{"title":"Serum oxidative stress is associated with the progression of knee osteoarthritis: A 5-year longitudinal cohort in the Yakumo study","authors":"Hiroaki Ido , Taisuke Seki , Yasuhiko Takegami , Yusuke Osawa , Hiroki Iida , Hiroaki Nakashima , Shinya Ishizuka , Yukiharu Hasegawa , Shiro Imagama","doi":"10.1016/j.knee.2025.05.023","DOIUrl":"10.1016/j.knee.2025.05.023","url":null,"abstract":"<div><h3>Introduction</h3><div>Knee osteoarthritis (KOA) is a chronic degenerative disease characterized by a reduction in joint cartilage in the in-knee joint. However, few reports have investigated the relationship between serum reactive oxygen species (ROS) and KOA. We aimed to investigate whether oxidative stress, assessed using d-ROM and biological antioxidant potential (BAP), is associated with the severity and progression of KOA in community-dwelling individuals.</div></div><div><h3>Method</h3><div>We enrolled 95 participants (190 knees) who participated in the Yakumo Study. We used a computer-aided diagnosis system for KOA to obtain the average joint space width (aJSW), minimal joint space width (mJSW), joint space area (JSA), and femorotibial angle; calculated the difference between JSW and JSA at 5 years and at baseline; and divided the study population into two groups based on median d-ROM and BAP values. Statistical analyses were conducted between the groups, including propensity score matching based on age, sex, body mass index, and medial mJSW at baseline between high d-ROMs (HD) and low d-ROMs (LD) groups.</div></div><div><h3>Results</h3><div>The median values for the lateral and medial mJSW, aJSW, and JSA were significantly narrower in the HD group than in the LD group. The medial mJSW, aJSW and JSA at the 5-year follow-up were significantly narrower in the HD group than those in the LD group.</div></div><div><h3>Conclusions</h3><div>Oxidative stress level was found to be associated with joint space narrowing and progression of joint space narrowing over the course of five years in clinical settings.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 323-331"},"PeriodicalIF":1.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-06-21DOI: 10.1016/j.knee.2025.05.036
Peter Larsen , Rasmus Elsoe
{"title":"Altered long-term patient-perceived outcome following lateral tibial plateau fractures – A matched register-based cohort study of 762 patients with a mean of 11 years of follow-up","authors":"Peter Larsen , Rasmus Elsoe","doi":"10.1016/j.knee.2025.05.036","DOIUrl":"10.1016/j.knee.2025.05.036","url":null,"abstract":"<div><h3>Background</h3><div>While several studies have examined lateral tibial plateau fracture (LTPF) outcomes, long-term follow-up data (exceeding 10 years) remain limited. We aim to compare the long-term patient-reported outcomes following LTPF to that of an age- and gender-matched group without an LTPF.</div></div><div><h3>Methods</h3><div>The study design was a national matched cohort study, including all patients admitted with an LTPF in Denmark between January 1, 1996, and December 31, 2017. The primary outcome measure was The Knee Injury Osteoarthritis Outcome Score (KOOS). The match group consisted of Danish citizens without LTPFs matched 1:10 to the LTPF group on age and gender.</div></div><div><h3>Results</h3><div>Total 1621 patients with a LTPF were included. Of these, 762 (47 %) responded to the survey invitation. The mean age of respondents was 61.5 years, and 65 % were women—the mean follow-up time since fracture was 11.2 years, ranging between 6.1 and 26.0 years. The match group was comprised of 16,210 citizens. Of these, 5050 (31 %) responded to the survey invitation. The mean age of respondents was 63.3 years, and 72 % were women. Patients with LTPFs reported significantly lower KOOS subscale scores compared to the match group. The differences in KOOS subscale scores ranged from a mean of 7.2 in activities of daily living (ADL) to 20.4 in sport and recreational activities (Sport/Rec).</div></div><div><h3>Conclusion</h3><div>Results suggested than LTPFs are associated with considerable long-term patients-perceived knee complaints compared to that of an age- and gender-matched population without a lateral tibial plateau fracture.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 317-322"},"PeriodicalIF":1.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-06-18DOI: 10.1016/j.knee.2025.05.033
