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Chromosomal defects in multiple myeloma 多发性骨髓瘤的染色体缺陷
IF 7.4 2区 医学
Blood Reviews Pub Date : 2024-03-01 DOI: 10.1016/j.blre.2024.101168
Sarah E. Clarke , Kathryn A. Fuller , Wendy N. Erber
{"title":"Chromosomal defects in multiple myeloma","authors":"Sarah E. Clarke ,&nbsp;Kathryn A. Fuller ,&nbsp;Wendy N. Erber","doi":"10.1016/j.blre.2024.101168","DOIUrl":"10.1016/j.blre.2024.101168","url":null,"abstract":"<div><p>Multiple myeloma is a plasma cell neoplasm driven by primary (e.g. hyperdiploidy; <em>IGH</em> translocations) and secondary (e.g. 1q21 gains/amplifications; del(17p); <em>MYC</em> translocations) chromosomal events. These are important to detect as they influence prognosis, therapeutic response and disease survival. Currently, cytogenetic testing is most commonly performed by interphase fluorescence in situ hybridisation (FISH) on aspirated bone marrow samples. A number of variations to FISH methodology are available, including prior plasma cell enrichment and incorporation of immunophenotypic plasma cell identification. Other molecular methods are increasingly being utilised to provide a genome-wide view at high resolution (e.g. single nucleotide polymorphism (SNP) microarray analysis) and these can detect abnormalities in most cases. Despite their wide application at diagnostic assessment, both FISH and SNP-array have relatively low sensitivity, limiting their use for identification of prognostically significant low-level sub-clones or for disease monitoring. Next-generation sequencing is increasingly being used to detect mutations and new FISH techniques such as by flow cytometry are in development and may address some of the current test limitations. Here we review the primary and secondary cytogenetic aberrations in myeloma and discuss the range of techniques available for their assessment.</p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0268960X24000018/pdfft?md5=4cbbd86c290549e3b2d6d8e05c96d26e&pid=1-s2.0-S0268960X24000018-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139096351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From microscope to micropixels: A rapid review of artificial intelligence for the peripheral blood film 从显微镜到微像素:外周血膜人工智能的快速回顾。
IF 7.4 2区 医学
Blood Reviews Pub Date : 2024-03-01 DOI: 10.1016/j.blre.2023.101144
Bingwen Eugene Fan , Bryan Song Jun Yong , Ruiqi Li , Samuel Sherng Young Wang , Min Yi Natalie Aw , Ming Fang Chia , David Tao Yi Chen , Yuan Shan Neo , Bruno Occhipinti , Ryan Ruiyang Ling , Kollengode Ramanathan , Yi Xiong Ong , Kian Guan Eric Lim , Wei Yong Kevin Wong , Shu Ping Lim , Siti Thuraiya Binte Abdul Latiff , Hemalatha Shanmugam , Moh Sim Wong , Kuperan Ponnudurai , Stefan Winkler
{"title":"From microscope to micropixels: A rapid review of artificial intelligence for the peripheral blood film","authors":"Bingwen Eugene Fan ,&nbsp;Bryan Song Jun Yong ,&nbsp;Ruiqi Li ,&nbsp;Samuel Sherng Young Wang ,&nbsp;Min Yi Natalie Aw ,&nbsp;Ming Fang Chia ,&nbsp;David Tao Yi Chen ,&nbsp;Yuan Shan Neo ,&nbsp;Bruno Occhipinti ,&nbsp;Ryan Ruiyang Ling ,&nbsp;Kollengode Ramanathan ,&nbsp;Yi Xiong Ong ,&nbsp;Kian Guan Eric Lim ,&nbsp;Wei Yong Kevin Wong ,&nbsp;Shu Ping Lim ,&nbsp;Siti Thuraiya Binte Abdul Latiff ,&nbsp;Hemalatha Shanmugam ,&nbsp;Moh Sim Wong ,&nbsp;Kuperan Ponnudurai ,&nbsp;Stefan Winkler","doi":"10.1016/j.blre.2023.101144","DOIUrl":"10.1016/j.blre.2023.101144","url":null,"abstract":"<div><p><span>Artificial intelligence (AI) and its application in classification of blood cells in the peripheral blood film is an evolving field in haematology. We performed a rapid review of the literature on AI and peripheral blood films, evaluating the condition studied, image datasets, machine learning models, training set size, testing set size and accuracy. A total of 283 studies were identified, encompassing 6 broad domains: malaria (</span><em>n</em> = 95), leukemia (<em>n</em> = 81), leukocytes (<em>n</em> = 72), mixed (<em>n</em> = 25), erythrocytes (<em>n</em><span> = 15) or Myelodysplastic syndrome (MDS) (n = 1). These publications have demonstrated high self-reported mean accuracy rates across various studies (95.5% for malaria, 96.0% for leukemia, 94.4% for leukocytes, 95.2% for mixed studies and 91.2% for erythrocytes), with an overall mean accuracy of 95.1%. Despite the high accuracy, the challenges toward real world translational usage of these AI trained models include the need for well-validated multicentre data, data standardisation, and studies on less common cell types and non-malarial blood-borne parasites.</span></p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling germline predisposition in hematological neoplasms: Navigating complexity in the genomic era 揭示血液学肿瘤的种系易感性:在基因组时代导航复杂性。
IF 7.4 2区 医学
Blood Reviews Pub Date : 2024-03-01 DOI: 10.1016/j.blre.2023.101143
Joaquín Jerez , Marta Santiago
