Journal of Rheumatic Diseases最新文献

{"title":"Transient sterile polyarthritis following ileostomy reversal in a premature infant.","authors":"Yoonkyo Oh, Su Jin Choi, Doo-Ho Lim","doi":"10.4078/jrd.2025.0060","DOIUrl":"10.4078/jrd.2025.0060","url":null,"abstract":"","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"33 3","pages":"232-234"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large vessel vasculitis reframed: integrating conceptual shifts and evidence into practice for Takayasu arteritis and giant cell arteritis.","authors":"Jiwon Hwang, Yeon-Ah Lee, Seung-Jae Hong","doi":"10.4078/jrd.2025.0155","DOIUrl":"10.4078/jrd.2025.0155","url":null,"abstract":"<p><p>Large vessel vasculitis, encompassing giant cell arteritis and Takayasu arteritis, represents a spectrum of granulomatous aortitides with substantially similar clinical presentation, pathophysiology, and therapeutic response. Recent advances have redefined epidemiological trends, expanded the role of multimodal imaging, and clarified the genetic and immunological pathways that shape disease heterogeneity. This review integrates contemporary data on clinical phenotypes, vascular distribution, pathogenesis, and treatment strategies, with attention to unmet clinical needs in Korean practice. Imaging has assumed a central role in diagnosis and monitoring, supported by updated classification criteria and novel activity scores. Although glucocorticoids remain the therapeutic cornerstone, accumulating evidence indicates the use of targeted biologics, and emerging small molecules. However, the optimal sequencing and long-term outcomes remain unelucidated. Persistent gaps include a lack of validated composite outcome measures, limited availability of reliable biomarkers, and uneven implementation of imaging standards. Coordinated multicenter research and improved access to advanced therapies can support the next steps in patient care.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"33 3","pages":"152-168"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and monitoring value of serum interleukin-33 and rs16924159 polymorphism in relation to disease activity and tumor necrosis factor inhibitor response in rheumatoid arthritis.","authors":"Ahmed Hilal Kamel, Ahmed Abdul-Hassan Abbas, Mohammed Hadi Alosami","doi":"10.4078/jrd.2025.0095","DOIUrl":"10.4078/jrd.2025.0095","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to establish the diagnostic and monitoring value of serum interleukin-33 (IL-33) levels and IL-33 rs16924159 polymorphism regarding disease activity and response to tumor necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA) patients.</p><p><strong>Methods: </strong>In a case-control study, 100 RA patients and 100 healthy individuals were enrolled. We intentionally sampled 50 responders and 50 non-responders after 6 months of TNF inhibitors. Serum IL-33 levels were determined by using enzyme-linked immunosorbent assay (ELISA). Rs16924159 genotyping was performed using TaqMan real-time polymerase chain reaction. Disease activity was evaluated by the clinical disease activity index (CDAI), and treatment response was evaluated after 6 months of TNF inhibitor therapy.</p><p><strong>Results: </strong>IL-33 was markedly elevated in RA patients compared to controls (p<0.001), and IL-33 possessed satisfactory diagnostic accuracy area under the curve (AUC)=0.810 (95% confidence interval [CI]=0.747~0.872, p<0.001). Homozygous mutant AA genotype of rs16924159 was associated with higher disease activity (p<0.001) and poorer response to TNF inhibitors (odds ratio=5.26, 95% CI=1.07~25.77, p=0.040). Non-responders were found to have more elevated serum levels of IL-33 compared to responders (p<0.001). Serum IL-33 levels (p=0.015) and rs16924159 genotype (p<0.001) were significantly associated with CDAI scores.</p><p><strong>Conclusion: </strong>Elevated IL-33 and the rs16924159 polymorphism were associated with higher RA disease activity and lower 6 month TNF inhibitor response in this cohort. IL-33 showed moderate diagnostic performance (AUC=0.81, sensitivity=66%, specificity=92%), and routine clinical use-especially to guide personalized treatment-requires external validation in independent cohorts and prospective, comparative studies.