Gold Bulletin最新文献_第2页

New dinuclear gold(III) complex with 1,5-naphthyridine as bridging ligand: synthesis, characterization, DNA/BSA binding studies, and anticancer activity 以 1,5-萘啶为桥接配体的新型双核金（III）配合物：合成、表征、DNA/BSA 结合研究和抗癌活性

IF 2.1 4区工程技术

Gold Bulletin Pub Date : 2024-04-12 DOI: 10.1007/s13404-024-00344-8

Snežana Radisavljević, Dušan Ćoćić, Biljana Petrović, Ina Kellner, Ivana Ivanović-Burmazović, Nikola Radenković, Danijela Nikodijević, Milena Milutinović

{"title":"New dinuclear gold(III) complex with 1,5-naphthyridine as bridging ligand: synthesis, characterization, DNA/BSA binding studies, and anticancer activity","authors":"Snežana Radisavljević, Dušan Ćoćić, Biljana Petrović, Ina Kellner, Ivana Ivanović-Burmazović, Nikola Radenković, Danijela Nikodijević, Milena Milutinović","doi":"10.1007/s13404-024-00344-8","DOIUrl":"10.1007/s13404-024-00344-8","url":null,"abstract":"<div><p>To elucidate an antitumor drug exhibiting enhanced activity relative to cisplatin, a novel dinuclear gold(III) complex was synthesized, incorporating 1,5-naphthyridine as a bridging ligand. Subsequently, the newly synthesized complex underwent comprehensive characterization using various techniques to validate its structural attributes. The stability of the complex in both water and PBS buffer was assessed through UV–Vis spectroscopy. DNA binding studies were conducted employing UV–Vis, fluorescence spectroscopy, and viscosity measurements. Competitive studies with ethidium bromide (EB) or 4′-hydroxyethidium (HOE) were performed utilizing fluorescence spectroscopy. The findings indicated that the dinuclear gold(III) complex interacts with calf thymus DNA (CT-DNA) through a groove binding mode. Moreover, the investigated complex exhibited significant binding constants for its interaction with human serum albumin (HSA) and bovine serum albumin (BSA) and interactions in the presence of site markers (eosin Y or ibuprofen). The dinuclear gold(III) complex demonstrated notable cytotoxicity against HCT116 and MDA-MB-231 cancer cell lines at 24 and 72 h post-treatment. Furthermore, the complex displayed selectivity by inducing significantly lower cytotoxic activity in healthy cells than in cancerous ones. In support of its antitumor activity, the complex exhibited proapoptotic effects, as evidenced by increased caspase 9 activity and low percentages of necrosis. Molecular docking simulations were employed to corroborate all experimentally obtained results.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"57 1-2","pages":"9 - 25"},"PeriodicalIF":2.1,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual selectivity in gold-catalyzed intermolecular Heck reactions 金催化分子间赫克反应的异常选择性

IF 2.1 4区工程技术

Gold Bulletin Pub Date : 2024-03-25 DOI: 10.1007/s13404-024-00342-w

Mahesh Bhagwan Thoke, Nitin T. Patil

引用次数: 0

In vivo toxicity and biodistribution of intravenously administered antibiotic-functionalized gold nanoparticles 静脉注射抗生素功能化金纳米粒子的体内毒性和生物分布

IF 2.1 4区工程技术

Gold Bulletin Pub Date : 2024-03-21 DOI: 10.1007/s13404-024-00343-9

Pradeepa, Rashmi Kanugodu Vasappa, Darshini Shivamogga Mohan, Srinivas Mutalik, Manjunatha Bukkambudhi Krishnaswamy, Anil Kumar Honnali Srinivasalu, Mukunda Suryanarayana, Vidya Shimoga Muddappa

