ACS Applied Materials & Interfaces最新文献

{"title":"Lysozyme-Associated Quercetin–Manganese Nanocomposites for Kidney-Targeted Antiferroptotic Therapy of Acute Kidney Injury","authors":"Yanzhu Sun,&nbsp;Haolin Zhang,&nbsp;Hengzhi Liu,&nbsp;Huiting Li,&nbsp;Xiangfei Han,&nbsp;Yan Zhao,&nbsp;Hongzhuo Liu,&nbsp;Yongjun Wang","doi":"10.1021/acsami.6c15192","DOIUrl":"10.1021/acsami.6c15192","url":null,"abstract":"<p>Acute kidney injury (AKI) is a life-threatening syndrome in which oxidative stress, ferroptosis, and inflammatory amplification converge to damage renal proximal tubular epithelial cells. Although antioxidant and antiferroptotic therapies are conceptually attractive, their efficacy is restricted by rapid clearance and insufficient accumulation in injured renal tubules. Here, we report lysozyme-associated quercetin–manganese metal–phenolic nanocomposites (QMLNCs) as a kidney-targeted therapeutic platform for AKI. In this design, quercetin (QCT) functions simultaneously as an antioxidant drug and a phenolic coordination ligand, while Mn²⁺ participates in metal–phenolic network formation. Lysozyme is incorporated through noncovalent protein–polyphenol interactions to enhance megalin-mediated uptake by proximal tubular cells. QMLNCs exhibited favorable colloidal stability, H₂O₂-responsive release, and broad-spectrum radical-scavenging ability. In cisplatin-injured human kidney 2 (HK-2) cells, QMLNCs reduced Fe²⁺ and reactive oxygen species (ROS) accumulation, preserved mitochondrial membrane potential. Mechanistically, Western blot analysis indicated that QMLNCs could restore the protein levels of SLC7A11, GPX4, and FTH-1, which are key mediators of ferroptosis resistance. In macrophages, QMLNCs suppressed M1 polarization, promoted M2 polarization, and reduced tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and nitric oxide (NO) production. <em>In vivo</em>, QMLNCs preferentially accumulated in injured kidneys and significantly alleviated renal dysfunction in both glycerol-induced and cisplatin-induced AKI models, as indicated by decreased serum creatinine, blood urea nitrogen, MDA and pro-inflammatory cytokines. Overall, QMLNCs integrate renal tubular targeting, ROS scavenging, ferroptosis inhibition, and inflammation modulation into a single metal-natural product nanoplatform, offering a promising strategy for multimodal AKI therapy.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55962–55975"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide-Reduced Platinum-Based Nanozymes for Wound Treatment of Methicillin-Resistant Staphylococcus aureus Infection","authors":"Ting Chen,&nbsp;Naidan Li,&nbsp;Peipei Li,&nbsp;Haixia Wu,&nbsp;Alideertu Dong","doi":"10.1021/acsami.6c12265","DOIUrl":"10.1021/acsami.6c12265","url":null,"abstract":"<p>Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA)-infected wounds remain difficult to treat because of antibiotic resistance, biofilm formation, and persistent inflammation, highlighting the need for alternative local antibacterial strategies. Herein, we developed a platinum-based nanozyme (FmY@Pt) through a UV-assisted green reduction process using a tyrosine-containing short peptide (FmY) and evaluated its antibacterial activity and therapeutic potential for treating MRSA-infected wounds. The physicochemical properties and peroxidase(POD)-like activity of FmY@Pt were characterized, and its antibacterial effects and possible mechanisms were evaluated <em>in vitro</em>. The resulting nanozyme exhibited peroxidase-like activity under the tested conditions. <em>In vitro</em> experiments showed that FmY@Pt disrupted bacterial membranes and increased intracellular reactive oxygen species (ROS) levels in MRSA cells. These effects were associated with the antibacterial activity of FmY@Pt. In a mouse model of MRSA-infected skin wounds, the FmY@Pt + H₂O₂ treatment accelerated wound closure, with the wound closure rate reached approximately 80.8% on day 7. Moreover, bacterial survival rate was reduced to approximately 6.13%, corresponding to a reduction of approximately 93.87% relative to the control group. The treatment was also associated with attenuated inflammatory responses and improvements in tissue repair-related histological indicators. These findings suggest that the antibacterial and inflammation-modulating effects of FmY@Pt may collectively contribute to wound repair under the conditions. This study provides experimental evidence supporting the further investigation of nanozyme-based strategies for the treatment of infected wounds.