Life-Basel最新文献

{"title":"Redefining the Tea Green Leafhopper: <i>Empoasca onukii</i> Matsuda (Hemiptera: Cicadellidae) as a Vital Asset in Premium Tea Production.","authors":"Unisa Conteh Kanu, Zhaohong Wang, Chenshi Qiu, Qiaojun Wen, Xueyan Li, Dongliang Qiu, Yinwei Gan, Runqian Mao","doi":"10.3390/life15010133","DOIUrl":"10.3390/life15010133","url":null,"abstract":"<p><p>This review explores the evolving role of the tea green leafhopper, <i>Empoasca onukii</i>, in the tea industry, transitioning from a recognized pest to a significant enhancer of tea quality. Recent research highlights how its feeding behavior stimulates the production of desirable secondary metabolites, thereby improving the flavor profiles and market value of premium teas, particularly varieties like Taiwan's \"Oriental Beauty\". As consumer demand for unique and artisanal teas rises, the economic benefits associated with <i>E. onukii</i> are becoming increasingly evident, prompting farmers to adopt sustainable agricultural practices that often involve reduced pesticide use. Furthermore, the dynamic interplay between climatic factors, <i>E. onukii</i> population dynamics, and tea cultivation practices necessitates integrated pest management strategies that balance the beneficial and detrimental impacts of this leafhopper. Understanding these complexities not only fosters sustainable production methods but also opens niche markets, benefiting local economies and promoting both economic viability and environmental sustainability in the tea industry.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":"15 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spleno-Mesenteric Venous Blood Flow Dynamics in Adult Patients with Chronic Portal Vein Thrombosis Analyzed by Sequential CT-Spleno- and Mesenterico-Portography.","authors":"Alexandra Schlitt, Andrea Goetz, Christian Stroszczynski, Florian Zeman, Christina Hackl, Hans J Schlitt, Ernst-Michael Jung, Wibke Uller, Simone Hammer","doi":"10.3390/life15010129","DOIUrl":"10.3390/life15010129","url":null,"abstract":"<p><strong>Background: </strong>Portal vein thrombosis (PVT) leads to portal hypertension (PH) with its sequelae. Computed tomography spleno-mesenterico-portography (CT-SMPG) combines sequential CT spleno-portography and CT mesenterico-portography. CT-SMPG comprehensively illustrates the venous hemodynamic changes due to PH.</p><p><strong>Objective: </strong>To assess the effects of PV confluence thrombosis (PVCT) and liver cirrhosis on venous blood flow characteristics of patients with PVT.</p><p><strong>Method: </strong>CT-SMPG was performed in 21 patients with chronic PVT. CT-SMPG was compared to standard contrast-enhanced CT (CECT) and gastroscopy concerning the patency of splanchnic veins, varices and venous congestion.</p><p><strong>Results: </strong>PVCT had a significant effect on perfusion patterns: in patients without PVCT, esophageal varices (EV) and gastric varices were supplied by either the splenic vein (SV), the superior mesenteric vein (SMV), or both. In patients with PVCT, EV and gastric varices were mostly supplied by the SV (<i>p</i> = 0.021, <i>p</i> = 0.016). In patients without PVCT, small bowel varices were fed by both systems or the SMV, while in patients with PVCT they were fed by the SMV (<i>p</i> = 0.031). No statistically significant changes were detected regarding gastropathy, colorectal varices and small bowel congestion. Liver cirrhosis had no statistically relevant effect on hemodynamics.</p><p><strong>Conclusions: </strong>In CT-SMPG, patients with PVCT showed different venous hemodynamics to patients without PVCT, and this can serve as a basis for selecting therapy options.