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Primary Breast Tuberculosis Mimicking Carcinomatous Mastitis: A Case Report 原发性乳腺结核模拟癌性乳腺炎1例报告
病理学期刊(英文) Pub Date : 2021-06-01 DOI: 10.4236/ojpathology.2021.113007
Z. I. Raivoherivony, L. Nomenjanahary, F. N. Rakotondrainibe, N. Randrianjafisamindrakotroka
{"title":"Primary Breast Tuberculosis Mimicking Carcinomatous Mastitis: A Case Report","authors":"Z. I. Raivoherivony, L. Nomenjanahary, F. N. Rakotondrainibe, N. Randrianjafisamindrakotroka","doi":"10.4236/ojpathology.2021.113007","DOIUrl":"https://doi.org/10.4236/ojpathology.2021.113007","url":null,"abstract":"The breast is a rare localization of extra-pulmonary tuberculosis, even in highly endemic countries. It is most often primitive. The clinical and radiological features are sometimes misleading. It poses diagnostic problems especially with cancer. We report a case of breast tuberculosis having clinical and radiological presentations as a breast carcinoma. Through this observation and a review of the literature, we provide an update on the epidemiological characteristics and the means of diagnosis of this lesion. It was a 52-year-old woman with inflammatory lump of the left breast, adherent to the skin. Ultrasonography and mammography revealed a homogeneous, poorly demarcated nodule of approximately 4 cm of diameter, classified ACR4. Surgical excision was performed. The histological diagnosis was breast tuberculosis. The diagnosis of tuberculous mastitis is made on bacteriological and pathological examinations. Histological examination helps for diagnostic confirmation while excluding a malignant lesion of the breast.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44729468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Utility of Tumor Markers 肿瘤标志物的临床应用
病理学期刊(英文) Pub Date : 2021-04-26 DOI: 10.4236/OJPATHOLOGY.2021.112005
Taro Mizuno, Takayuki Goto, Kota Shimojo, N. Watanabe, Takuji Tanaka
{"title":"Clinical Utility of Tumor Markers","authors":"Taro Mizuno, Takayuki Goto, Kota Shimojo, N. Watanabe, Takuji Tanaka","doi":"10.4236/OJPATHOLOGY.2021.112005","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2021.112005","url":null,"abstract":"Tumor markers comprise a wide spectrum of biomacromolecules excessively synthesized by a variety of neoplastic cells. These markers can be endogenous products of highly active metabolites from malignant neoplastic cells or the products of newly activated genes. Ideally, tumor markers should be highly sensitive, specific, and reliable with a high prognostic value and organ specificity. In addition, they should reflect the tumor stage. However, no tumor markers identified thus far have all of these characteristics. Nevertheless, most tumor markers show excellent clinical relevance for monitoring the efficacy of a variety of therapies. We herein review how to use the recommended tumor markers to diagnose malignancies, such as gastrointestinal carcinoma, liver cancer, bile duct/pancreatic cancer, lung cancer, breast cancer, gynecologic cancer, and urologic cancer.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49473552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dysplastic Gangliocytoma: A Rare Example of Cerebellar Tumor with An Evident Genetic Profile (Cowden Syndrome) 发育不良神经节细胞瘤:一例具有明显遗传特征的罕见小脑肿瘤(考登综合征)
病理学期刊(英文) Pub Date : 2021-04-26 DOI: 10.4236/OJPATHOLOGY.2021.112004
J. O. Rodríguez-Parets, Luis Miguel Chinchilla Tábora, Enrique Montero Mateos, E. M. Torres, M. Cruz
{"title":"Dysplastic Gangliocytoma: A Rare Example of Cerebellar Tumor with An Evident Genetic Profile (Cowden Syndrome)","authors":"J. O. Rodríguez-Parets, Luis Miguel Chinchilla Tábora, Enrique Montero Mateos, E. M. Torres, M. Cruz","doi":"10.4236/OJPATHOLOGY.2021.112004","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2021.112004","url":null,"abstract":"Objective: To describe the histological and immunohistochemical findings observed when studying a dysplastic cerebellar gangliocytoma observed in a 33-year-old man with a history of Thyroid Cancer. Material and Methods: Radiological images (MRI) and histological and immunohistochemical preparations obtained from the cerebellar tissue were received in our laboratory. Results: A neoplasm constituted by aberrant-looking mature neurons was observed that showed negativity for the immunohistochemical markers of the PTEN protein, expression of the activity of the PTEN gene. Conclusions: Verify the diagnosis of a rare entity, clearly related in scientific publications with Cowden’s Syndrome.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48410475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Study on Infertility of Males Infected with Mycoplasma hominis with Reference to Sperm Morphology 人支原体感染男性不育的精子形态学研究