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55834–55844"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical Insights into Stepwise NH3 Oxidation on Pocket-Reconstructed Cu/CeO2(100) under Oxygen-Rich Conditions","authors":"Zi-Yi Guo,&nbsp;Zhi-Qiang Wang,&nbsp;Xue-Qing Gong","doi":"10.1021/acsami.6c19046","DOIUrl":"10.1021/acsami.6c19046","url":null,"abstract":"<p>Cu-modified CeO₂(100) (Cu/CeO₂(100)) has been widely studied for NH₃-selective catalytic oxidation (NH₃-SCO), although most previous theoretical studies considered predefined Cu single atoms, Cu clusters, or CuO<em>_x</em> species, leaving the oxygen-induced reconstruction of the active Cu/CeO₂ surface and its catalytic effect unclear. Here, we employ density functional theory calculations with on-site Coulomb interaction corrections (DFT + U) to identify the stable reconstructed Cu/CeO₂(100) under O₂-rich conditions and elucidate the complete NH₃ oxidation pathways. The calculations reveal that the unique “pocket-like” reconstructed CeO₂(100) surface can drive the aggregation of the isolated Cu atoms into a stable Cu₃O₂ cluster within the pocket area. This restructuring generates active motifs comprising geometrically flexible CuO₄ units and adjacent Ce³⁺ sites, and each CuO₄ unit can facilitate the heterolytic NH₃ dissociation to NH₂*, while the Ce³⁺ site can activate O₂ into superoxide (<span>⁠<span></span><math><msubsup><mi>O</mi><mn>2</mn><mo>–</mo></msubsup></math>⁠</span>) species. The activated <span><span></span><math><msubsup><mi>O</mi><mn>2</mn><mo>–</mo></msubsup></math></span> species then reacts with NH₂* to form stable NH₂O* and O* intermediates. Moreover, a cooperative dynamic restructuring between NH₂O* and nearby O* species gives rise to a distinctive Ce─O─NH_<em>x</em>···O five-membered ring. This unique configuration enables a nearly barrierless (0.02 eV) proton transfer to produce NHO* and OH* species, ultimately driving the deep oxidation to form NO* and H₂O*. These findings reveal a previously unrecognized pocket-confinement effect on Cu aggregation and redox-site cooperation on Cu/CeO₂(100), providing mechanistic guidance for the rational design of Cu/CeO₂-based NH₃-SCO catalysts under oxygen-rich conditions.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56266–56273"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angular and Spectral Engineering of Red Organic Light-Emitting Diodes via Cavity-Induced Emission for Photobiomodulation-Related Cellular Responses","authors":"Chang Min Lee,&nbsp;Hyun Woo Cho,&nbsp;Hye-Ryung Choi,&nbsp;Yeong Beom Kim,&nbsp;Geon Lee,&nbsp;Mengdi Fu,&nbsp;Muhammad Waheed,&nbsp;Hyun Jae Lee,&nbsp;Insung Ha,&nbsp;Keum-Jin Ko,&nbsp;Deepak Rajaram Patil,&nbsp;P. Justin Jesuraj,&nbsp;Chang-Hun Huh,&nbsp;Seung Yoon Ryu","doi":"10.1021/acsami.6c09867","DOIUrl":"10.1021/acsami.6c09867","url":null,"abstract":"<p>Photobiomodulation using red and near-infrared light has emerged as a promising strategy for promoting skin regeneration because of its ability to stimulate mitochondrial activity and enhance cellular proliferation. However, the optical characteristics of the light source, including angular emission and spectral bandwidth, remain underexplored in terms of their influence on biological outcomes. Here, we demonstrate that emission-engineered red organic light-emitting diodes (OLEDs) can directly regulate cellular responses by tailoring both angular distribution and spectral properties. Flexible OLED devices were fabricated with three representative configurations: an indium tin oxide (ITO)-based Lambertian emission device (inflexible), a candle-emission device with a narrow spectral profile centered at 610 nm, and a batwing-emission device exhibiting angularly broadened and spectrally enriched output (610–650 nm). Systematic optical characterization revealed distinct differences in efficiency, full width at half maximum (FWHM), and angular emission patterns across these devices. Subsequent in vitro assays showed that both candle and batwing devices enhanced proliferation-related cellular responses relative to sham-irradiation and ITO controls, with the batwing device producing the strongest effect. The superior biological efficacy of the batwing device is attributed to its broadened multiwavelength emission, providing broader spectral overlap with biologically relevant wavelengths. The implications of these optical characteristics for tissue photobiomodulation are discussed based on previous studies. This work establishes a direct connection between OLED emission characteristics and biological efficacy, underscoring emission control as a key parameter in optimizing photobiomodulation.