Journal of Rheumatic Diseases最新文献

{"title":"Machine learning models with time-series clinical features to predict radiographic progression in patients with ankylosing spondylitis.","authors":"Bon San Koo, Miso Jang, Ji Seon Oh, Keewon Shin, Seunghun Lee, Kyung Bin Joo, Namkug Kim, Tae-Hwan Kim","doi":"10.4078/jrd.2023.0056","DOIUrl":"10.4078/jrd.2023.0056","url":null,"abstract":"<p><strong>Objective: </strong>Ankylosing spondylitis (AS) is chronic inflammatory arthritis causing structural damage and radiographic progression to the spine due to repeated and continuous inflammation over a long period. This study establishes the application of machine learning models to predict radiographic progression in AS patients using time-series data from electronic medical records (EMRs).</p><p><strong>Methods: </strong>EMR data, including baseline characteristics, laboratory findings, drug administration, and modified Stoke AS Spine Score (mSASSS), were collected from 1,123 AS patients between January 2001 and December 2018 at a single center at the time of first (T1), second (T2), and third (T3) visits. The radiographic progression of the (n+1)th visit (Pn+1=(mSASSSn+1-mSASSSn)/(Tn+1-Tn)≥1 unit per year) was predicted using follow-up visit datasets from T1 to Tn. We used three machine learning methods (logistic regression with the least absolute shrinkage and selection operation, random forest, and extreme gradient boosting algorithms) with three-fold cross-validation.</p><p><strong>Results: </strong>The random forest model using the T1 EMR dataset best predicted the radiographic progression P2 among the machine learning models tested with a mean accuracy and area under the curves of 73.73% and 0.79, respectively. Among the T1 variables, the most important variables for predicting radiographic progression were in the order of total mSASSS, age, and alkaline phosphatase.</p><p><strong>Conclusion: </strong>Prognosis predictive models using time-series data showed reasonable performance with clinical features of the first visit dataset when predicting radiographic progression.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"31 2","pages":"97-107"},"PeriodicalIF":2.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world effectiveness of a single conventional disease-modifying anti-rheumatic drug (cDMARD) plus an anti-TNF agent versus multiple cDMARDs in rheumatoid arthritis: a prospective observational study.","authors":"Min Wook So, Sang-Hyon Kim, Dong Wook Kim, Yoon-Kyoung Sung, Jung-Yoon Choe, Sang-Il Lee, Jin-Wuk Hur, Hye-Soon Lee, Sang-Heon Lee, Jin Ran Kim, PharmD","doi":"10.4078/jrd.2023.0045","DOIUrl":"10.4078/jrd.2023.0045","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this prospective, observational multicenter study (NCT03264703) was to compare the effectiveness of single conventional disease-modifying anti-rheumatic drug (cDMARD) plus anti-tumor necrosis factor (TNF) therapy versus multiple cDMARD treatments in patients with moderate-to-severe rheumatoid arthritis (RA) following cDMARD failure in the real-world setting in South Korea.</p><p><strong>Methods: </strong>At the treating physicians' discretion, patients received single cDMARD plus anti-TNF therapy or multiple cDMARDs. Changes from baseline in disease activity score 28-joint count with erythrocyte sedimentation rate (DAS28-ESR), corticosteroid use, and Korean Health Assessment Questionnaire (KHAQ-20) scores were evaluated at 3, 6, and 12 months.</p><p><strong>Results: </strong>Of 207 enrollees, the final analysis included 45 of 73 cDMARD plus anti-TNF and 91 of 134 multiple-cDMARD recipients. There were no significant between-group differences (BGDs) in ANCOVA-adjusted changes from baseline in DAS28-ESR at 3, 6 (primary endpoint), and 12 months (BGDs -0.18, -0.38, and -0.03, respectively). More cDMARD plus anti-TNF than multiple-cDMARD recipients achieved a >50% reduction from baseline in corticosteroid dosage at 12 months (35.7% vs 14.6%; p=0.007). Changes from baseline in KHAQ-20 scores at 3, 6, and 12 months were significantly better with cDMARD plus anti-TNF therapy than with multiple cDMARDs (BGD -0.18, -0.19, and -0.19 points, respectively; all p<i>≤</i>0.024).</p><p><strong>Conclusion: </strong>In the real-world setting, relative to multiple cDMARDs, single cDMARD plus anti-TNF therapy significantly improved quality-of-life scores and reduced corticosteroid use, with no significant BGD in disease activity, in RA patients in whom previous cDMARD therapy had failed.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"31 2","pages":"86-96"},"PeriodicalIF":2.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile systemic sclerosis.","authors":"Young Dae Kim","doi":"10.4078/jrd.2024.0018","DOIUrl":"10.4078/jrd.2024.0018","url":null,"abstract":"","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"31 2","pages":"65-67"},"PeriodicalIF":2.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative patient's expectations and clinical outcomes after rheumatoid forefoot deformity reconstruction by joint sacrificing surgery.","authors":"Sung-Jae Kim, Young-Woon Gil, Il-Hoon Sung","doi":"10.4078/jrd.2023.0044","DOIUrl":"10.4078/jrd.2023.0044","url":null,"abstract":"<p><strong>Objective: </strong>To study the clinical and radiologic factors related with overall patient satisfaction of joint scarifying reconstruction on severe rheumatoid forefoot deformity (RFD).