Minerva Pediatrics最新文献_第8页

The impact of antimicrobial use on potential major drug-drug interactions in the pediatric Intensive Care Unit patients at University Hospital in Türkiye. 抗菌药的使用对土耳其大学医院儿科重症监护室患者潜在的主要药物相互作用的影响。

IF 2.6

Minerva Pediatrics Pub Date : 2024-06-01 Epub Date: 2021-04-15 DOI: 10.23736/S2724-5276.21.06173-9

Aslınur Albayrak, Emine Akkuzu, Bensu Karahalil

{"title":"The impact of antimicrobial use on potential major drug-drug interactions in the pediatric Intensive Care Unit patients at University Hospital in Türkiye.","authors":"Aslınur Albayrak, Emine Akkuzu, Bensu Karahalil","doi":"10.23736/S2724-5276.21.06173-9","DOIUrl":"10.23736/S2724-5276.21.06173-9","url":null,"abstract":"Background: Antimicrobials, especially antibiotics, are among the most widely used drugs in the pediatric intensive care unit. Pediatrics patients in intensive care unit are exposed to potential drug-drug interactions (PDDIs) and suffered from their adverse and side effects. The aim of this study is to evaluate the impact of antimicrobial use on PDDIs, as well as to examine the rate and the risk factors PDDIs, furthermore the management of PDDIs.Methods: The present retrospective cohort study included 179 patients under 18 years of age who were hospitalized in Pediatric Intensive Care Unit in Türkiye. Drug interactions were evaluated using the Lexicomp® (Macedonia, OH, USA) drug interaction tool which provides evidence-based drug information.Results: Our study results showed that the frequency of the use of antimicrobial drugs (antibiotic, antifungal, antiviral) was found to be statistically significantly higher (P<0.05) in the group with PDDIs compared to the group without PDDIs. Especially, the use of carbapenem, cephalosporin among the antibiotic groups significantly increased the frequency of PDDIs (P<0.05). While the probability PDDIs statistically significantly increased 3.73 times (OR [odds ratio] = 3.73; 95% CI=1.47-9.50) in patients who used a single antibiotic compared to patients who did not use antibiotics (P=0.006), the probability of the occurrence of PDDIs by using more than one antibiotic was statistically significantly 8.5 times (95% CI=3.30-21.89) (P<0.001).Conclusions: Our study results showed that the use of antimicrobial drugs (antibiotic, antifungal, antiviral) was found to be statistically significantly higher (P<0.05) in the group with PDDIs.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38876707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of multimedia devices in pediatric age: risks or advantages? A survey in an Italian center. 儿科使用多媒体设备：风险还是优势？一项在意大利中心进行的调查。

IF 2.6

Minerva Pediatrics Pub Date : 2024-06-01 DOI: 10.23736/S2724-5276.22.06097-9

Ilaria Lazzareschi, Antonietta Curatola, Sabrina DE Pascalis, Luca Bernardo, Antonio Gatto, Serena Ferretti, Piero Valentini, Pietro Ferrara

{"title":"Use of multimedia devices in pediatric age: risks or advantages? A survey in an Italian center.","authors":"Ilaria Lazzareschi, Antonietta Curatola, Sabrina DE Pascalis, Luca Bernardo, Antonio Gatto, Serena Ferretti, Piero Valentini, Pietro Ferrara","doi":"10.23736/S2724-5276.22.06097-9","DOIUrl":"https://doi.org/10.23736/S2724-5276.22.06097-9","url":null,"abstract":"Background: Nowadays children live in a digital world, exposed to relevant risks for their health and safety. The aim of this study is to investigate the use of multimedia devices in a sample of children and adolescents.Methods: The study was performed between November 2018 and June 2019 in a third-level University Hospital, recruiting children and adolescents during general or specialistic follow-up visits. Anonymous, age-specific, questionnaires were distributed to 500 children and adolescents and 370 parents.Results: Among children, 25 (17.1%) had their own mobile device, of which 84% Italian. The 54.1% of them uses multimedia devices half an hour/an hour per day and many of them (37.5% of Italian and 40% of foreign) use it without their parents' control. Most of adolescents had a mobile phone since the age of 10-12 years old. WhatsApp (Meta Inc., Cambridge, MA, USA) is the most used social network, followed by Instagram and Facebook. The use of multimedia devices was widespread between teenagers during classroom hours, meals and before sleeping and they are an important mean for cyberbullying. In addition, in the 29.9% of cases there is no correspondence between information given by parents and respective sons/daughters.Conclusions: This study shows more risks than advantages derived from the use of multimedia devices in children and adolescents. Therefore, it is essential to educate them about their correct and responsible use.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Children with cow milk allergy could have feeding difficulties that must not be underestimated. 对牛奶过敏的儿童可能会出现喂养困难，这一点不容小觑。

