Biomaterials Translational最新文献_第3页

Meticulously engineered three-dimensional-printed scaffold with microarchitecture and controlled peptide release for enhanced bone regeneration. 精心设计的三维打印支架具有微结构和可控肽释放功能，可促进骨再生。

Biomaterials Translational Pub Date : 2024-03-28 eCollection Date: 2024-01-01 DOI: 10.12336/biomatertransl.2024.01.007

Jin Yang, Kanwal Fatima, Xiaojun Zhou, Chuanglong He

{"title":"Meticulously engineered three-dimensional-printed scaffold with microarchitecture and controlled peptide release for enhanced bone regeneration.","authors":"Jin Yang, Kanwal Fatima, Xiaojun Zhou, Chuanglong He","doi":"10.12336/biomatertransl.2024.01.007","DOIUrl":"10.12336/biomatertransl.2024.01.007","url":null,"abstract":"The repair of large load-bearing bone defects requires superior mechanical strength, a feat that a single hydrogel scaffold cannot achieve. The objective is to seamlessly integrate optimal microarchitecture, mechanical robustness, vascularisation, and osteoinductive biological responses to effectively address these critical load-bearing bone defects. To confront this challenge, three-dimensional (3D) printing technology was employed to prepare a polycaprolactone (PCL)-based integrated scaffold. Within the voids of 3D printed PCL scaffold, a methacrylate gelatin (GelMA)/methacrylated silk fibroin (SFMA) composite hydrogel incorporated with parathyroid hormone (PTH) peptide-loaded mesoporous silica nanoparticles (PTH@MSNs) was embedded, evolving into a porous PTH@MSNs/GelMA/SFMA/PCL (PM@GS/PCL) scaffold. The feasibility of fabricating this functional scaffold with a customised hierarchical structure was confirmed through meticulous chemical and physical characterisation. Compression testing unveiled an impressive strength of 17.81 ± 0.83 MPa for the composite scaffold. Additionally, in vitro angiogenesis potential of PM@GS/PCL scaffold was evaluated through Transwell and tube formation assays using human umbilical vein endothelium, revealing the superior cell migration and tube network formation. The alizarin red and alkaline phosphatase staining assays using bone marrow-derived mesenchymal stem cells clearly illustrated robust osteogenic differentiation properties within this scaffold. Furthermore, the bone repair potential of the scaffold was investigated on a rat femoral defect model using micro-computed tomography and histological examination, demonstrating enhanced osteogenic and angiogenic performance. This study presents a promising strategy for fabricating a microenvironment-matched composite scaffold for bone tissue engineering, providing a potential solution for effective bone defect repair.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"5 1","pages":"69-83"},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142117128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in electrode interface materials and modification technologies for brain-computer interfaces. 脑机接口电极界面材料和改性技术的进展。

Biomaterials Translational Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.12336/biomatertransl.2023.04.003

Yunke Jiao, Miao Lei, Jianwei Zhu, Ronghang Chang, Xue Qu

{"title":"Advances in electrode interface materials and modification technologies for brain-computer interfaces.","authors":"Yunke Jiao, Miao Lei, Jianwei Zhu, Ronghang Chang, Xue Qu","doi":"10.12336/biomatertransl.2023.04.003","DOIUrl":"10.12336/biomatertransl.2023.04.003","url":null,"abstract":"Recent advances in neuroelectrode interface materials and modification technologies are reviewed. Brain-computer interface is the new method of human-computer interaction, which not only can realise the exchange of information between the human brain and external devices, but also provides a brand-new means for the diagnosis and treatment of brain-related diseases. The neural electrode interface part of brain-computer interface is an important area for electrical, optical and chemical signal transmission between brain tissue system and external electronic devices, which determines the performance of brain-computer interface. In order to solve the problems of insufficient flexibility, insufficient signal recognition ability and insufficient biocompatibility of traditional rigid electrodes, researchers have carried out extensive studies on the neuroelectrode interface in terms of materials and modification techniques. This paper introduces the biological reactions that occur in neuroelectrodes after implantation into brain tissue and the decisive role of the electrode interface for electrode function. Following this, the latest research progress on neuroelectrode materials and interface materials is reviewed from the aspects of neuroelectrode materials and modification technologies, firstly taking materials as a clue, and then focusing on the preparation process of neuroelectrode coatings and the design scheme of functionalised structures.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"4 4","pages":"213-233"},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10817795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on Innovative design of minimal invasive biodegradable poly(glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration. 关于具有功能再生功能的微创生物可降解聚（甘油-十二酸酯）髓核支架的创新设计的评论。

