Knee最新文献

{"title":"Vastus medialis onset activation in patients who underwent medial patellofemoral ligament reconstruction with and without tibial tubercular osteotomy","authors":"Kensuke Oba ,&nbsp;Ryosuke Ono ,&nbsp;Moeka Ota ,&nbsp;Shohei Fujioka ,&nbsp;Takuya Kato ,&nbsp;Yoshinari Sakaki ,&nbsp;Kazuhiro Sasaki ,&nbsp;Hideji Kura","doi":"10.1016/j.knee.2025.05.009","DOIUrl":"10.1016/j.knee.2025.05.009","url":null,"abstract":"<div><h3>Background</h3><div>Medial patellofemoral ligament reconstruction (MPFLR) and tibial tubercular osteotomy (TTO) are common surgical treatments for patellar dislocation. However, the impact of isolated MPFLR and MPFLR combined with TTO (MPFLR+TTO) on vastus medialis oblique (VMO) onset activation remains unclear. This study investigated the VMO onset activation relative to the vastus lateralis (VL) among patients undergoing isolated MPFLR, MPFLR+TTO, and healthy controls during maximum voluntary isometric knee extension.</div></div><div><h3>Methods</h3><div>This study included 25 patients who underwent MPFLR, divided into two groups: isolated MPFLR (n = 12, age: 22.6 ± 11.9, follow-up time: 24.0 ± 16.8 months) and MPFLR+TTO (n = 15, age: 28.2 ± 12.8, follow-up time: 25.2 ± 15.6 months). A control group of 11 healthy adults (22 knees, age: 28.4 ± 1.3) was also included. Electromyographic (EMG) activities of the VMO and VL muscles were recorded during maximal voluntary isometric knee extensions at 30°, 60°, and 90° of flexion. Differences in VMO onset activation relative to VL (VMO-VL) were analyzed.</div></div><div><h3>Results</h3><div>At 30° knee flexion, the MPFLR group showed a significant delay in VMO activation compared to healthy controls (<em>p</em> &lt; 0.001). In contrast, the MPFLR+TTO group exhibited no significant differences in VMO activation relative to healthy controls. No significant differences were observed at 60° and 90° flexion among all groups.</div></div><div><h3>Conclusion</h3><div>Isolated MPFLR delayed VMO activation relative to VL. In contrast, MPFLR+TTO balanced the onset activation between VMO and VL. These findings highlight the need for targeted rehabilitation programs to address delayed VMO activation in patients undergoing isolated MPFLR.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imageless handheld robotic-assisted total knee arthroplasty showed better clinical outcomes than conventional total knee arthroplasty: A randomized controlled trial with preliminary results at 1-year follow up","authors":"Peter Bollars ,&nbsp;Dinesh Nathwani ,&nbsp;Ali Albelooshi ,&nbsp;Max Ettinger ,&nbsp;Frank Verheyden ,&nbsp;Jan Mievis ,&nbsp;Prashant Meshram ,&nbsp;Martijn Schotanus","doi":"10.1016/j.knee.2025.05.028","DOIUrl":"10.1016/j.knee.2025.05.028","url":null,"abstract":"<div><h3>Background</h3><div>Robotic-assisted total knee arthroplasty (RATKA) has been shown to achieve more accurate functional implant alignment than conventional instrumented TKA (CTKA). The aim of this randomized controlled trial was to assess differences in operative, clinical and functional outcome of RATKA compared with CTKA.</div></div><div><h3>Methods</h3><div>A total of 180 patients with osteoarthritis were included and randomized. Preoperative and 3- and 12-months postoperative patient-reported outcome measures (PROMs) and rate of serious adverse events (SAEs), requirement for ligament releases and implant sizes were compared.</div></div><div><h3>Results</h3><div>The preoperative baseline variables were not statistically different between RATKA and CTKA groups thus they were well matched. At 12 months follow up, RATKA had significantly better Oxford Knee Score (42.4 ± 5.4 vs. 38.7 ± 7.2, <em>P</em> &lt; 0.001), KSS^function (81.2 ± 12.3 vs. 72.7 ± 15.1, <em>P</em> &lt; 0.001), KSS^satisfaction (34.9 ± 5.2 vs. 31.2 ± 7.9, <em>P</em> &lt; 0.001), EQ5D^index (0.883 ± 0.141 vs. 0.833 ± 0.144, <em>P</em> &lt; 0.001), VAS pain^day (10.5 ± 12.5 vs. 21.5 ± 19.4, <em>P</em> &lt; 0.001), and VAS pain^night (8.1 ± 11.3 vs. 18.9 ± 19.5, <em>P</em> = 0.029), Patient satisfaction (93.2 ± 8.3 vs. 79.8 ± 20.3, <em>P</em> &lt; 0.001) and FJS-12 (73.2 ± 23.3 vs. 53.6 ± 29.0, <em>P</em> &lt; 0.001) as compared with the CTKA group. The proportion of patients in the RATKA group requiring ligament release was lower (six (7%) vs. 45 (50%), <em>P</em> &lt; 0.001) and those requiring a polyethylene thickness ≤ 10 (55 (62%) vs. 36 (40%), <em>P</em> &lt; 0.004). There was no difference in the rate of SAEs between the two groups.