Ahmed Mahmoud Gad, Mohamed Hussein Khalil
{"title":"Can tendon autograft function as a meniscal transplant?","authors":"Ahmed Mahmoud Gad, Mohamed Hussein Khalil","doi":"10.1016/j.knee.2025.05.033","DOIUrl":"10.1016/j.knee.2025.05.033","url":null,"abstract":"<div><h3>Background</h3><div>Various options have been advocated for the treatment of patients who developed post-meniscectomy symptoms, including meniscus allograft transplant (MAT), collagen meniscus implants, synthetic polymer meniscal implants, and tendon autografts. The aim of this study was to evaluate the functional outcomes after using the peroneus longus (PL) tendon autograft as meniscal transplantation in patients with knee joint line pain exacerbated by weight bearing following prior total or subtotal meniscectomy.</div></div><div><h3>Methods</h3><div>Twenty-five patients were treated using PL autograft as an alternative for meniscal transplantation between May 2022 and December 2022. Nineteen patients were male, and six patients were female. The medial meniscus was involved in 17 patients, while the lateral meniscus was affected in eight patients. All patients were followed up for at least 2 years following surgery. Functional outcomes were assessed using the Lysholm and Knee Injury and Osteoarthritis and Outcome (KOOS) scores preoperatively and at 2 years following surgery.</div></div><div><h3>Results</h3><div>A statistically significant improvement was found between preoperative and 2 years follow up values in terms of both the Lysholm and KOOS scores.</div></div><div><h3>Conclusions</h3><div>Meniscus transplantation using PL tendon autograft may be a successful treatment with satisfactory functional results for patients with post-meniscectomy symptoms following previous total or subtotal meniscectomy.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 309-316"},"PeriodicalIF":1.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simultaneous bilateral total knee arthroplasty may be safe in selected patients","authors":"Rajesh Malhotra , Deepak Gautam , Saurabh Gupta , Jaiben George","doi":"10.1016/j.knee.2025.05.024","DOIUrl":"10.1016/j.knee.2025.05.024","url":null,"abstract":"<div><h3>Background</h3><div>Simultaneous bilateral total knee arthroplasty (TKA) provides advantages in the form of single anaesthesia, lower cost, and faster overall rehabilitation for patients suffering from bilateral knee pathologies. However, there are concerns regarding the safety of performing simultaneous bilateral TKA. The present study was aimed at comparing the perioperative outcomes of patients undergoing simultaneous and staged bilateral TKA.</div></div><div><h3>Methods</h3><div>A total of 1696 patients (3392 knees) suffering from bilateral knee arthritis who either underwent a simultaneous (n = 1025) or staged TKA (n = 671) at a single institution were identified retrospectively from our institutional database. Major and minor complications within 90 days of the procedure were compared between simultaneous and staged procedures.</div></div><div><h3>Results</h3><div>Patients undergoing simultaneous surgery were younger (<em>P</em> < 0.001), had lower ASA score (<em>P</em> < 0.001), and had a lower number of comorbidities (<em>P</em> < 0.001). Overall, complications were comparable in both the groups (staged vs. simultaneous: 17.9% vs. 17.3%, <em>P</em> = 0.794). But after adjusting for the baseline differences, the simultaneous group had a higher risk of complications. When subgroup analysis was performed, in patients younger than 65 years simultaneous surgery did not increase the risk of complications while the risk was almost doubled in patients above 70 years.</div></div><div><h3>Conclusions</h3><div>Patients undergoing simultaneous bilateral surgery had an increased risk of complications especially when it was performed in patients over 70 years old. Bilateral simultaneous TKA may be safely performed in patients younger than 65 years. In those patients between 65 and 70 years, the slightly increased risk should be discussed with the patient if simultaneous surgery is being considered.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 302-308"},"PeriodicalIF":1.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-06-12DOI: 10.1016/j.knee.2025.05.019
