Food Science and Biotechnology最新文献

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Impacts of feed gases for micro-nano bubble water treatments: Antimicrobial efficacy against Escherichia coli and Staphylococcus aureus on ‘Fan Retief’ guava fruit 原料气对微纳气泡水处理的影响:对“Fan Retief”番石榴果的大肠杆菌和金黄色葡萄球菌的抗菌效果。
IF 3.1 3区 农林科学
Food Science and Biotechnology Pub Date : 2025-05-20 DOI: 10.1007/s10068-025-01897-w
Harold K. Malahlela, Zinash A. Belay, Rebogile R. Mphahlele, Lize Engelbrecht, Janica C. Theron, Oluwafemi J. Caleb
{"title":"Impacts of feed gases for micro-nano bubble water treatments: Antimicrobial efficacy against Escherichia coli and Staphylococcus aureus on ‘Fan Retief’ guava fruit","authors":"Harold K. Malahlela,&nbsp;Zinash A. Belay,&nbsp;Rebogile R. Mphahlele,&nbsp;Lize Engelbrecht,&nbsp;Janica C. Theron,&nbsp;Oluwafemi J. Caleb","doi":"10.1007/s10068-025-01897-w","DOIUrl":"10.1007/s10068-025-01897-w","url":null,"abstract":"<p>Microbes on fresh produce are often controlled by chlorine-based sanitizers, due to there is growing demand for safe alternatives. This work investigated effects of micro-nano bubble (MNB) water generated using air, oxygen (O<sub>2</sub>), or ozone (O<sub>3</sub>) against bacteria contaminants encountered along the fresh produce value chain. <i>Escherichia coli</i> (ATCC 25922) and <i>Staphylococcus aureus</i> (ATCC 25923) broth were treated with distilled water (DW), sodium hypochlorite (NaOCl, 200 mg/L, 5 min), air-MNB, O<sub>2</sub>-MNB, and O<sub>3</sub>-MNB for 30- and 60-min. Scanning-transmission electron microscopy confirmed that the bacterial survival population was reduced via various types of cell damage under O<sub>3</sub>-MNB. <i>S. aureus</i> was more resistant than <i>E. coli</i> to the MNB treatments. This could be due to the thicker layer of peptidoglycan surrounding the cell membrane protecting against oxidative species. On guava fruits, O<sub>3</sub>-MNB-60 min lowered <i>E. coli</i> counts immediately after treatment (p &lt; 0.05). MNB water offers a new paradigm for fruit decontamination.</p>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 12","pages":"2959 - 2970"},"PeriodicalIF":3.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of modified benzaldehyde derivatives as dual α-glucosidase and α-amylase inhibitors: a viable alternative to acarbose 改性苯甲醛衍生物作为α-葡萄糖苷酶和α-淀粉酶双重抑制剂的评价:阿卡波糖的可行替代品。
IF 3.1 3区 农林科学
Food Science and Biotechnology Pub Date : 2025-05-19 DOI: 10.1007/s10068-025-01900-4
Na-Hyun Lee, Jae Ho Yeom, Sangmin Lee, Namhyun Chung, Hoi-Seon Lee
{"title":"Evaluation of modified benzaldehyde derivatives as dual α-glucosidase and α-amylase inhibitors: a viable alternative to acarbose","authors":"Na-Hyun Lee,&nbsp;Jae Ho Yeom,&nbsp;Sangmin Lee,&nbsp;Namhyun Chung,&nbsp;Hoi-Seon Lee","doi":"10.1007/s10068-025-01900-4","DOIUrl":"10.1007/s10068-025-01900-4","url":null,"abstract":"<div><p>The inhibitory effects of the active constituent isolated from <i>Periploca sepium</i> barks and its derivatives against α-glucosidase and α-amylase were studied. The active constituent was identified as 4-methoxy-2-hydroxybenzaldehyde by various spectral analyses. 4-Methoxy-2-hydroxybenzaldehyde was 5.44 times more effective at blocking α-amylase than acarbose, but it reduced its blocking ability against α-glucosidase by 0.57 times. The K<sub>m</sub> values for α-glucosidase and α-amylase did not change with different amounts of 4-methoxy-2-hydroxybenzaldehyde, which is typical of non-competitive inhibition. To ascertain the structure–activity relationships, 3,4-dihydroxybenzaldehyde and 3,5-dihydroxybenzaldehyde demonstrated inhibitory activities against α-glucosidase. With regard to α-amylase, 2,4,5-trihydroxybenzaldehyde exhibited the most efficacious inhibitory effect, followed by 2,3,4-trihydroxybenzaldehyde, 2,4,6-trihydroxybenzaldehyde, and 3,4,5-trihydroxybenzaldehyde. The combination of benzaldehyde with hydroxyl, methyl, or methoxy groups suggests the potential for benzaldehyde to serve as a parent compound for the development of selective inhibitors. The results indicate that 3,4-dihydroxybenzaldehyde, 3,5-dihydroxybenzaldehyde, 2,5-dihydroxybenzaldehyde, 2,4,5-trihydroxybenzaldehyde, and 2,3,4-trihydroxybenzaldehyde may prove beneficial in alleviating diabetic pathological conditions.