Canadian Journal of Neurological Sciences最新文献_第9页

Carotid Stenosis and Stroke: Historical Perspectives Leading to Current Challenges. 颈动脉狭窄与中风：从历史角度看当前面临的挑战。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-11 DOI: 10.1017/cjn.2024.40

David M Pelz, Allan J Fox, J David Spence, Stephen P Lownie

引用次数: 0

Does Self-Reported BMI Modify the Association Between Stroke and Depressive Symptoms? 自我报告的体重指数是否会改变中风与抑郁症状之间的关联？

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-25 DOI: 10.1017/cjn.2024.41

Shakila Meshkat, Vanessa K Tassone, Michelle Wu, Sophie F Duffy, Josheil K Boparai, Hyejung Jung, Wendy Lou, Manav V Vyas, Venkat Bhat

{"title":"Does Self-Reported BMI Modify the Association Between Stroke and Depressive Symptoms?","authors":"Shakila Meshkat, Vanessa K Tassone, Michelle Wu, Sophie F Duffy, Josheil K Boparai, Hyejung Jung, Wendy Lou, Manav V Vyas, Venkat Bhat","doi":"10.1017/cjn.2024.41","DOIUrl":"10.1017/cjn.2024.41","url":null,"abstract":"Background: Depressive symptoms are common in stroke survivors. While obesity has been associated with stroke and depression, its influence on the association between stroke and depressive symptoms is unknown.Methods: Cross-sectional data from 2015 to 2016 Canadian Community Health Survey was used. History of stroke was self-reported and our outcome of interest was depressive symptoms in the prior 2 weeks, measured using the 9-item Patient Health Questionnaire. Self-reported body mass index (BMI) was modeled as cubic spline terms to allow for nonlinear associations. We used multivariable logistic regression to evaluate the association between stroke and depressive symptoms and added an interaction term to evaluate the modifying effect of BMI.Results: Of the 47,521 participants, 694 (1.0%) had a stroke and 3314 (6.5%) had depressive symptoms. Those with stroke had a higher odds of depressive symptoms than those without (aOR = 3.13, 95% CI 2.48, 3.93). BMI did not modify the stroke-depressive symptoms association (P interaction = 0.242) despite the observed variation in stroke-depressive symptoms association across BMI categories,: normal BMI [18.5-25 kg/m2] (aOR† = 3.91, 95% CI 2.45, 6.11), overweight [25-30 kg/m2] (aOR† = 2.63, 95% CI 1.58, 4.20), and obese [>30 kg/m2] (aOR† = 2.76, 95% CI 1.92, 3.94). Similar results were found when depressive symptoms were modeled as a continuous measure.Conclusion: The association between stroke and depressive symptoms is not modified by BMI, needing additional work to understand the role of obesity on depression after stroke.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"68-74"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botulinum Toxin Injection of the Flexor Digitorum Profundus: Are We Forgetting Something? 肉毒杆菌毒素注射深屈肌：我们是否遗忘了什么？

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-04-24 DOI: 10.1017/cjn.2024.59

Ahmad J Abdulsalam, Murat Kara, Bayram Kaymak

引用次数: 0

Migraine Association with Alzheimer's Disease Risk: Evidence from the UK Biobank Cohort Study and Mendelian Randomization. 偏头痛与阿尔茨海默病风险的关系：英国生物库队列研究和孟德尔随机化的证据。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-13 DOI: 10.1017/cjn.2024.35