Jae Ang Sim, Jehoon Sung, Byung Hoon Lee
{"title":"Tibial fixation in anterior cruciate ligament reconstruction using soft-tissue allograft: Cortical suspensory device versus aperture interference screw","authors":"Jae Ang Sim, Jehoon Sung, Byung Hoon Lee","doi":"10.1016/j.knee.2025.05.019","DOIUrl":"10.1016/j.knee.2025.05.019","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to compare clinical outcomes and tibial tunnel widening following anterior cruciate ligament reconstruction (ACLR) using allo-tibialis tendon performed with an all-inside technique (All-inside group) or an aperture fixation technique with a bioabsorbable screw (Aperture fixation group) for tibial side fixation.</div></div><div><h3>Methods</h3><div>A retrospective analysis of 36 patients between 2012 and 2022 was conducted. Patients who received a single-bundle anatomical ACLR with allo-tibialis tendon using suspensory femoral fixation were divided into two groups according to tibial fixation methods: adjustable suspensory fixative device or aperture fixation technique with a bioabsorbable screw.</div></div><div><h3>Results</h3><div>All-inside technique required a smaller skin incision (<5 mm) for tibial fixation. At postoperative 1-year radiographs, tunnel diameter showed no significant difference at the aperture level between both groups. More tunnel enlargement was observed in the All-inside group at the mid-substance level (<em>P</em> = 0.044). Postoperative 1-year MRI in the All-inside group showed a significantly larger cross-sectional area (CSA) at the aperture level than the mid-substance level (<em>P</em> = 0.003). CSA increments were larger in the All-inside group than the Aperture fixation group at insertion side and mid-substance level. No significant differences in clinical outcome measures were observed, including the Lysholm score, Tegner activity level. All-inside group showed higher failure cases and significantly lower rate of return to previous sports at postoperative 2-year follow up.</div></div><div><h3>Conclusions</h3><div>All-inside technique with soft allograft demonstrated cosmetic superiority and non-inferior clinical outcomes at the median 2-year follow up but showed larger tibial tunnel widening than aperture fixation technique with a bioabsorbable interference screw at the postoperative 1-year follow up.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 294-301"},"PeriodicalIF":1.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-06-11DOI: 10.1016/j.knee.2025.05.029
Ariana Lott, Jairo Triana, Carlos G. Sandoval, Vishal Sundaram, Guillem Gonzalez-Lomas, Michael J. Alaia, Laith M. Jazrawi, Eric J. Strauss, Kirk A. Campbell
{"title":"Donor-recipient sex mismatch does not affect graft survivorship after knee osteochondral allograft transplantation","authors":"Ariana Lott, Jairo Triana, Carlos G. Sandoval, Vishal Sundaram, Guillem Gonzalez-Lomas, Michael J. Alaia, Laith M. Jazrawi, Eric J. Strauss, Kirk A. Campbell","doi":"10.1016/j.knee.2025.05.029","DOIUrl":"10.1016/j.knee.2025.05.029","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to investigate the effect of donor-recipient sex-mismatch on graft survival, patient-reported outcomes (PROs), and return to sport (RTS) following knee osteochondral allograft (OCA) transplantation.</div></div><div><h3>Methods</h3><div>Patients who underwent knee OCA transplantation between 2011 and 2022 with minimum 2-year clinical follow-up were divided into two cohorts (same-sex (SS) and different-sex (DS) donor). Cumulative survival was compared via multivariable Cox regression analyses controlling for age, graft size, and body mass index (BMI). A sub-analysis comparing PROs between groups was performed, including the Visual Analog Scale (VAS) for pain and satisfaction, the Knee Injury and Osteoarthritis Outcome Score (KOOS), and RTS rates.