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"33 3","pages":"189-197"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific differences in associations between diet quality and hyperuricemia in Korean adults.","authors":"Jung Woo Lee, Yookyung Kim","doi":"10.4078/jrd.2025.0160","DOIUrl":"10.4078/jrd.2025.0160","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate the sex-specific associations between overall diet quality and hyperuricemia in Korean adults.</p><p><strong>Methods: </strong>We analyzed the data of 14,305 adults (6,131 men and 8,174 women) aged ≥20 years from the Korea National Health and Nutrition Examination Survey (2019~2021). We categorized dietary quality into quartiles Q1 (lowest, reference), Q2, Q3, and Q4 (highest) using the Korean Healthy Eating Index (HEI). We used restricted cubic spline (RCS) models and multivariate logistic regression to assess non-linear associations and examine dose-response and quartile associations with hyperuricemia, respectively.</p><p><strong>Results: </strong>The weighted prevalence of hyperuricemia was 35.6% in men and 12.6% in women. In men, RCS analyses showed a monotonic inverse association, with risk decreasing steadily at higher HEI scores; in women, the curve followed a U-shaped pattern. Logistic regression confirmed that in men, adjusted odds ratios (ORs) across quartiles (vs. Q1) were 0.92 (95% confidence interval [CI], 0.77~1.11) in Q2, 0.84 (95% CI, 0.70~1.01) in Q3, and 0.76 (95% CI, 0.61~0.94) in Q4 (p for trend<0.01). In women, crude inverse associations were attenuated after adjustment, with adjusted ORs of 0.83 (95% CI, 0.65~1.05) in Q2, 0.81 (95% CI, 0.64~1.01) in Q3, and 0.94 (95% CI, 0.73~1.20) in Q4, and no significant trend (p for trend=0.55).</p><p><strong>Conclusion: </strong>Higher diet quality was independently associated with a lower risk of hyperuricemia in men; no significant protective effect was evident in women. These results underscore the need for sex-specific dietary strategies in hyperuricemia prevention.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"33 3","pages":"205-215"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of chemiluminescent immunoassay and radioimmunoassay for the detection of anti-double-stranded DNA antibodies.","authors":"María Dolores Martín-Martínez, Gema García-de la Rosa, Juan De Castro-Córdova","doi":"10.4078/jrd.2025.0111","DOIUrl":"10.4078/jrd.2025.0111","url":null,"abstract":"<p><strong>Objective: </strong>Anti-double-stranded DNA antibodies are essential biomarkers for diagnosing and monitoring systemic lupus erythematosus. Given the logistical limitations of the Farr radioimmunoassay (RIA), this study aimed to determine whether chemiluminescent immunoassay (CLIA) can serve as a suitable replacement in routine practice.</p><p><strong>Methods: </strong>A total of 807 serum samples were analyzed by CLIA and RIA. Quantitative agreement was evaluated with Spearman's correlation, Passing-Bablok regression, and Bland-Altman analysis. Qualitative concordance and diagnostic performance were assessed using contingency tables, Cohen's kappa, prevalence- and bias-adjusted kappa (PABAK) and receiver operating characteristic (ROC) curves. Manufacturer thresholds guided binary classification, with the Youden index used to optimize the CLIA cut-off.</p><p><strong>Results: </strong>The correlation between CLIA and RIA was weak but statistically significant (p=0.108, p=0.002). Passing-Bablok regression was not feasible due to distributional constraints. Bland-Altman analysis revealed a mean difference of 14.16 IU/mL with wide limits of agreement (-87.05 to 115.37 IU/mL), indicating poor quantitative agreement. Cohen's kappa was 0.365, while PABAK was 0.812. CLIA showed low sensitivity (45%) but high specificity (94%) relative to RIA. ROC analysis yielded an area under the curve of 0.719, with an optimal diagnostic cut-off of 19.15 IU/mL, resulting in a modest gain in sensitivity (45% to 57%) accompanied by a decline in specificity (94% to 86%). Overall, a discordance rate of 9% was observed between methods.