{"title":"Unraveling germline predisposition in hematological neoplasms: Navigating complexity in the genomic era","authors":"Joaquín Jerez ,&nbsp;Marta Santiago","doi":"10.1016/j.blre.2023.101143","DOIUrl":"10.1016/j.blre.2023.101143","url":null,"abstract":"<div><p>Genomic advancements have yielded pivotal insights into hematological neoplasms, particularly concerning germline predisposition mutations. Following the WHO 2016 revisions, dedicated segments were proposed to address these aspects. Current WHO 2022, ICC 2022, and ELN 2022 classifications recognize their significance, introducing more mutations and prompting integration into clinical practice.</p><p>Approximately 5–10% of hematological neoplasm patients show germline predisposition gene mutations, rising with risk factors such as personal cancer history and familial antecedents, even in older adults.</p><p><span>Nevertheless, technical challenges persist. Optimal DNA samples are skin fibroblast-extracted, although not universally applicable. Alternatives such as </span>hair follicle use are explored. Moreover, the scrutiny of germline genomics mandates judicious test selection to ensure precise and accurate interpretation.</p><p>Given the significant influence of genetic counseling on patient care and post-assessment procedures, there arises a demand for dedicated centers offering specialized services.</p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iron deficiency anemia among women: An issue of health equity 妇女缺铁性贫血:健康公平问题。
IF 7.4 2区 医学
Blood Reviews Pub Date : 2024-03-01 DOI: 10.1016/j.blre.2023.101159
Grace H. Tang , Michelle Sholzberg
{"title":"Iron deficiency anemia among women: An issue of health equity","authors":"Grace H. Tang ,&nbsp;Michelle Sholzberg","doi":"10.1016/j.blre.2023.101159","DOIUrl":"10.1016/j.blre.2023.101159","url":null,"abstract":"<div><p><span>Iron deficiency<span><span> is the most common and widespread nutritional deficiency in the world. For women, the risk of iron deficiency and </span>iron deficiency anemia increases due to iron demands during pregnancy and regular iron losses due to menstruation during reproductive years. These interrelated conditions are of </span></span>public health<span><span> concern as they are highly prevalent, and the negative consequences such as chronic fatigue, cognitive impairment and poor </span>quality of life<span><span> are broad and multifaceted. People of low socioeconomic status are at higher risk of iron deficiency due to low intake of expensive iron-rich foods, and decreased access to healthcare. In this review, we applied a health equity lens to describe the current state of care for women with iron deficiency with or without anemia. We have highlighted several structural challenges that span from the laboratory diagnosis, inconsistent screening guidelines, and stigma associated with heavy menstrual bleeding, to </span>treatment barriers.</span></span></p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Idiopathic multicentric Castleman disease: An update in diagnosis and treatment advances 特发性多中心Castleman病:最新的诊断和治疗进展
IF 7.4 2区 医学
Blood Reviews Pub Date : 2024-03-01 DOI: 10.1016/j.blre.2023.101161
Evan Lang , Frits van Rhee
{"title":"Idiopathic multicentric Castleman disease: An update in diagnosis and treatment advances","authors":"Evan Lang ,&nbsp;Frits van Rhee","doi":"10.1016/j.blre.2023.101161","DOIUrl":"10.1016/j.blre.2023.101161","url":null,"abstract":"<div><p>Idiopathic multicentric Castleman disease (iMCD) is a rare disease, and it is likely underdiagnosed because of the heterogeneity of clinical manifestations and laboratory findings. While the disease leads to significant morbidity and mortality, its causes are not yet fully elucidated. There have been significant advances in diagnosis and treatment of iMCD in the past decade, including the approval of the anti-IL-6 antibody siltuximab. In this review, we provide an update of the many new developments and publications surrounding iMCD.</p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0268960X23001315/pdfft?md5=ccd844ecbcb062d737180f88229fb0ee&pid=1-s2.0-S0268960X23001315-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138541270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Αlpha-thalassemia: A practical overview α-地中海贫血：实用概述
IF 7.4 2区 医学
Blood Reviews Pub Date : 2024-03-01 DOI: 10.1016/j.blre.2023.101165
Khaled M. Musallam , M. Domenica Cappellini , Thomas D. Coates , Kevin H.M. Kuo , Hanny Al-Samkari , Sujit Sheth , Vip Viprakasit , Ali T. Taher