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"55806–55814"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149133970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sub-4 nm Pt5Sm Intermetallic Catalyst toward Efficient and Durable Oxygen Reduction for Fuel Cell Applications","authors":"Qing Gong,&nbsp;Hongmei Tang,&nbsp;Xianbin Li,&nbsp;Ruina Dong,&nbsp;Shengmei Huang,&nbsp;Chunhui Zhao,&nbsp;Gang Cheng,&nbsp;Junhua Zou,&nbsp;Bohong Chen","doi":"10.1021/acsami.6c08583","DOIUrl":"10.1021/acsami.6c08583","url":null,"abstract":"<p>It is remarkably attractive but challenging to develop fine Pt–rare-earth intermetallic catalysts toward efficient and stable oxygen reduction reaction (ORR) for fuel cell applications. In this work, an amino-assisted method was employed to prepare the carbon-supported Pt₅Sm (Pt₅Sm/C) catalyst, which exhibited an average size of 3.8 ± 1.0 nm with a core–shell structure consisting of a Pt-enriched surface over a hexagonal Pt₅Sm intermetallic core. The introduction of Sm into the Pt lattice induced strong electron interactions between Sm and Pt and enhanced the resistance to Pt oxidation, thereby improving the catalytic kinetics and durability for the ORR. In rotating disk electrode tests, the Pt₅Sm/C catalyst delivers a promising ORR activity of 430.3 A·g_Pt^–1 with only a 10.3% loss after 30,000 cycles, significantly outperforming commercial Pt/C. Furthermore, in H₂/air fuel cell tests, the Pt₅Sm/C catalyst exhibited a peak power density of 853 mW·cm^–2 with only a voltage drop of 56 mV at 0.8 A·cm^–2 after 30,000 cycles. This work demonstrates that Pt–rare-earth intermetallic catalysts are promising candidates for high-performance and durable fuel cell applications.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56029–56037"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery-Induced Spatial Engineering of Au/MXene Nanoarchitectures for Direct Ion-to-Electrode Conversion","authors":"Fei Li,&nbsp;Qian Wang,&nbsp;Artemii Ivanov,&nbsp;Yu Jiang,&nbsp;Jianhong Wei,&nbsp;Hang Li,&nbsp;Vasyl G. Kravets,&nbsp;Alexander N. Grigorenko,&nbsp;Hengrui Chen,&nbsp;Hong Huo,&nbsp;Altantuya Ochirkhuyag,&nbsp;Yang Su,&nbsp;Kostya S. Novoselov,&nbsp;Daria V. Andreeva","doi":"10.1021/acsami.6c14687","DOIUrl":"10.1021/acsami.6c14687","url":null,"abstract":"<p>Creating direct pathways that transform dissolved metal waste into functional architecture is central to sustainable nanomanufacturing and circular materials design. Here, we report a redox-driven strategy for the direct conversion of gold (Au) ions from electronic waste into spatially organized Au/MXene nanoarchitectures and electrocatalytic membranes. Ti₃C₂T<em>_x</em> MXene nanosheets exhibit an Au uptake capacity of 3720 mg g^–1 at 1 ppm, together with high selectivity in the presence of excess competing metal ions. Mechanistic studies reveal that the Au capture is coupled with spontaneous interfacial redox conversion, where ∼91% of Au(III) ions are reduced in situ into metallic Au nanoparticles on the MXene surface. Importantly, performing the recovery process in a dispersed colloidal state enables recovery-induced interlayer assembly, producing homogeneous Au distributions throughout the MXene framework after vacuum-assisted membrane formation. In contrast to surface-confined deposition in conventional filtration architectures, the interlayer nanoarchitecture preserves ion-transport pathways and maximizes catalytic accessibility. We further show that ultratrace Au concentrations promote the formation of highly dispersed confined Au domains, enabling efficient electrocatalytic membranes despite substantially lower gold loading. The resulting membranes function directly as flexible binder-free electrodes without additional refining, metal stripping, or catalyst deposition steps. This work establishes a recovery-as-fabrication strategy in which dissolved metal ions are directly transformed into functional nanoarchitectures through coupled redox reduction, confined nucleation, and interlayer assembly.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"18 41","pages":"56333–56342"},"PeriodicalIF":7.