</div></div><div><h3>Conclusion</h3><div>This randomized controlled trial found significantly higher PROMs in patients undergoing RATKA with no difference in SAEs as compared with CTKA. RATKA technology also showed reduced requirement for ligament release and smaller polyethylene sizes.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 232-240"},"PeriodicalIF":1.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT delivers satisfactory responses to the most frequent questions on meniscus surgery","authors":"Felix Winden,&nbsp;Markus Bormann,&nbsp;Fabian Gilbert,&nbsp;Boris M. Holzapfel,&nbsp;Daniel P. Berthold","doi":"10.1016/j.knee.2025.05.018","DOIUrl":"10.1016/j.knee.2025.05.018","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine ChatGPT’s effectiveness in responding to common patient questions related to meniscus surgery, including procedures such as meniscus repair and meniscectomy.</div></div><div><h3>Methods</h3><div>We identified 20 frequently asked questions (FAQs) about meniscus surgery from major orthopedic institutions recommended by ChatGPT, which were then refined by two authors into 10 questions commonly encountered in the outpatient setting. These questions were posted to ChatGPT. Answers were evaluated using a scoring system to assess accuracy and clarity and were rated as “excellent answer requires no clarification,” “satisfactory requires minimal clarification,” “satisfactory requires moderate clarification,” or “unsatisfactory requires substantial clarification.”</div></div><div><h3>Results</h3><div>Four responses were excellent, requiring no clarification, four responses were satisfactory, requiring minimal clarification, two were satisfactory, requiring moderate clarification, none of the answers were unsatisfactory.</div></div><div><h3>Conclusion</h3><div>As hypothesized, ChatGPT provides satisfactory and reliable information for frequently asked questions about meniscus surgery.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 249-257"},"PeriodicalIF":1.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards streamlining orthopedic consultations: Machine learning classification of knee diagnosis groups via computer-assisted history taking","authors":"Jacobien H.F. Oosterhoff ,&nbsp;Twan Slaats ,&nbsp;Tristan Warren ,&nbsp;Walter van der Weegen","doi":"10.1016/j.knee.2025.05.017","DOIUrl":"10.1016/j.knee.2025.05.017","url":null,"abstract":"<div><h3>Background</h3><div>The number of patients suffering from knee complaints is increasing, leading to increased orthopedic healthcare consumption. Predicting knee diagnoses prior to consultation may be valuable in optimizing the consultation workflow. Therefore, the purpose of this study was to develop and internally validate a machine learning (ML) algorithm for predicting a knee diagnosis group for patients aged 18 years and older, based on computer-assisted history taking.</div></div><div><h3>Methods</h3><div>A prospective cohort study at a single general district hospital was conducted to identify patients referred to an orthopedic surgeon for knee complaints. In total, 1172 patients were included, with an average age of 54 years (interquartile range 36–66), of which the majority were female (<em>n</em> = 594, 50.7%). The most frequent diagnosis group was knee osteoarthritis (<em>n</em> = 775, 66.1%), followed by ligamentous injuries (<em>n</em> = 208, 17.7%) and otherwise classified (<em>n</em> = 189, 16.1%). First, the dataset was randomly split 80:20 into training and test subsets. Then, a random forest algorithm was used to identify the variables predictive of a knee diagnosis group. Five different ML algorithms were developed, internally validated, and assessed by discrimination (area under the receiver operating characteristic curve, AUC), accuracy, precision (positive predictive value), recall (sensitivity), and F1‑score (the harmonic mean of precision and recall).</div></div><div><h3>Results</h3><div>The models included patient characteristics and computer-assisted history taking. The support vector machine algorithm had the best performance for knee diagnosis group prediction, with good discrimination (area under the receiver operating characteristic curve, AUC = 0.92), accuracy (0.84), precision (0.85), recall (0.84) and F1-score (0.82).