Jaro-Journal of the Association for Research in Otolaryngology最新文献_第7页

Sensitivity to Pulse Rate and Amplitude Modulation in an Animal Model of the Auditory Brainstem Implant (ABI). 听觉脑干植入（ABI）动物模型对脉率和振幅调制的敏感性。

IF 2.4 3区医学

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-06-01 Epub Date: 2023-05-08 DOI: 10.1007/s10162-023-00897-z

Stephen McInturff, Victor Adenis, Florent-Valéry Coen, Stéphanie P Lacour, Daniel J Lee, M Christian Brown

{"title":"Sensitivity to Pulse Rate and Amplitude Modulation in an Animal Model of the Auditory Brainstem Implant (ABI).","authors":"Stephen McInturff, Victor Adenis, Florent-Valéry Coen, Stéphanie P Lacour, Daniel J Lee, M Christian Brown","doi":"10.1007/s10162-023-00897-z","DOIUrl":"10.1007/s10162-023-00897-z","url":null,"abstract":"The auditory brainstem implant (ABI) is an auditory neuroprosthesis that provides hearing by electrically stimulating the cochlear nucleus (CN) of the brainstem. Our previous study (McInturff et al., 2022) showed that single-pulse stimulation of the dorsal (D)CN subdivision with low levels of current evokes responses that have early latencies, different than the late response patterns observed from stimulation of the ventral (V)CN. How these differing responses encode more complex stimuli, such as pulse trains and amplitude modulated (AM) pulses, has not been explored. Here, we compare responses to pulse train stimulation of the DCN and VCN, and show that VCN responses, measured in the inferior colliculus (IC), have less adaption, higher synchrony, and higher cross-correlation. However, with high-level DCN stimulation, responses become like those to VCN stimulation, supporting our earlier hypothesis that current spreads from electrodes on the DCN to excite neurons located in the VCN. To AM pulses, stimulation of the VCN elicits responses with larger vector strengths and gain values especially in the high-CF portion of the IC. Additional analysis using neural measures of modulation thresholds indicate that these measures are lowest for VCN. Human ABI users with low modulation thresholds, who score best on comprehension tests, may thus have electrode arrays that stimulate the VCN. Overall, the results show that the VCN has superior response characteristics and suggest that it should be the preferred target for ABI electrode arrays in humans.","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":"24 3","pages":"365-384"},"PeriodicalIF":2.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9789752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Types of Inheritance and Genes Associated with Familial Meniere Disease. 家族性梅尼埃病的遗传类型和相关基因。

IF 2.4 3区医学

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-06-01 DOI: 10.1007/s10162-023-00896-0

Alberto M Parra-Perez, Jose A Lopez-Escamez

{"title":"Types of Inheritance and Genes Associated with Familial Meniere Disease.","authors":"Alberto M Parra-Perez, Jose A Lopez-Escamez","doi":"10.1007/s10162-023-00896-0","DOIUrl":"https://doi.org/10.1007/s10162-023-00896-0","url":null,"abstract":"Meniere disease (MD) is a rare disorder of the inner ear defined by sensorineural hearing loss (SNHL) associated with episodes of vertigo and tinnitus. The phenotype is variable, and it may be associated with other comorbidities such as migraine, respiratory allergies, and several autoimmune disorders. The condition has a significant heritability according to epidemiological and familial segregation studies. Familial MD is found in 10% of cases, the most frequently found genes being OTOG, MYO7A, and TECTA, previously associated with autosomal dominant and recessive non-syndromic SNHL. These findings suggest a new hypothesis where proteins involved in the extracellular structures in the apical surface of sensory epithelia (otolithic and tectorial membranes) and proteins in the stereocilia links would be key elements in the pathophysiology of MD. The ionic homeostasis of the otolithic and tectorial membranes could be critical to suppress the innate motility of individual hair cell bundles. Initially, focal detachment of these extracellular membranes may cause random depolarization of hair cells and will explain changes in tinnitus loudness or trigger vertigo attacks in early stages of MD. With the progression of the disease, a larger detachment will lead to an otolithic membrane herniation into the horizontal semicircular canal with dissociation in caloric and head impulse responses. Familial MD shows different types of inheritance, including autosomal dominant and compound recessive patterns and implementation of genetic testing will improve our understanding of the genetic structure of MD.","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":"24 3","pages":"269-279"},"PeriodicalIF":2.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10148563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In Vivo Optical Characterization of Middle Ear Effusions and Biofilms During Otitis Media. 中耳炎期间中耳积液和生物膜的活体光学特征。