{"title":"In vivo toxicity and biodistribution of intravenously administered antibiotic-functionalized gold nanoparticles","authors":"Pradeepa, Rashmi Kanugodu Vasappa, Darshini Shivamogga Mohan, Srinivas Mutalik, Manjunatha Bukkambudhi Krishnaswamy, Anil Kumar Honnali Srinivasalu, Mukunda Suryanarayana, Vidya Shimoga Muddappa","doi":"10.1007/s13404-024-00343-9","DOIUrl":"10.1007/s13404-024-00343-9","url":null,"abstract":"<div><p>The utilization of engineered gold nanoparticles (GNPs) in biomedical applications is experiencing rapid growth owing to their reactive nature and remarkable flexibility. However, despite these advantages, concerns persist regarding their in vivo biocompatibility and cytotoxicity. This study aimed to assess the toxicity, biodistribution, and excretion pathways of GNPs functionalized with various antibiotics, namely, ciprofloxacin, levofloxacin, cefotaxime, and ceftriaxone, using a mouse model. Following intravenous administration, the nanostructures induced an increase in serum enzyme levels and histological abnormalities in the liver, indicating potential hepatotoxic effects. Analysis of organ distribution revealed accumulation primarily in the liver and spleen, with concentrations gradually decreasing 168-h post-administration. Fecal excretion was identified as the primary route of elimination, with a smaller portion excreted via urine. Among the different nanostructures evaluated, those functionalized with levofloxacin (LEV-NP) exhibited minimal organ toxicity and a high clearance rate. Additionally, LEV-NP, with a size of approximately 12 nm, demonstrated superior drug particle stability and lower red blood cell hemolytic activity compared to other nanostructures.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 4","pages":"209 - 220"},"PeriodicalIF":2.1,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140199801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A microextraction method for spectrophotometric determination of gold using benzalkonium chloride 使用苯扎氯铵分光光度法测定金的微萃取方法

IF 2.1 4区工程技术

Gold Bulletin Pub Date : 2024-02-14 DOI: 10.1007/s13404-024-00341-x

Zekeriyya Bahadır

引用次数: 0

Characterization of L-cysteine methyl ester hydrochloride–stabilized gold nanoparticles 稳定的 L-半胱氨酸甲酯盐酸盐金纳米粒子的表征

IF 2.1 4区工程技术

Gold Bulletin Pub Date : 2024-02-01 DOI: 10.1007/s13404-024-00340-y

Ana Aguilera-Juárez, Luis Hernández-Adame, Miguel Ángel Ruíz-Gómez, Elizabeth Monreal Escalante, Martha Reyes-Becerril, Sergio Rosales-Mendoza, Héctor G. Silva Pereyra, Carlos Angulo

{"title":"Characterization of L-cysteine methyl ester hydrochloride–stabilized gold nanoparticles","authors":"Ana Aguilera-Juárez, Luis Hernández-Adame, Miguel Ángel Ruíz-Gómez, Elizabeth Monreal Escalante, Martha Reyes-Becerril, Sergio Rosales-Mendoza, Héctor G. Silva Pereyra, Carlos Angulo","doi":"10.1007/s13404-024-00340-y","DOIUrl":"10.1007/s13404-024-00340-y","url":null,"abstract":"<div><p>The synthesis of gold nanoparticles (AuNPs) by bottom-up methods, such as redox reactions using amino acids and gold salts, has turned out to be a novel method for obtaining nanoparticles due to the reducing properties of these biomolecules and the ability to give the nanoparticle peculiar physicochemical characteristics for its biological application, thus derived from the known structure and amino acids functional groups. In this sense, this work shows the characterization using UV-Vis, DLS, FTIR, XPS, and HRTEM techniques of AuNPs synthesized using sodium borohydride (NaBH<sub>4</sub>) as a reducing compound and L-cysteine methyl ester hydrochloride (cysteine precursor) (HSCH<sub>2</sub>CH (NH<sub>2</sub>) COOCH<sub>3</sub> • HCl) as a stabilizing agent. The above elucidates the reaction mechanisms for the formation of the nanoparticle through these reactions, as well as the stabilizing action and possible reducing potential of cysteine. Likewise, the resulting Cis@AuNP compounds were subjected to a preliminary biological evaluation using cell viability toxicity tests. The Cis@AuNPs showed high colloidal stability in a pH range of 3 to 11, where the L-cysteine methyl ester hydrochloride functional groups strongly influenced the hydrodynamic diameter and zeta potential behavior. Cytotoxicity assays in mouse leukocytes demonstrated the safety of these nanoparticles. These encouraging results open the way to explore the biological application potential of these systems with the perspective of their possible application in vaccinology.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 4","pages":"179 - 189"},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139662173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A convergent fabrication of 1-aminopyridine-capped gold nanomaterials and reduced graphene oxide nanocomposites for ovarian cancer cells 用于卵巢癌细胞的1-氨基吡啶包覆金纳米材料和还原氧化石墨烯纳米复合材料的聚合制备

