Brain & Development最新文献

{"title":"Clinical factors related to bilirubin encephalopathy in preterm infants: A case-control study","authors":"Akihisa Okumura ,&nbsp;Masahiro Hayakawa ,&nbsp;Hiroshi Arai ,&nbsp;Yoshihiro Maruo ,&nbsp;Takashi Kusaka ,&nbsp;Tetsuya Kunikata ,&nbsp;Sota Iwatani ,&nbsp;Yoshiaki Sato ,&nbsp;Ichiro Morioka","doi":"10.1016/j.braindev.2025.104342","DOIUrl":"10.1016/j.braindev.2025.104342","url":null,"abstract":"<div><h3>Objectives</h3><div>Bilirubin encephalopathy in preterm infants (pBE) is becoming a growing concern in Japanese neonatal intensive care units. Definitive conclusions regarding the risk factors of pBE remain elusive. This study aimed to identify the risk factors for pBE.</div></div><div><h3>Methods</h3><div>We performed a 1:2 matched-pair analysis, selecting infants with pBE from previous nationwide surveys and matching them with control infants without evident neurodevelopmental delay based on year of birth, gestational age, or birth weight. We compared demographic data, neonatal complications, laboratory data within the first 8 weeks of life, and phototherapy between the two groups.</div></div><div><h3>Results</h3><div>We analyzed 20 infants with pBE and 40 control infants. Infants with pBE showed higher frequencies of bronchopulmonary dysplasia, gastrointestinal complications (excluding necrotizing enterocolitis), and bacteremia than the controls. Infants with pBE had higher peak total bilirubin levels and bilirubin/albumin ratios, alongside lower bottom albumin levels than controls. The difference in these laboratory values was prominent during the third to fourth weeks of life. Infants with pBE ended phototherapy significantly later than the controls. Multiple regression analysis showed that bronchopulmonary dysplasia, bacteremia, and peak total bilirubin levels were independently associated with pBE.</div></div><div><h3>Conclusions</h3><div>Bronchopulmonary dysplasia, bacteremia, and peak total bilirubin values were presumed to be associated with the occurrence of pBE. The results of this study will improve treatment approaches for neonatal jaundice in preterm infants.</div></div>","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 2","pages":"Article 104342"},"PeriodicalIF":1.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological outcome and health-related quality of life among Malaysian children with stroke","authors":"Choong Yi Fong ,&nbsp;Paranthaman al S.S. Kangatharan ,&nbsp;Wei Kang Lim ,&nbsp;Lai Choo Ong ,&nbsp;Limin Li ,&nbsp;Mohamad Shafiq Azanan ,&nbsp;Chee Ming Teh","doi":"10.1016/j.braindev.2025.104339","DOIUrl":"10.1016/j.braindev.2025.104339","url":null,"abstract":"<div><h3>Aim</h3><div>Describe the neurological and functional outcomes, and health-related quality of life (HRQL) of Malaysian children with stroke; and explore factors associated with poor outcomes and lower HRQL.</div></div><div><h3>Method</h3><div>Cross-sectional study of Malaysian stroke children who were followed-up for at least 2 years. Paediatric Stroke Outcome Measure (PSOM) and modified Rankin scale (mRS) were utilised to assess neurological and functional outcomes. HRQL was assessed using PedsQL (Paediatric Quality of Life inventory) 4.0. Multiple regression analysis was used to determine factors associated with poor PSOM, poor mRS, and lower HRQL.</div></div><div><h3>Results</h3><div>Seventy-six children were recruited. Majority have good mRS (72.4 %) and good PSOM (75 %). PedsQL total, physical health summary and psychosocial health summary mean scores were 74.2(SD 21.57), 74.2(SD 28.16) and 76.13(SD 18.66) respectively, which were significantly lower compared with healthy Malaysian children (<em>p</em> ≤ 0.001). Learning disability post-stroke was associated with poor PSOM and poor mRS; while cardiac surgery was associated with poor mRS. Learning disability post-stroke was associated with lower total, physical health summary and psychosocial health summary PedsQL scores. Poor mRS was associated with lower total PedsQL scores while poor PSOM was associated with lower total and physical health summary PedsQL.</div></div><div><h3>Conclusion</h3><div>Although majority of Malaysian children with stroke had good long-term neurological and functional outcomes, they had lower HRQL compared to healthy Malaysian children. Optimizing care for cardiac surgery to reduce the risk of perioperative stroke may lead to improved neurological outcome. There is a need to address the issues of learning disability post-stroke and poor neurological outcome to reduce their impact on HRQL.</div></div>","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 2","pages":"Article 104339"},"PeriodicalIF":1.