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 12","pages":"2725 - 2732"},"PeriodicalIF":3.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and characterization of chestnut porous starch by plasma-activated water combined with enzymatic hydrolysis 等离子体活化水-酶解法制备板栗多孔淀粉及表征。
IF 3.1 3区 农林科学
Food Science and Biotechnology Pub Date : 2025-05-17 DOI: 10.1007/s10068-025-01899-8
Peixuan Wang, Binbin Tao, Xiaojing Li, Dandan Zhou, Tingting Li, Caie Wu, Gongjian Fan
{"title":"Preparation and characterization of chestnut porous starch by plasma-activated water combined with enzymatic hydrolysis","authors":"Peixuan Wang,&nbsp;Binbin Tao,&nbsp;Xiaojing Li,&nbsp;Dandan Zhou,&nbsp;Tingting Li,&nbsp;Caie Wu,&nbsp;Gongjian Fan","doi":"10.1007/s10068-025-01899-8","DOIUrl":"10.1007/s10068-025-01899-8","url":null,"abstract":"<div><p>Porous starch is prevalently utilized for loading and transporting biologically active substances and constitutes an inexpensive sorbent with an extensive range of applications. In this study, an innovative and high-efficient preparation approach for chestnut porous starch was executed by integrating plasma-activated water with hydrolysis (α-amylase and glucosidase). Under the optimized conditions (jet power and time, enzyme dosage and hydrolysis time), the obtained chestnut porous starch showed to possess a uniformly porous structure under the electron microscope. Compared with normal enzymatic hydrolysis, the oil absorption rate of the starch was significantly enhanced and reached 141.28% ± 0.86%. The optimal condition for the adsorption of curcumin using PECS was for 350 min, when Qe was maximized and the adsorption process conformed to pseudo-first-order kinetics. This study provides a novel and effective alternative route for the development of chestnut porous starch material, which can fulfill the requirements of subsequent in-depth research.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 12","pages":"2807 - 2818"},"PeriodicalIF":3.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of phytochemical luteolin in restoring skin barrier by inhibiting antimicrobial peptides associated with TRAF6/TAK1/IKK/IκB in psoriasis-like HaCaT models 植物化学木犀草素在银屑病样HaCaT模型中通过抑制与TRAF6/TAK1/IKK/ i - κ b相关的抗菌肽恢复皮肤屏障的治疗潜力
IF 3.1 3区 农林科学
Food Science and Biotechnology Pub Date : 2025-05-16 DOI: 10.1007/s10068-025-01894-z
Hui Su Chung, Hyung Seo Hwang
{"title":"Therapeutic potential of phytochemical luteolin in restoring skin barrier by inhibiting antimicrobial peptides associated with TRAF6/TAK1/IKK/IκB in psoriasis-like HaCaT models","authors":"Hui Su Chung,&nbsp;Hyung Seo Hwang","doi":"10.1007/s10068-025-01894-z","DOIUrl":"10.1007/s10068-025-01894-z","url":null,"abstract":"<div><p>Autoimmune skin diseases, such as psoriasis are primarily characterized by excessive inflammation and skin barrier damage. The disrupted skin barrier is directly related to skin dryness. Luteolin, a flavonoid compound, has various biological activities such as antioxidant, anticancer, anti-aging, and anti-inflammatory. However, little has been known about the anti-psoriatic therapeutic function of luteolin. This study focused on the recovery of the skin barrier by luteolin through the regulation of antimicrobial peptides (AMPs) as well as anti-inflammatory activity, using TNF-α/IL-17A/IFN-γ-stimulated HaCaT cells. First, luteolin significantly inhibited the mRNA expression of antimicrobial peptides LL-37, human β-defensin-2 (hBD-2), S100A7, and S100A8 by regulating IκB/NF-κB signaling pathway through TRAF6/IκB. Moreover, luteolin increased the expression of filaggrin, loricrin and involucrin, which are essential of cornified envelope (CE) formation in epidermis. These results suggest anti-inflammatory luteolin has the function of restoring the disrupted skin barrier by regulating antimicrobial peptides and cornified envelope proteins.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 12","pages":"2909 - 2921"},"PeriodicalIF":3.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of Bifidobacterium animalis QC08 in antibiotic-associated diarrhea in mice 动物双歧杆菌QC08在小鼠抗生素相关性腹泻中的作用。
