Biomaterials Translational最新文献_第8页

On the mechanical aspect of additive manufactured polyether-ether-ketone scaffold for repair of large bone defects. 增材制造聚醚酮支架修复大骨缺损的力学研究。

Biomaterials Translational Pub Date : 2022-01-01 DOI: 10.12336/biomatertransl.2022.02.006

Seyed Ataollah Naghavi, Changning Sun, Mahbubeh Hejazi, Maryam Tamaddon, Jibao Zheng, Leilei Wang, Chenrui Zhang, Swastina Nath Varma, Dichen Li, Mehran Moazen, Ling Wang, Chaozong Liu, San, Cs, San, Mh, San, Mm, Lw, Cl, San, Cs, Mh, Mt, Jz, Lw, Cz, Snv, Dl, Mm, Lw, Cl

{"title":"On the mechanical aspect of additive manufactured polyether-ether-ketone scaffold for repair of large bone defects.","authors":"Seyed Ataollah Naghavi, Changning Sun, Mahbubeh Hejazi, Maryam Tamaddon, Jibao Zheng, Leilei Wang, Chenrui Zhang, Swastina Nath Varma, Dichen Li, Mehran Moazen, Ling Wang, Chaozong Liu, San, Cs, San, Mh, San, Mm, Lw, Cl, San, Cs, Mh, Mt, Jz, Lw, Cz, Snv, Dl, Mm, Lw, Cl","doi":"10.12336/biomatertransl.2022.02.006","DOIUrl":"https://doi.org/10.12336/biomatertransl.2022.02.006","url":null,"abstract":"Polyether-ether-ketone (PEEK) is widely used in producing prosthesis and have gained great attention for repair of large bone defect in recent years with the development of additive manufacturing. This is due to its excellent biocompatibility, good heat and chemical stability and similar mechanical properties which mimics natural bone. In this study, three replicates of rectilinear scaffolds were designed for compression, tension, three-point bending and torsion test with unit cell size of 0.8 mm, a pore size of 0.4 mm, strut thickness of 0.4 mm and nominal porosity of 50%. Stress-strain graphs were developed from experimental and finite element analysis models. Experimental Young's modulus and yield strength of the scaffolds were measured from the slop of the stress-strain graph to be 395 and 19.50 MPa respectively for compression, 427 and 6.96 MPa respectively for tension, 257 and 25.30 MPa respectively for three-point bending and 231 and 12.83 MPa respectively for torsion test. The finite element model was found to be in good agreement with the experimental results. Ductile fracture of the struct subjected to tensile strain was the main failure mode of the PEEK scaffold, which stems from the low crystallinity of additive manufacturing PEEK. The mechanical properties of porous PEEK are close to those of cancellous bone and thus are expected to be used in additive manufacturing PEEK bone implants in the future, but the lower yield strength poses a design challenge.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"3 2","pages":"142-151"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/16/bt-03-02-142.PMC9465988.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10588981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Skeletal interoception: an emerging area for musculoskeletal research. 骨骼内感受:肌肉骨骼研究的新兴领域。

Biomaterials Translational Pub Date : 2022-01-01 DOI: 10.12336/biomatertransl.2022.04.001

Zhidao Xia

引用次数: 1

Osteogenic differentiation of encapsulated cells in dexamethasone-loaded phospholipid-induced silk fibroin hydrogels. 地塞米松磷脂诱导丝素水凝胶中被包被细胞的成骨分化。

Biomaterials Translational Pub Date : 2022-01-01 DOI: 10.12336/biomatertransl.2022.03.005

Chavee Laomeephol, Helena Ferreira, Sorada Kanokpanont, Jittima Amie Luckanagul, Nuno M Neves, Siriporn Damrongsakkul