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Proton Conductivity in the Ce0.9Gd0.1O2–δ Electrolyte for Low-Temperature SOFCs via Surface Doping with a Cobalt Oxide Redox Mediator","authors":"Yong Yu,Xiaomeng Cheng,Muhammad Ali Khalid,Rongrui Shi,Fawei Ji,Hao Chen,Luyun Chen,Yuhao Zhao,Yijie Zhao,Jianbing Huang,Yubin Chen,Youjun Lu,Liejin Guo","doi":"10.1021/acsami.6c12971","DOIUrl":"https://doi.org/10.1021/acsami.6c12971","url":null,"abstract":"Developing oxide electrolytes with high ionic conductivity (∼0.1 S cm–1) at temperatures below 600 °C is essential for next-generation solid oxide fuel cells. However, current electrolyte materials rarely meet this benchmark, primarily because of limitations inherent in bulk doping and high-temperature sintering. To overcome this challenge, we demonstrate a surface engineering strategy that involves controlled cobalt doping onto the acid-etched surface of gadolinium-doped ceria (Ce0.9Gd0.1O2–δ, GDC), thereby constructing a Co3+/Co2+ redox mediator. The 3 mol% cobalt-surface-doped GDC (GDC-Co3) electrolyte exhibits optimal ionic transport behavior, achieving an ionic conductivity of 0.153 S cm–1 at 500 °C and a 30% improvement over pristine GDC (0.118 S cm–1), while simultaneously reducing the activation energy from 0.64 eV to 0.36 eV. X-ray photoelectron spectroscopy (XPS) and multi-wavelength Raman spectroscopy reveal that Co2+/Co3+ redox pairs are introduced onto the surfaces of GDC particles through doping with different Co(II)/GDC molar ratios. The formation of a Schottky junction, as evidenced by a rectifying effect, effectively prevents electron leakage across the electrolyte. Electrochemical impedance spectroscopy (EIS), combined with distribution of relaxation times (DRT) analysis, indicates that ionic conductivity is strongly correlated with electronic conductivity. These results collectively support a mechanism where surface-localized Co2+/Co3+ redox pairs act as mediators for the Ce4+/Ce3+ couples in GDC, establishing favorable surface pathways for proton transport via an alternating interstitial proton-hydrogen hopping process. The accompanying reduction in electrode polarization resistance suggests that accelerated interfacial reaction kinetics may also contribute to the improved cell performance, alongside enhanced proton transport. This work presents an innovative surface engineering approach that significantly enhances proton transport in fluorite oxide materials, with important implications for low-temperature solid oxide electrochemical devices.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"35 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing a Light-Activated Ruthenium(II) Complex Self-Delivery Nanoplatform for Tumor–Organelle Cascade-Targeted Immunotherapy via Type II Immunogenic Cell Death","authors":"Jun Wang,Tao Kuang,Bin Hu,Jun Yin,Zongtao Zhou,Guixiu Qin,Suisui He,Cui-Yun Yu,Hua Wei","doi":"10.1021/acsami.6c18179","DOIUrl":"https://doi.org/10.1021/acsami.6c18179","url":null,"abstract":"Immunogenic cell death (ICD) converts immunosuppressive “cold” tumors into immunogenic “hot” ones, yet ICD inducers with precise tumor–organelle cascade targeting and spatiotemporal controllability remain largely unexplored. Herein, we report a self-delivery nanoplatform (ER-Ru NPs) constructed via the self-assembly of well-defined tumor–endoplasmic reticulum (ER) cascade-targeting ruthenium(II) complexes. The intrinsic amphiphilicity enables self-assembly of the ruthenium(II) complexes into stabilized nanoparticles with efficient tumor accumulation properties via biotin-mediated active targeting, without any exogenous carriers. Following cellular internalization, the released ruthenium(II) complex monomer specifically accumulates in the ER to generate a cleaved Ru–H2O anticancer agent and in situ reactive oxygen species (ROS) upon red-light irradiation. The robust ROS burst triggers severe ER stress via activation of the PERK/eIF2α pathway, leading to the release of damage-associated molecular patterns and the type II ICD induction. Notably, this cascade-targeted ICD activation strategy enhances not only tumor specificity but also the immunogenicity of dying tumor cells, achieving effective primary tumor ablation in the 4T1 models and simultaneously suppressing distant tumors through dendritic cell maturation, cytotoxic T-cell infiltration, and memory T-cell generation. This study offers a paradigm for photoactivatable, self-delivery ICD inducers with cascade targeting, holding substantial promise for clinical translation in precision cancer immunotherapy.