{"title":"Gait adaptations following anterior cruciate ligament rupture are sex specific","authors":"Kim Lefebvre , Clémence Delestre , Neila Mezghani , Bujar Shabani , Laurence Chèze , Sébastien Lustig , Pascal-André Vendittoli , Patrick Lavigne , Nicola Hagemeister","doi":"10.1016/j.knee.2025.05.006","DOIUrl":"10.1016/j.knee.2025.05.006","url":null,"abstract":"<div><h3>Background</h3><div>Various gait kinematic adaptations have been reported for patients with an anterior cruciate ligament deficient (ACLD) knee. However, to our knowledge, no study has compared their kinematics to their sex-matched controls for the entire gait cycle. Therefore, this retrospective study aims to identify differences in gait kinematics between ACLD patients and sex-matched controls.</div></div><div><h3>Methods</h3><div>Two databases were merged in this study, comparing knee gait kinematics of 44 injured males (ACLD-M) and 27 injured females (ACLD-F) with 32 healthy males (Control-M) and 37 healthy females (Control-F), respectively. Participants walked on a treadmill at a comfortable speed, and their movements were captured using the KneeKG® system.</div></div><div><h3>Results</h3><div>The ACLD-M group showed a significantly decreased varus angle at several gait cycle sub-phases (from 17–32%, 57–73% and 86–97%; all <em>p</em> < 0.05) and an increased external tibial rotation from 67–86% of the gait cycle (<em>p</em> < 0.001) compared to the Control-M group. The ACLD-F group exhibited increased knee flexion from 1–53% (<em>p</em> < 0.001) and from 95–100% (<em>p</em> < 0.05) and increased valgus from 1–65% (<em>p</em> < 0.001) and from 94–100% (<em>p</em> < 0.05) of the gait cycle compared to Control-F group.</div></div><div><h3>Conclusion</h3><div>Our study reveals sex-specific adaptations following ACL rupture. Women exhibited more gait adaption in the sagittal and frontal planes during the stance phase while men demonstrated adaptations in frontal plane for sub-phases of stance and swing, and external tibial rotation during initial and mid-swing phases. These findings suggest that ACL injury kinematics and rehabilitation after injury should be sex-specific.</div><div>Level of evidence III.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 168-177"},"PeriodicalIF":1.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-05-30DOI: 10.1016/j.knee.2025.05.016
Jessica Sheldon , Sonu Bae , Parker A. Cavendish , Eric M. Milliron , Christopher C. Kaeding , Robert A. Magnussen , David C. Flanigan , Tyler Barker
{"title":"Age and body mass index associate with total knee arthroplasty after anterior cruciate ligament reconstruction: A retrospective study","authors":"Jessica Sheldon , Sonu Bae , Parker A. Cavendish , Eric M. Milliron , Christopher C. Kaeding , Robert A. Magnussen , David C. Flanigan , Tyler Barker","doi":"10.1016/j.knee.2025.05.016","DOIUrl":"10.1016/j.knee.2025.05.016","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association of age, body mass index (BMI), and systemic indices of the immune system and inflammation with the odds of undergoing total knee arthroplasty (TKA) following anterior cruciate ligament reconstruction (ACLR).</div></div><div><h3>Methods</h3><div>This retrospective, case-control study consisted of three groups of patients that underwent ACLR: (1) those with a documented knee osteoarthritis (OA) diagnosis and TKA procedure (Cases, <em>n</em> = 15), (2) those without a documented knee OA diagnosis or TKA procedure (control-1 [CON1], <em>n</em> = 15), and (3) those with a documented knee OA diagnosis but without a TKA procedure after ACLR (control-2 [CON2], <em>n</em> = 15). Control groups were matched to the Cases (1:1:1) based on sex and date of ACLR. Logistic regression analyses consisted of two models. Model 1 examined risk factors of TKA (Cases vs CON1 and CON2) and Model 2 examined risk factors of a documented knee OA diagnosis (Cases and CON2 vs CON1) following ACLR. Risk factors included age at ACLR, BMI, and systemic indices of the immune system and inflammation (systemic inflammation response index, systemic immune-inflammatory index [SII], and neutrophil-to-lymphocyte, platelet-to-lymphocyte [PLR], and monocyte-to-lymphocyte ratios).</div></div><div><h3>Results</h3><div>Increased age (<em>p</em> = 0.01) and BMI (<em>p</em> < 0.01) were associated with significantly high odds of undergoing TKA. Increased BMI (<em>p</em> = 0.02) and PLR (<em>p</em> = 0.05) and decreased SII (<em>p</em> = 0.03) were risk factors for a documented knee OA diagnosis.</div></div><div><h3>Conclusion</h3><div>Increased BMI and systemic inflammatory-immune indices associated with increased odds of subsequent knee OA diagnosis following ACLR. Increased age and BMI associated with increased odds of subsequent knee OA diagnosis and TKA following ACLR.</div><div><strong>Level of Evidence:</strong> III.</div><div>What are the new findings?<ul><li><span>•</span><span><div>Increased body mass index and peripheral inflammatory-immune system indices are associated with increased odds of subsequent knee osteoarthritis diagnosis following anterior cruciate ligament reconstruction.</div></span></li><li><span>•</span><span><div>Increased age and body mass index are associated with increased odds of subsequent total knee arthroplasty following anterior cruciate ligament reconstruction.</div></span></li></ul></div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 160-167"},"PeriodicalIF":1.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-05-30DOI: 10.1016/j.knee.2025.05.022