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":"15 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Connectivity and MRI Radiomics Biomarkers of Cognitive and Brain Reserve in Post-Stroke Cognitive Impairment Prediction-A Study Protocol.","authors":"Hanna Maria Dragoș, Adina Stan, Livia Livinț Popa, Roxana Pintican, Diana Feier, Nicu Cătălin Drăghici, Dragoș-Cătălin Jianu, Diana Chira, Ștefan Strilciuc, Dafin F Mureșanu","doi":"10.3390/life15010131","DOIUrl":"10.3390/life15010131","url":null,"abstract":"<p><p>Acute ischemic stroke (AIS) is frequently associated with long-term post-stroke cognitive impairment (PSCI) and dementia. While the mechanisms behind PSCI are not fully understood, the brain and cognitive reserve concepts are topics of ongoing research exploring the ability of individuals to maintain intact cognitive performance despite ischemic injuries. Brain reserve refers to the brain's structural capacity to compensate for damage, with markers like hippocampal atrophy and white matter lesions indicating reduced reserve. Cognitive reserve involves the brain's ability to optimize performance and use alternative networks to maintain function. Advanced methods of MRI and EEG processing may better assess brain reserve and cognitive reserve, with emerging predictive models integrating these measures to improve PSCI prediction. This article provides the design of a hospital-based study investigating the predictive role of functional connectivity and MRI radiomics in assessing PSCI occurrence one year after AIS. One hundred forty-four patients will be enrolled following strict inclusion/exclusion criteria. The patients will undergo comprehensive assessments, including neuropsychological testing, brain MRI, and quantitative EEG (QEEG), across four visits over a year. The primary outcome will be PSCI occurrence, and it will be assessed at six and twelve months after AIS. Secondary outcomes will include PSCI severity, recurrent AIS, and mortality. Statistical analyses will be performed to identify predictive factors using Cox proportional hazards models, and predictive models based on QEEG, MRI radiomics, and clinical data will be built. Early detection of AIS patients prone to developing PSCI might outline more effective therapeutic approaches, reducing the social and economic burden of ischemic stroke.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":"15 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Eight-Week Transcranial Direct-Current Stimulation Combined with Lat Pull-Down Resistance Training on Improving Pull-Up Performance for Male College Students.","authors":"Qian Li, Jiaqi Yan, Hanya Dai, Minjie Qiao, Mingxin Gong, Wenxin Niu, Ye Yang, Lejun Wang","doi":"10.3390/life15010128","DOIUrl":"10.3390/life15010128","url":null,"abstract":"<p><p>The aim of this study was to investigate the effects and potential mechanisms of 8-week transcranial direct-current stimulation (tDCS) combined with resistance training (RT) on pull-up performance in male college students. Twenty-five male college students were randomly assigned to either RT combined with anodal tDCS stimulation (RT + tDCS) or RT alone (RT). Participants of both groups engaged in lat pull-down training programs for 8 weeks, with the RT + tDCS group receiving 20 min tDCS before each RT session. Pre- and post-intervention tests included pull-up endurance (number of repetitions), flexed arm circumference (FAC), and lat pull-down maximal voluntary isometric contraction (MVIC) peak force. During the pull-up endurance test, surface electromyography (sEMG) was recorded for the bicep brachii (BB), tricep brachii (TB), brachioradialis (BR), anterior deltoid (AD), middle deltoid (MD), posterior deltoid (PD), pectoralis major (PM), and latissimus dorsi (LD) muscles. Both groups demonstrated significant improvements in pull-up endurance and lat pull-down MVIC peak force after training, but no significant difference between the two groups was observed in the post-training test. Additionally, muscle activation of BR, PD, and PM decreased significantly in both groups, while the RT + tDCS group also demonstrated a significant reduction in TB coactivation after training. These findings suggest that eight weeks of tDCS combined with lat pull-down training and lat pull-down training alone can both significantly improve pull-up performance, which may be attributed to enhanced muscle contraction capacity. Although no significant training gains were found between the two training groups, the RT + tDCS group showed a significant decrease in TB coactivation and the enhancement of elbow flexion muscle contraction efficiency after training.