Future Journal of Pharmaceutical Sciences最新文献

{"title":"Surface-engineered chitosan-coated nanostructured lipid carriers for intranasal delivery of Oxcarbazepine and Vitamin E oil in epilepsy management","authors":"Farhan Haider,&nbsp;Eman Aldosari,&nbsp;Rabea Parveen,&nbsp;Sanjula Baboota,&nbsp;Azka Gull,&nbsp;Saba Khan,&nbsp;Javed Ali","doi":"10.1186/s43094-025-00855-x","DOIUrl":"10.1186/s43094-025-00855-x","url":null,"abstract":"<div><h3>Background</h3><p>The effectiveness of conventional oral antiepileptic drug administration is hampered by issues such as inadequate bioavailability, dose-related adverse effects and non-compliance in alleviating epilepsy. Oral antiepileptic drugs have not been successful in treating epilepsy due to high first-pass metabolism, and restriction due to blood–brain barrier and oxidative damage is a significant problem experienced by epileptic patients taking antiepileptic drugs.</p><p>The major goal of the current study was to explore the ability of the developed chitosan-coated nanostructured lipid carriers of Oxcarbazepine (CS OXC-NLC) integrated with Vitamin E to lessen oxidative stress and offers neuroprotection and aids in boosting the antiepileptic efficacy through intranasal drug delivery.</p><h3>Results</h3><p>In the present work, CS OXC-NLC was fabricated using melt emulsification process. Central Composite Rotatable Design has been utilized to optimize formulation. The study findings showed that optimized CS OXC-NLC exhibited 1.8 times increment in in vitro release and a twofold enhancement in permeability in comparison with the Oxcarbazepine suspension. Confocal microscopy verified the improvement in penetration by showing greater fluorescence in CS OXC-NLC (40 µm) than Oxcarbazepine suspension (22.8 µm) through the nasal mucosa. The pharmacokinetic parameters and biodistribution of OXC levels in the brain and plasma were duly examined. The rise in the amount of drug inside the brain demonstrates the effectiveness of targeting via intranasal administration.</p><h3>Conclusion</h3><p>The study outcome demonstrated that the developed CS OXC-NLC is a viable synergistic method producing alluring results for alleviating epilepsy. It depicts the potential of chitosan coating in enhancing the in vivo prospect of the developed formulation through intranasal delivery. Chitosan plays a significant role in enhancing the performance of NLC for intranasal delivery owing to its mucoadhesion properties, controlled release, permeation enhancement and biocompatibility.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00855-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145171291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical insights into analytical methodologies for lidocaine hydrochloride and diltiazem hydrochloride: a comparative review","authors":"Shivani Patel,&nbsp;Archita Patel,&nbsp;Chandni Chandarana,&nbsp;Bhavesh Patel,&nbsp;Mehul Patel,&nbsp;Umang Shah,&nbsp;Swayamprakash Patel,&nbsp;Nilay Solanki,&nbsp;Drashti Shah,&nbsp;Ashish Patel","doi":"10.1186/s43094-025-00852-0","DOIUrl":"10.1186/s43094-025-00852-0","url":null,"abstract":"<div><h3>Background</h3><p>This study focuses on a fixed-dose combination of lidocaine hydrochloride and diltiazem hydrochloride for the treatment of anal fissures, where lidocaine acts as an anesthetic and diltiazem serves as a slow calcium channel blocker. The objective is to provide a concise overview of the fundamental principles of spectrophotometric and chromatographic methods for quantitative analysis from 2012 to 2022.</p><h3>Main text</h3><p>This review highlights the development of novel techniques for both individual and simultaneous quantification, including ultraviolet–visible spectrophotometry (UV–Vis), high-performance liquid chromatography, and high-performance thin-layer chromatography. Additionally, it addresses the capability of various analytical methods to detect and measure compounds at microgram to nanogram levels.</p><h3>Conclusions</h3><p>From 2012 to 2022, significant advancements in spectrophotometric and chromatographic methods for analyzing pharmaceutical compounds such as lidocaine and diltiazem have been made. These advancements have improved the sensitivity, accuracy, and efficiency of quantitative analyses, contributing to better quality control and therapeutic efficacy of pharmaceutical products. Modern techniques can detect and quantify compounds at microgram to nanogram levels, ensuring accurate dosing and safety assessments in pharmaceutical formulations.