Chaofan Geng, Chen Chen

{"title":"Migraine Association with Alzheimer's Disease Risk: Evidence from the UK Biobank Cohort Study and Mendelian Randomization.","authors":"Chaofan Geng, Chen Chen","doi":"10.1017/cjn.2024.35","DOIUrl":"10.1017/cjn.2024.35","url":null,"abstract":"Background: Epidemiological studies on the association between migraine and Alzheimer's disease (AD) risk have yielded inconsistent conclusions. We aimed to characterize the phenotypic and genetic relationships between migraine and AD.Methods: To investigate the association between migraine and the risk of AD by analyzing data from a large sample of 404,318 individuals who were initially free from all-cause dementia or cognitive impairment, utilizing the UK Biobank dataset. We employed Cox regression modeling and propensity score matching techniques to examine the relationship between migraine and subsequent occurrences of AD. Additionally, the study utilized Mendelian randomization (MR) analysis to identify the genetic relationship between migraine and the risk of AD.Results: Migraine patients had a significantly increased risk of developing AD, compared to non-migraine patients (adjusted hazard ratio (HR) = 2.34, 95% confidence interval (CI) = 2.01-0.74, P < 0.001). Moreover, the propensity scores matching analyses found that migraine patients had a significantly higher risk of developing AD compared to non-migraine patients (HR = 1.85, 95%CI = 1,68-2.05, P < 0.001). Additionally, the MR suggested that significant causal effects of migraine on AD risks were observed [odds ratio (OR) = 2.315; 95% confidence interval (CI) = 1.029-5.234; P = 0.002]. Moreover, no evidence supported the causal effects of AD on migraine (OR = 1.000; 95%CI = 0.999-1.006; P = 0.971).Conclusion: The present study concludes that migraine patients, compared to a matched control group, exhibit an increased risk of developing AD. Moreover, migraine patients exhibit an increased predisposition of genetic susceptibility to AD. These findings hold significant clinical value for early intervention and treatment of migraines to reduce the risk of AD.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"44-52"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontal Lobe Status Epilepticus Related to CAR T-Cell Therapy Responsive to Anakinra. 对 Anakinra 有反应的 CAR T 细胞疗法相关额叶状态癫痫。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-01-18 DOI: 10.1017/cjn.2024.7

Umberto Pensato, Chiara de Philippis, Daniele Mannina, Daniela Taurino, Barbara Sarina, Jacopo Mariotti, Federico Villa, Elena Costantini, Simona Marcheselli, Stefania Bramanti

引用次数: 0

Limb Temperature in Parkinson's Disease: Is It Symmetric? 帕金森病患者的肢体温度：是否对称？

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-02-01 DOI: 10.1017/cjn.2024.9

Rebecca George, Kimberley P Good, Heather Rigby

引用次数: 0

Age-Specific Association of Co-Morbidity With Home-Time After Acute Stroke. 并发症与急性中风后居家时间的相关性与年龄有关。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-27 DOI: 10.1017/cjn.2024.37

Raed A Joundi, James A King, Jillian Stang, Dana Nicol, Michael D Hill, Amy Y X Yu, Moira K Kapral, Eric E Smith

{"title":"Age-Specific Association of Co-Morbidity With Home-Time After Acute Stroke.","authors":"Raed A Joundi, James A King, Jillian Stang, Dana Nicol, Michael D Hill, Amy Y X Yu, Moira K Kapral, Eric E Smith","doi":"10.1017/cjn.2024.37","DOIUrl":"10.1017/cjn.2024.37","url":null,"abstract":"Objective: To examine the association of co-morbidity with home-time after acute stroke and whether the association is influenced by age.Methods: We conducted a province-wide study using linked administrative databases to identify all admissions for first acute ischemic stroke or intracerebral hemorrhage between 2007 and 2018 in Alberta, Canada. We used ischemic stroke-weighted Charlson Co-morbidity Index of 3 or more to identify those with severe co-morbidity. We used zero-inflated negative binomial models to determine the association of severe co-morbidity with 90-day and 1-year home-time, and logistic models for achieving ≥ 80 out of 90 days of home-time, assessing for effect modification by age and adjusting for sex, stroke type, comprehensive stroke center care, hypertension, atrial fibrillation, year of study, and separately adjusting for estimated stroke severity. We also evaluated individual co-morbidities.Results: Among 28,672 patients in our final cohort, severe co-morbidity was present in 27.7% and was associated with lower home-time, with a greater number of days lost at younger age (-13 days at age < 60 compared to -7 days at age 80+ years for 90-day home-time; -69 days at age < 60 compared to -51 days at age 80+ years for 1-year home-time). The reduction in probability of achieving ≥ 80 days of home-time was also greater at younger age (-22.7% at age < 60 years compared to -9.0% at age 80+ years). Results were attenuated but remained significant after adjusting for estimated stroke severity and excluding those who died. Myocardial infarction, diabetes, and cancer/metastases had a greater association with lower home-time at younger age, and those with dementia had the greatest reduction in home time.Conclusion: Severe co-morbidity in acute stroke is associated with lower home-time, more strongly at younger age.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"59-67"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Homozygous Variant in the MCOLN1 Gene Associated With Severe Oromandibular Dystonia and Parkinsonism. 与严重口颌肌张力障碍和帕金森症有关的 MCOLN1 基因新型同卵变异体。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-27 DOI: 10.1017/cjn.2024.47