IF 1

Minerva Pediatrics Pub Date : 2024-06-01 Epub Date: 2024-01-19 DOI: 10.23736/S2724-5276.23.07454-2

Vincenzo Raitano, Luca Pecoraro, Andrea Sboarina, Milena Brugnara, Giorgio Piacentini, Angelo Pietrobelli

引用次数: 0

Association of fluid overload with patent ductus arteriosus during the first postnatal day. 产后第一天体液超负荷与动脉导管未闭的关系

IF 2.6

Minerva Pediatrics Pub Date : 2024-06-01 Epub Date: 2021-04-12 DOI: 10.23736/S2724-5276.21.06060-6

Dimitrios Rallis, Foteini Balomenou, Aikaterini Drougia, Thomas Benekos, Antonios Vlahos, Meropi Tzoufi, Vasileios Giapros

{"title":"Association of fluid overload with patent ductus arteriosus during the first postnatal day.","authors":"Dimitrios Rallis, Foteini Balomenou, Aikaterini Drougia, Thomas Benekos, Antonios Vlahos, Meropi Tzoufi, Vasileios Giapros","doi":"10.23736/S2724-5276.21.06060-6","DOIUrl":"10.23736/S2724-5276.21.06060-6","url":null,"abstract":"Background: Evidence examining the association of over-hydration during early life with hemodynamically significant patent ductus arteriosus (hsPDA) and other morbidities is limited. Our aim was to evaluate the association of fluid overload during the first postnatal day with hsPDA and common neonatal morbidities such as bronchopulmonary dysplasia in preterm infants.Methods: A retrospective cohort study was conducted enrolling infants ≤30 weeks' gestation and ≤1500 grams' birth weight, admitted to a tertiary Neonatal Unit. We calculated the fluid balance, and we estimated the incidence of infants with fluid overload ≥5% during the first postnatal day, evaluating any possible correlation with hsPDA.Results: One hundred three infants of 27.3±1.6 weeks' gestation and 1009±225 grams' birth weight were enrolled, of whom 32 (31%) were diagnosed with HsPDA. Fluid overload during the first postnatal day was recorded in 42 infants (41%). Infants with fluid overload were diagnosed with hsPDA in 48%, compared to 20% of infants without fluid overload (P=0.004). No differences were recorded in the development of bronchopulmonary dysplasia or survival. Fluid overload of ≥5% was significantly correlated with hsPDA (r=0.37, P=0.003) and had an independent contribution to the risk of hsPDA (OR=1.17, 95% CI: 1.05-1.58), irrespective of other perinatal factors.Conclusions: In preterm infants, fluid overload ≥5% is significantly associated with hsPDA; therefore, fluid management during the first postnatal day should be closely regulated.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25584294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal poor glycemic control increases risk of neonatal left ventricular hypertrophy. 产妇血糖控制不佳会增加新生儿左心室肥大的风险。

IF 2.6

Minerva Pediatrics Pub Date : 2024-06-01 DOI: 10.23736/S2724-5276.21.06055-9

Chayaporn Vasinchatchawal, Somjate Suntratonpipat, Chokchai Ruangroj, Napol Chitsrisakda, Apiwat Chungsangfah, Pithi Chanvorachote, Nithipun Suksumek

