Biomaterials Translational最新文献

Human-Artificial intelligence dialogue: Beyond the language barrier. 人类与人工智能对话：超越语言障碍。

Biomaterials Translational Pub Date : 2026-06-16 eCollection Date: 2026-01-01 DOI: 10.12336/bmt.26.00056

Zhidao Xia

引用次数: 0

Chlorin e6-loaded ethosomes for photodynamic wound therapy. 用于光动力伤口治疗的含氯e6酶体。

Biomaterials Translational Pub Date : 2026-05-13 eCollection Date: 2026-01-01 DOI: 10.12336/bmt.25.00177

Nina A Kalyagina, Artem A Shiryaev, Oleg S Kudryavtsev, Dmitry V Yakovlev, Mikhail P Ivankov, Aleksey S Skobeltsin, Alim F Malikov, Victor B Loschenov

{"title":"Chlorin e6-loaded ethosomes for photodynamic wound therapy.","authors":"Nina A Kalyagina, Artem A Shiryaev, Oleg S Kudryavtsev, Dmitry V Yakovlev, Mikhail P Ivankov, Aleksey S Skobeltsin, Alim F Malikov, Victor B Loschenov","doi":"10.12336/bmt.25.00177","DOIUrl":"10.12336/bmt.25.00177","url":null,"abstract":"Improving and optimizing photosensitizers for photodynamic wound therapy remains an urgent task in this field. This study investigates the properties of an ethosomal chlorin e6 (Ce6) photosensitizer and its penetration into various tissues within a wound area. We obtained and analyzed spatial- and geometric configurations, absorption and fluorescence spectra of Ce6 in both molecular and ethosomal forms, alongside studying its penetration into skin and muscle tissue. The synthesized particles were spherical with convex surfaces. The average particle diameter in the samples was 47.7 nm. The absorption and fluorescence spectra of ethosomal Ce6 exhibited a bathochromic shift of 13-16 nm relative to molecular Ce6. This shift in the fluorescence peak was primarily attributed to the presence of lecithin in the ethosomal solution. In contrast, the variability in peak position along the wavelength axis (2-5 nm) was more likely due to ethanol in the solution. Encapsulation of Ce6 in ethosomes overcomes the stratum corneum barrier of the skin, providing 1.5- to 2-fold deeper penetration (up to 180 µm) into the epidermis and papillary dermis compared to free Ce6 (50-120 µm). Upon direct application to muscle tissue, which lacks an epithelial barrier, both formulations penetrate substantially deeper (up to 1500 µm for ethosomal Ce6); however, tissue heterogeneity introduces considerable variability. Therefore, when planning diagnosis or therapy using ethosomal Ce6, it is necessary to select irradiation sources with wavelengths corresponding to these new, shifted absorption peaks, along with appropriate filters for detecting fluorescence in the new spectral range. Furthermore, the potentially greater and more variable depth of tissue saturation compared to skin must be taken into account, as this is a decisive factor in determining the optimal parameters for laser or light-emitting diode irradiation.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"7 2","pages":"321-328"},"PeriodicalIF":0.0,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limitations of the porcine model in post-total laryngectomy research. 猪模型在全喉切除术后研究中的局限性。

Biomaterials Translational Pub Date : 2026-05-12 eCollection Date: 2026-01-01 DOI: 10.12336/bmt.25.00227

Emilien Chabrillac, Thomas Hubert, Agnès Dupret-Bories

引用次数: 0

Smart biomaterials in regenerative medicine. 再生医学中的智能生物材料。

Biomaterials Translational Pub Date : 2026-01-15 eCollection Date: 2026-01-01 DOI: 10.12336/bmt.25.00073

Naveen Chandra Talniya

引用次数: 0

The advancement of composite materials in future biomedical technologies. 复合材料在未来生物医学技术中的进展。

Biomaterials Translational Pub Date : 2025-12-30 eCollection Date: 2025-01-01 DOI: 10.12336/bmt.25.00237

Wei Xia, Song Chen, Bin Li

引用次数: 0

Advancing biomedical innovation through composite material strategies. 通过复合材料战略推进生物医学创新。

Biomaterials Translational Pub Date : 2025-12-24 eCollection Date: 2025-01-01 DOI: 10.12336/bmt.25.00252

Song Chen, Wei Xia, Bin Li

引用次数: 0

Recombinant human bone morphogenetic protein-2-engineered piezoplatform synergistically promotes bone regeneration through bone morphogenetic protein receptor activation. 重组人骨形态发生蛋白-2工程压电平台通过激活骨形态发生蛋白受体协同促进骨再生。

Biomaterials Translational Pub Date : 2025-12-18 eCollection Date: 2025-01-01 DOI: 10.12336/bmt.25.00019

Lijie Mao, Dong Zhang, Zehao Shen, Xinqing Wang, Chen Lai, Fangping Chen, Changsheng Liu