{"title":"Αlpha-thalassemia: A practical overview","authors":"Khaled M. Musallam ,&nbsp;M. Domenica Cappellini ,&nbsp;Thomas D. Coates ,&nbsp;Kevin H.M. Kuo ,&nbsp;Hanny Al-Samkari ,&nbsp;Sujit Sheth ,&nbsp;Vip Viprakasit ,&nbsp;Ali T. Taher","doi":"10.1016/j.blre.2023.101165","DOIUrl":"10.1016/j.blre.2023.101165","url":null,"abstract":"<div><p>α-Thalassemia is an inherited blood disorder characterized by decreased synthesis of α-globin chains that results in an imbalance of α and β globin and thus varying degrees of ineffective erythropoiesis, decreased red blood cell (RBC) survival, chronic hemolytic anemia, and subsequent comorbidities. Clinical presentation varies depending on the genotype, ranging from a silent or mild carrier state to severe, transfusion-dependent or lethal disease. Management of patients with α-thalassemia is primarily supportive, addressing either symptoms (eg, RBC transfusions for anemia), complications of the disease, or its transfusion-dependence (eg, chelation therapy for iron overload). Several novel therapies are also in development, including curative gene manipulation techniques and disease modifying agents that target ineffective erythropoiesis and chronic hemolytic anemia. This review of α-thalassemia and its various manifestations provides practical information for clinicians who practice beyond those regions where it is found with high frequency.</p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0268960X23001352/pdfft?md5=bfdf3f2cb6cd0f3a1be7f480cd63530b&pid=1-s2.0-S0268960X23001352-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139092770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune deficiency/dysregulation -associated lymphoproliferative disorders. Revised classification and management 免疫缺陷/失调-相关淋巴组织增生性疾病。修订分类和管理
IF 7.4 2区 医学
Blood Reviews Pub Date : 2024-03-01 DOI: 10.1016/j.blre.2023.101167
Antonino Carbone , Amy Chadburn , Annunziata Gloghini , Emanuela Vaccher , Mark Bower
{"title":"Immune deficiency/dysregulation -associated lymphoproliferative disorders. Revised classification and management","authors":"Antonino Carbone ,&nbsp;Amy Chadburn ,&nbsp;Annunziata Gloghini ,&nbsp;Emanuela Vaccher ,&nbsp;Mark Bower","doi":"10.1016/j.blre.2023.101167","DOIUrl":"10.1016/j.blre.2023.101167","url":null,"abstract":"<div><p>Significant advances in the field of lymphoma have resulted in two recent classification proposals, the International Consensus Classification (ICC) and the 5th edition WHO. A few entities are categorized differently in the ICC compared to the WHO. Nowhere is this more apparent than the immunodeficiency lymphoproliferative disorders<span>. The three previous versions of the WHO classification (3rd, 4th and revised 4th editions) and the ICC focused on four clinical settings in which these lesions arise for primary categorization. In contrast the 2023 WHO 5th edition includes pathologic characteristics including morphology and viral status, in addition to clinical setting, as important information for lesion classification. In addition, the 2023 WHO recognizes a broader number of clinical scenarios in which these lesions arise, including not only traditional types of immune deficiency but also immune dysregulation<span>. With this classification it is hoped that new treatment strategies will be developed leading to better patient outcomes.</span></span></p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139104308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Richter's transformation: Transforming the clinical landscape 里克特的转变改变临床格局
IF 7.4 2区 医学
Blood Reviews Pub Date : 2024-03-01 DOI: 10.1016/j.blre.2023.101163
A. Barrett , N. Appleby , H. Dreau , C.P. Fox , T. Munir , T.A. Eyre
{"title":"Richter's transformation: Transforming the clinical landscape","authors":"A. Barrett ,&nbsp;N. Appleby ,&nbsp;H. Dreau ,&nbsp;C.P. Fox ,&nbsp;T. Munir ,&nbsp;T.A. Eyre","doi":"10.1016/j.blre.2023.101163","DOIUrl":"10.1016/j.blre.2023.101163","url":null,"abstract":"<div><p><span><span><span>Richter transformation (RT) represents an aggressive histological transformation from </span>chronic lymphocytic leukaemia<span>, most often to a large B cell lymphoma. It is characterised by chemo-resistance and subsequent short survival. Drug development has struggled over recent years in light of the aggressive kinetics of the disease, lack of pivotal registrational trials and relative rarity of the phenomenon. In this review we will highlight the diagnostic and therapeutic challenges of managing patients with RT as well as taking a look to the future therapeutic landscape. Highly active </span></span>therapies<span> developed across B cell malignancies<span> are starting to impact this field, with T-cell activation therapies (CAR-T, bispecific antibodies), antibody-drug conjugates, and novel small molecule inhibitor combinations (</span></span></span><em>e.g.</em><span> BTKi-BCL2i) being actively studied. We will highlight the data supporting these developments and look to the studies to come to provide hope for patients suffering from this devastating disease.</span></p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138685608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary tools for evaluation of hemostasis in neonates. Where are we and where are we headed? 评价新生儿止血的现代工具。我们在哪里，我们要去哪里?