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of sulforaphane on ABC and SRS scales in patients with autism spectrum disorder: a meta-analysis","authors":"Jialing Guo ,&nbsp;Yichao Wang ,&nbsp;Weijun He ,&nbsp;Mingxing Lou ,&nbsp;Ying Peng ,&nbsp;Hui Shi ,&nbsp;Aojie Lian","doi":"10.1016/j.braindev.2025.104321","DOIUrl":"10.1016/j.braindev.2025.104321","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) has become an increasingly prominent global health issue. Sulforaphane is a phytochemical with multiple functions that target many of the same biochemical and molecular pathways (biomarkers) associated with ASD. This study aimed to conduct a meta-analysis based on sulforaphane's effect on Aberrant Behavior Checklist (ABC) and Social Responsiveness Scale (SRS) in patients with ASD. We conducted comprehensive searches in the PubMed, Medline, Cochrane, EMBASE, and Web of Science databases from their inception. The modified Cochrane risk of bias tool was used to check the risk of bias of the included studies. Review Manager 5.3 software was used to conduct this meta-analysis. The results of this meta-analysis showed that sulforaphane significantly improved irritability and hyperactivity symptoms, suggesting that sulforaphane has the potential for the combined treatment of autism. Additional studies are needed to confirm and explore the effect of sulforaphane.</div></div>","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 2","pages":"Article 104321"},"PeriodicalIF":1.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video game exposure in children with epilepsy: EEG and clinical findings","authors":"Hande Gazeteci Tekin ,&nbsp;Pınar Edem","doi":"10.1016/j.braindev.2025.104329","DOIUrl":"10.1016/j.braindev.2025.104329","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of video game exposure on pediatric epilepsy patients, focusing on electroencephalography (EEG) and clinical outcomes.</div></div><div><h3>Methods</h3><div>A total of 94 pediatric epilepsy patients aged 6–18 years (juvenile idiopathic generalized epilepsy, childhood absence epilepsy, self-limited idiopathic focal epilepsy [SeLEAS and SeLECTS]) and 57 non-epileptic controls were enrolled. EEG recordings were obtained while patients were awake, asleep, and during video game play. The impact of video games was analyzed across different epilepsy subgroups and according to epilepsy control status.</div></div><div><h3>Results</h3><div>Twenty-five patients with EEG deterioration in the entire group, three of whom were from the control group (<em>p</em> = 0.032). Among juvenile idiopathic generalized epilepsy patients, 2 of 21 controlled and 6 of 11 uncontrolled patients were adversely affected by video games (<em>p</em> = 0.01). In the SeLECTS group, none of the controlled patients and 3 of 11 uncontrolled patients showed adverse effects (<em>p</em> = 0.063). In the absence epilepsy and SeLEAS groups, epilepsy status did not significantly affect video game response (<em>p</em> = 0.250, <em>p</em> = 0.603). Patients with pattern sensitivity and photosensitivity had a higher risk of EEG deterioration during video game play than those without these sensitivities.</div></div><div><h3>Conclusions</h3><div>Playing selected video games is safer for patients with juvenile idiopathic generalized epilepsies and the SeLECTS group when precautions are taken, and both EEG and clinical conditions are under control. However, video games pose a risk for patients with absence epilepsy and SeLEAS, regardless of epilepsy control status. These findings underscore the need for individualized assessments and tailored recommendations for video game exposure in pediatric epilepsy patients.</div></div>","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 2","pages":"Article 104329"},"PeriodicalIF":1.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Levacetylleucine a game changer for Niemann-Pick disease type-C”","authors":"Muneaki Matsuo ,&nbsp;Yoichi Ishitsuka ,&nbsp;Tetsumi Irie","doi":"10.1016/j.braindev.2024.104301","DOIUrl":"10.1016/j.braindev.2024.104301","url":null,"abstract":"","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 1","pages":"Article 104301"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: “Levacetylleucine a game changer for Niemann pick disease type-C”","authors":"Mobeen Abid,&nbsp;Shanzay Akhtar,&nbsp;Mirza Ahmed Baig","doi":"10.1016/j.braindev.2024.10.002","DOIUrl":"10.1016/j.braindev.2024.10.002","url":null,"abstract":"","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 1","pages":"Article 