IF 3.1 3区 农林科学
Food Science and Biotechnology Pub Date : 2025-05-15 DOI: 10.1007/s10068-025-01881-4
Lixuan Ren, Fang Tan, Hyo-Eun Kim, Xin Ma, Chang-Suk Kong
{"title":"The role of Bifidobacterium animalis QC08 in antibiotic-associated diarrhea in mice","authors":"Lixuan Ren,&nbsp;Fang Tan,&nbsp;Hyo-Eun Kim,&nbsp;Xin Ma,&nbsp;Chang-Suk Kong","doi":"10.1007/s10068-025-01881-4","DOIUrl":"10.1007/s10068-025-01881-4","url":null,"abstract":"<div><p>Excessive antibiotic use can lead to gut microbiota dysbiosis, resulting in diarrhea. This study aimed to investigate the effects of <i>Bifidobacterium animalis</i> QC08 (QC08) on the antibiotic-induced diarrhea mouse model using lincomycin hydrochloride. Mice were divided into five groups: normal, diarrhea, a drug group, high-dose QC08 (QC08-H), low-dose QC08 (QC08-L). Compared with the diarrhea group, the QC08-H and QC08-L groups showed a decrease in serum serotonin, interleukin (IL)-17A, IL-6, and malondialdehyde levels, whereas total antioxidant capacity levels increased. In the colon and small intestine tissues of QC08-H and QC08-L treated mice, mRNA expression of cystic fibrosis transmembrane conductance regulator (CFTR), epidermal growth factor receptor (EGFR), and transforming growth factor β1 (TGFβ1) was significantly downregulated, whereas expression of sodium–hydrogen exchanger 1 (NHE1) and NHE4 was upregulated compared to the AAD model group. Altogether, this in vivo study demonstrates the potential of QC08 in alleviating AAD in mice, providing valuable insights for understanding and potentially treating antibiotic-related gut issues.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 11","pages":"2625 - 2634"},"PeriodicalIF":3.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stability, bioavailability, and cellular antioxidant activity of piperine complexed with cyclic glucans 胡椒碱与环葡聚糖络合的稳定性、生物利用度和细胞抗氧化活性。
IF 3.1 3区 农林科学
Food Science and Biotechnology Pub Date : 2025-05-12 DOI: 10.1007/s10068-025-01884-1
Solji Cho, Yunkyoung Jung, Shin-Joung Rho, Yong-Ro Kim
{"title":"Stability, bioavailability, and cellular antioxidant activity of piperine complexed with cyclic glucans","authors":"Solji Cho,&nbsp;Yunkyoung Jung,&nbsp;Shin-Joung Rho,&nbsp;Yong-Ro Kim","doi":"10.1007/s10068-025-01884-1","DOIUrl":"10.1007/s10068-025-01884-1","url":null,"abstract":"<div><p>Piperine, the primary bioactive compound in black pepper, was complexed with cyclic glucans, including cycloamylose (CA), α-cyclodextrin, and 2-hydroxypropyl-β-cyclodextrin, to investigate the complexation effects on its solubility, stability, bioavailability, and cellular antioxidant activity (CAA). The formation of inclusion complex (IC) significantly improved the phase solubility of piperine and enhanced its stability under ultraviolet light, heat, and acidic conditions. Additionally, IC increased the retention rate of piperine after in vitro digestion. Permeability analysis using a Caco-2 cell monolayer showed that IC samples, particularly CAIC, reduced the efflux ratio compared to free piperine by decreasing the apparent permeability coefficient from apical-to-basolateral (P<sub>app (B-A)</sub>). Moreover, the enhanced cellular uptake capacity of piperine in IC contributed to a marked improvement in its CAA, CAIC showing the most pronounced effect. Therefore, inclusion complexation with cyclic glucans, especially CA, can be a practical strategy to overcome the lower solubility and bioavailability of free piperine in various industrial applications.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 11","pages":"2475 - 2488"},"PeriodicalIF":3.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative assessment of microbial community of soybean paste prepared with different raw materials 不同原料大豆酱的微生物群落比较评价。
