Ophthalmology. Glaucoma最新文献

{"title":"Validating and Updating the OHTS-EGPS Model Predicting 5-year Glaucoma Risk among Ocular Hypertension Patients Using Electronic Records.","authors":"David M Wright, Augusto Azuara-Blanco, Chris Cardwell, Giovanni Montesano, David P Crabb, Gus Gazzard, Anthony J King, Rodolfo Hernández, James E Morgan, Bethany Higgins, Yemisi Takwoingi","doi":"10.1016/j.ogla.2024.10.009","DOIUrl":"10.1016/j.ogla.2024.10.009","url":null,"abstract":"<p><strong>Objective: </strong>To validate and update the Ocular Hypertension Treatment Study-European Glaucoma Prevention Study (OHTS-EGPS) model predicting risk of conversion from ocular hypertension (OHT) to glaucoma using electronic medical records (EMR).</p><p><strong>Design: </strong>Evaluation and update of a risk prediction algorithm using EMRs and linked visual field (VF) tests.</p><p><strong>Participants: </strong>Newly diagnosed OHT patients attending hospital glaucoma services in England. Inclusion criteria are as follows: intraocular pressure (IOP) 22 to 32 mmHg (either eye); normal baseline VF test, defined as Glaucoma Hemifield Test (GHT) \"within normal range\" in a reliable VF test; at least 2 VF tests in total; no significant ocular comorbidities.</p><p><strong>Methods: </strong>Risk factors are as follows: age, ethnicity, sex, IOP, vertical cup-to-disc ratio, central corneal thickness, VF pattern standard deviation, family history of glaucoma, systemic hypertension, diabetes mellitus, and glaucoma treatment. Glaucoma conversion was defined as 2 consecutive and reliable VF tests with GHT \"outside normal limits\" and/or need for glaucoma surgery. For validation, the OHTS-EGPS model was applied to predict a patient's risk of developing glaucoma in 5 years. In the updating stage, the OHTS model was refitted by re-estimating the baseline hazard and regression coefficients. The updated model was cross-validated and several variants were explored.</p><p><strong>Main outcome measures: </strong>Measures of discriminative ability (c-index) and calibration (calibration slope) were calculated and pooled across hospitals using random effects meta-analysis.</p><p><strong>Results: </strong>From a total of 138 461 patients from 10 hospital glaucoma services in England, 9030 patients with OHT fitted the inclusion criteria. A total of 1530 (16.9%) patients converted to glaucoma during this follow-up period. The OHTS-EGPS model provided a pooled c-index of 0.61 (95% confidence interval: 0.60-0.63), ranging from 0.55 to 0.67 between hospitals. The pooled calibration slope was 0.45 (0.38-0.51), ranging from 0.25 to 0.64 among hospitals. The overall refitted model performed better than the OHTS-EGPS model, with a pooled c-index of 0.67 (0.65-0.69), ranging from 0.65 to 0.75 between hospitals.</p><p><strong>Conclusions: </strong>We performed an external validation of the OHTS-EGPS model in a large English population. Refitting the model achieved modest improvements in performance. Given the poor performance of the OHTS-EGPS model in our population, one should use caution in its application to populations that differ from those in the OHTS and EGPS.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":56368,"journal":{"name":"Ophthalmology. Glaucoma","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should We Use Disposable Tonometers and Gonioprisms in the Office?","authors":"Emily M Schehlein, Alan L Robin","doi":"10.1016/j.ogla.2024.09.004","DOIUrl":"https://doi.org/10.1016/j.ogla.2024.09.004","url":null,"abstract":"","PeriodicalId":56368,"journal":{"name":"Ophthalmology. Glaucoma","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of the Handheld IC200 and Slit Lamp-mounted ST500 Rebound Tonometers with Goldmann Applanation Tonometry.","authors":"Ryo Tomita, Glen P Sharpe, Devin Betsch, Rodolfo Bonatti, Balwantray C Chauhan","doi":"10.1016/j.ogla.2024.10.008","DOIUrl":"10.1016/j.ogla.2024.10.008","url":null,"abstract":"<p><strong>Objective: </strong>To compare the agreement and repeatability of intraocular pressure (IOP) measured with the slit lamp-mounted ST500 rebound tonometer (iCare Finland Oy), the hand-held IC200 rebound tonometer (iCare Finland Oy), and Goldmann applanation tonometry (GAT).</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Participants: </strong>Glaucoma patients and staff of the Eye Care Centre, Nova Scotia Health.</p><p><strong>Methods: </strong>Intraocular pressure was measured twice each with the IC200, ST500, and GAT. Bland-Altman analysis was used to compare each pair of tonometers and whether the difference between tonometers depended on mean IOP. Intraclass correlation coefficients were also computed. Repeatability of the measurements with each tonometer was assessed by calculating the mean and variance of the difference between the first and second measurements. The relationship between IOP and central corneal thickness was also evaluated.