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":"15 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limitations of the Boston Carpal Tunnel Questionnaire in Assessing Severity in a Homogeneous Occupational Cohort.","authors":"Venera Cristina Dinescu, Marius Bica, Ramona Constantina Vasile, Andrei Gresita, Bogdan Catalin, Alexandra Daniela Rotaru-Zavaleanu, Florentin Ananu Vreju, Lorena Sas, Marius Bunescu","doi":"10.3390/life15010132","DOIUrl":"10.3390/life15010132","url":null,"abstract":"<p><p><b>Background</b>: Carpal tunnel syndrome (CTS) is a common peripheral neuropathy, often assessed using the Boston Carpal Tunnel Questionnaire (BCTQ). The BCTQ evaluates symptom severity (SSS) and functional status (FSS) but has limitations in stratifying CTS severity, particularly in severe cases. <b>Objective</b>: This study aimed to evaluate the utility of the BCTQ in a homogeneous cohort of female workers engaged in repetitive manual tasks, exploring its correlation with objective clinical measures and its performance in detecting CTS severity. <b>Methods</b>: A cross-sectional study was conducted on 24 right-hand-dominant female workers with repetitive occupational tasks. CTS diagnosis was confirmed via clinical and electrodiagnostic criteria. Subjects completed the BCTQ, and correlations between BCTQ scores and objective measures such as median nerve cross-sectional area and nerve conduction studies were analyzed. Statistical analyses included comparisons across CTS severity groups and subgroup evaluations based on age and tenure. <b>Results</b>: The BCTQ demonstrated moderate correlations with objective measures, with a strong correlation between SSS and FSS scores (r = 0.86, <i>p</i> < 0.001). However, the sensitivity of the SSS and FSS was limited, particularly for severe CTS cases. Paradoxically lower scores in severe cases may reflect questionnaire limitations or adaptive responses. Targeted questions addressing pain and sensory symptoms showed better sensitivity (>80%) and may guide clinicians in identifying slight CTS cases. <b>Conclusions</b>: While the BCTQ remains a valuable tool for assessing CTS, its limitations necessitate complementary use of objective diagnostic tools, particularly for severe cases. Future refinements, such as tailored scoring systems and integration with clinical measures, could enhance its diagnostic utility and ensure comprehensive assessment of CTS severity.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":"15 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin for Treating Gestational Diabetes: What Have We Learned During the Last Two Decades? A Systematic Review.","authors":"Angeliki Gerede, Ekaterini Domali, Christos Chatzakis, Chrysoula Margioula-Siarkou, Stamatios Petousis, Sofoklis Stavros, Konstantinos Nikolettos, Evanthia Gouveri, Sotirios Sotiriou, Panagiotis Tsikouras, Konstantinos Dinas, Nikolaos Nikolettos, Nikolaos Papanas, Dimitrios G Goulis, Alexandros Sotiriadis","doi":"10.3390/life15010130","DOIUrl":"10.3390/life15010130","url":null,"abstract":"<p><p>There has been accumulating evidence over the past two decades that metformin can be an effective treatment for gestational diabetes mellitus (GDM) in women whose diet and exercise fail to attain optimal glycemic control. The objective of this review was to comprehensively analyze all studies investigating the effectiveness of metformin compared to insulin and other drugs utilized for the treatment of GDM. After a comprehensive literature review based on PRISMA 2020, 35 studies were included after a selection process utilizing predetermined inclusion and exclusion criteria. A variety of short-term maternal and neonatal outcomes were assessed. Metformin is a highly efficient medication for attaining optimal control of blood sugar levels in women with GDM, resulting in a significant reduction in the amount of weight gained during pregnancy. Regarding additional maternal outcomes, such as pregnancy-induced hypertension and cesarean deliveries, some studies demonstrate a link between metformin and a reduced occurrence of both conditions. In contrast, others do not find an association. Regarding short-term neonatal outcomes, metformin does not exhibit any changes in gestational age at delivery. In contrast, metformin demonstrated substantial decreases in the likelihood of greater gestational birth weight and neonatal hospitalization when compared to other drugs. When compared primarily to insulin, metformin decreases the probability of several short-term outcomes related to pregnancy and newborns. Additional data are necessary for extended follow-up studies, including patients with GDM treated with metformin.