IF 3.1 3区 农林科学
Food Science and Biotechnology Pub Date : 2025-05-11 DOI: 10.1007/s10068-025-01885-0
Peng Jiang, Xueling Chen, Xiaoyan Lan, Zhuo Chen, Yihong Gu, Longquan Xiao
{"title":"Comparative assessment of microbial community of soybean paste prepared with different raw materials","authors":"Peng Jiang,&nbsp;Xueling Chen,&nbsp;Xiaoyan Lan,&nbsp;Zhuo Chen,&nbsp;Yihong Gu,&nbsp;Longquan Xiao","doi":"10.1007/s10068-025-01885-0","DOIUrl":"10.1007/s10068-025-01885-0","url":null,"abstract":"<div><p>Soybean paste as one of the most extensively used traditional fermented condiments in our daily lives. The quality of soybean paste has been proven to be related to microbial metabolic activities. However, the effect of different raw materials on the microbial diversity of soybean paste under the same incubation conditions remains unclear. For this, we investigated variation of microbial communities in soybean paste manufactured with two different raw materials (Tartary buckwheat flour and wheat flour) analyzed by amplicon sequencing. The results showed that the dominant bacteria in the two soybean pastes were γ-proteobacteria, Cyanobacteria and Bacilli, the dominant fungal were Mucoromycetes, Tremellomycetes, Eurotiomycetes and Saccharomycetes. Bacterial diversity and abundance showed no significant difference in the two soybean pastes; fungal abundance showed no significant difference, whereas fungal diversity differed significantly (P &lt; 0.05). Also, Bacterial abundance correlated positively with amino acid nitrogen (AAN) and total acidity (TA) in flour bean paste, while fungal diversity correlated negatively with AAN and TA in buckwheat bean paste. Collectively, raw materials have a significant effect on the microbial community of soybean paste. Besides, these results could provide valuable reference data for enhancing the quality and safety of soybean paste in manufacture.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 11","pages":"2543 - 2552"},"PeriodicalIF":3.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A β-glucosidase extracted from walnut (Juglans regia L.) green husk induces human hepatoma cell apoptosis via ROS-mediated p53 and NF-κB pathway 从核桃绿皮中提取的β-葡萄糖苷酶通过ros介导的p53和NF-κB途径诱导人肝癌细胞凋亡。
IF 3.1 3区 农林科学
Food Science and Biotechnology Pub Date : 2025-05-10 DOI: 10.1007/s10068-025-01890-3
Siyu Han, Lixia Zhao, Li Song, Yuying Li
{"title":"A β-glucosidase extracted from walnut (Juglans regia L.) green husk induces human hepatoma cell apoptosis via ROS-mediated p53 and NF-κB pathway","authors":"Siyu Han,&nbsp;Lixia Zhao,&nbsp;Li Song,&nbsp;Yuying Li","doi":"10.1007/s10068-025-01890-3","DOIUrl":"10.1007/s10068-025-01890-3","url":null,"abstract":"<div><p>Walnut green husk is the outermost green peel of walnut, which contains multiple natural ingredients with a variety of biological activities. In this study, an anti-tumor protein called <i>Juglans</i> regia L. husk protein (JRLHP) was isolated. Mass spectrometry and enzymatic activity analysis revealed that JRLHP was a β-glucosidase. JRLHP inhibited human hepatoma cancer cell growth and promoted apoptosis. JRLHP caused the decline of mitochondrial membrane potential and Bcl-2. Moreover, cytochrome c and Bax were elevated, and caspase-9 and caspase-3 were activated. JRLHP treatment led to excess reactive oxygen species (ROS). This was accompanied by increased p53 protein levels and the suppression of NF-κB pathway. NAC treatment reversed the effects of JRLHP on p53 and NF-κB pathway. Consequently, NAC also reduced the impacts of JRLHP on cell apoptosis and proteins related to apoptosis. Taken together, above results indicated that JRLHP induced HCC cell apoptosis by ROS-mediated p53 and NF-κB pathway.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 11","pages":"2581 - 2589"},"PeriodicalIF":3.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of ultra-high pressure treatment on the physico-chemical properties of emulsified meat analogs 超高压处理对乳化肉类类似物理化性质的影响。
