Knee最新文献

{"title":"Quantifying performance and joint kinematics in functional tasks crucial for anterior cruciate ligament rehabilitation using smartphone video and pose detection","authors":"Nicolas Lambricht ,&nbsp;Alexandre Englebert ,&nbsp;Laurent Pitance ,&nbsp;Paul Fisette ,&nbsp;Christine Detrembleur","doi":"10.1016/j.knee.2024.11.006","DOIUrl":"10.1016/j.knee.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>The assessment of performance during functional tasks and the quality of movement execution are crucial metrics in the rehabilitation of patients with anterior cruciate ligament (ACL) injuries. While measuring performance is feasible in clinical practice, quantifying joint kinematics poses greater challenges. The aim of this study was to investigate whether smartphone video, using deep neural networks for human pose detection, can enable the clinicians not only to measure performance in functional tasks but also to assess joint kinematics.</div></div><div><h3>Methods</h3><div>Twelve healthy participants performed the forward reach of the Star Excursion Balance Test 10 times, along with 10 repetitions of forward jumps and vertical jumps, with simultaneous motion capture via a marker-based reference system and a smartphone. OpenPifPaf was utilized for markerless detection of anatomical landmarks in video recordings. The OpenPifPaf coordinates were scaled using anthropometric data of the thigh, and task performance and joint kinematics were computed for both the marker-based and markerless systems.</div></div><div><h3>Results</h3><div>Comparing results for marker-based and markerless systems revealed similar joint angles, with mean root mean square errors of 2.8° for the knee, 3.1° for the hip, and 3.9° for the ankle. Excellent agreement was observed for clinically pertinent parameters, i.e., the performance, the peak knee flexion, and the knee range of motion (intraclass correlation coefficient &gt; 0.97).</div></div><div><h3>Conclusion</h3><div>The results underscore the feasibility of using markerless methods based on OpenPifPaf for assessing performance and joint kinematics in functional tasks crucial for ACL patients’ rehabilitation. The simplicity of this approach makes it suitable for integration into clinical practice.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"52 ","pages":"Pages 171-178"},"PeriodicalIF":1.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPECT-CT may aid in determining which side of a revision stemmed implant problematic total knee replacement is loose when planning revision surgery","authors":"Daniel Hill,&nbsp;Patrick Rogers,&nbsp;Jonathan Phillips,&nbsp;Ben Waterson,&nbsp;Andrew D. Toms","doi":"10.1016/j.knee.2024.10.016","DOIUrl":"10.1016/j.knee.2024.10.016","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate SPECT-CT in the diagnosis of single component aseptic loosening in patients with a problematic cemented stemmed TKR (Total Knee Replacement).</div></div><div><h3>Methods</h3><div>SPECT-CT was performed where aseptic loosening was suspected but was not clear on plain radiography. Demographics, suspected diagnosis and intention to revise were collected prospectively before and after SPECT-CT.</div></div><div><h3>Results</h3><div>30 patients were investigated. 43% (95% CI: 0.5–0.9) had clear evidence of loosening on SPECT-CT. In 23% (95% CI: 0.1–0.4) intention to perform revision surgery following SPECT-CT changed (7/30) (<em>p</em> = 0.0004, standard error = 42.1, <em>z</em> = 3.5).</div><div>Intentions to perform revision surgery according to the radiologist’s overall summary were:</div><div>Normal SPECT-CT – 0% (95% CI: 0.0–0.8) intention to revise (0/2).</div><div>Possibly abnormal SPECT-CT – 13% (95% CI: 0.0–0.4) intention to revise (2/15).</div><div>Definitely abnormal SPECT-CT – 77% (95% CI: 0.5–0.9) intention to revise (10/13).</div><div>We report that SPECT-CT had a test sensitivity of 90.9% (95% CI: 0.6–1.0), a specificity of 100% (95% CI: 0.9–1.0), a positive predictive value of 100% and a negative predictive value of 97.7%.</div><div>In 70% (95% CI: 0.3–0.9) of cases where revision surgery was performed for aseptic loosening SPECT-CT provided information that guided pre-operative planning with regards single component or both component revision surgery (7/10).</div></div><div><h3>CONCLUSION</h3><div>When positive SPECT-CT was useful in determining single component revision. A normal SPECT-CT may have a negative predictive value; however, overall half of our series had a possibly abnormal or equivocal investigation.