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":"15 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Insulin in Insulin-Deficient Islets of Patients with Type 1 Diabetes.","authors":"Yuliya Krivova, Alexandra Proshchina, Dmitry Otlyga, Anastasia Kharlamova, Sergey Saveliev","doi":"10.3390/life15010125","DOIUrl":"10.3390/life15010125","url":null,"abstract":"<p><p>Type 1 diabetes (T1D) is related to the autoimmune destruction of β-cells, leading to their almost complete absence in patients with longstanding T1D. However, endogenous insulin secretion persists in such patients as evidenced by the measurement of plasma C-peptide. Recently, a low level of insulin has been found in non-β islet cells of patients with longstanding T1D, indicating that other islet cell types may contribute to persistent insulin secretion. The present study aimed to test the ability of various antibodies to detect insulin in insulin-deficient islets of T1D patients. Pancreatic autopsies from two children with recent-onset T1D, two adults with longstanding T1D, and three control subjects were examined using double immunofluorescent labeling with antibodies to insulin, glucagon and somatostatin. Immunoreactivity to insulin in glucagon+ cells of insulin-deficient islets was revealed using polyclonal antibodies and monoclonal antibodies simultaneously recognizing insulin and proinsulin. Along with this, immunoreactivity to insulin was observed in the majority of glucagon+ cells of insulin-containing islets of control subjects and children with recent-onset T1D. These results suggest that islet α-cells may contain insulin and/or other insulin-like proteins (proinsulin, C-peptide). Future studies are needed to evaluate the role of α-cells in insulin secretion and diabetes pathogenesis.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":"15 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Collective: Nanoparticle-Assisted Identification of Leader Cancer Cells During Migration.","authors":"Anastasia Alexandrova, Elizaveta Kontareva, Margarita Pustovalova, Sergey Leonov, Yulia Merkher","doi":"10.3390/life15010127","DOIUrl":"10.3390/life15010127","url":null,"abstract":"<p><p>Cancer-related deaths primarily occur due to metastasis, a process involving the migration and invasion of cancer cells. In most solid tumors, metastasis occurs through collective cell migration (CCM), guided by \"cellular leaders\". These leader cells generate forces through actomyosin-mediated protrusion and contractility. The cytoskeletal mechanisms employed by metastatic cells during the migration process closely resemble the use of the actin cytoskeleton in endocytosis. In our previous work, we revealed that tumor cells exhibiting high metastatic potential (MP) are more adept at encapsulating 100-200 nm nanoparticles than those with lower MP. The objective of this study was to investigate whether nanoparticle encapsulation could effectively differentiate leader tumor cells during their CCM. To achieve our objectives, we employed a two-dimensional CCM model grounded in the wound-healing (\"scratch\") assay, utilizing two breast cancer cell lines, MCF7 and MDA-MB-231, which display low and high migratory potential, respectively. We conducted calibration experiments to identify the \"optimal time\" at which cells exhibit peak speed during wound closure. Furthermore, we carried out experiments to assess nanoparticle uptake, calculating the colocalization coefficient, and employed phalloidin staining to analyze the anisotropy and orientation of actin filaments. The highest activity for low-MP cells was achieved at 2.6 h during the calibration experiments, whereas high-MP cells were maximally active at 3.9 h, resulting in 8% and 11% reductions in wound area, respectively. We observed a significant difference in encapsulation efficiency between leader and peripheral cells for both high-MP (<i>p</i> < 0.013) and low-MP (<i>p</i> < 0.02) cells. Moreover, leader cells demonstrated a considerably higher anisotropy coefficient (<i>p</i> < 0.029), indicating a more organized, directional structure of actin filaments compared to peripheral cells. Thus, nanoparticle encapsulation offers a groundbreaking approach to identifying the most aggressive and invasive leader cells during the CCM process in breast cancer. Detecting these cells is crucial for developing targeted therapies that can effectively curb metastasis and improve patient outcomes.