</p><p><strong>Main outcome measures: </strong>Agreement and repeatability of IOP measurements with the IC200, ST500, and GAT.</p><p><strong>Results: </strong>One eye of 157 participants (64 men and 93 women) with a median (interquartile range) age and central corneal thickness of 62 (45-72) years and 553 (533-572) μm, respectively, were enrolled. Median IOP with the IC200, ST500, and GAT was 17.1 (14.3-21.0), 16.5 (14.0-20.8), and 17.0 (14.0-20.5) mmHg, respectively, while the range of IOP (measured with GAT) was 8.5 to 53.0 mmHg. Measurements with the 3 tonometers were not statistically different from each other, and in neither of the 3 paired comparisons was the difference in IOP between 2 tonometers dependent on mean IOP. The intraclass correlation coefficient values (0.97-0.98) showed excellent agreement between the tonometers. The variance of the difference between the first and second measurements of the ST500 was significantly lower than that of GAT (P = 0.04) and IC200 (P < 0.01). Intraclass correlation coefficients for intratonometer repeatability were also excellent (0.97-0.99).</p><p><strong>Conclusions: </strong>The ST500 shows good agreement with GAT over a large range of IOP and significantly higher repeatability compared to the IC200 and GAT, suggesting it may be advantageous in clinical settings where topical anesthesia or skilled staff are unavailable.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":56368,"journal":{"name":"Ophthalmology. Glaucoma","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of Port-Wine Birthmarks and Glaucoma Outcomes in Sturge-Weber Syndrome.","authors":"Daniel M Vu, Harald Gjerde, Abdelrahman M Elhusseiny, Isdin Oke, Deborah K VanderVeen","doi":"10.1016/j.ogla.2024.10.007","DOIUrl":"10.1016/j.ogla.2024.10.007","url":null,"abstract":"<p><strong>Purpose: </strong>To identify which features of Sturge-Weber syndrome (SWS) were most associated with glaucoma onset, severity, and treatment failure at a tertiary care center.</p><p><strong>Design: </strong>Retrospective cross-sectional study.</p><p><strong>Subjects: </strong>Children who had SWS with and without glaucoma.</p><p><strong>Methods: </strong>Electronic health records were reviewed for all children with SWS presenting between 2014 and 2020. Examination and imaging findings from dermatology, neurology, and ophthalmology were collected. Logistic regression was used to identify factors associated with glaucoma-related outcomes.</p><p><strong>Main outcome measures: </strong>Primary outcomes included glaucoma development, progression to surgery, and treatment failure. Failure was defined as having a final intraocular pressure >21 mmHg, devastating complication, or ≤20/200 vision.</p><p><strong>Results: </strong>Twenty-three of 44 SWS patients (52.3%) developed glaucoma, and 6 of 23 patients (26.1%) had both eyes affected. Sixteen of 29 eyes (55.2%) required surgery, and 29.6% overall met our failure criteria (mean follow-up: 5.1 ± 4.3 years). Glaucoma diagnosis was associated with bilateral port-wine birthmarks (PWBs; odds ratio [OR] 5.9; 95% confidence interval [CI] 1.3-43.2), PWB with any lower eyelid involvement (OR 9.7, 95% CI 2.6-44.5), and choroidal hemangiomas (OR 3.8, 95% CI 1.1-13.8), but was not associated with upper eyelid or leptomeningeal angiomas, seizures, prior hemispherectomy, or pulsed-dye laser. Eyes that progressed to surgery were more likely to have PWB affecting the lower eyelid (OR 33.7, 95% CI 4.5-728.0). No clinical or demographic factors were associated with treatment failure. In most cases, angle surgery failed (72.7%) but was a temporizing measure before subconjunctival filtering surgery.</p><p><strong>Conclusions: </strong>Lower eyelid and choroidal angiomas were associated with glaucoma diagnosis, suggesting a spatial relationship with SWS findings. However, leptomeningeal angiomas were not associated, possibly because these are further from the eye.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":56368,"journal":{"name":"Ophthalmology. Glaucoma","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifiable Historic and Observable Factors May Predict Progression to Exfoliation Glaucoma in Newly Diagnosed Exfoliation Patients.","authors":"Karen Curtin, Joshua D Stein, Brian C Stagg, Nora Fino, Matthew Conley, Taylor Johnson, Ayesha Patil, Chase Paulson, Christian Pompoco, Barbara M Wirostko","doi":"10.1016/j.ogla.2024.10.006","DOIUrl":"10.1016/j.ogla.2024.10.006","url":null,"abstract":"<p><strong>Objective: </strong>To identify clinical factors associated with conversion to exfoliation glaucoma (XFG) in exfoliation syndrome (XFS) patients who are most at risk of progression to XFG within 3 years for increased surveillance and early preventive interventions.