104294"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which aEEG patterns could predict neurodevelopmental outcome in preterm neonates? – A systematic review","authors":"Mariana Martins Dantas Santos ,&nbsp;Isadora Souza Eilers ,&nbsp;Taís Michele Werle ,&nbsp;Gabriel Lorentz Trein ,&nbsp;Lara Michel da Silva ,&nbsp;Luiz Eduardo Leal Canton ,&nbsp;Magda Lahorgue Nunes","doi":"10.1016/j.braindev.2024.104315","DOIUrl":"10.1016/j.braindev.2024.104315","url":null,"abstract":"<div><h3>Objective</h3><div>Amplitude-integrated electroencephalogram (aEEG) enables continuous and simplified bedside monitoring of brain function. This review aims to investigate aEEG's value as a predictor of neurodevelopment outcome in preterm infants.</div></div><div><h3>Methods</h3><div>PubMed, Embase and Web of Science were systematically searched according to the PRISMA in April 2023 and updated in October 2023. The protocol was registered on PROSPERO platform and the methodological quality of studies was analyzed using the Newcastle–Ottawa Scale (NOS).</div></div><div><h3>Results</h3><div>Nineteen articles (18 cohort and 1 case-control study) were included, reporting the recording of aEEG in 2074 preterm neonates and its association to neurodevelopment outcome. In most studies, aEEG recording started within 72 h of life. The mean NOS score for prospective and retrospective cohort studies were 6 (4–7, median 6) and 6.6 (6–7, median 7), respectively. The case-control study received 7 stars. Burst suppression and low voltage background were associated with poor neurodevelopmental outcome, while normal background and established cyclicity was correlated with a favorable outcome, especially when they occurred in the first week of life.</div></div><div><h3>Conclusion</h3><div>The background patterns and cyclicity of aEEG seems to be reliable patterns to help predict neurodevelopmental outcome in premature infants, especially when monitorization started early.</div></div>","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 1","pages":"Article 104315"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor function and compound muscle action potential amplitude in children with spinal muscular atrophy treated with nusinersen","authors":"Yingshuang Peng,&nbsp;Lianying Feng,&nbsp;Jinfeng Wu,&nbsp;Qianyun Zhou,&nbsp;Hailang Liu,&nbsp;Jin Chen,&nbsp;Xiaojie Song,&nbsp;Wei Han,&nbsp;Fuyi Zhang,&nbsp;Ping Yuan,&nbsp;Zhengxiong Yao,&nbsp;Lingling Xie,&nbsp;Mei Li,&nbsp;Li Jiang,&nbsp;Siqi Hong","doi":"10.1016/j.braindev.2024.104316","DOIUrl":"10.1016/j.braindev.2024.104316","url":null,"abstract":"<div><h3>Background</h3><div>Disease-modifying therapies can improve motor function in patients with spinal muscular atrophy (SMA), but efficacy varies between individuals. The aim was to evaluate the efficacy and safety of nusinersen treatment in children with SMA and to investigate prognostic factors.</div></div><div><h3>Methods</h3><div>Motor function, compound muscle action potential (CMAP), and other indicators were prospectively collected before and 14 months after nusinersen treatment.</div></div><div><h3>Results</h3><div>A total of 55 children were included in our study to assess safety. 41 patients (with at least 6 months of nusinersen treatment) were included in the final efficacy analyses, with a median age at first treatment of 4.2 years. After 14 months of treatment with nusinersen, motor function improved, with increases in CHOP INTEND (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders), HINE-2 (Hammersmith Infant Neurological Exam-Part 2), HFMSE (Hammersmith Functional Motor Scale-Expanded) and RULM (Revised Upper Limb Module) of 5.5 (95 % CI –2.4–13.4), 0.8 (95 % CI –0.2–1.9), 5.0 (95 % CI 2.5–7.4) and 2.4 (95 % CI 0.7–4.1) points, respectively. The CMAP amplitudes of the bilateral tibial, median and ulnar nerves increased, with greatest improvements of 0.87 ± 1.41 mV, 1.08 ± 1.71 mV and 0.59 ± 1.01 mV, respectively. Spearman correlation analysis showed that age at first treatment, disease duration, joint contractures and scoliosis were associated with treatment efficacy (<em>r</em> = −0.4–0.7, <em>P</em> &lt; 0.05). Subgroup analyses showed that the mean HFMSE and RULM scores improved in the Physical therapy group (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Early treatment, mild bone and joint complications, and regular rehabilitation training were associated with better outcomes. The other motor-related functions, such as respiratory and bullar function, and prognostic factors should be studied in the future.