</div></div><div><h3>Conclusions</h3><div>The developed ML algorithm shows promise in predicting a knee diagnosis group in patients presenting with knee complaints to an orthopedic practice. Integrating this algorithm could streamline the consultation workflow by directing patients predicted to have knee osteoarthritis to orthopedic surgeons specializing in knee osteoarthritis, and those predicted to have ligamentous injuries to orthopedic surgeons specializing in sports and traumatic injuries.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 241-248"},"PeriodicalIF":1.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The recovery trajectory of people undergoing treatment for knee articular cartilage damage: A systematic review and meta-analysis","authors":"Henry K.C. Searle ,&nbsp;Siddarth Raj ,&nbsp;Ali Ridha ,&nbsp;Imran Ahmed ,&nbsp;Chetan Khatri ,&nbsp;Andrew Metcalfe ,&nbsp;Nick Smith","doi":"10.1016/j.knee.2025.05.031","DOIUrl":"10.1016/j.knee.2025.05.031","url":null,"abstract":"<div><h3>Background</h3><div>Knowledge of recovery trajectories helps interpret studies, manage patient expectations and plan future trials. The purpose of this review was to summarise the recovery trajectory of participants undergoing the main treatments of full-thickness knee articular cartilage defects: microfracture, scaffold-based repair, cell expansion therapy or non-operative treatment.</div></div><div><h3>Methods</h3><div>The search included Medline, Embase, Web of Science and the Cochrane Central Register of Controlled trials until April 2024. The primary outcome measure was International Knee Documentation Centre (IKDC) scores over time. Standardised mean change (SMC) with 95% confidence intervals (CI) was calculated to assess treatment response.</div></div><div><h3>Results</h3><div>46 studies were included. There were no non-operative studies. All participants demonstrated an improvement in IKDC scores from baseline. Pooled SMC scores for all arms were: 0.67 (95% CI −0.01 to 1.34) at 3 months, 1.39 (95% CI 0.84–1.93) at 6 months, 1.85 (95% CI 1.40–2.30) at 12 months, 1.99 (95% CI 1.55–2.42) at 24 months, 2.27 (95% CI 1.15–3.40) at 36 months, and 2.31 (95% CI 1.67–2.95) at 60 months. Participants undergoing each procedure demonstrated a plateau in IKDC scores at 24 months. Scores were maintained at 60 months for microfracture and cell expansion therapy. No data existed beyond 36 months for scaffold-based repair.</div></div><div><h3>Conclusion</h3><div>All arms showed an improvement in IKDC scores from baseline up until 24 months before plateauing. This was maintained at 60 months for those undergoing microfracture and cell expansion therapy. More long-term data are needed for scaffold-based repair.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 211-223"},"PeriodicalIF":1.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased force and contact area in the lateral compartment may predispose to arthritis progression after balanced unicompartmental knee arthroplasty: A cadaveric comparison","authors":"Farid Amirouche ,&nbsp;Nirav Mungalpara ,&nbsp;Brandon Z. Gligor ,&nbsp;Crystal Lin ,&nbsp;Michael Redondo ,&nbsp;Hristo Piponov","doi":"10.1016/j.knee.2025.05.026","DOIUrl":"10.1016/j.knee.2025.05.026","url":null,"abstract":"<div><h3>Introduction</h3><div>Unicompartmental knee arthroplasty (UKA) offers advantages such as faster recovery and improved function compared to total knee arthroplasty. This study evaluates the biomechanical differences in contact pressure, force, and area between conventional and robotic-assisted UKA techniques.</div></div><div><h3>Methods</h3><div>Sixteen fresh-frozen cadaveric lower limb specimens underwent UKA, with eight using standardized cutting jigs (conventional UKA) and eight using CORI robotic-assisted technology. FlexiForce (Tekscan) sensors measured contact pressure, force, and area in the medial (replaced) and lateral (native) compartments during controlled knee extension from 90° flexion to 0°. Biomechanical parameters were statistically compared.