</p><p><strong>Methods: </strong>Forty cases of RFD were retrospectively enrolled. A questionnaire on the factors for patient's expectations and satisfactions of the greater and lesser toes was administered, including repression of relapse in deformity (D), pain reduction (P), improvement in shoe wearing (S), barefoot activity (B), and appearance (A). Overall satisfaction were assessed using the 5-digit-scale. Hallux valgus angle, 1, 2 intermetatarsal angle, and other radiologic parameters were measured. Pearson's correlation and multiple linear regression analyses were used to evaluate the relationships between these factors and overall satisfaction.</p><p><strong>Results: </strong>Overall satisfaction was 4.0±0.82. Postoperative radiologic parameters were corrected in adequate range. Visual analog scale (VAS) was reduced from 7.2±2.1 to 2.2±1.8. For the greater toe, patient's expectations (D, P, S, B, and A) were 4.2, 4.1, 3.0, 2.5, 2.7 and satisfactions were 4.2, 4.0, 3.4, 3.5, 3.3, respectively. For the lesser toes, patient's expectations (D, P, S, B, and A) were 3.9, 4.1, 3.4, 3.0, 2.8, and satisfactions were 3.4, 4.0, 3.4, 3.6, 2.9, respectively. Satisfactions with P and B, and reduction amounts of VAS were significantly correlated with overall satisfaction.</p><p><strong>Conclusion: </strong>Although forefoot reconstruction with a joint sacrificing procedure is non-physiological, it could be a good surgical option for severe RFD. Each patient's expectations and satisfactions with this procedure could vary. Thus, it seems important to inform patients preoperatively that expectation could be fulfilled well or less.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"31 1","pages":"33-40"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Korean treatment recommendations for patients with axial spondyloarthritis.","authors":"Mi Ryoung Seo, Jina Yeo, Jun Won Park, Yeon-Ah Lee, Ju Ho Lee, Eun Ha Kang, Seon Mi Ji, Seong-Ryul Kwon, Seong-Kyu Kim, Tae-Jong Kim, Tae-Hwan Kim, Hye Won Kim, Min-Chan Park, Kichul Shin, Sang-Hoon Lee, Eun Young Lee, Hoon Suk Cha, Seung Cheol Shim, Youngim Yoon, Seung Ho Lee, Jun Hong Lim, Han Joo Baek","doi":"10.4078/jrd.2023.0025C","DOIUrl":"https://doi.org/10.4078/jrd.2023.0025C","url":null,"abstract":"<p><p>[This corrects the article on p. 151 in vol. 30, PMID: 37476674.].</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"31 1","pages":"62-63"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139076045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights from the COVID-19 pandemic: underscoring the paramount value of patient education and counseling for rheumatic diseases.","authors":"Byoong Yong Choi, Myeung-Su Lee, Geun Tae Kim, Seung-Jae Hong, Eun Bong Lee, Han Joo Baek","doi":"10.4078/jrd.2023.0068","DOIUrl":"10.4078/jrd.2023.0068","url":null,"abstract":"","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"31 1","pages":"59-61"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urate-lowering therapy is associated with a reduced risk of arrhythmias: a systematic review and meta-analysis","authors":"Palapun Waitayangkoon, T. Leesutipornchai, W. Techasatian, Noppawit Aiumtrakul, M. Tanariyakul, Chinnawat Arayangkool, Tatchaya Kanthajan, Todd Nagamine, J. Kewcharoen","doi":"10.4078/jrd.2023.0059","DOIUrl":"https://doi.org/10.4078/jrd.2023.0059","url":null,"abstract":"","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"57 46","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal prognosis in patients with new-onset microscopic polyangiitis and granulomatosis with polyangiitis requiring dialysis and potential predictor of renal function recovery","authors":"S. Ahn","doi":"10.4078/jrd.2023.0079","DOIUrl":"https://doi.org/10.4078/jrd.2023.0079","url":null,"abstract":"","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"19 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138587843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of juvenile systemic sclerosis in Korea: 31-year single-center study","authors":"Ji Eun Jeong, Seong Heon Kim","doi":"10.4078/jrd.2023.0046","DOIUrl":"https://doi.org/10.4078/jrd.2023.0046","url":null,"abstract":"","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"60 12","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and immunological responses to COVID-19 vaccination in rheumatoid arthritis patients on disease modifying antirheumatic drugs: a cross-sectional study","authors":"Madhavi Eerike, Vijaya Prasanna Parimi, Anand Pyati, Raja Sundaramurthy, Varadharajan Sakthivadivel, Aswini Bramarambika Pidugu, Bhavana Surapareddy, Naga Tejaswini Ramineni, Rekha Priyadarshini, Parag Parshuram Patil","doi":"10.4078/jrd.2023.0054","DOIUrl":"https://doi.org/10.4078/jrd.2023.0054","url":null,"abstract":"Madhavi Eerike, M.D., Vijaya Prasanna Parimi, M.D., D.M., Anand Pyati, M.D., Ph.D., Raja Sundaramurthy, M.D., Varadharajan Sakthivadivel, M.D., Aswini Bramarambika Pidugu, Pharm.D., Bhavana Surapareddy, M.D., Naga Tejaswini Ramineni, M.D., Rekha Priyadarshini, M.D., Parag Parshuram Patil, M.D.. J Rheum Dis -0001;0:. https://doi.org/10.4078/jrd.2023.0054","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"99 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135092047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}