{"title":"Osteogenic differentiation of encapsulated cells in dexamethasone-loaded phospholipid-induced silk fibroin hydrogels.","authors":"Chavee Laomeephol, Helena Ferreira, Sorada Kanokpanont, Jittima Amie Luckanagul, Nuno M Neves, Siriporn Damrongsakkul","doi":"10.12336/biomatertransl.2022.03.005","DOIUrl":"https://doi.org/10.12336/biomatertransl.2022.03.005","url":null,"abstract":"The tissue engineering triad comprises the combination of cells, scaffolds and biological factors. Therefore, we prepared cell- and drug-loaded hydrogels using in situ silk fibroin (SF) hydrogels induced by dimyristoyl glycerophosphoglycerol (DMPG). DMPG is reported to induce rapid hydrogel formation by SF, facilitating cell encapsulation in the hydrogel matrix while maintaining high cell viability and proliferative capacity. In addition, DMPG can be used for liposome formulations in entrapping drug molecules. Dexamethasone (Dex) was loaded into the DMPG-induced SF hydrogels together with human osteoblast-like SaOS-2 cells, then the osteogenic differentiation of the entrapped cells was evaluated in vitro and compared to cells cultured under standard conditions. Calcium production by cells cultured in DMPG/Dex-SF hydrogels with Dex-depleted osteogenic medium was equivalent to that of cells cultured in conventional osteogenic medium containing Dex. The extended-release of the entrapped Dex by the hydrogels was able to provide a sufficient drug amount for osteogenic induction. The controlled release of Dex was also advantageous for cell viability even though its dose in the hydrogels was far higher than that in osteogenic medium. The results confirmed the possibility of using DMPG-induced SF hydrogels to enable dual cell and drug encapsulation to fulfil the practical applications of tissue-engineered constructs.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"3 3","pages":"213-220"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/33/bt-03-03-213.PMC9840088.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9114837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration. 生物材料辅助骨软骨再生的骨关节炎动物模型。

Biomaterials Translational Pub Date : 2022-01-01 DOI: 10.12336/biomatertransl.2022.04.006

Yi Wang, Yangyang Chen, Yulong Wei

{"title":"Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration.","authors":"Yi Wang, Yangyang Chen, Yulong Wei","doi":"10.12336/biomatertransl.2022.04.006","DOIUrl":"https://doi.org/10.12336/biomatertransl.2022.04.006","url":null,"abstract":"Clinical therapeutics for the regeneration of osteochondral defects (OCD) in the early stages of osteoarthritis remain an enormous challenge in orthopaedics. For in-depth studies of tissue engineering and regenerative medicine in terms of OCD treatment, the utility of an optimal OCD animal model is crucial for assessing the effects of implanted biomaterials on the repair of damaged osteochondral tissues. Currently, the most frequently used in vivo animal models for OCD regeneration include mice, rats, rabbits, dogs, pigs, goats, sheep, horses and nonhuman primates. However, there is no single \"gold standard\" animal model to accurately recapitulate human disease in all aspects, thus understanding the benefits and limitations of each animal model is critical for selecting the most suitable one. In this review, we aim to elaborate the complex pathological changes in osteoarthritic joints and to summarise the advantages and limitations of OCD animal models utilised for biomaterial testing along with the methodology of outcome assessment. Furthermore, we review the surgical procedures of OCD creation in different species, and the novel biomaterials that promote OCD regeneration. Above all, it provides a significant reference for selection of an appropriate animal model for use in preclinical in vivo studies of biomaterial-assisted osteochondral regeneration in osteoarthritic joints.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"3 4","pages":"264-279"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/3d/bt-03-04-264.PMC9947734.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10800490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Advances and perspective on animal models and hydrogel biomaterials for diabetic wound healing. 糖尿病创面愈合动物模型及水凝胶生物材料研究进展与展望。

Biomaterials Translational Pub Date : 2022-01-01 DOI: 10.12336/biomatertransl.2022.03.003

Yiqiang Hu, Yuan Xiong, Ranyang Tao, Hang Xue, Lang Chen, Ze Lin, Adriana C Panayi, Bobin Mi, Guohui Liu