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"52 ","pages":"Pages 179-194"},"PeriodicalIF":1.6,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The third gap – The forgotten space in total knee arthroplasty","authors":"William Brown ,&nbsp;Nicola Gallagher ,&nbsp;Dai Roberts ,&nbsp;Richard Napier ,&nbsp;David Barrett ,&nbsp;David Beverland","doi":"10.1016/j.knee.2024.10.011","DOIUrl":"10.1016/j.knee.2024.10.011","url":null,"abstract":"<div><h3>Aims</h3><div>Total Knee Arthroplasty (TKA) aims to leave the proximal flange of the femoral component flush with the femoral cortex. Manually, the requisite plane is found using the anterior femoral cortex or the intramedullary canal, whereas navigation uses hip and knee centre. Presently, no system prioritises restoration of the third space or native trochlear groove height (TGH) and there is a deficiency of published data on the variation of TGH with respect to the anterior cortex. This study aims to address this deficit. Hypothetically, restoration of the third space occurs when trochlear component depth equals TGH.</div></div><div><h3>Materials and Methods</h3><div>Relative to the posterior femoral axis the height of the anterior femoral cortex is higher laterally than centrally. For simplicity, this study reports MRI measurements of TGH relative to the centre in 110 normal subjects.</div></div><div><h3>Results</h3><div>TGH varied from the anterior femoral cortex by a mean of 2.32 mm (standard deviation, SD 1.77 mm, range −1.50 mm to 6.80 mm). If a femoral component trochlear depth of 2.2 mm is assumed, then 24.5% would be either over- or understuffed by more than 2 mm.</div></div><div><h3>Conclusion</h3><div>There is significant variation in TGH relative to the anterior femoral cortex. Assuming a femoral component trochlear depth of 2.2 mm, approximately one quarter of patients (24.5%) will be over- or understuffed by more than 2 mm. Variation in femoral component flexion and extension combined with whether or not it is left proud or notched will add further variation. Failure to restore the third space is likely to contribute to unsatisfactory results following TKA. Future surgical workflows should address this.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"52 ","pages":"Pages 164-170"},"PeriodicalIF":1.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-steroidal anti-inflammatory drugs influence cartilage healing","authors":"Asma Sajjad Khawaja ,&nbsp;Maria Zafar ,&nbsp;Rana Muhammad Zeeshan ,&nbsp;Muhammad Saad Ilyas ,&nbsp;Amer Aziz ,&nbsp;Uruj Zehra","doi":"10.1016/j.knee.2024.10.021","DOIUrl":"10.1016/j.knee.2024.10.021","url":null,"abstract":"<div><h3>Background</h3><div>Retrograde intramedullary nailing is commonly performed to stabilize distal femoral shaft fractures which may lead to iatrogenic injuries of the knee articular cartilage. The limited regenerative capability of cartilage may further be hindered by intake of non-steroidal anti-inflammatory drugs (NSAIDs) which are usually advised for injuries of the musculoskeletal system. The current study was designed to evaluate the histological changes in the femoral articular cartilage of knee joint after retrograde femoral nailing of rats.</div></div><div><h3>Methods</h3><div>Retrograde intramedullary nailing was performed in 36 adult male Wistar rats, divided into three groups of 12 each. Groups 1 and 2 were given nonselective and selective COX 2 inhibitors, respectively, while the third group was taken as control. Half of the animals from each group were sacrificed at the second week, and remainder on the seventh week, and samples of the femoral articular cartilage were assessed for cartilage regeneration according to the modified Mankin scoring on histology while BMP-2 expression was evaluated on immunohistochemistry.</div></div><div><h3>Results</h3><div>Mean modified Mankin scores for cartilage degradation were increased in animals taking NSAIDs at the second and seventh weeks of healing (<em>P</em> = 0.02, <em>P</em> &lt; 0.001 respectively). There was a significant decrease in chondrocytes at the second week (<em>P</em> = 0.001), along with the loss of proteoglycan content in these animals at both time points (<em>P</em> = 0.001). The BMP-2 expression was significantly enhanced in the control group at the second (<em>P</em> = 0.001) and seventh weeks (<em>P</em> = 0.001).