Journal of Rheumatic Diseases最新文献

{"title":"Impact of anti-tumor necrosis factor treatment on lipid profiles in Korean patients with ankylosing spondylitis","authors":"Inbeom Kwon, Nayeon Choi, Ji Hui Shin, Seunghun Lee, Bora Nam, Tae-Hwan Kim","doi":"10.4078/jrd.2023.0040","DOIUrl":"https://doi.org/10.4078/jrd.2023.0040","url":null,"abstract":"","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":" 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135243611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage activation syndrome in neonatal lupus presenting with fever and rash","authors":"Ji Yoon Yu, Tae Hwan Kim, Ye Ji Kim, Hyun Mi Kang, In Hyuk Yoo, Jung Woo Rhim, Soo Young Lee, Dae Chul Jeong","doi":"10.4078/jrd.2023.0039","DOIUrl":"https://doi.org/10.4078/jrd.2023.0039","url":null,"abstract":"Ji Yoon Yu, M.D., Tae Hwan Kim, M.D., Ye Ji Kim, M.D., Hyun Mi Kang, M.D. Ph.D., In Hyuk Yoo, M.D. Ph.D., Jung Woo Rhim, M.D., Ph.D., Soo Young Lee, M.D., Ph.D., Dae Chul Jeong, M.D., Ph.D.. J Rheum Dis -0001;0:. https://doi.org/10.4078/jrd.2023.0039","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"101 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135390061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiologic approach and progressive exploration of connective tissue disease-related interstitial lung disease: meeting the curiosity of rheumatologists","authors":"Hyeji Jeon, Bo Da Nam, Chong-Hyeon Yoon, Hyun-Sook Kim","doi":"10.4078/jrd.2023.0042","DOIUrl":"https://doi.org/10.4078/jrd.2023.0042","url":null,"abstract":"","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"211 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135824348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Administrative regional variation in cardiovascular risk among patients with gout: implications for the management of cardiovascular complications.","authors":"Sang Tae Choi","doi":"10.4078/jrd.2023.0047","DOIUrl":"https://doi.org/10.4078/jrd.2023.0047","url":null,"abstract":"in Korea between August 2019 and January 2021. This study is particularly noteworthy for its focus on geographic differences according to administrative divisions, rather than rural-urban disparities. The findings indicate that patients with gout in Jeolla/ Gwangju had a significantly high risk of myocardial infarction. As for cerebral infarction in patients with gout, residing in Gangwon, Jeolla/Gwangju, and Gyeongsang/Busan/Daegu/ Ulsan was associated with a significantly increased risk. Korea has a relatively high racial similarity and minor climate differences. Nevertheless, the findings of this study that the CV risk of patients with gout differs depending on the administrative region have significant implications for the management of patients with gout not only in Korea but also in other countries or regions. These results are expected to serve as valuable data for assessing the CV risk of patients with gout in the regions and devising appropriate treatment plans accordingly. Several factors must be considered when evaluating this","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"30 4","pages":"209-210"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b4/f4/jrd-30-4-209.PMC10509636.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of COVID-19-associated multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease shock syndrome: case reports and literature review.","authors":"Songmi Lee,&nbsp;Danbi Kim,&nbsp;Beom Joon Kim,&nbsp;Jung Woo Rhim,&nbsp;Soo-Young Lee,&nbsp;Dae Chul Jeong","doi":"10.4078/jrd.2023.0022","DOIUrl":"https://doi.org/10.4078/jrd.2023.0022","url":null,"abstract":"<p><p>Multisystem inflammatory syndrome in children (MIS-C) is a serious post-infectious complication of COVID-19 characterized by hyperinflammation and multi-organ dysfunction including shock. Shock is also seen in a severe form of Kawasaki disease (KD) called KD shock syndrome (KDSS). Here, we present one MIS-C and one KDSS case and compare similarities and differences between them. Both MIS-C (case 1) and KDSS (case 2) showed hyperinflammation, KD-related features, gastrointestinal problems, hypotension, and coagulopathy. The extent of systemic inflammation and organ dysfunction was more severe in KDSS than in MIS-C. Case 1 was diagnosed as MIS-C because SARS-CoV-2 was confirmed, and case 2 was diagnosed as KDSS because no pathogen was identified in microbiological studies. We believe that the most important difference between MIS-C and KDSS was whether SARS-CoV-2 was identified as an infectious trigger. Organ dysfunction is a hallmark of MIS-C and KDSS, but not KD, so MIS-C shares more clinical phenotypes with KDSS than with KD. Comparison of MIS-C and KDSS will be an interesting and important topic in the field of KD-like hyperinflammatory disease research.