{"title":"Advances and perspective on animal models and hydrogel biomaterials for diabetic wound healing.","authors":"Yiqiang Hu, Yuan Xiong, Ranyang Tao, Hang Xue, Lang Chen, Ze Lin, Adriana C Panayi, Bobin Mi, Guohui Liu","doi":"10.12336/biomatertransl.2022.03.003","DOIUrl":"https://doi.org/10.12336/biomatertransl.2022.03.003","url":null,"abstract":"Diabetic wounds are a common complication in diabetes patients. Due to peripheral nerve damage and vascular dysfunction, diabetic wounds are prone to progress to local ulcers, wound gangrene and even to require amputation, bringing huge psychological and economic burdens to patients. However, the current treatment methods for diabetic wounds mainly include wound accessories, negative pressure drainage, skin grafting and surgery; there is still no ideal treatment to promote diabetic wound healing at present. Appropriate animal models can simulate the physiological mechanism of diabetic wounds, providing a basis for translational research in treating diabetic wound healing. Although there are no animal models that can fully mimic the pathophysiological mechanisms of diabetic wounds in humans, it is vital to explore animal simulation models used in basic research and preclinical studies of diabetic wounds. In addition, hydrogel materials are regarded as a promising treatment for diabetic wounds because of their good antimicrobial activity, biocompatibility, biodegradation and appropriate mechanical properties. Herein, we review and discuss the different animal models used to investigate the pathological mechanisms of diabetic wounds. We further discuss the promising future application of hydrogel biomaterials in diabetic wound healing.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"3 3","pages":"188-200"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/db/bt-03-03-188.PMC9840091.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9100298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stem cell-derived extracellular vesicles: a possible therapeutic strategy for orthopaedic diseases: a narrative review. 间充质干细胞衍生的细胞外囊泡:一种可能的骨科疾病治疗策略:叙述性回顾。

Biomaterials Translational Pub Date : 2022-01-01 DOI: 10.12336/biomatertransl.2022.03.002

Zhao-Lin Zeng, Hui Xie

{"title":"Mesenchymal stem cell-derived extracellular vesicles: a possible therapeutic strategy for orthopaedic diseases: a narrative review.","authors":"Zhao-Lin Zeng, Hui Xie","doi":"10.12336/biomatertransl.2022.03.002","DOIUrl":"https://doi.org/10.12336/biomatertransl.2022.03.002","url":null,"abstract":"Accumulating evidence suggests that the therapeutic role of mesenchymal stem cells (MSCs) in bone diseases is closely related to paracrine-generated extracellular vesicles (EVs). MSC-derived EVs (MSC-EVs) carry proteins, nucleic acids, and lipids to the extracellular space and affect the bone microenvironment. They have similar biological functions to MSCs, such as the ability to repair organ and tissue damage. In addition, MSC-EVs also have the advantages of long half-life, low immunogenicity, attractive stability, ability to pass through the blood-brain barrier, and demonstrate excellent performance with potential practical applications in bone diseases. In this review, we summarise the current applications and mechanisms of MSC-EVs in osteoporosis, osteoarthritis, bone tumours, osteonecrosis of the femoral head, and fractures, as well as the development of MSC-EVs combined with materials science in the field of orthopaedics. Additionally, we explore the critical challenges involved in the clinical application of MSC-EVs in orthopaedic diseases.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"3 3","pages":"175-187"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/82/bt-03-03-175.PMC9840092.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9100299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Engineered exosomes for future gene-editing therapy. 用于未来基因编辑治疗的工程外泌体。

Biomaterials Translational Pub Date : 2022-01-01 DOI: 10.12336/biomatertransl.2022.04.003