</div></div><div><h3>Conclusion</h3><div>The results reveal that intake of NSAIDs hinders the process of cartilage healing by reducing the number of chondrocytes and loss of proteoglycan content and decreased expression of BMP-2.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"52 ","pages":"Pages 121-130"},"PeriodicalIF":1.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional models demonstrate differences in correction depending on femoral derotational osteotomy site and may enhance the planning and precision in femoral derotational osteotomy – An observational study in eight femora and two surgeons","authors":"Caterina Chiappe ,&nbsp;Alejandro Roselló-Añón ,&nbsp;Vicente Sanchis-Alfonso ,&nbsp;Joan Carles Monllau ,&nbsp;Julio Domenech-Fernández","doi":"10.1016/j.knee.2024.10.023","DOIUrl":"10.1016/j.knee.2024.10.023","url":null,"abstract":"<div><h3>Background</h3><div>Increased femoral anteversion (FAV) is crucial in the genesis of anterior knee pain (AKP) and a femoral derotational osteotomy (FDO) has demonstrated good clinical results. It remains unclear at what level of the femur the osteotomy should be performed. Resulting degrees of FAV measured by Murphy’s method do not always correspond to the degrees that had been planned after an FDO. The hypothesis of this study is that the femur rotation axis and the osteotomy rotation axis do not coincide. Three-dimensional (3D) technology is used to objectify the discrepancy between these two axes and to find solutions so that the two axes can coincide. The objective is to demonstrate the reliability and reproducibility of the 3D technique for osteotomy adjustment through an intraobserver and interobserver study.</div></div><div><h3>Methods</h3><div>Images of eight computed tomography scans of the femur, corresponding to seven patients with a diagnosis of AKP and increased FAV, were selected. Two surgeons performed the FAV measurement and simulation of FDO on 3D biomodels. The femoral osteotomies were defined at three levels, at 10°, 20°, 30°. To determine interobserver agreement, measurements were performed independently by two surgeons. To evaluate intraobserver differences each surgeon repeated all measurements after 15 days.</div></div><div><h3>Results</h3><div>Interobserver and intraobserver agreement: intraclass correlation coefficient 0.930 (95% confidence interval (CI) 0.799–0.975) and 0.986 (95% CI 0.959–0.995). Significant differences between the resulting values were observed when the osteotomy was performed at the intertrochanteric level.</div></div><div><h3>Conclusions</h3><div>The misalignment of the axes results in hypocorrection when the osteotomy is intertrochanteric. This phenomenon is not observed when the osteotomy is diaphyseal or supracondylar.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"52 ","pages":"Pages 131-138"},"PeriodicalIF":1.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical differences of Asian knee osteoarthritis patients during standing and walking using statistical parametric mapping: A cross-sectional study","authors":"Yi Hu ,&nbsp;Phillis Teng ,&nbsp;Tsung-Lin Wu ,&nbsp;Ross Clark ,&nbsp;Yong-Hao Pua ,&nbsp;Oliver Roberts ,&nbsp;Jia Wei Yong ,&nbsp;Amr Alhossary ,&nbsp;Lek Syn Lim ,&nbsp;Desmond Y.R. Chong ,&nbsp;Wei Tech Ang ,&nbsp;Bryan Yijia Tan","doi":"10.1016/j.knee.2024.10.022","DOIUrl":"10.1016/j.knee.2024.10.022","url":null,"abstract":"<div><h3>Background</h3><div>Biomechanics of knee osteoarthritis (KOA) patients have been extensively studied using motion capture systems, but less have explored standing knee joint angles with the walking parameters, particularly in Asians. We aim to determine gait biomechanical differences between healthy and KOA participants in an Asian population using One-dimensional Statistical Parametric Mapping (SPM1D) and explore if they are associated with standing joint angles.</div></div><div><h3>Methods</h3><div>A total of 20 KOA and 24 healthy stood upright and walked 10 m at self-selected speeds. The standing angles, walking kinematic and kinetic parameters of the ankle, knee, hip and trunk were analysed. Lower limb muscle excitation was measured via electromyography. SPM1D was used to compare the healthy group with the KOA group, and for further subgroup analysis.