IF 2.4 3区医学

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-06-01 Epub Date: 2023-05-30 DOI: 10.1007/s10162-023-00901-6

Jungeun Won, Guillermo L Monroy, Pawjai Khampang, Ronit Barkalifa, Wenzhou Hong, Eric J Chaney, Edita Aksamitiene, Ryan G Porter, Michael A Novak, Darold R Spillman, Joseph E Kerschner, Stephen A Boppart

{"title":"In Vivo Optical Characterization of Middle Ear Effusions and Biofilms During Otitis Media.","authors":"Jungeun Won, Guillermo L Monroy, Pawjai Khampang, Ronit Barkalifa, Wenzhou Hong, Eric J Chaney, Edita Aksamitiene, Ryan G Porter, Michael A Novak, Darold R Spillman, Joseph E Kerschner, Stephen A Boppart","doi":"10.1007/s10162-023-00901-6","DOIUrl":"10.1007/s10162-023-00901-6","url":null,"abstract":"Otitis media (OM), a common ear infection, is characterized by the presence of an accumulated middle ear effusion (MEE) in a normally air-filled middle ear cavity. While assessing the MEE plays a critical role in the overall management of OM, identifying and examining the MEE is challenging with the current diagnostic tools since the MEE is located behind the semi-opaque eardrum. The objective of this cross-sectional, observational study is to non-invasively visualize and characterize MEEs and bacterial biofilms in the middle ear. A portable, handheld, otoscope-integrated optical coherence tomography (OCT) system combined with novel analytical methods has been developed. In vivo middle ear OCT images were acquired from 53 pediatric subjects (average age of 3.9 years; all awake during OCT imaging) diagnosed with OM and undergoing a surgical procedure (ear tube surgery) to aspirate the MEE and aerate the middle ear. In vivo middle ear OCT acquired prior to the surgery was compared with OCT of the freshly extracted MEEs, clinical diagnosis, and post-operative evaluations. Among the subjects who were identified with the presence of MEEs, 89.6% showed the presence of the TM-adherent biofilm in in vivo OCT. This study provides an atlas of middle ear OCT images exhibiting a range of depth-resolved MEE features, which can only be visualized and assessed non-invasively through OCT. Quantitative metrics of OCT images acquired prior to the surgery were statistically correlated with surgical evaluations of MEEs. Measurements of MEE characteristics will provide new readily available information that can lead to improved diagnosis and management strategies for the highly prevalent OM in children.","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":"24 3","pages":"325-337"},"PeriodicalIF":2.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Inverse Relationship Between Gray Matter Volume and Speech-in-Noise Performance in Tinnitus Patients with Normal Hearing Sensitivity. 听觉灵敏度正常的耳鸣患者的灰质体积与噪音中的语音表现之间存在反比关系

IF 2.4 3区医学

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-06-01 Epub Date: 2023-03-03 DOI: 10.1007/s10162-023-00895-1