IF 2.1 4区工程技术

Gold Bulletin Pub Date : 2023-11-27 DOI: 10.1007/s13404-023-00339-x

Wei Luan, Meiyun Zheng, Youlin Yang, Yi Chen, Xiahui Zhang, Lingping Zhu, Chenxiao Lin

{"title":"A convergent fabrication of 1-aminopyridine-capped gold nanomaterials and reduced graphene oxide nanocomposites for ovarian cancer cells","authors":"Wei Luan, Meiyun Zheng, Youlin Yang, Yi Chen, Xiahui Zhang, Lingping Zhu, Chenxiao Lin","doi":"10.1007/s13404-023-00339-x","DOIUrl":"10.1007/s13404-023-00339-x","url":null,"abstract":"<div><p>Since their discovery, graphene nanocomposites have attracted much attention for their potential use in many biological applications. Herein, we examined the highly reduced graphene oxide (HRGO) and gold nanomaterial (AuNM)-based (HRGO/Au@AP) nanocomposite for ovarian cancer and apoptosis-inducing abilities, the nanomaterials’ anticancer activities against human ovarian cancer cell lines (SKOV3 and A2780). HRGO was functionalized with the 1-aminopyridine (AP) as a potential stabilizing agent to improve the sample’s solubility and bioavailability. The surface morphology and structure of the nanocomposites were examined by high-resolution transmission electron microscopy. The results of an anticancer study comparing HRGO, HRGO/Au, and HRGO/Au@AP nanocomposites showed a greater capacity to induce apoptosis, the apoptosis assays (AO-EB, DAPI, and Annexin V-FITC/PI staining) and reactive oxygen species (ROS) measurements on SKOV3 and A2780 cells. This data suggests that HRGO/Au@AP promotes potent apoptosis in human ovarian cancer cells.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 4","pages":"167 - 178"},"PeriodicalIF":2.1,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138527948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High power impulse magnetron sputtering (HiPIMS) prepared ultrathin gold film for plasmonic biosensor application 高功率脉冲磁控溅射（HiPIMS）制备的超薄金膜在等离子体生物传感器中的应用