</div></div><div><h3>Results</h3><div>The all KOA group had significantly greater standing knee flexion angles (KFA) (<em>p</em> &lt; 0.001), standing ankle dorsiflexion angles (ADA) (<em>p</em> &lt; 0.001), walking KFA during terminal stance (<em>p</em> = 0.001) and terminal swing (<em>p</em> = 0.02) and walking ADA during terminal stance (<em>p</em> = 0.02) and mid-swing to terminal swing (<em>p</em> = 0.001). Knee adduction moment (<em>p</em> = 0.04) and knee flexion moment (<em>p</em> = 0.03) were higher in severe KOA. A positive correlation was found between standing KFA and initial KFA (<em>R</em>² = 0.579), and mean walking KFA (<em>R</em>² = 0.801) in the KOA group.</div></div><div><h3>Conclusion</h3><div>The increase in standing KFA was associated with an increase in walking KFA in the KOA group. Static joint angles remain as an essential parameter, although further studies need to be carried out to determine if the increase in standing joint angles can be recommended as an adjunctive measure during gait analysis of KOA using motion capture.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"52 ","pages":"Pages 155-163"},"PeriodicalIF":1.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients submitted to re-revision ACL reconstruction present more knee laxity, more complications, and a higher failure rate than patients submitted to the first revision ACL reconstruction","authors":"Camilo Partezani Helito ,&nbsp;Andre Giardino Moreira da Silva ,&nbsp;Riccardo Cristiani ,&nbsp;Anders Stålman ,&nbsp;Vitor Barion Castro de Pádua ,&nbsp;Riccardo Gomes Gobbi ,&nbsp;José Ricardo Pécora","doi":"10.1016/j.knee.2024.11.004","DOIUrl":"10.1016/j.knee.2024.11.004","url":null,"abstract":"<div><h3>Background</h3><div>Few comparative studies have evaluated patients who underwent two revision anterior cruciate ligament reconstruction (ACLR) and patients who underwent one revision ACLR, and many of them have a short postoperative follow-up and a relatively small number of patients. The objective of this study is to evaluate the functional results, complications, and failure rates of patients who underwent one revision ACLR and patients who underwent two revision ACLRs.</div></div><div><h3>Methods</h3><div>This is a retrospective study comparing patients who underwent one revision ACLR (Group 1) with patients who underwent a re-revision ACLR (Group 2). Baseline demographic variables, operative data and post-operative data were evaluated.</div></div><div><h3>Results</h3><div>Among the 266 patients included, 226 were from Group 1 and 40 from Group 2. Patients in Group 2 had greater rotatory laxity and were more often subjected to associated osteotomy at the time of revision surgery. Postoperatively, patients from Group 2 reported poorer subjective IKDC score and showed greater knee laxity measured with the KT-1000 arthrometer, although both probably not clinically relevant. The complication rate was high in both groups, with a higher incidence in Group 2. Reconstruction failures were also higher in Group 2 (20% vs. 8.8%, <em>p</em> = 0.03).</div></div><div><h3>Conclusion</h3><div>Patients from Group 2 underwent a higher rate of associated osteotomy procedures, present higher complication rates and a higher failure rate compared with patients from Group 1. However, the functional scores (Lysholm and IKDC score) and the physical examination (KT-1000 and pivot-shift) did not show clinically relevant differences between the groups.</div></div><div><h3>Level of Evidence</h3><div>III, retrospective comparative therapeutic trial.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"52 ","pages":"Pages 147-154"},"PeriodicalIF":1.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patellar tendon–Hoffa fat pad interface: From anatomy to high-resolution ultrasound imaging","authors":"Vincenzo Ricci ,&nbsp;Giulio Cocco ,&nbsp;Kamal Mezian ,&nbsp;Ke-Vin Chang ,&nbsp;Jorge Barbosa ,&nbsp;Ondřej Naňka ,&nbsp;Levent Özçakar","doi":"10.1016/j.knee.2024.10.024","DOIUrl":"10.1016/j.knee.2024.10.024","url":null,"abstract":"<div><h3>Aim</h3><div>To propose a standardized, high-resolution ultrasound (US) protocol to assess the patellar tendon–Hoffa fat pad interface (PTHFPI) in patients with (proximal) patellar tendinopathy (PPT).</div></div><div><h3>Methods</h3><div>Using a high-frequency transducer and a high-level machine, we matched the cadaveric and histological microarchitecture of the PTHFPI with multiple sonographic patterns of patients with PPT. Likewise, high-sensitive color/power Doppler assessments were also performed to evaluate the microcirculation of the soft tissues beneath the patellar tendon.