血液恶性肿瘤化疗和免疫疗法的神经毒性：从机制到管理。

IF 6.9 2区医学 Q1 HEMATOLOGY

Blood Reviews Pub Date : 2025-01-01 DOI:10.1016/j.blre.2024.101254

David Kegyes , Vlad Moisoiu , Catalin Constantinescu , Alina Tanase , Gabriel Ghiaur , Hermann Einsele , Ciprian Tomuleasa , Hillard M. Lazarus , Robert Peter Gale

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引用次数: 0

摘要

化疗和免疫疗法用于治疗恶性血液病经常引起神经损伤。不良事件的范围从轻微的认知障碍和头痛到严重的情况，如癫痫、中风和脑炎。我们进行了全面的文献综述，并报告了这些疗法在产生这些毒性作用的受试者中引起的神经毒性的类型、机制、管理和预防。我们的论文将不讨论放射治疗，因为它已经被许多作者广泛地回顾过。我们的重点将放在最近开发的抗癌药物上。

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Neuro-toxicities of chemo- and immune-therapies in haematologic malignancies: from mechanism to management

Chemo- and immune therapies administered to treat haematologic malignancies frequently cause neurologic injury. The adverse events range from mild cognitive impairment and headaches to severe conditions such as seizures, stroke and encephalitis. We performed a comprehensive literature review and report the types, mechanisms, management and prevention of neuro-toxicity resulting from these therapies in subjects who develop these toxic effects. Our paper will not discuss radiation therapy, as it has already been extensively reviewed by many authors. Our focus will be on recently developed anti-cancer drugs.

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来源期刊

Blood Reviews 医学-血液学

CiteScore

13.80

自引率

1.40%

发文量

期刊介绍： Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.