</div></div><div><h3>Results</h3><div>Medial contact pressure increased significantly from 251.73 KPa at 90° to 1863.83 KPa at 0° (<em>p</em> &lt; 0.05), while lateral pressures remained lower, ranging from 319.83 KPa to 733.94 KPa (<em>p</em> &lt; 0.05). The lateral compartment exhibited consistently higher contact areas, increasing from 81.46 mm2 at 90° to 134.38 mm2 at 0°, compared to the medial compartment’s 43.91 mm2 to 44.65 mm2 (<em>p</em> &lt; 0.05). Force values were also higher in the lateral compartment across all angles, peaking at 97.84 N compared to 83.01 N medially at 0° (<em>p</em> &lt; 0.05). No significant differences were observed between conventional and robotic-assisted techniques (<em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Both UKA techniques demonstrated comparable biomechanical outcomes. Achieving soft tissue balance remains critical for reducing medial compartment pressure and optimizing load distribution. The lateral compartment exhibits higher forces and contact areas compared to the medial compartment, potentially accelerating the development of arthritis in the lateral side after UKA due to load imbalance.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 196-210"},"PeriodicalIF":1.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological examination of post-arthroscopy osteonecrosis of the knee: a scoping review","authors":"Pierangelo Za ,&nbsp;Giuseppe Francesco Papalia ,&nbsp;Luca Ambrosio ,&nbsp;Sebastiano Vasta ,&nbsp;Fabrizio Russo ,&nbsp;Gianluca Vadalà ,&nbsp;Rocco Papalia","doi":"10.1016/j.knee.2025.05.025","DOIUrl":"10.1016/j.knee.2025.05.025","url":null,"abstract":"<div><h3>Background</h3><div>Post-arthroscopy osteonecrosis of the knee (PONK) was originally described based on magnetic resonance imaging (MRI) findings in the absence of any histopathological evidence. However, several authors have demonstrated the absence of necrosis in histological samples of patients undergoing reoperation after diagnosis of PONK. The aim of this study was to evaluate and synthesize the available literature related to the histopathological characteristics of PONK cases and to determine the appropriateness of related terminology.</div></div><div><h3>Methods</h3><div>A PRISMA-compliant scoping review of PubMed, Scopus, and Cochrane was performed. Studies reporting histological analyses performed on bone samples harvested from patients with a presumptive diagnosis of PONK were included. General study characteristics, radiographic and MRI features, time elapsed between arthroscopy and histological sampling, and results of histological analysis of the bone samples were extracted.</div></div><div><h3>Results</h3><div>Five articles were included, for a total of 22 patients (23 knees, mean age 63.5 years), resulting in 17 bone samples available for histological examination. The most common finding was the presence of subchondral insufficiency fractures (SIF) (94.1%), with necrosis being reported only in one case.</div></div><div><h3>Conclusions</h3><div>Due to the absence of necrosis in most histopathological examinations, the term “PONK” seems inadequate to describe the corresponding clinical condition. Considering the pathological features of the analysed bone samples, SIF should be considered along with PONK when diagnosing and managing these cases until more definitive evidence becomes available.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 187-195"},"PeriodicalIF":1.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait adaptations following anterior cruciate ligament rupture are sex specific","authors":"Kim Lefebvre ,&nbsp;Clémence Delestre ,&nbsp;Neila Mezghani ,&nbsp;Bujar Shabani ,&nbsp;Laurence Chèze ,&nbsp;Sébastien Lustig ,&nbsp;Pascal-André Vendittoli ,&nbsp;Patrick Lavigne ,&nbsp;Nicola Hagemeister","doi":"10.1016/j.knee.2025.05.006","DOIUrl":"10.1016/j.knee.2025.05.006","url":null,"abstract":"<div><h3>Background</h3><div>Various gait kinematic adaptations have been reported for patients with an anterior cruciate ligament deficient (ACLD) knee. However, to our knowledge, no study has compared their kinematics to their sex-matched controls for the entire gait cycle. Therefore, this retrospective study aims to identify differences in gait kinematics between ACLD patients and sex-matched controls.</div></div><div><h3>Methods</h3><div>Two databases were merged in this study, comparing knee gait kinematics of 44 injured males (ACLD-M) and 27 injured females (ACLD-F) with 32 healthy males (Control-M) and 37 healthy females (Control-F), respectively. Participants walked on a treadmill at a comfortable speed, and their movements were captured using the KneeKG® system.