Point-of-care diagnostic test accuracy in children and adolescents with sickle cell disease: A systematic review and meta-analysis

IF 6.9 2区医学 Q1 HEMATOLOGY

Blood Reviews Pub Date : 2025-01-01 DOI:10.1016/j.blre.2024.101243

Robert Bagnall , Danielle Guy , Rebecca L. Morgan , Ifeoluwa Babatunde , Agathe Nevière , Gabriela Friedrich , Liga Bennetts , Omar Irfan , Isaac Odame

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引用次数: 0

Abstract

Background

Detection of sickle cell disease (SCD) could be improved with greater use of point-of-care testing (POCT). This review assessed the accuracy of POCTs for SCD in children and adolescents.

Methods

We systematically searched EMBASE, PubMed, Cochrane libraries, registries and conference proceedings from inception to 28th February 2023. We included cross-sectional and case-control studies that tested for SCD using POCTs and reference tests in individuals aged 0–19. We conducted meta-analysis to assess sensitivity and specificity of individual POCTs.

Findings

The review included 31 studies overall, with 20 covering lateral flow immunoassays (LFIAs) and four covering micro-engineered electrophoresis. When detecting homozygous SCD, the pooled sensitivity and specificity of the included LFIAs and micro-engineered electrophoresis POCTs was 92 % or higher in all individual meta-analyses. Sensitivities and specificities were also nearly 100 % when detecting haemoglobin SC disease for these POCTs.

Interpretation

POCTs could be used to accurately diagnose SCD.

查看原文本刊更多论文

儿童和青少年镰状细胞病的即时诊断测试准确性：一项系统回顾和荟萃分析

背景：镰状细胞病（SCD）的检测可以通过更多地使用即时检测（POCT）来改善。本综述评估了POCTs对儿童和青少年SCD的准确性。方法：我们系统地检索了EMBASE、PubMed、Cochrane图书馆、注册库和会议记录，检索时间从成立到2023年2月28日。我们纳入了在0-19岁的个体中使用POCTs和参考测试测试SCD的横断面和病例对照研究。我们进行了荟萃分析来评估个体poct的敏感性和特异性。结果：本综述共纳入31项研究，其中20项涉及侧流免疫测定（LFIAs）， 4项涉及微工程电泳。当检测纯合子SCD时，在所有个体荟萃分析中，纳入的LFIAs和微工程电泳POCTs的总灵敏度和特异性为92%或更高。在检测这些poct的血红蛋白SC疾病时，敏感性和特异性也接近100%。结论：POCTs可用于SCD的准确诊断。

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来源期刊

Blood Reviews 医学-血液学

CiteScore

13.80

自引率

1.40%

发文量

期刊介绍： Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.