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00852-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bitter lemon extract mitigates obesity-exacerbated osteoarthritis by suppressing Mmp-13 and restoring redox balance through Nrf2/Ho-1 upregulation","authors":"Ayodeji Johnson Ajibare,&nbsp;Olabode Oluwadare Akintoye,&nbsp;Oluwatobiloba Adesewa Oriowo,&nbsp;Abosede Mary Ayoola,&nbsp;Isaac Adeola Oriyomi,&nbsp;Joshua Favour Adedara,&nbsp;Favour Oluwaferanmi Oluwamoroti,&nbsp;Kehinde Olaniyi,&nbsp;Kayode Tajudeen Salami","doi":"10.1186/s43094-025-00845-z","DOIUrl":"10.1186/s43094-025-00845-z","url":null,"abstract":"<div><h3>Background</h3><p>Osteoarthritis, the most common joint disease, affects over 500 million people globally, especially the elderly. Due to the increasing aging population and obesity rate, obesity is expected to increase over time, making it a significant public health challenge. This study investigated the protective effects of bitter lemon extract against obesity-exacerbated osteoarthritis.</p><h3>Methods</h3><p>Thirty male Wistar rats were randomly grouped into six (<i>n</i> = 5). Group 1(control) received 1 ml/100 g water daily. Groups 2–6 were induced in obesity using a high-fat diet. Groups 3–6 were induced with osteoarthritis using 4 mg/kg sodium monoacetate. Group 4 received 40 mg/kg ibuprofen, while groups 5 and 6 received 100 mg/kg and 200 mg/kg <i>Mormordica charantia</i> (MC), respectively, orally for 18 days.</p><h3>Results</h3><p>MC Treatment conferred a marked reversal of the cardinal signs of obesity-linked osteoarthritis, restricted inflammatory markers, such as TNF-α and IL-1β, and adipokines, such as leptin. There is also a possible mechanism for MC cartilage protection by suppressing the collagen-damaging enzyme MMP-13, while reversing the cartilage-building block aggrecan suppression.</p><h3>Conclusion</h3><p>Current research suggests that bitter melon extract can serve as an alternative therapy for obesity-related Osteoarthritis. Its multi-target actions on inflammation, oxidative stress, and cartilage degradation may offer advantages over the current treatments that focus on symptom relief.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00845-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking barriers: targeted delivery of resveratrol in lung cancer using folate-integrated and pH-responsive hybrid nanocarriers","authors":"Sanjoy Das,&nbsp;Malay K. Das,&nbsp;Taison Jamatia,&nbsp;Nayan Ranjan Ghose Bishwas,&nbsp;Dhritiman Roy,&nbsp;Emdormi Rymbai","doi":"10.1186/s43094-025-00850-2","DOIUrl":"10.1186/s43094-025-00850-2","url":null,"abstract":"<div><h3>Background</h3><p>Targeting lung cancer while sparing healthy cells is the cornerstone of chemotherapy; however, bioavailability issues and complex biological barriers prevent their accumulation in the tumor sites. Working on this rationale, the present study was aimed to develop novel and affordable hybrid nanocarriers combined with folate and pH-responsive functionalities for targeted delivery of Resveratrol (FOL-RSV-LPHNCs).</p><h3>Methods</h3><p>The developed FOL-RSV-LPHNCs were first optimized by the design of experiment with Box–Behnken design and then characterized for physicochemical properties, cytotoxicity, in vivo pharmacokinetic behavior and anticancer efficacy in the xenograft mouse model.</p><h3>Results</h3><p>Results showed that optimized FOL-RSV-LPHNCs had a monodisperse spherical size of 247.86 ± 0.30 nm, entrapment efficiency of 93.72 ± 0.10% and drug loading of 4.16 ± 0.02%, respectively. The amount of RSV released from FOL-RSV-LPHNCs was 96.53 ± 2.16% at pH 5.8 and 23.21 ± 2.01% at pH 7.4, indicative of a pH-responsive release pattern and good physiological stability. In vitro cytotoxicity study revealed that FOL-RSV-LPHNCs remarkably inhibited the viability of A549 cells and produced negligible toxic effect on Wi-38 healthy cells. The single-dose intravenous administration of FOL-RSV-LPHNCs displayed 3.79-fold longer AUC_0-∞, 3.54-fold greater t_1/2 and 4.16-fold higher MRT_0-∞ than free RSV. Finally, in vivo targeting and anticancer studies demonstrated that FOL-RSV-LPHNCs selectively internalized to the cancerous region and suppressed the tumor volume with an 8.66-fold higher rate in the xenograft mouse model. The folate receptor-mediated uptake mainly facilitates this superior therapeutic response which was further confirmed by in silico molecular docking and dynamic simulation.</p><h3>Conclusions</h3><p>Our findings suggested that FOL-RSV-LPHNCs might serve as an auspicious nanoplatform for targeted drug delivery and treatment of lung cancer.