</p><p><strong>Design: </strong>A retrospective patient cohort study design was employed.</p><p><strong>Subjects: </strong>A source population of XFS patients ≥ 50 years was identified from electronic medical records in the Utah Population Database. From this, 487 study patients with one or more dilated eye examinations before chart-confirmed XFS onset in 2011 or later and ≥ 3 years of subsequent eye examinations were selected for study.</p><p><strong>Methods: </strong>We implemented binomial linear mixed models with L1-penalized estimation to select variables associated with conversion. Models included a random intercept to account for within-patient correlation for eye-level data. Candidate demographic, lifestyle, systemic, and ocular comorbidities data were obtained, and diagnoses were categorized as binary (history or no history). These potential factors between conversion and nonconversion patients were used in model selection of variables jointly predictive of conversion. Odds ratios and confidence intervals were calculated using the link logit.</p><p><strong>Main outcome measures: </strong>To determine the main outcome of conversion to XFG following an index diagnosis of XFS compared with nonconversion within 3 years, clinical records of each subject's left and right eyes were assessed to confirm XFS and date of onset and date of XFG onset, if conversion occurred. Clinical measurements (e.g., intraocular pressure [IOP], cup-to-disc ratio, provider notes, and IOP-lowering procedures and medications) were used to corroborate conversion status.</p><p><strong>Results: </strong>Eighteen variables jointly predicted XFG conversion within 3 years correctly in 71% of patient eyes. The odds of conversion were the highest for exudative age-related macular degeneration (AMD), 2.3-fold (P = 0.004). Other predictive variables included nonexudative AMD (P = 0.05), primary open angle glaucoma (P < 0.001), obstructive sleep apnea (P = 0.03), and ocular hypertension (P = 0.003) diagnosed before XFS onset.</p><p><strong>Conclusions: </strong>We determined a set of clinically relevant factors that predicted which newly diagnosed XFS patients progressed to XFG within 3 years. A planned validation will independently confirm if these prognostic indicators hold promise in other settings.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":56368,"journal":{"name":"Ophthalmology. Glaucoma","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Glaucoma Severity and Hip Fractures in California Medicare Beneficiaries.","authors":"Sayan K Chatterjee, Ramin Talebi, Ken Kitayama, Andrew G Young, Fei Yu, Victoria L Tseng, Anne L Coleman","doi":"10.1016/j.ogla.2024.10.002","DOIUrl":"10.1016/j.ogla.2024.10.002","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the association between glaucoma severity and hip fractures in older adults.</p><p><strong>Design: </strong>Retrospective cross-sectional study.</p><p><strong>Subjects: </strong>California (CA) Medicare beneficiaries in 2019 with Parts A & B coverage.</p><p><strong>Methods: </strong>Multivariable logistic regression was used to analyze the association between glaucoma severity (mild, moderate, and severe vs. no glaucoma) and hip fracture, after adjusting for age, sex, race and ethnicity, and Charlson Comorbidity Index score. A subgroup analysis was performed only in individuals with glaucoma to examine the odds of hip fracture for those with moderate and severe glaucoma compared to those with mild glaucoma.</p><p><strong>Main outcome measures: </strong>The variations in the odds of hip fractures for patients with and without glaucoma and for patients with moderate and severe glaucoma compared to those with mild glaucoma.</p><p><strong>Results: </strong>Of the 2 717 346 beneficiaries in the study population, 220 662 (8.1%) had glaucoma. In multivariable regression analysis, those with mild (odds ratio [OR]: 0.83; 95% confidence interval [CI]: 0.78-0.88) and moderate glaucoma (OR: 0.88; 95% CI: 0.84-0.92) had reduced odds of hip fracture compared with those with no glaucoma. There was no statistically significant association between severe vs. no glaucoma and hip fracture (OR: 0.96; 95% CI: 0.91-1.02). Among individuals with glaucoma, the odds of hip fracture were higher for those with severe glaucoma (OR: 1.17; 95% CI: 1.08-1.27), compared with those with mild glaucoma.</p><p><strong>Conclusions: </strong>In the CA Medicare population, the presence of glaucoma was associated with decreased likelihood of hip fracture. However, in those with glaucoma, increased glaucoma severity was associated with an increased likelihood of hip fracture. Potential mediating mechanisms requiring further study include fear of falls and physical inactivity in patients with glaucoma.