K. Goto, H. Iwaso, E. Honda, S. Sameshima, M. Inagawa, Y. Ishida, K. Matsuo, R. Kuzuhara, T. Sanada
{"title":"Graft diameter does not affect re-rupture rates or clinical outcomes in double-bundle anterior cruciate ligament reconstruction","authors":"K. Goto, H. Iwaso, E. Honda, S. Sameshima, M. Inagawa, Y. Ishida, K. Matsuo, R. Kuzuhara, T. Sanada","doi":"10.1016/j.knee.2025.05.022","DOIUrl":"10.1016/j.knee.2025.05.022","url":null,"abstract":"<div><h3>Background</h3><div>While a graft diameter of less than 8 mm is considered a risk factor for re-rupture in single-bundle anterior cruciate ligament reconstruction (ACLR), no studies have investigated the threshold for risk in double-bundle ACLR (DB-ACLR). This study aimed to evaluate the relationship between graft diameter and re-rupture rates in DB-ACLR.</div></div><div><h3>Methods</h3><div>This study included 589 knees that underwent DB-ACLR with a minimum follow-up of 2 years. The total cross sectional area (CSA) of the grafts was calculated from the diameters of the anteromedial bundle (AMB) and posterolateral bundle (PLB). A restricted cubic spline regression model was applied to evaluate the relationship between total CSA and graft re-rupture. Although no statistically significant cutoff value was identified, the analysis suggested potential differences in re-rupture rates between knees with extremely small or large CSAs. Based on this finding, knees were classified into two groups: Group S (total CSA < 39 mm<sup>2</sup>, corresponding to a single-bundle diameter < 7 mm) and Group L (total CSA > 50 mm<sup>2</sup>, corresponding to a single-bundle diameter > 8 mm). Propensity score matching was conducted to adjust for confounding factors, including age, height, and weight, and re-rupture rates and Knee injury and Osteoarthritis Outcome Score (KOOS) were compared between the groups.</div></div><div><h3>Results</h3><div>Graft re-rupture was observed in 37 out of 589 knees (6.3%). The mean graft diameter was 5.3 ± 0.4 mm for AMB, 5.0 ± 0.4 mm for PLB, and 41.5 ± 7.1 mm<sup>2</sup> for total CSA. Restricted cubic spline regression analysis showed a slight decrease in the log odds of re-rupture with increasing CSA, but no significant cutoff value was identified, and the observed trend was not statistically significant. After propensity score matching, there were no significant differences in re-rupture rates (13.5% in Group S vs. 8.1% in Group L, <em>p</em> = 0.71) or KOOS scores between the groups.</div></div><div><h3>Conclusion</h3><div>In DB-ACLR, no clear cutoff value for graft diameter was identified, and total CSA was not a significant risk factor for re-rupture. Knees with small-diameter grafts demonstrated comparable re-rupture rates and KOOS scores to those with larger-diameter grafts.</div><div><strong>Level of Evidence:</strong> Level III.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 178-186"},"PeriodicalIF":1.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-05-29DOI: 10.1016/j.knee.2025.05.015
Alexander H. Matthews , William K. Gray , Jonathan P. Evans , Jonathan T. Evans , Tim Briggs , Shiraz A. Sabah , Andrew Price , Andrew D. Toms
{"title":"The effect of minimum volume recommendations on surgeon activity for first revision total knee replacement: an analysis of 2009–2019 United Kingdom National Joint Registry data","authors":"Alexander H. Matthews , William K. Gray , Jonathan P. Evans , Jonathan T. Evans , Tim Briggs , Shiraz A. Sabah , Andrew Price , Andrew D. Toms","doi":"10.1016/j.knee.2025.05.015","DOIUrl":"10.1016/j.knee.2025.05.015","url":null,"abstract":"<div><h3>Aims</h3><div>The aim of this study was to investigate changes in first time revision knee replacement (RevKR) volumes following the publication of a report identifying low surgeon volumes in England. As a secondary aim we sought to investigate the rate of accrual of volumes for early career surgeons.</div></div><div><h3>Methods</h3><div>This population-based cohort study used data from the United Kingdom National Joint Registry. Patients undergoing first time RevKR between 1st January 2009 and 31 December 2019. Annual revision volumes for each surgeon were calculated and trends in surgeon volumes plotted as medians and bootstrapped 95% confidence intervals. Data before and after the report was compared. The rate of accrual of experience for new surgeons inclusive of both first-time revisions and re-revisions was calculated and adjusted for unit volume.</div></div><div><h3>Results</h3><div>A total of 21,067 patients were included. Over the whole study period, 123/1433 (8.58%) of surgeons achieved a mean annual volume of 15 or more revisions. Temporal trends in surgeon revision volumes observed an increase for non-acute indications. New surgeons in lower volume units have 42% lower chance of reaching 15 operations per year compared to those in the highest volume units (HR 0.52; 95% CI 0.33 to 0.83).</div></div><div><h3>Conclusions</h3><div>We observed an increase in surgeon volumes following the report in first time non acute RevKRs. New RevKR surgeons were more likely to achieve and maintain revision volume targets in higher volume centres, this supports the drive for dual consultant operating and prospective revision knee consultants being appointed to highest volume units.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 150-158"},"PeriodicalIF":1.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-05-29DOI: 10.1016/j.knee.2025.04.010