{"title":"Maternal poor glycemic control increases risk of neonatal left ventricular hypertrophy.","authors":"Chayaporn Vasinchatchawal, Somjate Suntratonpipat, Chokchai Ruangroj, Napol Chitsrisakda, Apiwat Chungsangfah, Pithi Chanvorachote, Nithipun Suksumek","doi":"10.23736/S2724-5276.21.06055-9","DOIUrl":"https://doi.org/10.23736/S2724-5276.21.06055-9","url":null,"abstract":"Background: Left ventricular hypertrophy (LVH) is an important complication of infants of diabetic mothers (IDMs). However, the defined factors, such as the influence of glycemic control, insulin administration of diabetic mothers and large for gestational age (LGA) in infants, are largely unknown on the incidence of LVH. Therefore, this study aimed to evaluate the prevalence of maternal and neonatal risk factors associated with LVH in IDMs.Methods: This prospective analytic study was conducted at tertiary care hospitals in a 1-year period. Inborn IDMs were enrolled, and ventricular hypertrophy was identified by 2D echocardiography in the first 72 hours after birth.Results: A total of 160 IDMs met the inclusion criteria, 33 (20.6%) of which had LVH. The incidence of infants with LVH born to mothers with poor glycemic control (fasting blood sugar >95 mg/dL) was significantly elevated than those with good glycemic control (45.5% vs. 14.4%, P<0.001). Twelve IDMs (12/33, 36.5%) of LVH and 17 IDMs (17/127, 13.4%) of non-LVH were LGA. IDMs with LVH, compared those with non-LVH, had significantly increased left ventricular (LV) geometry; IVSd (6.5±0.8 vs. 4.0±0, 7 mm), LV IDd (16.8±3.3 mm vs. 18.4±1.1), left ventricular ejection fraction (LVEF) (68.3±8.5% vs. 62.9±17.5%), left ventricular fraction shortening (LVFS) (35.9±6.6% vs. 32.2±5.5%), LV mass (15.3±11.6 vs. 9.3±2.5 g) and LV mass index (66.2±17.5 vs. 46.6±9.7 g/m2), all with P<0.001. There was significant correlation in LV mass with infants' weight, height and body surface area (BSA) (r=0.408, 0.337 and 0.424, respectively; P<0.001).Conclusions: The prevalence of neonatal ventricular hypertrophy in IDMs was 20.6%. Maternal poor glycemic control and LGA status in IDMs were dominant risk factors of LVH.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The right to oblivion from oncological history for children cured of cancer: in a few months, it will also become a law in Italy. 癌症治愈儿童从肿瘤史中被遗忘的权利：几个月后，它也将成为意大利的一项法律。

IF 1

Minerva Pediatrics Pub Date : 2024-06-01 Epub Date: 2023-10-06 DOI: 10.23736/S2724-5276.23.07393-7

Roberto Miniero, Giuseppe A Mazza, Santina Marrazzo, Valentina Talarico

引用次数: 0

Machine learning trial to detect sex differences in simple sticker arts of 1606 preschool children. 检测 1606 名学龄前儿童简单贴纸艺术性别差异的机器学习试验。

IF 2.6

Minerva Pediatrics Pub Date : 2024-06-01 DOI: 10.23736/S2724-5276.21.06067-5

Keiko Matsubara, Yuko Ohgami, Koji Okamura, Saki Aoto, Maki Fukami, Yukiko Shimada