{"title":"Recombinant human bone morphogenetic protein-2-engineered piezoplatform synergistically promotes bone regeneration through bone morphogenetic protein receptor activation.","authors":"Lijie Mao, Dong Zhang, Zehao Shen, Xinqing Wang, Chen Lai, Fangping Chen, Changsheng Liu","doi":"10.12336/bmt.25.00019","DOIUrl":"10.12336/bmt.25.00019","url":null,"abstract":"Bone morphogenetic protein-2 (BMP-2) is a potent cytokine that promotes bone formation in orthopedic procedures. However, the delivery of recombinant human BMP-2 (rhBMP-2) with sustained release kinetics, while maximizing osteogenic potential, remains a challenge. In this study, we constructed a novel rhBMP-2-engineered piezoplatform for sustained release of rhBMP-2 and synergistic enhancement of osteoinductive activity. The piezoelectric signals are capable of initiating rapid biomineralization and promoting the early adhesion, proliferation, and osteogenic differentiation of bone marrow stromal cells (BMSCs), as well as enabling efficient immobilization and sustained release of rhBMP-2 through electrostatic interactions. Notably, piezoelectric stimulation synergizing with rhBMP-2 enhances osteogenesis-related protein production. This is achieved by amplifying the expression of BMP-2 receptors (Bmpr1a and Bmpr2) in BMSCs by approximately three-fold, which in turn reinforces the regenerative capacity of rhBMP-2. The rat femur defect model further confirms the osteogenic efficacy of the rhBMP-2-engineered piezoplatform. These findings are expected to advance the development of biopiezoelectric implants incorporating growth factor therapy for tissue engineering.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"6 4","pages":"450-464"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating nanomedicine and immunotherapy: Bacterial membrane-derived vesicle-encapsulated prodrug assemblies for chronic infections. 整合纳米医学和免疫疗法：细菌膜来源的囊泡包封前药组件用于慢性感染。

Biomaterials Translational Pub Date : 2025-12-17 eCollection Date: 2025-01-01 DOI: 10.12336/bmt.25.00153

Xinnan Zhong, Jiaqi Chen, Yijun Li, Zilin Zhou, Jiyao Li, Jun Luo, Jiaojiao Yang

引用次数: 0

Cellular mechanisms of osteoporosis: A comprehensive perspective on ferroptosis, cuproptosis and lipid metabolism abnormalities. 骨质疏松的细胞机制：铁下垂、铜下垂和脂质代谢异常的综合视角。

Biomaterials Translational Pub Date : 2025-12-17 eCollection Date: 2026-01-01 DOI: 10.12336/bmt.24.00078

Hongfa Zhou, Jinhao Deng, Jingyuan Chen, Xuan Zhang, Liangbin Wu, Tiantian Qi, Hui Zeng, Kai Ren, Fei Yu

{"title":"Cellular mechanisms of osteoporosis: A comprehensive perspective on ferroptosis, cuproptosis and lipid metabolism abnormalities.","authors":"Hongfa Zhou, Jinhao Deng, Jingyuan Chen, Xuan Zhang, Liangbin Wu, Tiantian Qi, Hui Zeng, Kai Ren, Fei Yu","doi":"10.12336/bmt.24.00078","DOIUrl":"10.12336/bmt.24.00078","url":null,"abstract":"Osteoporosis is a prevalent skeletal disorder characterised by reduced bone mineral density and compromised bone microarchitecture, leading to increased bone fragility and increased risk of fracture. Recent studies have implicated ferroptosis, cuproptosis, and dysregulated lipid metabolism as pivotal factors in the pathogenesis of osteoporosis. Ferroptosis is an iron-dependent form of cell death that disrupts the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption by promoting lipid peroxidation and inducing cellular injury. Cuproptosis, associated with disruptions in copper homeostasis, influences bone cell integrity through oxidative stress and inflammatory responses, thereby impacting bone density. Aberrant lipid metabolism may exacerbate osteoporosis by disrupting bone-fat homeostasis, oxidative stress, and inflammatory responses. This review synthesizes the interplay between cuproptosis, ferroptosis, and lipid metabolism, elucidates the cellular mechanisms underlying osteoporosis, and accordingly provides novel therapeutic targets and intervention strategies, potentially enhancing osteoporosis prevention and treatment.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"7 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13190110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An exploration into the principles and theoretical progress of fracture treatment based on the mechanism of fracture healing. 从骨折愈合机制探讨骨折治疗的原理和理论进展。

Biomaterials Translational Pub Date : 2025-12-16 eCollection Date: 2025-01-01 DOI: 10.12336/bmt.24.00069

Haiming Ye, Qi Yang, Jiadi Hou, Xuan Zhang, Yien Zheng, Tiantian Qi, Fei Yu

{"title":"An exploration into the principles and theoretical progress of fracture treatment based on the mechanism of fracture healing.","authors":"Haiming Ye, Qi Yang, Jiadi Hou, Xuan Zhang, Yien Zheng, Tiantian Qi, Fei Yu","doi":"10.12336/bmt.24.00069","DOIUrl":"10.12336/bmt.24.00069","url":null,"abstract":"Fractures are a common category of diseases in the field of orthopaedics with a high incidence in archaeologically obtained bones. These diseases may occur in various human activities. In the context of technological advancement, the annual incidence of fractures is increasing due to traffic accidents, sports injuries, and ageing. Besides, the classification of fracture diseases is also changing, making them one of the main orthopaedic diseases that affect the quality of life of patients and national medical expenditure. There are some basic principles in the treatment of fractures, and the understanding of the causes, types, and pathogenesis of fractures is constantly improved with technological development. Hence, there are sustained efforts to explore fracture treatment methods and examine even widely popular concepts, such as Arbeitsgemeinschaft für Osteosynthesis (AO) and biological osteosynthesis (BO) principles. However, nonhealing fractures, fracture infections, and other treatment problems can still not be eliminated based on these concepts. In addition, some new perspectives on the treatment principles of fractures have been proposed by surgeons based on their clinical experience. In this paper, the latest research results on fracture healing are summarised, and our views and opinions on the application of AO or other new concepts in fracture treatment are also elucidated. During the investigation of the advantages and disadvantages of fracture treatment concepts, the shortcomings of current fracture treatment strategies or theories are also reviewed. These findings may provide clinicians with theoretical support for fracture treatment and inspire scholars to delve into fracture treatment principles.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"6 4","pages":"402-415"},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0