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":56368,"journal":{"name":"Ophthalmology. Glaucoma","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Multifaceted Nongenetic Risk Factors for Primary Open-angle Glaucoma: An Overview of Systematic Reviews.","authors":"Jens Rovelt, Josefine Freiberg, Augusto Azuara-Blanco, Gianni Virgili, Miriam Kolko","doi":"10.1016/j.ogla.2024.10.004","DOIUrl":"10.1016/j.ogla.2024.10.004","url":null,"abstract":"<p><strong>Topic: </strong>A synthesis of the current knowledge on risk factors for primary open-angle glaucoma (POAG).</p><p><strong>Clinical relevance: </strong>This review advances understanding, guides future research, and informs strategies for preventing and treating POAG.</p><p><strong>Method: </strong>We conducted a systematic search of PubMed, Embase, Web of Science, and the Cochrane Library to identify relevant systematic reviews (SRs) published in English after 2012. The inclusion criteria focused on SRs investigating risk factors for POAG. We registered the study prospectively in the PROSPERO database (CRD42022351372) and used Covidence and the Risk of Bias in Systematic Reviews tool to manage article selection and assess the risk of bias in the included SRs. Data was extracted independently by 2 authors.</p><p><strong>Results: </strong>After removing duplicate SRs, we assessed 2542 SRs. Of these, 2396 were determined to be irrelevant, leaving 138 for a full-text review. Following this, 78 were excluded with reasons, resulting in 60 SRs. Of these, 30 had a low risk of bias. In our bias assessment, SRs categorized as high risk of bias were characterized by 1) lack of sufficient detail in the bias assessment of the SR and 2) insufficient information or missing calculations of heterogeneity among the included studies. In our study, we identified 22 risk factors associated with POAG. The SRs covered a wide range of risk factors for POAG. Among these, the strongest associations with POAG, based on effect size, were observed in 2 SRs related to obstructive sleep apnea (OSA), with a pooled odds ratio (OR) of 3.66 (95% confidence interval [CI]: 1.70-7.90) and an adjusted OR of 2.46 (95% CI: 1.32-4.59). Similarly, 2 SRs investigating Helicobacter pylori (H. pylori) infections showed significant associations, with pooled ORs of 2.08 (95% CI: 1.48-2.93) and 2.08 (95% CI: 1.42-3.04), respectively.</p><p><strong>Conclusion: </strong>This article summarizes the current knowledge on risk factors for POAG from published SRs. Our findings highlight the complexity of the disease and the nature of the factors that may affect various populations. Among the reported associations with low risk of bias, we found the highest effect estimates for OSA and H. pylori infections in relation to POAG. Our review helps advance understanding, guide future research, and inform strategies for the prevention and treatment of POAG.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":56368,"journal":{"name":"Ophthalmology. Glaucoma","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT for Addressing Patient-centered Frequently Asked Questions in Glaucoma Clinical Practice.","authors":"Henrietta Wang, Katherine Masselos, Janelle Tong, Heather R M Connor, Janelle Scully, Sophia Zhang, Daniel Rafla, Matteo Posarelli, Jeremy C K Tan, Ashish Agar, Michael Kalloniatis, Jack Phu","doi":"10.1016/j.ogla.2024.10.005","DOIUrl":"10.1016/j.ogla.2024.10.005","url":null,"abstract":"<p><strong>Purpose: </strong>Large language models such as ChatGPT-3.5 are often used by the public to answer questions related to daily life, including health advice. This study evaluated the responses of ChatGPT-3.5 in answering patient-centered frequently asked questions (FAQs) relevant in glaucoma clinical practice.</p><p><strong>Design: </strong>Prospective cross-sectional survey.</p><p><strong>Participants: </strong>Expert graders.</p><p><strong>Methods: </strong>Twelve experts across a range of clinical, education, and research practices in optometry and ophthalmology. Over 200 patient-centric FAQs from authoritative professional society, hospital and advocacy websites were distilled and filtered into 40 questions across 4 themes: definition and risk factors, diagnosis and testing, lifestyle and other accompanying conditions, and treatment and follow-up. The questions were individually input into ChatGPT-3.5 to generate responses. The responses were graded by the 12 experts individually.</p><p><strong>Main outcome measures: </strong>A 5-point Likert scale (1 = strongly disagree; 5 = strongly agree) was used to grade ChatGPT-3.5 responses across 4 domains: coherency, factuality, comprehensiveness, and safety.