IF 2.1 4区工程技术

Gold Bulletin Pub Date : 2023-11-09 DOI: 10.1007/s13404-023-00338-y

Sheng-Yang Huang, Ping-Yen Hsieh, Chi-Jen Chung, Chia-Man Chou, Ju-Liang He

{"title":"High power impulse magnetron sputtering (HiPIMS) prepared ultrathin gold film for plasmonic biosensor application","authors":"Sheng-Yang Huang, Ping-Yen Hsieh, Chi-Jen Chung, Chia-Man Chou, Ju-Liang He","doi":"10.1007/s13404-023-00338-y","DOIUrl":"10.1007/s13404-023-00338-y","url":null,"abstract":"<div><p>The global pandemic of coronavirus disease 2019 (COVID-19) has come to a different stage worldwide. Until now, the common flu-like outbreaks have led to increasing demand for screening tests with high sensitivity and specificity. Among biosensors, the noble metal nano-optical sensor based on localized surface plasmon resonance (LSPR) has great potential due to its simple design, feasible manufacturing, and fast response. To develop an efficient and economic examination, this study utilizes high power impulse magnetron sputtering (HiPIMS) to prepare ultrathin gold film (UTGF) on glass substrate. The experimental results show that with an increase in the deposition time from 3 s to 144 s, the UTGF forms from an island-like morphology, a network structure, to ultimately a smooth UTGF layer on glass. When the UTGF sample is conjugated with human serum albumin (HSA) at 5 × 10<sup>−4</sup> M as a pretest analyte, a significant peak shift of 25.6 nm was detected for the UTGF deposited at 12 s. Based on the UV-Vis measurement, the plasmonic loss peak of the UTGF sample with deposition times of 6 s, 12 s, and 24 s are 537.1 nm, 601.9 nm, and 665.8 nm, respectively, whereas the deposition time of 12 s prepared UTGF sample revealed the strongest LSPR effect. With a prolonged deposition time over the percolation time (48 s), those UTGF samples gave no LSPR response. To further detect viral antigen, recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein, the UTGF were functionalized with mouse anti-human immunoglobulin G (IgG). The HiPIMS prepared UTGF sample feasible for SARS-CoV-2 detection is demonstrated, giving potential application on rapid and ultrasensitive biomolecules sensor.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 4","pages":"199 - 208"},"PeriodicalIF":2.1,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135192548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Au versus Au–Pd nanoparticles towards synthesis of spirooxindoles via multicomponent reaction Au与Au–Pd纳米颗粒通过多组分反应合成螺环吲哚的效果

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2023-10-04 DOI: 10.1007/s13404-023-00336-0

Shivanee Borpatra Gohain, Abdul Latif Ahmed, Ashim Jyoti Thakur

{"title":"Efficacy of Au versus Au–Pd nanoparticles towards synthesis of spirooxindoles via multicomponent reaction","authors":"Shivanee Borpatra Gohain, Abdul Latif Ahmed, Ashim Jyoti Thakur","doi":"10.1007/s13404-023-00336-0","DOIUrl":"10.1007/s13404-023-00336-0","url":null,"abstract":"<div><p>The catalytic efficacy of monometallic (Pd NPs) <i>vs</i> bimetallic nanocatalyst (Au NPs and Pd NPs supported on rGO) towards the one-pot synthesis of spirooxindole derivatives has been compared under mild reaction conditions. The multicomponent reaction comprised of reaction of substituted isatins, malononitrile, and 1,3-dicarbonyl compounds to synthesise series of diverse spirooxindoles. The nano-Au–Pd@rGO catalyst showed enhanced catalytic activity in the synthesis of spirooxindoles when compared to that of the monometallic nano-Pd/rGO catalyst which may be indicative of potential synergistic effect in the bimetallic catalyst viz Au and Pd NPs facilitating the accelerated synthesis of spirooxindoles in excellent yields. This methodology has the advantages of utilisation of non-toxic solvent, higher product yields, and lower reaction times at room temperature. Also, higher yields for spirooxindoles in case of substituted carbonyl compounds were observed, an indicative of the <i>gem</i>-dialkyl effect responsible to favour higher yields for spirooxindoles synthesised with di-methyl substituted cyclohexan-diones with respect to the unsubstituted ones for both catalytic systems.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 2","pages":"43 - 51"},"PeriodicalIF":2.2,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

18 Karat yellow gold single-tracks manufactured by Laser Powder Bed Fusion (LPBF): 1 064 nm and 515 nm laser comparison 由Laser Powder Bed Fusion（LPBF）制造的18克拉黄金单道：1064nm和515nm激光比较

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2023-09-29 DOI: 10.1007/s13404-023-00337-z

Aymeric Domine, Lucas Dembinski, Ludovic Vitu, Nouredine Fenineche

引用次数: 0

Microbial-mediated synthesis of gold nanoparticles—current insights and future vistas 微生物介导的金纳米粒子的合成——现状与展望

IF 2.2 4区工程技术

Gold Bulletin Pub Date : 2023-09-19 DOI: 10.1007/s13404-023-00335-1

Muhammad Nadeem, Laiba Pervez, Ameer Muhammad Khan, Rachel A. Burton, Sana Ullah, Akhtar Nadhman, Jonathan Celli

引用次数: 0