病理学期刊(英文) Pub Date : 2021-01-14 DOI: 10.4236/OJPATHOLOGY.2021.111002
M. Al-Jebouri, A. Mohamed
{"title":"A Study on Infertility of Males Infected with Mycoplasma hominis with Reference to Sperm Morphology","authors":"M. Al-Jebouri, A. Mohamed","doi":"10.4236/OJPATHOLOGY.2021.111002","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2021.111002","url":null,"abstract":"Objectives: The main objective of this study was to investigate the effect of Mycoplasma hominis infection on the morphology of sperms and its association with the infertility of men. The patients were referred to the Urology Departments of Mosul General Hospital and Soran Hospital in Mosul and Erbil respectively. Methods: The present study was carried out from April 2019 to March 2020 and the number of the patients group was 108. The patients aged 20 to 60 years. Semen was collected from infertile men of a couple that female failed to become pregnant after one year of regular and unprotected intercourse of marriage and submitted for seminal fluid analysis as well as for bacteriological investigations Results: M. hominis was detected in 14 semen specimens (12.9%) from the infertile men. The teratozoospermia, normozoospermia, asthenoteratozoospermia, oligoasthenoteratozoospermia, asthenozoospermia, oligozoospermia, oligoasthenozoospermia and leukospermia were seen among patients examined. Statistically, there were no significant differences between these forms of infected infertile men and non-infected infertile men (P > 0.05). Conclusions: The results of present study demonstrated that the genital Mycoplasma hominis seems to be widespread among male partners of infertile couples in Iraq. The present data did not show any significant differences between forms of the sperm concentration and sperm morphology related to the infection by M. hominis.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"11 1","pages":"7-21"},"PeriodicalIF":0.0,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44344188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Schistosomiasis with Cervical Cancer: About 2 Cases and Literature Review 血吸虫病伴子宫颈癌2例及文献复习
病理学期刊(英文) Pub Date : 2021-01-01 DOI: 10.4236/ojpathology.2021.111001
Nomenjanahary Lalaina, Raivoherivony Zo Irène, M. Patrick, Randaoharison Pierana Gabriël, R. Soa
{"title":"Schistosomiasis with Cervical Cancer: About 2 Cases and Literature Review","authors":"Nomenjanahary Lalaina, Raivoherivony Zo Irène, M. Patrick, Randaoharison Pierana Gabriël, R. Soa","doi":"10.4236/ojpathology.2021.111001","DOIUrl":"https://doi.org/10.4236/ojpathology.2021.111001","url":null,"abstract":"Schistosomiasis is a chronic disease, and remains a major public health problem. It holds second place among parasitic endemics in the world. Schistosoma can infect various organs through the blood vessels. The genital form affects at least 16 million women in endemic areas, and the uterine cervix is the most common site. Two cases of cervical cancer associated with schistosomiasis of the cervix are presented. The aim of this study is to discuss the epidemiological, clinical and histopathological features. Both of the patients lived in Mahanjaga, aged respectively 57 and 43 years old. They complained of uterine bleeding disorder and presented cauliflower lesions with ulceration of the uterine cervix that extended to the vagina in one case. They were undergone cervical biopsies. The diagnosis was, in both cases, invasive, well-differentiated squamous cell carcinoma with cervical schistosomiasis.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"11 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70494910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis of the Sigmoid Colon Mimicking Malignant Lesion 乙状结肠模拟恶性病变的子宫内膜异位症
病理学期刊(英文) Pub Date : 2021-01-01 DOI: 10.4236/ojpathology.2021.114010
L. Nomenjanahary, Z. I. Raivoherivony, H. Andrianjafitrimo, N. Randrianjafisamindrakotroka