</div></div>","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 1","pages":"Article 104316"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ictal EEG of benign convulsion with mild gastroenteritis with in infants and children","authors":"Xiaoqing Luo ,&nbsp;Xiaoli Yu ,&nbsp;Jun Jiang","doi":"10.1016/j.braindev.2024.104312","DOIUrl":"10.1016/j.braindev.2024.104312","url":null,"abstract":"<div><h3>Objective</h3><div>There are fewer reports on the ictal electroencephalogram(EEG) of convulsions in infants and children with mild gastroenteritis (BCWG). Our study retrospectively analyzed the ictal EEG characteristics of convulsive episodes of BCWG.</div></div><div><h3>Methods</h3><div>The seizure-phase EEGs of children diagnosed with BCWG from September 2016 to January 2022 were searched and analyzed, and a total of thirteen seizure-phase EEGs of eight cases were analyzed retrospectively.</div></div><div><h3>Results</h3><div>The age of onset of the disease in the eight children ranged from one year to two years and seven months. No epileptiform discharges were found during the interictal EEG. A total of thirteen epileptic seizures were monitored, of which nine were focal with secondary generalisation. Scalp EEG showed three onset of EEG seizures were in the right occipital region, two were in the right parietal and occipital regions, one was in the right parietal, occipital and posterior temporal region, one was in the right posterior temporal region, one was in the right occipital and posterior temporal region and one was in the right central and central midline region. In addition, four non-convulsive epileptic seizures, which manifested themselves as a decrease in movement and consciousness, with local δ slow-wave activity in bilateral occipital regions evolved to diffuse δ slow wave activity in epileptic seizures.</div></div><div><h3>Conclusion</h3><div>Focal secondary generalised tonic clonic seizures were the main type of seizures in BCWG, and the seizure onset may been mostly in posterior cephalic cortex. It was previously unreported that some children of BCWG may combine with non-convulsive epileptic seizures with the onset of slow wave activity in the occipital region bilaterally and evolving into diffuse δ slow wave activity, which was not easily detected by parents and clinicians.</div></div>","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 1","pages":"Article 104312"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paroxysmal delta waves of awake EEG in childhood adrenoleukodystrophy: Possible indicator of the hematopoietic stem cell therapy (HSCT)","authors":"Kotoe Sakihara ,&nbsp;Atsuko Gunji ,&nbsp;Makiko Kaga ,&nbsp;Wakana Furushima ,&nbsp;Seiko Suzuki ,&nbsp;Yoshimi Kaga ,&nbsp;Masumi Inagaki","doi":"10.1016/j.braindev.2024.104310","DOIUrl":"10.1016/j.braindev.2024.104310","url":null,"abstract":"<div><h3>Background</h3><div>Childhood cerebral type of Adrenoleukodystrophy (CC-ALD) is fatal without hematopoietic stem cell transplantation (HSCT). We consider whether EEGs showing focal paroxysmal delta waves can be a candidate of early detector of the apparent ALD and HSCT therapy.</div></div><div><h3>Methods</h3><div>Twenty-two male children with ALD (5–16 years; 10.4 ± 2.8) were evaluated. Fourteen children were diagnosed as CC-ALD and the rest 8 were yet asymptomatic both clinical and MRI findings. CC-ALD patients with frontal or occipital MRI main lesions were classified as Types F and O (4 and 10 patients). Asymptomatic patients were classified as Type A whose clinical types had not been known. Awake electroencephalogram was recorded during cognitive tasks and analyzed using fast Fourier transform (FFT). Eight children (1/4 F, 3/10 O and 4/8 A patients) were evaluated pre- and post-HSCT.</div></div><div><h3>Results</h3><div>FFT analysis revealed the high voltage slow wave characterized by an increased delta band wave power volume (DBPV) in all children. The DBPV of Type F and O patients showed anterior and posterior dominance in 4/4 and 9/10 patients. Dominant DBPV in Type A patients were anterior and posterior in 6/8 and 1/8, respectively. We classified them as Type F′ and O′. DBPV decreased in all (8/8) patients after HSCT therapy.</div></div><div><h3>Conclusion</h3><div>All patients showed paroxysmal delta wave. In symptomatic patients, abnormal delta wave appeared in their corresponding cortical lesions and decreased after therapy. In asymptomatic patients it may be the first sign of the apparent ALD onset and suggesting when to consider HSCT therapy.</div></div>","PeriodicalId":56137,"journal":{"name":"Brain & Development","volume":"47 1","pages":"Article 104310"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}