Yihsin Tai, Somayeh Shahsavarani, Rafay A Khan, Sara A Schmidt, Fatima T Husain

{"title":"An Inverse Relationship Between Gray Matter Volume and Speech-in-Noise Performance in Tinnitus Patients with Normal Hearing Sensitivity.","authors":"Yihsin Tai, Somayeh Shahsavarani, Rafay A Khan, Sara A Schmidt, Fatima T Husain","doi":"10.1007/s10162-023-00895-1","DOIUrl":"10.1007/s10162-023-00895-1","url":null,"abstract":"Speech-in-noise (SiN) recognition difficulties are often reported in patients with tinnitus. Although brain structural changes such as reduced gray matter (GM) volume in auditory and cognitive processing regions have been reported in the tinnitus population, it remains unclear how such changes influence speech understanding, such as SiN performance. In this study, pure-tone audiometry and Quick Speech-in-Noise test were conducted on individuals with tinnitus and normal hearing and hearing-matched controls. T1-weighted structural MRI images were obtained from all participants. After preprocessing, GM volumes were compared between tinnitus and control groups using whole-brain and region-of-interest analyses. Further, regression analyses were performed to examine the correlation between regional GM volume and SiN scores in each group. The results showed decreased GM volume in the right inferior frontal gyrus in the tinnitus group relative to the control group. In the tinnitus group, SiN performance showed a negative correlation with GM volume in the left cerebellum (Crus I/II) and the left superior temporal gyrus; no significant correlation between SiN performance and regional GM volume was found in the control group. Even with clinically defined normal hearing and comparable SiN performance relative to controls, tinnitus appears to change the association between SiN recognition and regional GM volume. This change may reflect compensatory mechanisms utilized by individuals with tinnitus who maintain behavioral performance.","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":"24 3","pages":"385-395"},"PeriodicalIF":2.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9778841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Finite-Element Modelling Based on Optical Coherence Tomography and Corresponding X-ray MicroCT Data for Three Human Middle Ears. 基于光学相干断层扫描和相应 X 射线显微 CT 数据的三只人类中耳有限元模型。

IF 2.4 3区医学

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-06-01 Epub Date: 2023-05-10 DOI: 10.1007/s10162-023-00899-x

Marzieh Golabbakhsh, Xuan Wang, Dan MacDougall, Joshua Farrell, Thomas Landry, W Robert J Funnell, Robert Adamson

{"title":"Finite-Element Modelling Based on Optical Coherence Tomography and Corresponding X-ray MicroCT Data for Three Human Middle Ears.","authors":"Marzieh Golabbakhsh, Xuan Wang, Dan MacDougall, Joshua Farrell, Thomas Landry, W Robert J Funnell, Robert Adamson","doi":"10.1007/s10162-023-00899-x","DOIUrl":"10.1007/s10162-023-00899-x","url":null,"abstract":"Purpose: Optical coherence tomography (OCT) is an emerging imaging modality which is non-invasive, can be employed in vivo, and can record both anatomy and vibrations. The purpose here is to explore the application of finite-element (FE) modelling to OCT data.Methods: We recorded vibrations for three human cadaver middle ears using OCT. We also have X-ray microCT images from the same ears. Three FE models were built based on geometries obtained from the microCT images. The material properties and boundary conditions of the models were obtained from previously reported studies.Results: Tympanic-membrane (TM) vibration patterns were computed for the three models and compared with the patterns measured using OCT. Frequency responses were also computed for all three models for several locations in the middle ear and compared with the OCT displacements and with the literature. The three models were compared with each other in terms of geometry and function. Parameter sensitivity analyses were done and the results were compared among the models and with the literature. The simulated TM displacement patterns are qualitatively similar to the OCT results. The simulated displacements are closer to the OCT results for 500 Hz and 1 kHz but the differences are greater at 2 kHz.Conclusion: This study provides an initial look at the combined use of OCT measurements and FE modelling based on subject-specific anatomy. The geometries and parameters of the existing FE models could be modified for individual patients in the future to help identify abnormalities in the middle ear.","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":"24 3","pages":"339-363"},"PeriodicalIF":2.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9790202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bandpass Shape of Distortion-Product Otoacoustic Emission Ratio Functions Reflects Cochlear Frequency Tuning in Normal-Hearing Mice. 畸变积耳声发射比函数的带通形状反映正常听力小鼠耳蜗频率调谐。

IF 2.4 3区医学

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-06-01 DOI: 10.1007/s10162-023-00892-4