IF 3.1 3区 农林科学
Food Science and Biotechnology Pub Date : 2025-05-06 DOI: 10.1007/s10068-025-01868-1
Jeong-Heon Kim, Yoo-Jeong Choi, Yea-Ji Kim, Ji Yoon Cha, Tae-Kyung Kim, Dong-Hyun Kim, Yun-Sang Choi
{"title":"Effect of ultra-high pressure treatment on the physico-chemical properties of emulsified meat analogs","authors":"Jeong-Heon Kim,&nbsp;Yoo-Jeong Choi,&nbsp;Yea-Ji Kim,&nbsp;Ji Yoon Cha,&nbsp;Tae-Kyung Kim,&nbsp;Dong-Hyun Kim,&nbsp;Yun-Sang Choi","doi":"10.1007/s10068-025-01868-1","DOIUrl":"10.1007/s10068-025-01868-1","url":null,"abstract":"<div><p>The aim of this study was to evaluate the effects of ultra-high pressure (UHP) treatment on the physicochemical and structural properties of emulsified alternative meat products. Emulsified samples were treated at pressures of 100–500 MPa and their pH, color, moisture contents, WHC (water holding capacity), viscosity, emulsion stability and textural properties were analyzed. The results showed that UHP significantly improved pH, lightness and redness in all treatment groups. Treatment at 300 MPa showed minimal differences from the control group in most parameters, but viscosity, water holding capacity, hardness, cohesiveness were significantly improved. These results confirm that UHP treatment positively affects the water holding capacity and structural stability of emulsified alternative meat products. Therefore, this study provides a basis for the practical application of UHP technology in the development of alternative meat products with improved functional and structural properties.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 11","pages":"2489 - 2496"},"PeriodicalIF":3.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxicological and antioxidant evaluations of the effects of different drying temperatures of the calyx of Hibiscus sabdariffa in experimental rats 不同干燥温度下芙蓉花萼对实验大鼠的毒理学及抗氧化作用评价。
IF 3.1 3区 农林科学
Food Science and Biotechnology Pub Date : 2025-04-30 DOI: 10.1007/s10068-025-01893-0
John Osarenren Efosa, Kingsley Omage, Marshall Arebojie Azeke
{"title":"Toxicological and antioxidant evaluations of the effects of different drying temperatures of the calyx of Hibiscus sabdariffa in experimental rats","authors":"John Osarenren Efosa,&nbsp;Kingsley Omage,&nbsp;Marshall Arebojie Azeke","doi":"10.1007/s10068-025-01893-0","DOIUrl":"10.1007/s10068-025-01893-0","url":null,"abstract":"<div><p><i>Hibiscus sabdariffa</i> calyx is widely used in traditional medicine and as a food ingredient due to its antioxidant potential. This study investigated the toxicological and antioxidant effects of calyx extracts obtained after drying at four temperatures (− 58 °C, 30 °C, 40 °C, and 50 °C) in Wistar rats. Acute toxicity was assessed following the modified Lorke method (24-h observation), and chronic toxicity was evaluated over 28 days using doses of 250, 500, and 1000 mg/kg, in accordance with OECD guideline 407. Although no signs of acute toxicity or significant alterations in organ weights were observed, the antioxidant markers—GSH, CAT, and SOD—were dose-dependently enhanced, with the most potent activity recorded in extracts dried at 30 °C. These findings suggest that drying at 30 °C preserves key bioactive compounds, thereby maximizing the antioxidant potential of <i>H. sabdariffa calyx</i>. The study provides practical insights for optimizing processing conditions for medicinal and nutraceutical applications.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 12","pages":"2881 - 2895"},"PeriodicalIF":3.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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