Haoyu Guo, Xin Huang

{"title":"Engineered exosomes for future gene-editing therapy.","authors":"Haoyu Guo, Xin Huang","doi":"10.12336/biomatertransl.2022.04.003","DOIUrl":"https://doi.org/10.12336/biomatertransl.2022.04.003","url":null,"abstract":"The RNA-guided clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated nuclease protein 9 (Cas9)-based technology is an advanced and popular gene-editing technology, which has shown great potential in treating genetic disorders in both animal models and even in clinical trials.1, 2 Many transportation strategies are available for delivery of the CRISPR-Cas9 system, among which Cas9 ribonucleoprotein (RNP) delivery has some competitive advantages over other options, such as faster editing onset speed with a reduced immune response and lower off-target activity.3, 4 However, the low in vivo delivery efficiency and poor tissue specificity of RNP delivery have limited further clinical applications.5 Writing in Science Advances, Wan et al.6 reported a previously-unidentified genome editing delivery system, named exosomeRNP which transported RNPs within exosomes extracted from hepatic stellate cells via electroporation. The exosomeRNP exhibited effective intracellular and intercellular delivery and accumulation of RNPs to hepatocytes in vitro and in vivo, resulting in significant therapeutic effects in several hepatic diseases. The system was tested in mouse models of acute liver injury, chronic liver fibrosis, and hepatocellular carcinoma by targeting p53 upregulated modulator of apoptosis, cyclin-E1, and K(lysine) acetyltransferase-5, respectively, providing a potential strategy for high-efficiency, precise and tissue-specific gene editing in liver diseases.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"3 4","pages":"240-242"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/10/bt-03-04-240.PMC9947735.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10782881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

New perspective of skeletal stem cells. 骨骼干细胞的新视角。

Biomaterials Translational Pub Date : 2022-01-01 DOI: 10.12336/biomatertransl.2022.04.007

Guixin Yuan, Zan Li, Xixi Lin, Na Li, Ren Xu

{"title":"New perspective of skeletal stem cells.","authors":"Guixin Yuan, Zan Li, Xixi Lin, Na Li, Ren Xu","doi":"10.12336/biomatertransl.2022.04.007","DOIUrl":"https://doi.org/10.12336/biomatertransl.2022.04.007","url":null,"abstract":"Tissue-resident stem cells are a group of stem cells distinguished by their capacity for self-renewal and multilineage differentiation capability with tissue specificity. Among these tissue-resident stem cells, skeletal stem cells (SSCs) were discovered in the growth plate region through a combination of cell surface markers and lineage tracing series. With the process of unravelling the anatomical variation of SSCs, researchers were also keen to investigate the developmental diversity outside the long bones, including in the sutures, craniofacial sites, and spinal regions. Recently, fluorescence-activated cell sorting, lineage tracing, and single-cell sequencing have been used to map lineage trajectories by studying SSCs with different spatiotemporal distributions. The SSC niche also plays a pivotal role in regulating SSC fate, such as cell-cell interactions mediated by multiple signalling pathways. This review focuses on discussing the spatial and temporal distribution of SSCs, and broadening our understanding of the diversity and plasticity of SSCs by summarizing the progress of research into SSCs in recent years.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"3 4","pages":"280-294"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/3a/bt-03-04-280.PMC9947737.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10794835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Optimising soft tissue in-growth in vivo in additive layer manufactured osseointegrated transcutaneous implants. 在添加剂层制造的经皮骨整合植入物中优化体内生长的软组织。

Biomaterials Translational Pub Date : 2022-01-01 DOI: 10.12336/biomatertransl.2022.04.004

Elena Giusto, Gordon Blunn, Roberta Ferro de Godoy, Chaozong Liu, Catherine Pendegrass