</p><p><strong>Conclusion: </strong>CLIA cannot replace RIA without compromising diagnostic accuracy. Despite its operational advantages and high specificity, the limited sensitivity, quantitative discordance, and risk of misclassification at low titers highlight the importance of threshold recalibration and clinical context.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"33 3","pages":"198-204"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal tuberculous myositis: a case series from a tuberculosis endemic region.","authors":"Usha Holla, Anjum Siddiqui, Abhishek Gollarahalli Patel, Neha Mishra, Urmila Dhakad, Vikas Agarwal, Abhishek Patil","doi":"10.4078/jrd.2025.0128","DOIUrl":"10.4078/jrd.2025.0128","url":null,"abstract":"<p><strong>Objective: </strong>Multifocal tubercular myositis is rare but important entity that often mimics autoimmune rheumatic or inflammatory muscle diseases. This study aims to collect and analyse cases of multifocal muscular tuberculosis (TB) reported in tertiary care settings in India.</p><p><strong>Methods: </strong>This retrospective, multicentre, observational study was conducted at two tertiary care centres in India between 2019 and 2025. Patients with confirmed TB and evidence of muscle involvement at ≥2 non-contiguous sites were included. Muscle involvement was confirmed by imaging (CT, MRI, ultrasound, FDG-PET) with or without clinical/myopathic features. Clinical, biochemical, radiological, and treatment data were extracted from records.</p><p><strong>Results: </strong>Among 74 patients with musculoskeletal TB, six (8.1%) had multifocal muscle involvement. Median age was 42.5 years, with equal sex distribution. The mean diagnostic delay was 13.4 months. Inflammatory markers were elevated (mean erythrocyte sedimentation rate 51.2 mm/hr, C-reactive protein 93 mg/L), while muscle enzymes were normal or mildly elevated. Only one patient (16.7%) had isolated muscle TB; others had lymph node (66.7%), skeletal (50.0%), or pulmonary involvement (33.3%). Two patients had underlying connective tissue diseases, and three (50.0%) were on immunosuppressive therapy at diagnosis. GeneXpert-PCR had an 83% yield from muscle tissue or pus. Clinical and radiological improvement was noted in all cases, three (50.0%) required concurrent immunosuppression.</p><p><strong>Conclusion: </strong>The consideration of multifocal tubercular myositis in the differential diagnosis of inflammatory myopathies, is paramount to reduce diagnostic delays and improve outcomes. A high index of suspicion, use of advanced imaging, and microbiological confirmation are key to the early diagnosis of this entity.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"33 3","pages":"216-226"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraosseous migration of calcific supraspinatus tendonitis: a case report.","authors":"Chaimae Charoui, Imane El Binoune, Nada Jaouad, Bouchra Amine, Rachid Bahiri","doi":"10.4078/jrd.2025.0037","DOIUrl":"10.4078/jrd.2025.0037","url":null,"abstract":"<p><p>Calcific tendinitis is a common and generally benign condition caused by the deposition of calcium hydroxyapatite crystals within tendons, most frequently affecting the rotator cuff, particularly the supraspinatus tendon. While often asymptomatic, some cases can present with acute pain and functional impairment. In rare instances, intraosseous migration of these calcifications can occur, leading to diagnostic challenges due to imaging findings that may mimic infectious or neoplastic bone lesions. We report the case of a 50-year-old woman presenting with acute, severe right shoulder pain without trauma history. Conventional radiography showed a calcific density adjacent to the lesser tuberosity. Magnetic resonance imaging confirmed intraosseous migration of the calcification, with perilesional bone marrow edema, cortical erosion, and associated subscapularis tendinitis without tendon rupture. The patient received conservative treatment, including analgesics, non-steroidal anti-inflammatory drugs, rest, and physical therapy, resulting in significant clinical improvement without the need for invasive procedures. This case highlights the importance of recognizing intraosseous migration of calcific tendinitis as a rare but benign entity.