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00850-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin promoted the therapeutic potential of cisplatin in a rat model of hepatocellular carcinoma: COX-2 and MDM2/p53/miR-155 modulation associated with cytoprotection and tumour regression","authors":"Asmaa Mohammed ShamsEldeen,&nbsp;Laila Rashed,&nbsp;Abbas Mohamed,&nbsp;Ebtehal Gamal Abdelhady,&nbsp;Sara Adel Hosny,&nbsp;Hala Hassan Mohamed,&nbsp;Yara Sayed Eldosouky,&nbsp;Mohamed Hassan Gad,&nbsp;Hind Awad Zafrah,&nbsp;Hayam Ateyya,&nbsp;Hend Ashour","doi":"10.1186/s43094-025-00846-y","DOIUrl":"10.1186/s43094-025-00846-y","url":null,"abstract":"<div><p>Globally, hepatocellular carcinoma (HCC) presents a clinical and financial burden, as it is often diagnosed at a later stage. Cisplatin is one of the most commonly used chemotherapeutics for treating various types of solid tumours; however, it is a double-edged sword due to its cytotoxic effects. Consequently, we hypothesized that combining cisplatin with melatonin could be effective in treating HCC. Additionally, melatonin may mitigate the severe adverse effects of cisplatin on normal cells through its cellular protection, immunomodulation, and antioxidant activities. Forty male adult Wistar rats were randomly divided into five groups: Group 1(<i>n = </i>8), negative control group. HCC was induced in 32 rats with diethyl nitrosamine and carbon tetrachloride injection. Following induction, rats were divided into group 2 (HCC): diseased control; group 3 (HCC-Cis): HCC rats received cisplatin (2.5 mg/kg I.P. once every week for 3 weeks); group 4 (HCC-Melatonin): HCC rats received melatonin in drinking water (20 mg/L for 3 weeks); and group 5 (HCC-Cis-Melatonin; Combined therapy): the HCC rats received both cisplatin and melatonin<b>.</b> HCC group revealed significant elevation in ALT, AST, and AFP associated with increased TNF-α and MDA levels. Hepatic tissue exhibited a significant increase in VEGF, MDM2, COX-2, and miR-155, and a decrease in caspase-3 associated with hepatic damage, ballooning of hepatocytes, and increased BCL-2 and CD68 immunostaining. Although cisplatin was able to induce HCC apoptosis by COX-2 and MDM2/p53/ miR-155 modulation, it aggravated normal hepatocytic damage that was improved by the antioxidant and anti-inflammatory effects of melatonin. In conclusion, melatonin and cisplatin co-administration may be a viable strategy to preserve liver function by shielding healthy hepatocytes from the cytotoxic effects of cisplatin. </p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00846-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive identification of chemical fingerprint and potential quality markers of leaves and roots of two Aloe species via LC–MS/MS and computational analyses in relation to anti-virulence activity","authors":"Passent M. Abdel-Baki,&nbsp;Rana M. Ibrahim,&nbsp;Mai E. Hussein,&nbsp;Mohammed Abu-Elghait,&nbsp;Mona Shaban E. M. Badawy,&nbsp;Maha Hanafi,&nbsp;Mansour Sobeh,&nbsp;Nariman E. Mahdy","doi":"10.1186/s43094-025-00847-x","DOIUrl":"10.1186/s43094-025-00847-x","url":null,"abstract":"<div><h3>Background</h3><p>Over the past centuries<i>, Aloe</i> species have been traditionally used in managements of infectious ailments. However, no scientific investigation has been conducted into their mechanistic actions behind their antimicrobial activities. The main purpose of this study is to investigate the anti-virulence activities of <i>Aloe marlothii</i> A. Berger (AM) and <i>Aloe striata</i> Haw (AS) leaves and roots against <i>Pseudomonas aeruginosa</i> based on biofilm, pyocyanin and motility assays. Besides, the metabolic profiling of their different organs was evaluated via HPLC–MS/MS analysis. A molecular docking study of marker compounds into a LasR target was conducted to gain an insight into the bioactive metabolites involved into mechanism of action.</p><h3>Results</h3><p><i>A. marlothii</i> roots (AMR) and <i>A. striata</i> leaves (ASL) displayed significant activity against <i>P. aeruginosa</i> at 0.5 MIC via decreasing the biofilm development, pyocyanin production, swarming and swimming motilities. HPLC–MS/MS analysis led to the identification of one hundred metabolites belonging to different chemical classes. Additionally, it revealed the richness of AMR and ASL with anthraquinones and anthrones. Molecular docking of tentatively identified anthraquinones and anthrones was performed, revealing that chrysophanol-8-<i>O</i>-glucoside and 6-malonylnataloin revealed superior binding affinities and stabilities within the pocket of LasR system, compared to TP-4.