{"title":"Optimising soft tissue in-growth in vivo in additive layer manufactured osseointegrated transcutaneous implants.","authors":"Elena Giusto, Gordon Blunn, Roberta Ferro de Godoy, Chaozong Liu, Catherine Pendegrass","doi":"10.12336/biomatertransl.2022.04.004","DOIUrl":"https://doi.org/10.12336/biomatertransl.2022.04.004","url":null,"abstract":"Osseointegrated transcutaneous implants could provide an alternative and improved means of attaching artificial limbs for amputees, however epithelial down growth, inflammation, and infections are common failure modalities associated with their use. To overcome these problems, a tight seal associated with the epidermal and dermal adhesion to the implant is crucial. This could be achieved with specific biomaterials (that mimic the surrounding tissue), or a tissue-specific design to enhance the proliferation and attachment of dermal fibroblasts and keratinocytes. The intraosseous transcutaneous amputation prosthesis is a new device with a pylon and a flange, which is specifically designed for optimising soft tissue attachment. Previously the flange has been fabricated using traditional machining techniques, however, the advent of additive layer manufacturing (ALM) has enabled 3-dimensional porous flanges with specific pore sizes to be used to optimise soft tissue integration and reduce failure of osseointegrated transcutaneous implants. The study aimed to investigate the effect of ALM-manufactured porous flanges on soft tissue ingrowth and attachment in an in vivo ovine model that replicates an osseointegrated percutaneous implant. At 12 and 24 weeks, epithelial downgrowth, dermal attachment and revascularisation into ALM-manufactured flanges with three different pore sizes were compared with machined controls where the pores were made using conventional drilling. The pore sizes of the ALM flanges were 700, 1000 and 1250 μm. We hypothesised that ALM porous flanges would reduce downgrowth, improve soft tissue integration and revascularisation compared with machined controls. The results supported our hypothesis with significantly greater soft tissue integration and revascularisation in ALM porous flanges compared with machined controls.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"3 4","pages":"243-249"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/7b/bt-03-04-243.PMC9947732.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10790741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenous repair theory enriches construction strategies for orthopaedic biomaterials: a narrative review. 内源性修复理论丰富了骨科生物材料的构建策略：叙述性综述。

Biomaterials Translational Pub Date : 2021-12-28 eCollection Date: 2021-01-01 DOI: 10.12336/biomatertransl.2021.04.008

Yizhong Peng, Jinye Li, Hui Lin, Shuo Tian, Sheng Liu, Feifei Pu, Lei Zhao, Kaige Ma, Xiangcheng Qing, Zengwu Shao

{"title":"Endogenous repair theory enriches construction strategies for orthopaedic biomaterials: a narrative review.","authors":"Yizhong Peng, Jinye Li, Hui Lin, Shuo Tian, Sheng Liu, Feifei Pu, Lei Zhao, Kaige Ma, Xiangcheng Qing, Zengwu Shao","doi":"10.12336/biomatertransl.2021.04.008","DOIUrl":"10.12336/biomatertransl.2021.04.008","url":null,"abstract":"The development of tissue engineering has led to new strategies for mitigating clinical problems; however, the design of the tissue engineering materials remains a challenge. The limited sources and inadequate function, potential risk of microbial or pathogen contamination, and high cost of cell expansion impair the efficacy and limit the application of exogenous cells in tissue engineering. However, endogenous cells in native tissues have been reported to be capable of spontaneous repair of the damaged tissue. These cells exhibit remarkable plasticity, and thus can differentiate or be reprogrammed to alter their phenotype and function after stimulation. After a comprehensive review, we found that the plasticity of these cells plays a major role in establishing the cell source in the mechanism involved in tissue regeneration. Tissue engineering materials that focus on assisting and promoting the natural self-repair function of endogenous cells may break through the limitations of exogenous seed cells and further expand the applications of tissue engineering materials in tissue repair. This review discusses the effects of endogenous cells, especially stem cells, on injured tissue repairing, and highlights the potential utilisation of endogenous repair in orthopaedic biomaterial constructions for bone, cartilage, and intervertebral disc regeneration.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"2 4","pages":"343-360"},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b5/8f/bt-02-04-343.PMC9255795.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10681524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0