{"title":"Machine learning trial to detect sex differences in simple sticker arts of 1606 preschool children.","authors":"Keiko Matsubara, Yuko Ohgami, Koji Okamura, Saki Aoto, Maki Fukami, Yukiko Shimada","doi":"10.23736/S2724-5276.21.06067-5","DOIUrl":"https://doi.org/10.23736/S2724-5276.21.06067-5","url":null,"abstract":"Background: Previous studies suggested that drawings made by preschool boys and girls show distinguishable differences. However, children's drawings on their own are too complexly determined and inherently ambiguous to be a reliable indicator. In the present study, we attempted to develop a machine learning algorithm for classification of sex of the subjects using children's artworks.Methods: We studied three types of simple sticker artworks from 1606 Japanese preschool children aged 51-83 months (803 boys and 803 girls). Those artworks were processed into digitalized data. Simulated data based on the original data were also generated. Logistic regression approach was applied to each dataset to make a classifier, and run on each dataset in a stratified ten-fold cross-validation with hyperparameter tuning. A probability score was calculated in each sample and utilized for sex classification. Prediction performance was evaluated using accuracy, recall, and precision scores, as well as learning curves.Results: Two models created from the original and simulated data showed comparably low metrics. The distributions of probability scores in the samples from boys and girls mostly overlapped and were indistinguishable. Learning curves of the models showed an extremely under-fitted pattern.Conclusions: Our machine learning algorithm was unable to distinguish simple sticker arts created by boys and girls. More complex tasks will enable to develop an accurate classifier.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nailfold capillaroscopy shows microvascular dysfunction in children and adolescents with poorly controlled type 1 diabetes and normal retinal assessment. 甲襞毛细血管镜检查显示1型糖尿病控制不良和视网膜评估正常的儿童和青少年微血管功能障碍。

IF 1

Minerva Pediatrics Pub Date : 2024-06-01 Epub Date: 2023-11-28 DOI: 10.23736/S2724-5276.23.07328-7

Francesco Martino, Francesco Barillà, Eliana Martino, Giuseppe Placanica, Vincenzo Paravati, Pier P Bassareo

引用次数: 0

Study on early intervention strategies of children's snoring: a meta-analysis based on network. 儿童打鼾早期干预策略研究：基于网络的荟萃分析。

IF 1

Minerva Pediatrics Pub Date : 2024-06-01 Epub Date: 2024-03-06 DOI: 10.23736/S2724-5276.24.07533-5

Tingting Li, Yongjun Wang, Ying Zhu, Qijun Zhao

引用次数: 0

Effects of dietary sugar restriction on hepatic fat in youth with obesity. 限制糖分摄入对肥胖症青少年肝脏脂肪的影响

IF 1

Minerva Pediatrics Pub Date : 2024-06-01 Epub Date: 2023-06-07 DOI: 10.23736/S2724-5276.23.07209-9

Johanna K Distefano, Glenn S Gerhard

{"title":"Effects of dietary sugar restriction on hepatic fat in youth with obesity.","authors":"Johanna K Distefano, Glenn S Gerhard","doi":"10.23736/S2724-5276.23.07209-9","DOIUrl":"10.23736/S2724-5276.23.07209-9","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in children. Like adults, children can develop the progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), which is characterized by hepatic inflammation, often in the presence of fibrosis. Children with NAFLD are at higher risk of liver-related complications, metabolic dysfunction, and cardiovascular disease in adulthood. Many factors contribute to the escalating prevalence of NAFLD in the pediatric population, among which are an array of dietary patterns such as overnutrition, poor diet quality, and heavy consumption of fat and sugar, including fructose. Findings from an increasing number of epidemiological studies support a connection between high habitual sugar consumption and NAFLD, especially within the context of obesity, but these studies are not able to demonstrate whether sugar is a contributing factor or instead an indicator of an overall poor diet (or lifestyle) quality. To date, only four randomized controlled dietary interventions assessing the effects of sucrose/fructose restriction on hepatic fat fraction in youth with obesity have been published. The objectives of this review are to summarize the key findings from these dietary interventions to achieve a better understanding of the strength of the relationship between dietary sugar restriction and liver fat reduction, despite their inherent limitations, and to discuss the potential impact of weight loss and fat mass reduction on improvement in hepatic steatosis.","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9578413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0