中国地球物理学会年刊最新文献_第6页

Noninvasive and non-contact assessment of corneal hydration in real time using optical coherent tomography 利用光学相干断层成像对角膜水合作用进行无创、无接触的实时评估

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053284

K. Hosseini, A. Kholodnykh, I. Petrova, R. Esenaliev, M. Motamedi

引用次数: 1

High incident fluence and long pulse laser irradiation in conjunction with cryogen spray cooling: an ex-vivo study 高入射通量和长脉冲激光照射结合冷冻剂喷雾冷却:离体研究

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053277

T. Dai, J. Tunnell, B. Pikkula, D. Chang, B. Anvari

引用次数: 0

Increased radiant exposures during cutaneous laser therapy: a mathematical model based on histology 皮肤激光治疗期间增加的辐射暴露:基于组织学的数学模型

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053278

J. Tunnell, L.H. Wang, B. Anvari

引用次数: 0

Development of a highly porous, flexible and biodegradable poly(ester urethane)urea scaffold for tissue engineering 组织工程用高多孔、柔性、可生物降解聚(酯聚氨酯)尿素支架的研制

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1137058

J. Guan, M. Sacks, W. Wagner

{"title":"Development of a highly porous, flexible and biodegradable poly(ester urethane)urea scaffold for tissue engineering","authors":"J. Guan, M. Sacks, W. Wagner","doi":"10.1109/IEMBS.2002.1137058","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1137058","url":null,"abstract":"For mechanically demanding applications in tissue engineering an ideal scaffold might possess high elastance and strength together with controllable biodegradative and cell adhesive properties. Toward this end, we have synthesized a biodegradable poly(ester-urethane)urea (PEUU) from polycaprolactone and 1,4-diisocyanatobutane, with putrescine used as a chain extender. Porous PEUU scaffolds were created by thermally induced phase separation of a polymer/solvent mixture. The formed scaffolds had open and interconnected pores with pore sizes ranging from several microns to 100 microns and porosities of 80-94%. The scaffolds were flexible with breaking strains greater than 210% and tensile strengths on the order of 1 MPa. The biodegradation rate of PEUU scaffolds was dependent on pore morphology and porosity with the highest weight loss being 21% over 8 weeks. For cellular ingrowth studies, scaffolds were modified with radio frequency glow discharge followed by surface coupling of RGDS peptide. Smooth muscle cells were cultured on scaffolds with and without adhesion peptide treatment. Cells penetrated deeper and distributed more uniformly in RGDS-modified scaffolds than in unmodified scaffolds, and cell number was consistently higher over time in RGDS-modified scaffolds. In summary, these biodegradable PEUU scaffolds offer a platform that is compatible with mechanical training of cell/scaffold constructs. Such training may prove necessary in the development of functional tissues for the cardiovascular system.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77796935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mechanical properties of the elbow joint in spastic hemiparetic stroke subjects 痉挛性偏瘫中风患者肘关节的力学特性

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053369

M. Mirbagheri, R. Harvey, W. Rymer

引用次数: 2

Nanoparticles and ultrasound for delivery of model macromolecular anti-cancer drugs in tumors 纳米粒子和超声在肿瘤中传递模型大分子抗癌药物

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1136917

Y. Ivanova, B. Evers, R. Thomas, T.V. Ashitkov, R. Esenaliev

{"title":"Nanoparticles and ultrasound for delivery of model macromolecular anti-cancer drugs in tumors","authors":"Y. Ivanova, B. Evers, R. Thomas, T.V. Ashitkov, R. Esenaliev","doi":"10.1109/IEMBS.2002.1136917","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1136917","url":null,"abstract":"Penetration of macromolecular anti-cancer agents from blood into tumor cells is poor due to the physiological barriers: tumor capillary wall, interstitium, and cancer cell membrane. We proposed to use laser- or ultrasound-induced cavitation to enhance anti-cancer drug delivery through these barriers. Interaction of ultrasound with exogenous nanoparticles with certain acoustic properties may provide cavitation selectively in tumors and, therefore, may provide safe and efficient delivery of anti-cancer drugs in cancer cells without damage to normal tissues. In this paper, we studied enhanced delivery of model macromolecular anti-cancer drugs with ultrasound-induced cavitation in mice bearing human colon (KM20) and breast (MCF-7) tumors. Fluorescent rhodamine-dextrans of different molecular weight (10, 70, and 2,000 kDa) served as model drugs simulating antisense oligonucleotides, antibodies, and genes, respectively. Immunohistochemical staining of tumor vasculature with CD31 was used to visualize tumor blood vessels. Our studies demonstrated enhanced penetration of the drugs from blood vessels into tumor interstitium when ultrasound was applied in combination with polymer nanoparticle injections. Our results suggest that this drug delivery technique can potentially be used for efficient cancer chemo- and biotherapy.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82548006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

In vitro primary hepatocyte proliferation with nonparenchymal liver cell activation 体外原代肝细胞增殖与非实质肝细胞活化

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1137068

Y. H. Kang, B. Dwarakanath, F. Berthiaume, M. Yarmush

引用次数: 0

Automated detection of respiratory phenotypes during sleep 睡眠期间呼吸表型的自动检测

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1106529

H. Schneider, S. Patil, E. Gladmon, S. Haeussler, M. Wagner, P.L. Smith, A. Schwartz

{"title":"Automated detection of respiratory phenotypes during sleep","authors":"H. Schneider, S. Patil, E. Gladmon, S. Haeussler, M. Wagner, P.L. Smith, A. Schwartz","doi":"10.1109/IEMBS.2002.1106529","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1106529","url":null,"abstract":"We hypothesized that normal individuals can be distinguished on the basis of specific respiratory phenotypes during sleep that determine one's susceptibility to the development of obstructive sleep apnea. To test this hypothesis, methods have been developed to 1) rapidly assess baseline upper airway and respiratory timing characteristics and compensatory responses in these parameters to experimentally induced upper airway obstruction during sleep in normal individuals, and 2) automate the detection of the respiratory pattern and the presence of flow limitation during these experimentally induced upper airway obstructions. We demonstrated that: (1) marked variability in the responses to upper airway obstruction exist among normal individuals, and that (2) upper airway collapsibility (critical pressure) is modulated dynamically by a number of reflex neuromuscular responses triggered by breathing through an obstructed upper airway. Moreover, (3) our methods allowed us to assess the relative strength of compensatory neuromuscular responses to upper airway obstruction in normal individuals. Our findings indicate that the normal individual's susceptibility to the development of upper airway obstruction during sleep is determined by the passive upper airway properties and/or by a lack of vigorous compensatory neuromuscular responses.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83240998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closed-loop fuzzy control of resuscitation of hemorrhagic shock in sheep 绵羊失血性休克复苏的闭环模糊控制

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1106545

Hao Ying, C. A. Bonnerup, Robert A. Kirschner, D. Deyo, Michael W. Michell, George C. Kramer

引用次数: 15

Analysis of chronically recorded autonomic nerve signals for the control of artificial heart systems 长期记录的自主神经信号分析用于人工心脏系统的控制

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1106546

T. Suzuki, M. Mitsui, T. Isoyama, I. Saito, A. Wagatsuma, M. Ohkura, T. Chinzei, K. Imachi, K. Mabuchi

引用次数: 2