</p><h3>Conclusions</h3><p>These findings give sound evidence for the use of AMR and ASL as effective anti-virulence agents against <i>P. aeruginosa</i>.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00847-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145166984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemicals as emerging therapeutics for acne vulgaris: a comprehensive review","authors":"Riham A. El-Shiekh,&nbsp;Rana M. Merghany,&nbsp;Nada Fayez,&nbsp;Mariam Hassan,&nbsp;Alaa F. Bakr,&nbsp;Omneya Eid,&nbsp;Dalia E. Ali,&nbsp;Sherouk Hussein Sweilam","doi":"10.1186/s43094-025-00842-2","DOIUrl":"10.1186/s43094-025-00842-2","url":null,"abstract":"<div><h3>Background</h3><p>Interest in using phytochemicals and herbal medicines to treat skin conditions like acne vulgaris has grown steadily over the last few decades and is described as a chronic inflammatory condition of the pilosebaceous unit that affects teenagers and young adults. Its treatment emphasizes the four main factors that contribute to its development: inflammation, excessive growth of <i>Cutibacterium acne</i>, hyperkeratinization, and sebum production.</p><h3>Main body</h3><p>Topical retinoids, oral isotretinoin, benzoyl peroxide, and antibiotics are all part of the treatment. Herbal medicine is a potential complementary and alternative medicine approach in this respect. Additionally, this review gives a full picture concerning acne pathogenesis, molecular targets for acne treatment, antibiotic resistance and existing medications and their pros and cons, herbal skincare products, and bioactive plant chemicals.</p><h3>Short conclusion</h3><p>This comprehensive study offers proof that phytochemicals and medicinal plants act as promising therapies for mild to moderate acne vulgaris through shed light on medicinal plants that have a long history of use and have been shown to possess low adverse effects. These plants are a reliable source for the preparation of new drugs. However, to substantiate their efficacy and safety claims, higher-quality research and clinical trials are required.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00842-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145165920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autism and α7-nicotinic acetylcholine receptors: new pharmacological and herbal interventions","authors":"Nourhan A. Khattab,&nbsp;Aya H. El-Kadem,&nbsp;Nada A. Ashour,&nbsp;Nageh Ahmed El-Mahdy,&nbsp;Nagla A. El-Shitany","doi":"10.1186/s43094-025-00843-1","DOIUrl":"10.1186/s43094-025-00843-1","url":null,"abstract":"<div><h3>Background</h3><p>Autism spectrum disorder (ASD) is a worldwide concern that affects 75 million people globally. ASD is characterized by neurological abnormalities that include impaired social interactions, stereotyped patterns of behavior, and cognitive difficulties. Numerous studies have focused on acetylcholine (ACh), which plays a significant role in modulating neuronal and immunological function via acting on muscarinic and nicotinic receptors. The α7-nicotinic acetylcholine receptors (α7nAChRs) are a key subtype of ACh receptors that directly activate to influence neuroprotective actions. Furthermore, it is a relatively recent hypothesis that α7nAChRs may indirectly influence neuronal behavior by regulating oxidative stress, inflammation, and apoptosis, which is becoming increasingly prevalent.</p><h3>Main text</h3><p>This review aims to provide a comprehensive overview of drugs and herbs promising to treat autism. Furthermore, great concern for the evidence suggesting that activation of α7nAChRs through some drugs or herbal medicine may impact brain function and clarify underlying molecular mechanisms, including oxidative stress, inflammation, and apoptosis. The review also discusses the challenges in targeting α7nAChR and its implications for medication development and prospective avenues for further investigation.</p><h3>Conclusion</h3><p>ASD is a substantial global issue due to the annual rise in case numbers; therefore, additional study is essential to identify effective therapeutic strategies targeting various pathways, including α7nAChRs.