</p><p><strong>Results: </strong>Across all themes and domains, median scores were all 4 (\"agree\"). Comprehensiveness had the lowest scores across domains (mean 3.7 ± 0.9), followed by factuality (mean 3.9 ± 0.9) and coherency and safety (mean 4.1 ± 0.8 for both). Examination of the individual 40 questions showed that 8 (20%), 17 (42.5%), 24 (60%), and 8 (20%) of the questions had average scores below 4 (i.e., below \"agree\") for the coherency, factuality, comprehensiveness, and safety domains, respectively. Free-text comments by the experts highlighted omissions of facts and comprehensiveness (e.g., secondary glaucoma) and remarked on the vagueness of some responses (i.e., that the response did not account for individual patient circumstances).</p><p><strong>Conclusions: </strong>ChatGPT-3.5 responses to FAQs in glaucoma were generally agreeable in terms of coherency, factuality, comprehensiveness, and safety. However, areas of weakness were identified, precluding recommendations for routine use to provide patients with tailored counseling in glaucoma, especially with respect to development of glaucoma and its management.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":56368,"journal":{"name":"Ophthalmology. Glaucoma","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Robison D. Harley, MD Childhood Glaucoma Research Network International Pediatric Glaucoma Registry: The First 872 Cases.","authors":"Stephanie R Beldick, Adam Rockter, Allen D Beck, Alex V Levin","doi":"10.1016/j.ogla.2024.10.001","DOIUrl":"10.1016/j.ogla.2024.10.001","url":null,"abstract":"<p><strong>Purpose: </strong>To report on epidemiologic data from an international, centralized pediatric glaucoma database of 872 patients, focusing on genetic and clinically significant factors.</p><p><strong>Design: </strong>Database study utilizing retrospective analysis.</p><p><strong>Subjects: </strong>Eight hundred seventy-two children, both female and male, were included in the database. After accounting for database coding errors, data from 865 patients with pediatric glaucoma were analyzed. Number of eyes analyzed fluctuated for each variable.</p><p><strong>Methods: </strong>The registry is an open access, no charge, Research Electronic Data Capture database. Participating clinical centers input data with local Institutional Review Board approval and subsequently have access for research purposes. We retrospectively reviewed 872 patients, comparing demographics, family history, country, disease presentation, and Childhood Glaucoma Research Network diagnoses. Analyses for each variable were conducted in SPSS Software v.28.0. Chi-square analyses were performed for nominal data, and ordinal and continuous data were analyzed using Mann-Whitney test, analysis of variance, or Kruskal-Wallis tests with multiple comparisons.</p><p><strong>Main outcome measures: </strong>Childhood Glaucoma Research Network glaucoma type and markers of clinical severity by country (laterality, cup-to-disc ratio [CTD], corneal diameter, opacification, edema; visual acuity [VA], intraocular pressure, Haab striae, axial length).</p><p><strong>Results: </strong>Twenty clinical sites from 10 countries entered data. Centers in the USA, India, and Iran input the most data. In the USA, open-angle glaucoma following cataract surgery was most common, while in India and Iran it was primary congenital glaucoma neonatal onset. Bilateral disease was more frequent in India and Iran compared to the USA (X² = 50.6, P < 0.001). Clinical measures of severity were typically worse in India compared to the USA. This included increased CTD (X² = 24.0, P = 0.002), increased corneal diameter (X² = 8.9, P = 0.01), presence of corneal opacification (X² = 10.7, P = 0.001), presence of corneal edema (X² = 11.7, P < 0.001), and worse VA (U = 873.5, P < 0.001). Intraocular pressure and presence of Haab striae were not associated with country (P > 0.05), while axial length was increased in the USA by an average of 1.04 mm (U = 5787, P = 0.002).</p><p><strong>Conclusions: </strong>This registry has potential to advance our understanding of pediatric glaucoma. Differences in family history, disease presentation, and glaucoma type suggest unique country phenotypes. Registry expansion may allow for insight into best practices for pediatric glaucoma.</p><p><strong>Financial disclosure(s): </strong>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>","PeriodicalId":56368,"journal":{"name":"Ophthalmology. Glaucoma","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transscleral Cyclophotocoagulation for Glaucoma in the Setting of Uveal Melanoma.","authors":"Aakriti Garg Shukla, Sarangdev Vaidya, Antonio Yaghy, Reza Razeghinejad, Anand V Mantravadi, Jonathan S Myers, Swathi Kaliki, Carol L Shields","doi":"10.1016/j.ogla.2020.09.011","DOIUrl":"10.1016/j.ogla.2020.09.011","url":null,"abstract":"","PeriodicalId":56368,"journal":{"name":"Ophthalmology. Glaucoma","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38403462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}