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":"15 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer.","authors":"Pathea Shawnae Bruno, Aneeta Arshad, Maria-Raluca Gogu, Natalie Waterman, Rylie Flack, Kimberly Dunn, Costel C Darie, Anca-Narcisa Neagu","doi":"10.3390/life15010126","DOIUrl":"10.3390/life15010126","url":null,"abstract":"<p><p>Post-translational modifications (PTMs) of proteins dynamically build the buffering and adapting interface between oncogenic mutations and environmental stressors, on the one hand, and cancer cell structure, functioning, and behavior. Aberrant PTMs can be considered as enabling characteristics of cancer as long as they orchestrate all malignant modifications and variability in the proteome of cancer cells, cancer-associated cells, and tumor microenvironment (TME). On the other hand, PTMs of proteins can enhance anticancer mechanisms in the tumoral ecosystem or sustain the beneficial effects of oncologic therapies through degradation or inactivation of carcinogenic proteins or/and activation of tumor-suppressor proteins. In this review, we summarized and analyzed a wide spectrum of PTMs of proteins involved in all regulatory mechanisms that drive tumorigenesis, genetic instability, epigenetic reprogramming, all events of the metastatic cascade, cytoskeleton and extracellular matrix (ECM) remodeling, angiogenesis, immune response, tumor-associated microbiome, and metabolism rewiring as the most important hallmarks of cancer. All cancer hallmarks develop due to PTMs of proteins, which modulate gene transcription, intracellular and extracellular signaling, protein size, activity, stability and localization, trafficking, secretion, intracellular protein degradation or half-life, and protein-protein interactions (PPIs). PTMs associated with cancer can be exploited to better understand the underlying molecular mechanisms of this heterogeneous and chameleonic disease, find new biomarkers of cancer progression and prognosis, personalize oncotherapies, and discover new targets for drug development.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":"15 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid Resuscitation and Initial Management in Patients Presenting with Sepsis in the General Ward.","authors":"Sung Won Chang, Juwhan Choi, Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Jae Kyeom Sim","doi":"10.3390/life15010124","DOIUrl":"10.3390/life15010124","url":null,"abstract":"<p><p>The optimal management of hospital-presenting sepsis remains poorly understood. We investigated the initial management in patients presenting with sepsis in the general ward, the association between fluid resuscitation and clinical outcomes, and the factors affecting fluid resuscitation. A retrospective study was conducted on patients who presented with sepsis-induced hypotension in the general ward. Patients were divided into Less 30 (fluid resuscitation less than 30 mL/kg) and More 30 (fluid resuscitation 30 mL/kg or more) groups. Multivariable logistic regression analysis was performed. The median resuscitation fluid volume was 500 mL (9.2 mL/kg) and 2000 mL (35.9 mL/kg) in the Less 30 (<i>n</i> = 79) and More 30 (<i>n</i> = 11) groups, respectively. The intensive care unit (ICU) mortality was similar between the two groups (43.0% vs. 45.5%). Twenty-two patients received continuous renal replacement therapy (CRRT) in the Less 30 group, whereas none received it in the More 30 group (27.8% vs. 0%). Fluid resuscitation ≥30 mL/kg was not associated with ICU mortality. Low body weight and systolic blood pressure were associated with fluid resuscitation ≥30 mL/kg. Most hospital-presenting sepsis patients received less than 30 mL/kg of fluid, and fluid resuscitation was not associated with ICU mortality.</p>","PeriodicalId":56144,"journal":{"name":"Life-Basel","volume":"15 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}