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00843-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145165921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mussels: a treasure trove of nutrients, bioactive peptides, and minerals-a review of their applications in food, pharmaceuticals, and biomedicine","authors":"Joshna Koodathil,&nbsp;Kiranvikas Elavarasan,&nbsp;Hema Munusamy,&nbsp;Nithish kumar Arivukkarasu,&nbsp;Kamesh Sendhil Murugan,&nbsp;Dharshini jeyasankar","doi":"10.1186/s43094-025-00840-4","DOIUrl":"10.1186/s43094-025-00840-4","url":null,"abstract":"<div><h3>Background</h3><p>Marine ecosystems are essential for sustaining biodiversity and providing nutritional resources. Mussels are a sustainable and highly nutritious protein source with growing significance in addressing global food security. Their high protein content, bioactive compounds, and eco-friendly cultivation make them an ideal alternative to traditional protein sources. </p><h3>Main body</h3><p>Mussel proteins offer remarkable nutritional value, with an amino acid score of 107 and significant biological activities, including antioxidant, antihypertensive, and anticancer properties. Mussel-derived bioactive peptides, obtained through enzymatic hydrolysis, have shown pharmacological benefits such as anti-inflammatory, immunoregulatory, and cardiovascular health-promoting effects. Additionally, mussel shells, rich in calcium carbonate, have potential applications in food fortification, pharmaceuticals, and biomedical fields. The extraction and utilization of mussel-derived compounds for functional foods and nutraceuticals enhance their industrial relevance. By isolating these compounds from various types of mussel, various pharmaceutical researches may lead to various uses. Isolation may contain various methods but some of important methods are discussed below; even waste mussel shell also has rich nutritional values where extraction is done by double displacement and neutralization method. This calcium content can be used as calcium supplements and for various dental treatments, and mussel protein extraction is isolated by the pH-shift method. However, refining protein extraction techniques and improving consumer acceptance remain key challenges. </p><h3>Conclusion</h3><p>Mussels are an excellent source of sustainable nutrition and bioactive compounds with diverse applications in food, pharmaceutical, and biomedical industries. Their inclusion in functional foods enhances nutritional quality and health benefits. Future research should focus on refining processing techniques, expanding consumer awareness, and exploring novel applications to fully use mussel-based ingredients for a sustainable and health-conscious future. </p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00840-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended stability of bivalirudin in intravenous solutions","authors":"Sherif Hanafy Mahmoud,&nbsp;Forugh Sanaee,&nbsp;Jenna Smith,&nbsp;Lindsay Ryerson,&nbsp;Mary Bauman,&nbsp;Yvonne Rees,&nbsp;Elona Turley,&nbsp;Rashid Alobaidi,&nbsp;Marcel Romanick,&nbsp;Afsaneh Lavasanifar","doi":"10.1186/s43094-025-00841-3","DOIUrl":"10.1186/s43094-025-00841-3","url":null,"abstract":"<div><h3>Background</h3><p>Bivalirudin is the preferred anticoagulant for pediatric ventricular assist device (VAD) patients. The manufacturer only permits the diluted drug to be used for 24 h once mixed with the sterile solutions. Most infants on VAD require much less than a single infusion bag in 24 h and any remaining infusion at 24 h must be discarded, resulting in increased medication waste and health care costs. The objective of this study was to examine the effect of storage containers and temperature on the stability and activity of intravenous (IV) bivalirudin solutions. </p><h3>Results</h3><p>Diluted bivalirudin (AngioMax®) IV solutions (1 and 5 mg/mL in dextrose 5% in water) were prepared in bags and syringes and stored at room temperature and at 2–8 °C. Bivalirudin concentrations were determined at different time points. Bivalirudin activity was determined by assessing its anticoagulating effect on human plasma via partial thromboplastin time (PTT) prolongation. Results suggest that a compounded bivalirudin infusion solution maintains its therapeutic activity and stability at room temperature for up to 48 h.</p><h3>Conclusions</h3><p>Data suggest that bivalirudin solutions in dextrose 5% in water and protected from light are potentially stable at room temperature for up to 48 h. Further studies are needed to confirm our study findings.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00841-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145163075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}