</div></div><div><h3>Results</h3><div>The ACLD-M group showed a significantly decreased varus angle at several gait cycle sub-phases (from 17–32%, 57–73% and 86–97%; all <em>p</em> &lt; 0.05) and an increased external tibial rotation from 67–86% of the gait cycle (<em>p</em> &lt; 0.001) compared to the Control-M group. The ACLD-F group exhibited increased knee flexion from 1–53% (<em>p</em> &lt; 0.001) and from 95–100% (<em>p</em> &lt; 0.05) and increased valgus from 1–65% (<em>p</em> &lt; 0.001) and from 94–100% (<em>p</em> &lt; 0.05) of the gait cycle compared to Control-F group.</div></div><div><h3>Conclusion</h3><div>Our study reveals sex-specific adaptations following ACL rupture. Women exhibited more gait adaption in the sagittal and frontal planes during the stance phase while men demonstrated adaptations in frontal plane for sub-phases of stance and swing, and external tibial rotation during initial and mid-swing phases. These findings suggest that ACL injury kinematics and rehabilitation after injury should be sex-specific.</div><div>Level of evidence III.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 168-177"},"PeriodicalIF":1.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and body mass index associate with total knee arthroplasty after anterior cruciate ligament reconstruction: A retrospective study","authors":"Jessica Sheldon ,&nbsp;Sonu Bae ,&nbsp;Parker A. Cavendish ,&nbsp;Eric M. Milliron ,&nbsp;Christopher C. Kaeding ,&nbsp;Robert A. Magnussen ,&nbsp;David C. Flanigan ,&nbsp;Tyler Barker","doi":"10.1016/j.knee.2025.05.016","DOIUrl":"10.1016/j.knee.2025.05.016","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association of age, body mass index (BMI), and systemic indices of the immune system and inflammation with the odds of undergoing total knee arthroplasty (TKA) following anterior cruciate ligament reconstruction (ACLR).</div></div><div><h3>Methods</h3><div>This retrospective, case-control study consisted of three groups of patients that underwent ACLR: (1) those with a documented knee osteoarthritis (OA) diagnosis and TKA procedure (Cases, <em>n</em> = 15), (2) those without a documented knee OA diagnosis or TKA procedure (control-1 [CON1], <em>n</em> = 15), and (3) those with a documented knee OA diagnosis but without a TKA procedure after ACLR (control-2 [CON2], <em>n</em> = 15). Control groups were matched to the Cases (1:1:1) based on sex and date of ACLR. Logistic regression analyses consisted of two models. Model 1 examined risk factors of TKA (Cases vs CON1 and CON2) and Model 2 examined risk factors of a documented knee OA diagnosis (Cases and CON2 vs CON1) following ACLR. Risk factors included age at ACLR, BMI, and systemic indices of the immune system and inflammation (systemic inflammation response index, systemic immune-inflammatory index [SII], and neutrophil-to-lymphocyte, platelet-to-lymphocyte [PLR], and monocyte-to-lymphocyte ratios).</div></div><div><h3>Results</h3><div>Increased age (<em>p</em> = 0.01) and BMI (<em>p</em> &lt; 0.01) were associated with significantly high odds of undergoing TKA. Increased BMI (<em>p</em> = 0.02) and PLR (<em>p</em> = 0.05) and decreased SII (<em>p</em> = 0.03) were risk factors for a documented knee OA diagnosis.</div></div><div><h3>Conclusion</h3><div>Increased BMI and systemic inflammatory-immune indices associated with increased odds of subsequent knee OA diagnosis following ACLR. Increased age and BMI associated with increased odds of subsequent knee OA diagnosis and TKA following ACLR.</div><div><strong>Level of Evidence:</strong> III.</div><div>What are the new findings?<ul><li><span>•</span><span><div>Increased body mass index and peripheral inflammatory-immune system indices are associated with increased odds of subsequent knee osteoarthritis diagnosis following anterior cruciate ligament reconstruction.</div></span></li><li><span>•</span><span><div>Increased age and body mass index are associated with increased odds of subsequent total knee arthroplasty following anterior cruciate ligament reconstruction.</div></span></li></ul></div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 160-167"},"PeriodicalIF":1.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee trauma and its sequalae","authors":"Oday Al-Dadah Editors-in-Chief,&nbsp;Caroline Hing Editors-in-Chief","doi":"10.1016/j.knee.2025.05.032","DOIUrl":"10.1016/j.knee.2025.05.032","url":null,"abstract":"","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 226-227"},"PeriodicalIF":1.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}