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"33 3","pages":"227-231"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile idiopathic arthritis (JIA) in Korea: epidemiology and biologic treatments.","authors":"Jiwon Jung, Soo-Young Lee","doi":"10.4078/jrd.2026.0077","DOIUrl":"10.4078/jrd.2026.0077","url":null,"abstract":"","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"33 3","pages":"149-151"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-specific cutaneous lupus erythematosus and clinical significance: a literature review.","authors":"Nattanicha Chaisrimaneepan, Thunyaporn Khoruamklang, Tulaton Sodsri, Natnicha Jakramonpreeya","doi":"10.4078/jrd.2025.0035","DOIUrl":"10.4078/jrd.2025.0035","url":null,"abstract":"<p><p>Cutaneous lupus erythematosus (CLE) is classified into LE-specific cutaneous lesions and LE-non-specific cutaneous lesions. LE-specific lesions, which include acute cutaneous LE, sub-acute cutaneous LE, and chronic cutaneous LE have been well-described and studied regarding their association with systemic lupus erythematosus (SLE) and disease activity. Non-specific CLE is divided into thrombogenic (vascular), neutrophilic, or uncertain pathogenesis. Some features such as Raynaud, vasculitis, and alopecia have been well-documented with reported association with other clinical features of SLE and its disease activity. Still, some are under-recognized and not well-studied for their correlation with SLE disease activity, or clinical significance concerning SLE. This review aims to encompass each non-specific CLE and its clinical relevance in SLE. However, the literature was limited in many non-specific LE conditions with the lack of statistical evidence to prove its correlation to SLE or other signs and symptoms of SLE, including morbidity and mortality. Future research can provide predictions of the disease based on non-specific CLE.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"33 3","pages":"169-188"},"PeriodicalIF":3.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence rate and risk factors for interstitial nephritis in patients with ankylosing spondylitis: a nationwide population-based study.","authors":"Subin Hwang, Ye-Jee Kim, Soo Min Ahn, Bon San Koo","doi":"10.4078/jrd.2025.0096","DOIUrl":"10.4078/jrd.2025.0096","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we aimed to investigate the incidence and risk factors for interstitial nephritis in patients with ankylosing spondylitis (AS).</p><p><strong>Methods: </strong>We retrospectively analyzed the claims records of patients diagnosed with AS in Korea's Health Insurance Review and Assessment Service Database between 2016 and 2019. The Assessment of Spondyloarthritis International Society nonsteroidal anti-inflammatory drugs (NSAIDs) intake score was used to calculate the NSAID dosage over 1 year after AS diagnosis. The incidence rate of interstitial kidney disease was calculated as the number of events per 1,000 person-years. The risks associated with sex, age, Charlson Comorbidity Index, comorbidities, and concomitant medications were assessed using the Cox proportional hazards model, with results presented as hazard ratios (HRs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>In total, 11,749 patients with AS were included in this study. Of these, 79 patients had interstitial nephritis, with an incidence rate of 2.50 per 1,000 person-years. In multivariable analysis, female sex (HR, 2.44; 95% CI, 1.56~3.83), hypertension (HR, 2.08; 95% CI, 1.15~3.76), and renal failure (HR, 3.70; 95% CI, 1.30~10.55) showed significant associations. However, NSAID use in the first year after AS diagnosis was not associated with interstitial nephritis occurrence.</p><p><strong>Conclusion: </strong>The incidence of interstitial nephritis in patients with AS was 2.50 per 1,000 person-years, with female sex and comorbidities identified as significant risk factors. However, NSAID use during the first year after AS diagnosis was not associated with interstitial nephritis development.</p>","PeriodicalId":56161,"journal":{"name":"Journal of Rheumatic Diseases","volume":"33 2","pages":"102-110"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}