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"88 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Functionalization Tunes Twist Angles of MoS2 Moiré Superlattices for Surface-Enhanced Raman Scattering","authors":"Shamim Hossain Shah,Arun Chattopadhyay","doi":"10.1021/acsami.6c13436","DOIUrl":"https://doi.org/10.1021/acsami.6c13436","url":null,"abstract":"In the quest for surface-enhanced Raman spectroscopy (SERS) substrates without noble metals, transition-metal dichalcogenides (TMDs) have emerged as an important class of alternatives. In this regard, molybdenum disulfide (MoS2)-based SERS substrates have been extensively studied; however, their moiré superlattices (with controlled twist angles) could be potent candidates for significant signal enhancement. Here, we employed a molecular functionalization method using 4-aminothiophenol (4-ATP) as a linker to tune the twist angles of MoS2 moiré superlattices. Transmission electron microscopy (TEM) and Raman spectroscopy experiments confirmed the formation of moiré patterns in 4-ATP functionalized MoS2 (4ATP-MoS2), with reduced twist angles in contrast to pristine MoS2 superlattices. Furthermore, we used 4ATP-MoS2 moiré superlattices as SERS substrates to probe molecules, such as rhodamine 6G, rhodamine B, methylene blue, and crystal violet. We observed significant enhancement of Raman signal intensity (on the order of 105) for all the molecules. Interestingly, pristine MoS2 did not show any significant enhancements of the SERS signals. We attribute the enhancement to the moiré interface-induced charge transfer from MoS2 to the probe molecules through 4-ATP, thereby increasing the Raman signals. This strategy could open possibilities to design moiré superlattices for improved SERS substrates and light–matter interactions.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"12 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled Carbon Nanotube/Extracellular Matrix Hydrogel as a Promising Matrix for Organoid Growth and Functional Maturation","authors":"Zhen Cao,Huiyi Song,Mingqi Wang,Lina Guo,Xu Zheng,Chenghong Zhang,Dong Shang,Xiaoqin Wang,Xiuli Wang","doi":"10.1021/acsami.6c09854","DOIUrl":"https://doi.org/10.1021/acsami.6c09854","url":null,"abstract":"Organoids are three-dimensional, self-organized structures derived from tissue-specific cells that recapitulate key architectural and functional features of native tissues in vitro. Current organoid culture systems primarily rely on tumor-derived Matrigel, which suffers from batch-to-batch variability, high cost, and safety concerns, thereby limiting reproducibility and clinical translation. Notably, existing natural and synthetic polymeric hydrogels have not simultaneously supported efficient organoid formation and functional maturation comparable to Matrigel. Here, we present an improved composite hydrogel composed of carbon nanotubes (CNTs) and porcine small intestinal submucosa extracellular matrix (SIS-ECM) as a versatile and biologically active promising alternative matrix for organoid culture. We demonstrate its broad applicability by successfully culturing adult stem cell-derived mouse intestinal organoids (mIOs), human intestinal organoids (hIOs), and human embryonic stem cell-derived vascular organoids (hVOs). Organoids grown within the CNT-SIS-ECM hydrogel exhibited formation efficiency, structural integrity, and functional maturation comparable to, and in certain aspects exceeding, those cultured in Matrigel, underscoring their advantages for transplantation-oriented applications. Mechanistic investigations revealed that CNT incorporation provides instructive bioactive cues that promote organoid development, including upregulation of high mobility group box 1 (Hmgb1), which enhances mIO proliferation and differentiation. Additionally, CNTs augment the WNT signaling pathway, thereby facilitating hVO growth and vascular maturation. Together, these findings establish the CNT/SIS-ECM composite hydrogel as a promising matrix alternative that supports organoid formation and maturation across multiple lineages, offering a practical platform for organoid-based research and tissue regeneration.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"2 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}