IF 7.4 2区 医学
Blood Reviews Pub Date : 2024-03-01 DOI: 10.1016/j.blre.2023.101157
Rozeta Sokou , Stavroula Parastatidou , Aikaterini Konstantinidi , Andreas G. Tsantes , Nicoletta Iacovidou , Daniele Piovani , Stefanos Bonovas , Argirios E. Tsantes
{"title":"Contemporary tools for evaluation of hemostasis in neonates. Where are we and where are we headed?","authors":"Rozeta Sokou ,&nbsp;Stavroula Parastatidou ,&nbsp;Aikaterini Konstantinidi ,&nbsp;Andreas G. Tsantes ,&nbsp;Nicoletta Iacovidou ,&nbsp;Daniele Piovani ,&nbsp;Stefanos Bonovas ,&nbsp;Argirios E. Tsantes","doi":"10.1016/j.blre.2023.101157","DOIUrl":"10.1016/j.blre.2023.101157","url":null,"abstract":"<div><p><span>The assessment of hemostatic disorders<span><span><span> in neonates is crucial, but remains challenging for clinicians. Although the concept of developmental hemostasis<span> is widely accepted among hemostasis specialists globally, it is probably under-recognized by clinicians and laboratory practitioners. In parallel with age-dependent </span></span>hemostatic status maturation, comprehension of the differences between </span>normal values is crucial for the accurate diagnosis of potential hemorrhagic and thrombotic disorders of the vulnerable neonatal population. This review outlines the basics of developmental hemostasis and the features of the available </span></span>coagulation testing methods, with a focus on novel tools for evaluating the neonatal hemostatic profile. Common errors, issues, and pitfalls during the assessment of neonatal hemostasis are discussed, along with their impact on patient management. Current knowledge gaps and research areas are addressed. Further studying to improve our understanding of developmental hemostasis and its reflection on everyday clinical practice is warranted.</p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paroxysmal nocturnal hemoglobinuria: Review of the patient experience and treatment landscape 阵发性夜间血红蛋白尿:回顾患者的经验和治疗前景
IF 7.4 2区 医学
Blood Reviews Pub Date : 2024-03-01 DOI: 10.1016/j.blre.2023.101158
Anem Waheed , Jamile Shammo , David Dingli
{"title":"Paroxysmal nocturnal hemoglobinuria: Review of the patient experience and treatment landscape","authors":"Anem Waheed ,&nbsp;Jamile Shammo ,&nbsp;David Dingli","doi":"10.1016/j.blre.2023.101158","DOIUrl":"10.1016/j.blre.2023.101158","url":null,"abstract":"<div><p>Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder caused by complement-mediated hemolysis and thrombosis through the alternative pathway. The most common symptom of PNH is fatigue due to chronic anemia, which can negatively impact quality of life (QoL) and affect overall well-being. The currently approved therapies for PNH significantly limit intravascular hemolysis (IVH) and reduce the risk of thrombosis; however, they are associated with an infusion schedule that can become burdensome, and not all patients experience complete disease control. Several new complement inhibitors are in development that address the need for convenient routes of administration and aim to provide better disease control. With the variety of new treatment options on the horizon, hematologic markers as well as QoL concerns, patient opinion, and lifestyle factors should be considered to choose the optimal PNH treatment for each specific patient.</p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":7.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0268960X23001285/pdfft?md5=0a811d3725af088dfae7b9baa97cfdf4&pid=1-s2.0-S0268960X23001285-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138541269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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