Biomaterials Translational Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.12336/biomatertransl.2023.04.010

Hao Zhou, Aimin Wu

引用次数: 0

Harvest of functional mesenchymal stem cells derived from in vivo osteo-organoids. 收获来自体内骨组织的功能性间充质干细胞。

Biomaterials Translational Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.12336/biomatertransl.2023.04.006

Shunshu Deng, Fuwei Zhu, Kai Dai, Jing Wang, Changsheng Liu

{"title":"Harvest of functional mesenchymal stem cells derived from in vivo osteo-organoids.","authors":"Shunshu Deng, Fuwei Zhu, Kai Dai, Jing Wang, Changsheng Liu","doi":"10.12336/biomatertransl.2023.04.006","DOIUrl":"10.12336/biomatertransl.2023.04.006","url":null,"abstract":"Bone marrow-derived mesenchymal stem cells (BM-MSCs) play a crucial role in stem cell therapy and are extensively used in regenerative medicine research. However, current methods for harvesting BM-MSCs present challenges, including a low yield of primary cells, long time of in vitro expansion, and diminished differentiation capability after passaging. Meanwhile mesenchymal stem cells (MSCs) recovered from cell banks also face issues like toxic effects of cryopreservation media. In this study, we provide a detailed protocol for the isolation and evaluation of MSCs derived from in vivo osteo-organoids, presenting an alternative to autologous MSCs. We used recombinant human bone morphogenetic protein 2-loaded gelatin sponge scaffolds to construct in vivo osteo-organoids, which were stable sources of MSCs with large quantity, high purity, and strong stemness. Compared with protocols using bone marrow, our protocol can obtain large numbers of high-purity MSCs in a shorter time (6 days vs. 12 days for obtaining passage 1 MSCs) while maintaining higher stemness. Notably, we found that the in vivo osteo-organoid-derived MSCs exhibited stronger anti-replicative senescence capacity during passage and amplification, compared to BM-MSCs. The use of osteo-organoid-derived MSCs addresses the conflict between the limitations of autologous cells and the risks associated with allogeneic sources in stem cell transplantation. Consequently, our protocol emerges as a superior alternative for both stem cell research and tissue engineering.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"4 4","pages":"270-279"},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10817801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Converging technologies in biomaterial translational research. 生物材料转化研究中的融合技术。

Biomaterials Translational Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.12336/biomatertransl.2023.04.001

Long Bai, Jiacan Su

引用次数: 0

Recent advances of medical polyhydroxyalkanoates in musculoskeletal system. 肌肉骨骼系统中医用聚羟基烷酸酯的最新进展。

Biomaterials Translational Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.12336/biomatertransl.2023.04.004

Chen-Hui Mi, Xin-Ya Qi, Yan-Wen Ding, Jing Zhou, Jin-Wei Dao, Dai-Xu Wei

{"title":"Recent advances of medical polyhydroxyalkanoates in musculoskeletal system.","authors":"Chen-Hui Mi, Xin-Ya Qi, Yan-Wen Ding, Jing Zhou, Jin-Wei Dao, Dai-Xu Wei","doi":"10.12336/biomatertransl.2023.04.004","DOIUrl":"10.12336/biomatertransl.2023.04.004","url":null,"abstract":"Infection and rejection in musculoskeletal trauma often pose challenges for natural healing, prompting the exploration of biomimetic organ and tissue transplantation as a common alternative solution. Polyhydroxyalkanoates (PHAs) are a large family of biopolyesters synthesised in microorganism, demonstrating excellent biocompatibility and controllable biodegradability for tissue remodelling and drug delivery. With different monomer-combination and polymer-types, multi-mechanical properties of PHAs making them have great application prospects in medical devices with stretching, compression, twist in long time, especially in musculoskeletal tissue engineering. This review systematically summarises the applications of PHAs in multiple tissues repair and drug release, encompassing areas such as bone, cartilage, joint, skin, tendons, ligament, cardiovascular tissue, and nervous tissue. It also discusses challenges encountered in their application, including high production costs, potential cytotoxicity, and uncontrollable particle size distribution. In conclusion, PHAs offer a compelling avenue for musculoskeletal system applications, striking a balance between biocompatibility and mechanical performance. However, addressing challenges in their production and application requires further research to unleash their full potential in tackling the complexities of musculoskeletal regeneration.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"4 4","pages":"234-247"},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10817797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early immunomodulation by magnesium ion: catalyst for superior osteogenesis. 镁离子的早期免疫调节作用：优质成骨的催化剂