Aida Ghasemi, Mahdieh Eslami Ardakani, Mansoureh Togha, Narges Yazdi, Anthony E Lang, Elahe Amini, Mohammad Rohani, Afagh Alavi

{"title":"A Novel Homozygous Variant in the MCOLN1 Gene Associated With Severe Oromandibular Dystonia and Parkinsonism.","authors":"Aida Ghasemi, Mahdieh Eslami Ardakani, Mansoureh Togha, Narges Yazdi, Anthony E Lang, Elahe Amini, Mohammad Rohani, Afagh Alavi","doi":"10.1017/cjn.2024.47","DOIUrl":"10.1017/cjn.2024.47","url":null,"abstract":"Background: Mucolipidosis type IV (MLIV) is a rare, progressive lysosomal storage disorder characterized by severe intellectual disability, delayed motor milestones and ophthalmologic abnormalities. MLIV is an autosomal recessive disease caused by mutations in the MCOLN1 gene, encoding mucolipin-1 which is responsible for maintaining lysosomal function.Objectives and methods: Here, we report a family of four Iranian siblings with cognitive decline, progressive visual and pyramidal disturbances, and abnormal movements manifested by severe oromandibular dystonia and parkinsonism. MRI scans of the brain demonstrated signal abnormalities in the white matter and thinning of the corpus callosum.Results and conclusions: Whole-exome sequencing identified a novel homozygous variant, c.362C > T:p. Thr121Met in the MCOLN1 gene consistent with a diagnosis of MLIV. The presentation of MLIV may overlap with a variety of other neurological diseases, and genetic analysis is an important strategy to clarify the diagnosis. This is an important point that clinicians should be familiar with. The novel variant c.362C > T:p. Thr121Met herein described may be related to a comparatively older age at onset. Our study also expands the clinical spectrum of MLIV associated with the MCOLN1 variants and introduces a novel likely pathogenic variant for testing in MLIV cases that remain unresolved.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"110-118"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Assessment of Sex and Gender Considerations in Migraine Calcitonin Gene-Related Peptide Clinical Trials. 偏头痛降钙素基因相关肽临床试验中性别和性别因素的评估。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2024-12-18 DOI: 10.1017/cjn.2024.361

Melissa S O'Brien, Jessica A J Dawe

{"title":"An Assessment of Sex and Gender Considerations in Migraine Calcitonin Gene-Related Peptide Clinical Trials.","authors":"Melissa S O'Brien, Jessica A J Dawe","doi":"10.1017/cjn.2024.361","DOIUrl":"10.1017/cjn.2024.361","url":null,"abstract":"Background: Published guidelines for conducting clinical trials for migraine therapeutics recommend recruiting participants based on disease epidemiology and including sex/gender-based subpopulation analyses. These recommendations aim to improve the quality and generalizability of migraine clinical trials. The aim of this study was to summarize participant demographics in migraine clinical trials for FDA-approved calcitonin gene-related peptide (CGRP)-targeting drugs (receptor antagonists [gepants], CGRP peptide or receptor monoclonal antibodies [mAbs]) and assess the use of sex/gender-based subpopulation analyses in these studies.Methods: We conducted a review of industry-sponsored migraine clinical trials for FDA-approved CGRP-targeting medications. Demographic data (sex and/or gender) from phase II or III trials were abstracted, and the use of sex/gender-based analyses was recorded.Results: Fourteen trials of gepants were included in this analysis. Participants who were identified as females or women were more likely to participate in these trials (87.0 ± 2.2%). Twenty-four trials of CGRP mAbs were reviewed. These studies also reported that participants were predominantly identified as female or women (84.9 ± 2.3%). None of the clinical trials reviewed reported sex/gender-based analyses of their results.Conclusions: This study suggests that men are underrepresented in migraine CGRP clinical trials. Greater attention to sex and gender is needed in migraine clinical trial design so that they better align with current recommendations made by headache societies and regulatory agencies.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-7"},"PeriodicalIF":2.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Variant in the SUOX Gene in the Oldest Individual with Late-Onset Isolated Sulfite Oxidase Deficiency. 最年长的晚发性孤立亚硫酸盐氧化酶缺乏症患者 SUOX 基因中的一个新变异。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2024-12-16 DOI: 10.1017/cjn.2024.360

Susanna Rizzi, Carlo Alberto Cesaroni, Carlotta Spagnoli, Anna Cavalli, Marzia Pollazzon, Stefano Giuseppe Caraffi, Claudia Dittadi, Daniele Frattini, Livia Garavelli, Carlo Fusco

引用次数: 0