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"30 4","pages":"272-277"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/44/jrd-30-4-272.PMC10509640.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of systemic lupus erythematosus in Korea.","authors":"Jung-Yong Han, Soo-Kyung Cho, Yoon-Kyoung Sung","doi":"10.4078/jrd.2023.0037","DOIUrl":"10.4078/jrd.2023.0037","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by diverse organ system disabilities, predominantly affecting young females. The clinical manifestations of SLE encompass various organs, including the kidney, cardiovascular system, and central nervous system. Young females with SLE experience higher mortality rates than the general population, making it imperative to gain insights into the disease patterns and associated factors. The current review examines the epidemiological studies to analyze the prevalence, incidence, and mortality trends of SLE in Korea and compares them with the findings from other countries. We aim to identify potential similarities, differences, and factors contributing to the burden of SLE in different populations by exploring the comparative epidemiological aspects. The knowledge derived from this comparison would aid in advancing the overall management of SLE in Korea.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"30 4","pages":"211-219"},"PeriodicalIF":2.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/49/jrd-30-4-211.PMC10509641.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41175533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery and long-term renal outcome of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis who are on dialysis at presentation.","authors":"Yeo-Jin Lee,&nbsp;Soo-Min Ahn,&nbsp;Ji-Seon Oh,&nbsp;Yong-Gil Kim,&nbsp;Chang-Keun Lee,&nbsp;Bin Yoo,&nbsp;Seokchan Hong","doi":"10.4078/jrd.2023.0031","DOIUrl":"https://doi.org/10.4078/jrd.2023.0031","url":null,"abstract":"<p><strong>Objective: </strong>Renal involvement in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) can lead to severe renal dysfunction requiring dialysis at diagnosis. We aimed to study the clinical and pathologic characteristics of patients with AAV dependent on dialysis at presentation and the long-term renal outcomes of patients who recovered from dialysis.</p><p><strong>Methods: </strong>This retrospective study analyzed data of patients diagnosed with AAV who were on dialysis from July 2005 to May 2021 at a single tertiary center in Korea.</p><p><strong>Results: </strong>Thirty-four patients were included in the study (median age 64.5 years, females 61.8%), of which 13 discontinued and 21 continued dialysis. The proportion of normal glomeruli (p<0.001) and interstitial fibrosis (p=0.024) showed significant differences between both groups. Multivariable analysis showed that the proportion of normal glomeruli was associated with dialysis discontinuation (odds ratio=1.29, 95% confidence interval 0.99~1.68, p=0.063), although without statistical significance. Treatment modalities, including plasmapheresis, did not show significance with dialysis discontinuation. In the follow-up analysis of 13 patients who had discontinued dialysis for a median of 81 months, 12 did not require dialysis, and their glomerular filtration rate values significantly increased at follow-up time compared to when they stopped dialysis (37.5 [28.5~45.5] vs. 24.0 [18.5~30.0] mL/min/1.73 m²; p=0.008).</p><p><strong>Conclusion: </strong>Approximately 38% of AAV patients on dialysis discontinued dialysis, and the recovered patients had improved renal function without dialysis during longer follow-up. Patients with AAV on dialysis should be given the possibility of dialysis discontinuation and renal recovery, especially those with normal glomeruli in kidney pathology.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"30 4","pages":"251-259"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/22/jrd-30-4-251.PMC10509644.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic steatosis index at diagnosis has the potential for forecasting end-stage kidney disease in patients with antineutrophil cytoplasmic antibody-associated vasculitis.","authors":"Hyun Joon Choi,&nbsp;Pil Gyu Park,&nbsp;Yong-Beom Park,&nbsp;Ji Hye Huh,&nbsp;Sang-Won Lee,&nbsp;Ph D","doi":"10.4078/jrd.2023.0032","DOIUrl":"https://doi.org/10.4078/jrd.2023.0032","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated whether the hepatic steatosis index (HSI) at antineutrophil cytoplasmic antibody-associated vasculitis (AAV) diagnosis could forecast poor outcomes during the disease course in AAV patients.</p><p><strong>Methods: </strong>This study included 260 AAV patients. The equation for HSI is as follows HSI=8×(alanine aminotransferase/aspartate aminotransferase)+body mass index+(2, diabetes mellitus)+(2, female). The cut-off of HSI was obtained using the receiver operating characteristic curve.