Biomaterials Translational Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.12336/biomatertransl.2023.04.009

Bo Li

引用次数: 0

Organoid extracellular vesicle-based therapeutic strategies for bone therapy. 基于细胞外囊泡的有机体骨治疗策略。

Biomaterials Translational Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.12336/biomatertransl.2023.04.002

Han Liu, Jiacan Su

{"title":"Organoid extracellular vesicle-based therapeutic strategies for bone therapy.","authors":"Han Liu, Jiacan Su","doi":"10.12336/biomatertransl.2023.04.002","DOIUrl":"10.12336/biomatertransl.2023.04.002","url":null,"abstract":"With the rapid development of population ageing, bone-related diseases seriously affecting the life of the elderly. Over the past few years, organoids, cell clusters with specific functions and structures that are self-induced from stem cells after three-dimensional culture in vitro, have been widely used for bone therapy. Moreover, organoid extracellular vesicles (OEVs) have emerging as promising cell-free nanocarriers due to their vigoroso physiological effects, significant biological functions, stable loading capacity, and great biocompatibility. In this review, we first provide a comprehensive overview of biogenesis, internalisation, isolation, and characterisation of OEVs. We then comprehensively highlight the differences between OEVs and traditional EVs. Subsequently, we present the applications of natural OEVs in disease treatment. We also summarise the engineering modifications of OEVs, including engineering parental cells and engineering OEVs after isolation. Moreover, we provide an outlook on the potential of natural and engineered OEVs in bone-related diseases. Finally, we critically discuss the advantages and challenges of OEVs in the treatment of bone diseases. We believe that a comprehensive discussion of OEVs will provide more innovative and efficient solutions for complex bone diseases.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"4 4","pages":"199-212"},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10817793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of magnesium-doped porous polylactic acid microsphere for bone regeneration. 用于骨再生的掺镁多孔聚乳酸微球的制备。

Biomaterials Translational Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.12336/biomatertransl.2023.04.007

Ziwei Tao, Ziyang Yuan, Dong Zhou, Lang Qin, Lan Xiao, Shihao Zhang, Changsheng Liu, Jinzhong Zhao, Yulin Li

{"title":"Fabrication of magnesium-doped porous polylactic acid microsphere for bone regeneration.","authors":"Ziwei Tao, Ziyang Yuan, Dong Zhou, Lang Qin, Lan Xiao, Shihao Zhang, Changsheng Liu, Jinzhong Zhao, Yulin Li","doi":"10.12336/biomatertransl.2023.04.007","DOIUrl":"10.12336/biomatertransl.2023.04.007","url":null,"abstract":"Biodegradable polymer microspheres that can be used as drug carriers are of great importance in biomedical applications, however, there are still challenges in controllable preparation of microsphere surface morphology and improvement of bioactivity. In this paper, firstly, poly(L-lactic acid) (PLLA) was synthesised by ring-opening polymerisation under anhydrous anaerobic conditions and further combined with the emulsion method, biodegradable PLLA microspheres (PM) with sizes ranging from 60-100 μm and with good sphericity were prepared. In addition, to further improve the surface morphology of PLLA microspheres and enhance their bioactivity, functionalised porous PLLA microspheres loaded with magnesium oxide (MgO)/magnesium carbonate (MgCO3) (PMg) were also prepared by the emulsion method. The results showed that the loading of MgO/MgCO3 resulted in the formation of a porous structure on the surface of the microspheres (PMg) and the dissolved Mg2+ could be released slowly during the degradation of microspheres. In vitro cellular experiments demonstrated the good biocompatibility of PM and PMg, while the released Mg2+ further enhanced the anti-inflammatory effect and osteogenic activity of PMg. Functionalised PMg not only show promise for controlled preparation of drug carriers, but also have translational potential for bone regeneration.","PeriodicalId":58820,"journal":{"name":"Biomaterials Translational","volume":"4 4","pages":"280-290"},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10817799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139572388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI accelerated discovery of self-assembling peptides. 人工智能加速了自组装肽的发现。

Biomaterials Translational Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.12336/biomatertransl.2023.04.008

Yejiao Shi, Honggang Hu

引用次数: 0