</div></div><div><h3>Results</h3><div>285 patients were included (189 SS, 96 DS) with mean follow-up of 4.8 ± 2.0 years. There was a graft failure rate of 6.0% with no significant difference in graft survival rate between DS and SS groups (<em>p</em> = 0.70). Sub-analyses between the four donor-recipient groups (male-male, female-male, male–female, and female-female) and between female and male donor groups demonstrated no significant differences in graft survival. Among patients who failed the procedure, time to failure was significantly shorter for those with sex-mismatched grafts (353 days vs. 864 days, <em>p</em> = 0.002). Sub-analysis of a 71-patient cohort with two-year PROs demonstrated no differences between SS and DS groups with respect to satisfaction, pain, or KOOS scores after controlling for sex (<em>p</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>Patients undergoing knee OCA transplantation demonstrated no observable differences in graft survivorship based on donor-recipient graft sex-matching, suggesting that surgeons can use sex-mismatched grafts and expect limited effect on graft survivorship.</div><div><strong>Level of Evidence:</strong> IV.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 285-292"},"PeriodicalIF":1.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-06-11DOI: 10.1016/j.knee.2025.05.030
Alexander J. Nedopil , Stefano Ghirardelli , S.M. Howell , M.L. Hull
{"title":"Corrigendum to “Does the posterior tibial slope in caliper-verified unrestricted kinematically aligned TKA using manual instruments match the slope in the contralateral healthy knee and improve function?” [Knee 53 (2025) 62–68]","authors":"Alexander J. Nedopil , Stefano Ghirardelli , S.M. Howell , M.L. Hull","doi":"10.1016/j.knee.2025.05.030","DOIUrl":"10.1016/j.knee.2025.05.030","url":null,"abstract":"","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Page 293"},"PeriodicalIF":1.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-06-10DOI: 10.1016/j.knee.2025.05.035
V. Digennaro, D. Cecchin, E. Villari, A. Panciera, R. Ferri, L. Benvenuti, C. Faldini
{"title":"Distribution of knee alignment in the Italian arthritic population based on the CPAK classification","authors":"V. Digennaro, D. Cecchin, E. Villari, A. Panciera, R. Ferri, L. Benvenuti, C. Faldini","doi":"10.1016/j.knee.2025.05.035","DOIUrl":"10.1016/j.knee.2025.05.035","url":null,"abstract":"<div><h3>Purpose</h3><div>The CPAK classification categorizes coronal knee alignment matching the arithmetic hip-knee-ankle angle and joint line obliquity. While several studies have evaluated alignment variability in different populations, no data exist for the Italian population. This study aims to assess the distribution of CPAK classification in Italian patients undergoing TKA for osteoarthritis, with secondary objectives exploring gender differences and correlations with anthropometric parameters.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 978 consecutive patients who underwent total knee arthroplasty or unicompartmental knee arthroplasty between May 2016 and April 2024. After excluding 284 patients, 620 patients were included in the study. Mechanical hip-knee-angle, Lateral Distal Femur Ange and Medial Proximal Tibial Angle were measured on long leg radiograph. Arithmetic HKA and Joint Line Obliquity were than calculated and patients were divided into the 9 phenotypes of the CPAK classification.</div></div><div><h3>Results</h3><div>A total of 620 patients were evaluated: The mean age was 69.3 years. The mean BMI was 28.51. The mean mHKA was −4,63 (SD = 8,19) while the mean aHKA was −0.84° (SD = 5). The mean JLO was 174,18° (SD = 4.58). The three most frequent CPAK phenotypes were I (186; 30%), II (147; 23,7%), and III (126; 20,3%), indicating a prevalence of apex distal joint line obliquity. The most common alignment was varus. Female patients showed a greater tendency for valgus alignment (24,4%) compared to males (13%). No correlation was found between anthropometric parameters and alignment.</div></div><div><h3>Conclusion</h3><div>The CPAK classification distribution in the Italian osteoarthritic population is consistent to that reported in the literature.</div><div><strong>Level of evidence</strong> Level III.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 276-284"},"PeriodicalIF":1.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-06-09DOI: 10.1016/j.knee.2025.05.027
Marta Santolini , Jaqueline Lourdes Rios , Roel J.H. Custers , Laura B. Creemers , Jasmijn V. Korpershoek