</p><p><strong>Results: </strong>The median age of the 260 patients was 59.5 years, and 65.0% were female. Among the continuous variables excluding the parameters composing the equation for HSI, HSI was significantly correlated with Birmingham vasculitis activity score, five-factor score, haemoglobin, blood urea nitrogen, serum creatinine, and total cholesterol. Among poor outcomes, the area under the curve of HSI for end-stage renal disease (ESRD) was significant, and the cut-off of HSI for ESRD was set at ≤30.82. AAV patients with HSI ≤30.82 exhibited a significantly higher risk of ESRD (relative risk 3.489) and a significantly lower cumulative ESRD-free survival rate than those with HSI >30.82.</p><p><strong>Conclusion: </strong>This study is the first to demonstrate that HSI at AAV diagnosis could forecast ESRD during the disease course in AAV patients.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"30 4","pages":"260-267"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/cc/jrd-30-4-260.PMC10509637.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated BMPR2 expression amplifies osteoblast differentiation in ankylosing spondylitis.","authors":"Sungsin Jo,&nbsp;Seung Hoon Lee,&nbsp;Chanhyeok Jeon,&nbsp;Hye-Ryeong Jo,&nbsp;Eunae Ko,&nbsp;Min Whangbo,&nbsp;Tae-Jong Kim,&nbsp;Ye-Soo Park,&nbsp;Tae-Hwan Kim","doi":"10.4078/jrd.2023.0024","DOIUrl":"https://doi.org/10.4078/jrd.2023.0024","url":null,"abstract":"<p><strong>Objective: </strong>Bone morphogenetic protein receptor type 2 (BMPR2) has been associated with radiographic changes in ankylosing spondylitis (AS), but further characterization of the cellular signaling pathway in osteoprogenitor (OP) is not clearly understood. The aim of this study was to investigate the expression of BMPR2 and bone morphogenetic protein 2 (BMP2)-mediated responsibility in AS.</p><p><strong>Methods: </strong>We collected 10 healthy control (HC) and 14 AS-OPs derived from facet joints. Subsequently, we then conducted RNA sequencing with two samples per group and selected BMP-related genes. Facet joint tissues and derived primary OPs were evaluated by validation of selected RNA sequencing data, immunohistochemistry, and comparison of osteogenic differentiation potential.</p><p><strong>Results: </strong>Based on RNA-sequencing analysis, we found that BMPR2 expression is higher in AS-OPs compared to in HC-OPs. We also validated the increased BMPR2 expression in facet joint tissues with AS and its derived OPs in messenger RNA and protein levels. Additionally, primary AS-OPs showed much greater response to osteogenic differentiation induced by BMP2 and a higher capacity for smad1/5/8-induced RUNX2 expression compared to HCs.</p><p><strong>Conclusion: </strong>The expression of BMPR2 was found to be significantly increased in facet joint tissues of patients with AS. These findings suggest that BMPR2 may play a role in the BMP2-mediated progression of AS.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"30 4","pages":"243-250"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/08/c7/jrd-30-4-243.PMC10509643.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41180487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates on ankylosing spondylitis: pathogenesis and therapeutic agents.","authors":"Se Hee Kim,&nbsp;Sang-Hoon Lee","doi":"10.4078/jrd.2023.0041","DOIUrl":"https://doi.org/10.4078/jrd.2023.0041","url":null,"abstract":"<p><p>Ankylosing spondylitis (AS) is an autoinflammatory disease that manifests with the unique feature of enthesitis. Gut microbiota, HLA-B*27, and biomechanical stress mutually influence and interact resulting in setting off a flame of inflammation. In the HLA-B*27 positive group, dysbiosis in the gut environment disrupts the barrier to exogenous bacteria or viruses. Additionally, biomechanical stress induces inflammation through enthesial resident or gut-origin immune cells. On this basis, innate and adaptive immunity can propagate inflammation and lead to chronic disease. Finally, bone homeostasis is regulated by cytokines, by which the inflamed region is substituted into new bone. Agents that block cytokines are constantly being developed to provide diverse therapeutic options for preventing the progression of inflammation. In addition, some antibodies have been shown to distinguish disease selectively, which support the involvement of autoimmune immunity in AS. In this review, we critically analyze the complexity and uniqueness of the pathogenesis with updates on the findings of immunity and provide new information about biologics and biomarkers.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"30 4","pages":"220-233"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/9f/jrd-30-4-220.PMC10509639.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41141435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}