{"title":"Endometriosis of the Sigmoid Colon Mimicking Malignant Lesion","authors":"L. Nomenjanahary, Z. I. Raivoherivony, H. Andrianjafitrimo, N. Randrianjafisamindrakotroka","doi":"10.4236/ojpathology.2021.114010","DOIUrl":"https://doi.org/10.4236/ojpathology.2021.114010","url":null,"abstract":"Endometriosis is defined as the presence of endometrial tissue outside the uterus. It is a benign pathology involving 15% of women of reproductive age. The sigmoid site represents 7% of endometriosis but it is the most frequent area in the digestive tract. We report two cases of colonic endometriosis in which the initial diagnosis suspected a malignant disease. Respectively, the patients were 31 and 48 years old. The first patient complained about abdominal pain with symptoms of intestinal obstruction and was classified after radiological examination as an intrasigmoid tumor with bladder adhesion. The second patient was undergone for a radiological examination because of a bowel obstruction syndrom and a mass in the sigmoid colon was suspected. In both cases, sigmoid colon resection was performed and histological diagnosis was sigmoid endometriosis. Sigmoid endometriosis is rarely diagnosed before surgical excision. Suspicious bowel obstruction and malignant origin lead to large surgical excision. Histological examination is important to establish the diagnosis.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70494658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Ovarian Carcinosarcoma: Cytological, Pathological, Immunocytochemical, and Immunohistochemical Features 原发性卵巢癌肉瘤:细胞学、病理、免疫细胞化学和免疫组织化学特征
病理学期刊(英文) Pub Date : 2021-01-01 DOI: 10.4236/OJPATHOLOGY.2021.111003
K. Niwa, S. Mori, Keigo Kuwabara, K. Nagata, M. Takenaka, T. Shiga, Y. Yamaguchi, Kentaro Niwa, Takuji Tanaka
{"title":"Primary Ovarian Carcinosarcoma: Cytological, Pathological, Immunocytochemical, and Immunohistochemical Features","authors":"K. Niwa, S. Mori, Keigo Kuwabara, K. Nagata, M. Takenaka, T. Shiga, Y. Yamaguchi, Kentaro Niwa, Takuji Tanaka","doi":"10.4236/OJPATHOLOGY.2021.111003","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2021.111003","url":null,"abstract":"Ovarian carcinosarcoma composed of high-grade carcinoma and sarcoma is an extremely rare neoplasm and typically occurs in postmenopausal women aged over 60 years. A 73-year-old female, gravida three para three, presented to our hospital with right lower abdominal pain. Right pelvic solid tumor with ascites was detected on pelvic ultrasound examination. She underwent hysterectomy, bilateral salpingo-oophorectomy and partial omentectomy, but the tumor had invaded to the right ureter, and some fragile tumor could not be taken (sub-optimal surgery). On the imprint and ascitic cytology specimens during operation, atypical cells suggestive of adenocarcinoma and spindle atypical cells with immunocytochemically vimentin positive were found. The resected tumor was histopathologically carcinosarcoma consisted of serous adenocarcinoma, chondrosarcoma and fibrosarcoma. Immunohistochemical analysis revealed that adenocarcinoma cells were positive for AE1/AE3 and fibrosarcoma cells stained with vimentin. The final diagnosis was the right ovarian carcinosarcoma (stage pT3CNxMx). Microsatellite instability was stable and BRCA1/2 mutations could not be found in the carcinosarcoma cells. The patient was given four cycles of chemotherapy with paclitaxel, carboplatin and bevacizumab regimen, and thereafter she was treated with the ifosfamide and cisplatin because of slight elevation of serum CA125.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"11 1","pages":"22-31"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70495013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Appendicular Abscess Revealing Gastrointestinal Stromal Tumor of the Appendix 阑尾脓肿显示胃肠道间质肿瘤
病理学期刊(英文) Pub Date : 2021-01-01 DOI: 10.4236/ojpathology.2021.114011
L. Nomenjanahary, Z. I. Raivoherivony, Adriana Tongavelona, R. Soa
{"title":"Appendicular Abscess Revealing Gastrointestinal Stromal Tumor of the Appendix","authors":"L. Nomenjanahary, Z. I. Raivoherivony, Adriana Tongavelona, R. Soa","doi":"10.4236/ojpathology.2021.114011","DOIUrl":"https://doi.org/10.4236/ojpathology.2021.114011","url":null,"abstract":"Gastrointestinal stromal tumor (GIST) is a rare tumor of the digestive tract, but it is the most common of the mesenchymal tumors. The location is often gastric and small intestine. GIST of the appendix is extremely rare. We report one case in a 48-year-old man. He complained of severe pain in the right iliac region. The clinical presentation was typically like acute appendicitis. Abdominal ultrasound was performed and suspected an appendicular abscess. Surgical excision of the appendix was performed and histological diagnosis was “gastrointestinal stromal tumor of the appendix”.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70494739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical Biomarkers in Ductal Carcinoma In Situ 原位导管癌的免疫组织化学生物标志物
