-prostate cancer efficacy of cabazitaxel (CTX) and reduce its immunosuppression and systemic toxicity by developing CTX-loaded liposomes modified with ginsenoside Rk1 (Rk1/CTX-Lip).\u0000 \u0000 \u0000 \u0000 Physical and chemical properties of Rk1/CTX-Lip were investigated. We evaluated the biological functions of Rk1/CTX-Lip, both in vitro and in vivo. A subcutaneous prostate cancer (RM-1)-bearing mouse model was established to study the efficacy of Rk1/CTX-Lip inhibition in tumors. Simultaneously, a Candida albicans infection model was established in tumor-bearing mice to study the infection-relieving efficacy of Rk1/CTX-Lip. Finally, biocompatibility and in vivo safety of Rk1/CTX-Lip were evaluated.\u0000 \u0000 \u0000 \u0000 We successfully prepared Rk1/CTX-Lip, achieving high CTX encapsulation efficiency (97.24 ± 0.75%) and physical stability. Rk1/CTX-Lip demonstrated evasion of macrophage phagocytosis, effective tumor tissue targeting, and a significant reduction (>50%) in average tumor volume compared to Chol/CTX-Lip. Moreover, it relieved the concurrent infection burden and effectively regulated immune organs and cells, demonstrating superior biocompatibility.\u0000 \u0000 \u0000 \u0000 Rk1/CTX-Lip presents a promising new therapy for prostate cancer and holds potential for relieving concurrent fungal infections in cancer patients with low immunity. http://links.lww.com/AHM/A92\u0000 \u0000","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"111 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139810631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel Cabazitaxel Liposomes Modified with Ginsenoside Rk1 for Cancer Targeted Therapy","authors":"Dandan Huang, Zhongjie Tang, Pu Xiao, Feiyan Gao, Chong Li","doi":"10.1097/hm9.0000000000000096","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000096","url":null,"abstract":"\u0000 \u0000 In this study, we aimed to enhance the anti-prostate cancer efficacy of cabazitaxel (CTX) and reduce its immunosuppression and systemic toxicity by developing CTX-loaded liposomes modified with ginsenoside Rk1 (Rk1/CTX-Lip).\u0000 \u0000 \u0000 \u0000 Physical and chemical properties of Rk1/CTX-Lip were investigated. We evaluated the biological functions of Rk1/CTX-Lip, both in vitro and in vivo. A subcutaneous prostate cancer (RM-1)-bearing mouse model was established to study the efficacy of Rk1/CTX-Lip inhibition in tumors. Simultaneously, a Candida albicans infection model was established in tumor-bearing mice to study the infection-relieving efficacy of Rk1/CTX-Lip. Finally, biocompatibility and in vivo safety of Rk1/CTX-Lip were evaluated.\u0000 \u0000 \u0000 \u0000 We successfully prepared Rk1/CTX-Lip, achieving high CTX encapsulation efficiency (97.24 ± 0.75%) and physical stability. Rk1/CTX-Lip demonstrated evasion of macrophage phagocytosis, effective tumor tissue targeting, and a significant reduction (>50%) in average tumor volume compared to Chol/CTX-Lip. Moreover, it relieved the concurrent infection burden and effectively regulated immune organs and cells, demonstrating superior biocompatibility.\u0000 \u0000 \u0000 \u0000 Rk1/CTX-Lip presents a promising new therapy for prostate cancer and holds potential for relieving concurrent fungal infections in cancer patients with low immunity. http://links.lww.com/AHM/A92\u0000 \u0000","PeriodicalId":60507,"journal":{"name":"Acupuncture and Herbal Medicine","volume":"111 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139870539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}