James B Dewey, Christopher A Shera

{"title":"Bandpass Shape of Distortion-Product Otoacoustic Emission Ratio Functions Reflects Cochlear Frequency Tuning in Normal-Hearing Mice.","authors":"James B Dewey, Christopher A Shera","doi":"10.1007/s10162-023-00892-4","DOIUrl":"https://doi.org/10.1007/s10162-023-00892-4","url":null,"abstract":"The frequency selectivity of the mammalian auditory system is critical for discriminating complex sounds like speech. This selectivity derives from the sharp tuning of the cochlea's mechanical response to sound, which is largely attributed to the amplification of cochlear vibrations by outer hair cells (OHCs). Due to its nonlinearity, the amplification process also leads to the generation of distortion products (DPs), some of which propagate out to the ear canal as DP otoacoustic emissions (DPOAEs). However, the insight that these signals provide about the tuned micro- and macro-mechanics underlying their generation remains unclear. Using optical coherence tomography to measure cochlear vibrations in mice, we show that the cochlea's frequency tuning is reflected in the bandpass shape that is observed in DPOAE amplitudes when the ratio of the two evoking stimulus frequencies is varied (here termed DPOAE \"ratio functions\"). The tuning sharpness of DPOAE ratio functions and cochlear vibrations co-varied with stimulus level, with a similar quantitative agreement in tuning sharpness observed for both apical and mid-cochlear locations. Measurement of intracochlear DPs revealed that the tuning of the DPOAE ratio functions was not caused by mechanisms that shape DPs locally near where they are generated. Instead, simple model simulations indicate that the bandpass shape is due to a more global wave interference phenomenon. It appears that the filtering of DPOAEs by wave interactions over an extended spatial region allows them to provide a window onto the frequency tuning of single cochlear locations.","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":"24 3","pages":"305-324"},"PeriodicalIF":2.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10149599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Connexin36 RNA Expression in the Cochlear Nucleus of the Echolocating Bat, Eptesicus fuscus. 回声定位蝙蝠耳蜗核中的 Connexin36 RNA 表达

IF 2.4 3区医学

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-06-01 Epub Date: 2023-05-30 DOI: 10.1007/s10162-023-00898-y

Alyssa W Accomando, Mark A Johnson, Madeline A McLaughlin, James A Simmons, Andrea Megela Simmons

{"title":"Connexin36 RNA Expression in the Cochlear Nucleus of the Echolocating Bat, Eptesicus fuscus.","authors":"Alyssa W Accomando, Mark A Johnson, Madeline A McLaughlin, James A Simmons, Andrea Megela Simmons","doi":"10.1007/s10162-023-00898-y","DOIUrl":"10.1007/s10162-023-00898-y","url":null,"abstract":"Purpose: The echolocating bat is used as a model for studying the auditory nervous system because its specialized sensory capabilities arise from general mammalian auditory percepts such as pitch and sound source localization. These percepts are mediated by precise timing within neurons and networks of the lower auditory brainstem, where the gap junction protein Connexin36 (CX36) is expressed. Gap junctions and electrical synapses in the central nervous system are associated with fast transmission and synchronous patterns of firing within neuronal networks. The purpose of this study was to identify areas where CX36 was expressed in the bat cochlear nucleus to shed light on auditory brainstem networks in a hearing specialist animal model.Methods: We investigated the distribution of CX36 RNA throughout the cochlear nucleus complex of the echolocating big brown bat, Eptesicus fuscus, using in situ hybridization. As a qualitative comparison, we visualized Gjd2 gene expression in the cochlear nucleus of transgenic CX36 reporter mice, species that hear ultrasound but do not echolocate.Results: In both the bat and the mouse, CX36 is expressed in the anteroventral and in the dorsal cochlear nucleus, with more limited expression in the posteroventral cochlear nucleus. These results are generally consistent with previous work based on immunohistochemistry.Conclusion: Our data suggest that the anatomical substrate for CX36-mediated electrical neurotransmission is conserved in the mammalian CN across echolocating bats and non-echolocating mice.","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":"24 3","pages":"281-290"},"PeriodicalIF":2.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NIDCD's 5-Year Strategic Plan Describes Scientific Priorities and Commitment to Basic Science. NIDCD 的五年战略计划描述了科学优先事项和对基础科学的承诺。