</div></div><div><h3>Results</h3><div>Modern US equipment allows for detailed assessment of the potential pain generators located inside the PTHFPI in patients with PPT. They include anterosuperior portion of the Hoffa body and the loose connective tissue of the deep paratenon with its microvascular plexus.</div></div><div><h3>Conclusions</h3><div>In patients with PPT, accurate sonographic assessment of the PTHFPI can be performed using adequate technological equipment. Accordingly, tailored ultrasound-guided interventions can also be planned if/when clinically indicated.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"52 ","pages":"Pages 139-146"},"PeriodicalIF":1.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of frontal plane osteotomy angle on lateral cortex fracture in medial open wedge high tibial osteotomy procedure","authors":"Alper Kirilmaz ,&nbsp;Mustafa Özkaya ,&nbsp;Turgut Emre Erdem ,&nbsp;Faik Türkmen","doi":"10.1016/j.knee.2024.10.007","DOIUrl":"10.1016/j.knee.2024.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Precise high tibial osteotomy is crucial, especially for middle-aged individuals with medial compartment arthritis, aiming to prevent complications like lateral cortex fractures. This study explores how frontal plane osteotomy inclination impacts lateral cortex fractures during medial open-wedge high tibial osteotomy.</div></div><div><h3>Methods</h3><div>Using finite element analysis, tibia models underwent osteotomies at angles of 10°, 13°, 16°, 19°, and 22°, forming five models. Forces from 5 N to 75 N were applied incrementally, recording bone stresses (MPa) at the lateral hinge, angle changes (°) along the osteotomy line, and gap distances (mm).</div></div><div><h3>Results</h3><div>Models with higher frontal inclination showed increased gap distances under identical forces. For instance, at 5 N force, the 10° inclination model displayed a correction angle of 0.28° and a 1.43 mm gap, while the 22° model had a correction angle of 0.35° and a 1.37 mm gap. Under 75 N force, the 10° model had a correction angle of 10.81° and a 14.02 mm gap, while the 22° model had a correction angle of 16.86° and a 19.31 mm gap.</div></div><div><h3>Conclusion</h3><div>The osteotomy starting point’s distance from the joint doesn’t significantly impact final stress on the lateral cortex when the same gap distance is achieved. However, in cases requiring a higher degree of correction, we can say that the surgeon can achieve the result with less resistance by keeping the osteotomy starting point more distal to the joint line.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"52 ","pages":"Pages 108-120"},"PeriodicalIF":1.6,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of different types of physical activity on the risk of knee osteoarthritis: A Mendelian randomization study","authors":"Guiguan Wang ,&nbsp;Long Chen ,&nbsp;Yancheng Chen ,&nbsp;Jie Xu","doi":"10.1016/j.knee.2024.10.019","DOIUrl":"10.1016/j.knee.2024.10.019","url":null,"abstract":"<div><h3>Background</h3><div>We aim to evaluate the causal relationship between different types of physical activity and the risk of knee osteoarthritis (KOA) through a two-sample Mendelian randomization study.</div></div><div><h3>Methods</h3><div>We performed a two-sample Mendelian randomization analysis using publicly available Genome-wide association study associated with physical activity (460 376 individuals) and KOA (403 124 individuals). Two-sample Mendelian randomization analyses were performed to investigate the effects of exposure traits on KOA risk.</div></div><div><h3>Results</h3><div>In this Mendelian randomization analysis, we investigated the impact of different types of physical activity on the risk of KOA. Light do-it-yourself and walking for pleasure demonstrated a protective effect on the risk of KOA (P = 8.19 × 10−4 and P = 4.24 × 10−6, respectively). No statistically significant differences were observed for heavy do-it-yourself, strenuous sports, other exercises or physical inactivity.</div></div><div><h3>Conclusion</h3><div>This study has revealed that engaging in light do-it-yourself activities and walking may serve as potential protective factors against KOA. These findings underscore the significance of introducing such activities into public health strategies designed for the prevention and management of KOA. Additional research is warranted to reveal the underlying mechanisms further.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"52 ","pages":"Pages 90-98"},"PeriodicalIF":1.6,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}