{"title":"Mesenchymal stromal cell injections for osteoarthritis: In vitro mechanisms of action and clinical evidence","authors":"Marta Santolini , Jaqueline Lourdes Rios , Roel J.H. Custers , Laura B. Creemers , Jasmijn V. Korpershoek","doi":"10.1016/j.knee.2025.05.027","DOIUrl":"10.1016/j.knee.2025.05.027","url":null,"abstract":"<div><h3>Purpose</h3><div>Existing osteoarthritis treatments are primarily symptomatic, with limited efficacy in modifying the disease’s progression. Mesenchymal stromal cells (MSCs) hold promise due to their multilineage potency, immunomodulation, and pain regulation. This narrative review summarizes the preclinical evidence of different mechanisms of action of MSCs in osteoarthritis treatment. In addition, the clinical evidence supporting these mechanisms is reviewed.</div></div><div><h3>Results</h3><div>In vitro evidence of MSC differentiation is extensive, while direct confirmation of in vivo differentiation remains scarcer, and no direct clinical evidence exists. The chondro-inductive effect of MSCs is demonstrated in vitro in co-culture with chondrocytes and chondrons. Clinically, treatment of cartilage defects with chondrons and MSCs results in cartilage formation in the absence of (differentiated) MSCs in the final repair tissue, suggesting a chondro-inductive role of the MSCs. MSCs reduce pro-inflammatory cytokine production and promote an anti-inflammatory environment in vitro and in vivo, although the few clinical reports of immunomodulation are limited to short-term outcomes. MSCs directly interact with pain mediators, such as substance P and CGRP, leading to reduced pain signalling in vitro. Clinical studies consistently demonstrate decrease in pain, but this effect does not always exceed that of placebo controls.</div></div><div><h3>Conclusions</h3><div>Despite promising outcomes in vitro, the disease modifying potential of MSCs in treatment of degenerative joint disease is currently not demonstrated unambiguously in clinical trials. Future clinical trials should aim not only at demonstrating clinical effect, but also aligning clinical outcomes with mechanisms of action.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 267-275"},"PeriodicalIF":1.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-term outcomes, satisfaction, and survival rates of a medial pivot knee design","authors":"Matteo Innocenti, Filippo Leggieri, Alessandro Civinini, Fernando Nahuel Martín Cocilova, Davide Stimolo, Roberto Civinini","doi":"10.1016/j.knee.2025.05.020","DOIUrl":"10.1016/j.knee.2025.05.020","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to evaluate the long-term clinical outcomes, satisfaction, perceived joint stability, and survival rates following medial pivot TKA.</div></div><div><h3>Methods</h3><div>Data from TKAs performed at a single institution between 2008 and 2014 were retrospectively reviewed. Patients without consent were excluded. Inclusion: medial pivot TKA surgery. All patients received the same cemented Microport Advanced® and Evolution® Medial Pivot Knee System. Data collection comprised clinical and radiological outcomes, time of failure and/or death, surgical techniques (measured resection (MR) femur first technique following mechanical alignment principles vs. gap balancing (GB) tibia first technique preserving preoperative varus deformity up to 4°). Kaplan–Meier survival analysis compared survival between surgical techniques. Logistic regression evaluated surgical technique as a predictor for revision status. Risk analysis calculated relative and absolute risk differences between surgical techniques.</div></div><div><h3>Results</h3><div>Of the 137 patients included in the final analysis, there were 24 deaths (17.5%), 15 lost to follow up (10.9%), four revisions (2.9%). The final follow up was obtained for 94 patients (68.6%) without revision. The mean survival was 16.14 years (95% CI: 15.96–16.32; standard error = 0.93) at the final follow up with a median of 11.32 years (IQR, 9.57–14.04). The Kaplan–Meier/Mantel–Cox indicated no difference in survival between MR and GB (Chi-squared = 0.02, <em>P</em> = 0.876). No other predictors for revision were found (CPAK (<em>P</em> = 0.78), aHKA (<em>P</em> = 0.55), MPTA (<em>P</em> = 0.73)). Nine (6.6%) patients stated that they were not satisfied with no difference for surgical technique (Chi-squared = 0.59, <em>P</em> = 0.824).</div></div><div><h3>Conclusions</h3><div>The overall mean survival time was estimated to be 16.14 years with 97% survival rate.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 258-266"},"PeriodicalIF":1.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}