病理学期刊(英文) Pub Date : 2020-09-14 DOI: 10.4236/OJPATHOLOGY.2020.104013
I. Petrone, F. Rodrigues, P. Fernandes, E. Abdelhay
{"title":"Immunohistochemical Biomarkers in Ductal Carcinoma In Situ","authors":"I. Petrone, F. Rodrigues, P. Fernandes, E. Abdelhay","doi":"10.4236/OJPATHOLOGY.2020.104013","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2020.104013","url":null,"abstract":"Introduction: Breast ductal carcinoma In Situ (DCIS) can be defined as a malignant epithelial proliferation with growth limited by the basal membrane of the ductal epithelium, with no evidence of stromal invasion. There has been a trend of trying to subcategorize DCIS based on cell proliferation assays (Ki67) and the expression of hormone receptors and the human epidermal growth receptor (HER-2) as detected by immunohistochemistry, similar to invasive breast carcinomas (IBC). The aims were to evaluate the expression of breast cancer marker proteins in DCIS by immunohistochemistry to better categorize it. Methods: 46 biopsies from women with DCIS and IBC Luminal A-like were evaluated by immunohistochemistry staining of proteins already known to be biomarkers in IBC. For controls, normal breast tissue from mammoplasty (n = 3) was used. Results: Our results showed an increase of estrogen receptor (ER) and progesterone receptor (PR) expression relative to that in normal tissue samples (p","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":"10 1","pages":"129-146"},"PeriodicalIF":0.0,"publicationDate":"2020-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47472310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Primary Small Cell Neuroendocrine Carcinoma of the Endometrium: A Cytologically Diagnosed Case with Immunocytochemical, Immunohistochemical, and Electron Microscopic Features 子宫内膜原发性小细胞神经内分泌癌：一例免疫细胞化学、免疫组织化学和电镜特征的细胞学诊断病例
病理学期刊(英文) Pub Date : 2020-09-14 DOI: 10.4236/OJPATHOLOGY.2020.104011
K. Nagata, K. Niwa, S. Mori, Keigo Kuwabara, M. Takenaka, Y. Yamaguchi, Kentaro Niwa, Takuji Tanaka
{"title":"Primary Small Cell Neuroendocrine Carcinoma of the Endometrium: A Cytologically Diagnosed Case with Immunocytochemical, Immunohistochemical, and Electron Microscopic Features","authors":"K. Nagata, K. Niwa, S. Mori, Keigo Kuwabara, M. Takenaka, Y. Yamaguchi, Kentaro Niwa, Takuji Tanaka","doi":"10.4236/OJPATHOLOGY.2020.104011","DOIUrl":"https://doi.org/10.4236/OJPATHOLOGY.2020.104011","url":null,"abstract":"Endometrial neuroendocrine tumors are rare, accounting less than 1% of endometrial cancers. They include small cell neuroendocrine carcinoma (NEC) and large cell NEC and usually occur in postmenopausal patients. Although common symptoms include postmenopausal bleeding, most patients are diagnosed at an advanced stage. We report an extremely rare case of small cell NEC developed in the endometrium of a 75-year-old Japanese woman. This case was initially suspected based on the findings of endometrial cytology: a number of small round malignant cells were present on the endometrial smear specimens. The immunocytochemical and immunohistochemical examinations revealed diffusely cytoplasmic positive reaction of neuron specific enolase (NSE) and partially membranous positive reaction of CD56 in the small cancer cells. They showed PAX-8-positive reaction, but did not express microsatellite instability high. Electron micrography showed several dense-core secretory granules in the cytoplasm of cancer cells. Despite multiple lung metastases, the patient underwent a hysterectomy and salpingo-oophorectomy in order to control excessive genital bleeding. She received six courses of adjuvant chemotherapy based on etoposide and cisplatin, and survived healthy eight months after the first visit without any viability of lung metastases.","PeriodicalId":57444,"journal":{"name":"病理学期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47316667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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