{"title":"通过 MAPK 信号通路调节微生物群，简便制备金纳米粒子装饰的硫酸软骨素复合制剂，以减少卵巢切除大鼠的骨质疏松症。","authors":"Xinyi Guo, Haoyu Feng","doi":"10.1007/s13404-024-00347-5","DOIUrl":null,"url":null,"abstract":"<div><p>Osteoporosis represents a prevalent disease that involves the degeneration of bone. The development of potent therapies is desired because the current clinical treatments are not able to provide a satisfying therapeutic effect. Recently, gold (Au) nanomaterials and chondroitin sulfate (CS) have been attracted a lot of attention in the field of drug delivery. The purpose of this research was to investigate exactly CS-AuNP function and its positive influences on anti-osteoporosis in ovariectomized (OVX) rats. The outcome of the OVX rats experimental results revealed effective anti-osteoporosis molecular targets of developed CS-AuNP formulation and their influence on the gut microbiota. Importantly, CS-AuNPs significantly improved lipid profiles, bone microstructure, metabolism markers, and bone mineral density. The findings provide more evidence that CS-AuNPs have effective therapeutic potential in anti-osteoporotic treatment by the MAPK signaling pathway.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"57 1-2","pages":"49 - 63"},"PeriodicalIF":2.1000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Facile preparation of gold nanoparticle-decorated chondroitin sulfate composited formulation to reduce osteoporosis in rats with ovariectomies by regulating the microbiota by MAPK signaling pathway.\",\"authors\":\"Xinyi Guo, Haoyu Feng\",\"doi\":\"10.1007/s13404-024-00347-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Osteoporosis represents a prevalent disease that involves the degeneration of bone. The development of potent therapies is desired because the current clinical treatments are not able to provide a satisfying therapeutic effect. Recently, gold (Au) nanomaterials and chondroitin sulfate (CS) have been attracted a lot of attention in the field of drug delivery. The purpose of this research was to investigate exactly CS-AuNP function and its positive influences on anti-osteoporosis in ovariectomized (OVX) rats. The outcome of the OVX rats experimental results revealed effective anti-osteoporosis molecular targets of developed CS-AuNP formulation and their influence on the gut microbiota. Importantly, CS-AuNPs significantly improved lipid profiles, bone microstructure, metabolism markers, and bone mineral density. The findings provide more evidence that CS-AuNPs have effective therapeutic potential in anti-osteoporotic treatment by the MAPK signaling pathway.</p></div>\",\"PeriodicalId\":581,\"journal\":{\"name\":\"Gold Bulletin\",\"volume\":\"57 1-2\",\"pages\":\"49 - 63\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gold Bulletin\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13404-024-00347-5\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gold Bulletin","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s13404-024-00347-5","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Facile preparation of gold nanoparticle-decorated chondroitin sulfate composited formulation to reduce osteoporosis in rats with ovariectomies by regulating the microbiota by MAPK signaling pathway.
Osteoporosis represents a prevalent disease that involves the degeneration of bone. The development of potent therapies is desired because the current clinical treatments are not able to provide a satisfying therapeutic effect. Recently, gold (Au) nanomaterials and chondroitin sulfate (CS) have been attracted a lot of attention in the field of drug delivery. The purpose of this research was to investigate exactly CS-AuNP function and its positive influences on anti-osteoporosis in ovariectomized (OVX) rats. The outcome of the OVX rats experimental results revealed effective anti-osteoporosis molecular targets of developed CS-AuNP formulation and their influence on the gut microbiota. Importantly, CS-AuNPs significantly improved lipid profiles, bone microstructure, metabolism markers, and bone mineral density. The findings provide more evidence that CS-AuNPs have effective therapeutic potential in anti-osteoporotic treatment by the MAPK signaling pathway.
期刊介绍：
Gold Bulletin is the premier international peer reviewed journal on the latest science, technology and applications of gold. It includes papers on the latest research advances, state-of-the-art reviews, conference reports, book reviews and highlights of patents and scientific literature. Gold Bulletin does not publish manuscripts covering the snthesis of Gold nanoparticles in the presence of plant extracts or other nature-derived extracts. Gold Bulletin has been published over 40 years as a multidisciplinary journal read by chemists, physicists, engineers, metallurgists, materials scientists, biotechnologists, surface scientists, and nanotechnologists amongst others, both within industry and academia. Gold Bulletin is published in Association with the World Gold Council.
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