IF 2.4 3区医学

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-06-01 DOI: 10.1007/s10162-023-00902-5

Debara L Tucci

{"title":"NIDCD's 5-Year Strategic Plan Describes Scientific Priorities and Commitment to Basic Science.","authors":"Debara L Tucci","doi":"10.1007/s10162-023-00902-5","DOIUrl":"10.1007/s10162-023-00902-5","url":null,"abstract":"The National Institute on Deafness and Other Communication Disorders (NIDCD) recently issued a new strategic plan that describes the institute's scientific priorities over the next five years. Developed in collaboration with informed stakeholders, the 2023-2027 NIDCD Strategic Plan: Advancing the Science of Communication to Improve Lives creates a unified vision to stimulate discoveries in basic research, model systems, innovative technologies, individualized treatment approaches, scientific data sharing, and translation of research findings into clinical practice. To further accelerate scientific discoveries, the institute encourages collaborations and information sharing among interdisciplinary teams conducting research in these priority areas, and advocates for the utilization of biomedical databases to share scientific findings. NIDCD also welcomes investigator-driven applications that capitalize on advances in basic research to better understand normal and disordered processes; develop or improve model systems to inform research; or facilitate the use of biomedical data utilizing best practices. Through these efforts, NIDCD will continue to conduct and support research that improves the quality of life for the millions of American impacted by conditions affecting hearing, balance, taste, smell, voice, speech, or language.","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":"24 3","pages":"265-268"},"PeriodicalIF":2.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10175472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell. 了不起的外毛细胞：纪念 W. E. Brownell 研讨会论文集》。

IF 2.4 3区医学

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-04-01 Epub Date: 2023-01-17 DOI: 10.1007/s10162-022-00852-4

Jonathan F Ashmore, John S Oghalai, James B Dewey, Elizabeth S Olson, Clark E Strimbu, Yi Wang, Christopher A Shera, Alessandro Altoè, Carolina Abdala, Ana B Elgoyhen, Ruth Anne Eatock, Robert M Raphael

引用次数: 0

The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea. 长外毛细胞RC时间常数:哺乳动物耳蜗的特征，而不是缺陷。

IF 2.4 3区医学

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-04-01 Epub Date: 2023-02-01 DOI: 10.1007/s10162-022-00884-w

Alessandro Altoè, Christopher A Shera

{"title":"The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.","authors":"Alessandro Altoè, Christopher A Shera","doi":"10.1007/s10162-022-00884-w","DOIUrl":"10.1007/s10162-022-00884-w","url":null,"abstract":"The cochlea of the mammalian inner ear includes an active, hydromechanical amplifier thought to arise via the piezoelectric action of the outer hair cells (OHCs). A classic problem of cochlear biophysics is that the RC (resistance-capacitance) time constant of the hair-cell membrane appears inconveniently long, producing an effective cut-off frequency much lower than that of most audible sounds. The long RC time constant implies that the OHC receptor potential-and hence its electromotile response-decreases by roughly two orders of magnitude over the frequency range of mammalian hearing, casting doubt on the hypothesized role of cycle-by-cycle OHC-based amplification in mammalian hearing. Here, we review published data and basic physics to show that the \"RC problem\" has been magnified by viewing it through the wrong lens. Our analysis finds no appreciable mismatch between the expected magnitude of high-frequency electromotility and the sound-evoked displacements of the organ of Corti. Rather than precluding significant OHC-based boosts to auditory sensitivity, the long RC time constant appears beneficial for hearing, reducing the effects of internal noise and distortion while increasing the fidelity of cochlear amplification.","PeriodicalId":56283,"journal":{"name":"Jaro-Journal of the Association for Research in Otolaryngology","volume":"24 2","pages":"129-145"},"PeriodicalIF":2.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9466204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2