Alejandro Sánchez García , David González Quevedo , Miguel Sáez Casado , Diego Moriel Garceso , Laura de la Puerta Migueles , David Montes Molinero , Ignacio Vieitez Riestra , Manuel Marfil Romero , Sergio Palacios Penedo , David García de Quevedo , Iskandar Tamimi
{"title":"The functional outcome and complication rates in tibial plateau fractures: A comparison between three different classification systems","authors":"Alejandro Sánchez García , David González Quevedo , Miguel Sáez Casado , Diego Moriel Garceso , Laura de la Puerta Migueles , David Montes Molinero , Ignacio Vieitez Riestra , Manuel Marfil Romero , Sergio Palacios Penedo , David García de Quevedo , Iskandar Tamimi","doi":"10.1016/j.knee.2025.04.010","DOIUrl":"10.1016/j.knee.2025.04.010","url":null,"abstract":"<div><h3>Background</h3><div>Tibial plateau fractures are relatively common injuries, but research comparing the functional outcomes using different classification systems is scarce.</div></div><div><h3>Objectives</h3><div>This study aimed to analyse complication rates and functional outcomes in tibial plateau fractures by comparing three classification systems: Schatzker, AO/OTA, and the three-column classification system.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted on 125 consecutive tibial plateau fractures treated at our institution between 2016 and 2021. Functional outcomes were assessed using the International Knee Documentation Committee (IKDC) and Oxford Knee scores. Demographic data and information on postoperative complications were obtained from our institutional digital database.</div></div><div><h3>Results</h3><div>Of the 62 patients who met the inclusion criteria, the most significant functional decline was observed in AO/OTA C3 fractures, and three-column fractures of the tibial plateau (IKDC change: −38.4 ± 28.7; <em>P</em> = 0.004; and –32.2 ± 30.9; <em>P</em> = 0.022, respectively; and Oxford score change: −16.5 ± 14.2; <em>P</em> = 0.005; and −15.2 ± 12.3; <em>P</em> = 0.008; respectively). A strong correlation was found between the AO/OTA classification and the number of complications (R = 0.956, <em>P</em> = 0.005), but no correlation was found between age and functional decline.</div></div><div><h3>Conclusions</h3><div>Compared with Schatzker’s classification the AO/OTA classification is a better tool for the prediction of the functional outcome and complication rates in patients with tibial plateau fractures. AO/OTA C3 fractures were associated with the highest functional decline. There was no significant correlation between functional decline and the patient’s age.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"55 ","pages":"Pages 214-225"},"PeriodicalIF":1.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-05-28DOI: 10.1016/j.knee.2025.05.001
Andy Deprato , Juliana Onesi , Prushoth Vivekanantha , Amit Meena , Shahbaz Malik , Darren de SA
{"title":"High continuous fragility index values amongst trials comparing anterior cruciate ligament reconstruction with and without anterolateral complex procedures: A systematic review","authors":"Andy Deprato , Juliana Onesi , Prushoth Vivekanantha , Amit Meena , Shahbaz Malik , Darren de SA","doi":"10.1016/j.knee.2025.05.001","DOIUrl":"10.1016/j.knee.2025.05.001","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review aimed to determine the statistical fragility of randomized controlled trials (RCTs) comparing anterior cruciate ligament reconstruction (ACLR) with or without anterolateral complex (ALC) procedures.</div></div><div><h3>Methods</h3><div>PubMed, MEDLINE, and EMBASE were searched from inception to April 22, 2024 for RCTs comparing ACLR with or without ALC procedures (lateral extra-articular tenodesis or anterolateral ligament reconstruction). Studies that reported ≥1 statistically significant continuous outcome, statistically significant dichotomous outcome, and/or non-significant dichotomous outcome were included. The fragility index (FI), continuous fragility index (CFI), and reverse fragility index (RFI) were calculated for these outcomes, respectively.</div></div><div><h3>Results</h3><div>20 RCTs including 2,292 patients were included (mean study size: 114.6 patients). The median FI across 21 outcomes from 11 studies was 2.0 (interquartile range [IQR], 2.0). The median CFI across 20 outcomes from seven studies was 16.9 (IQR, 227.7). The median RFI across 107 outcomes from 19 studies was 5.0 (IQR, 2.0). The number of patients lost to follow-up at the final follow-up period was more than the study-specific FI in eight (72.7%) studies, CFI in two (28.6%) studies, and RFI in 12 (63.2%) studies.</div></div><div><h3>Conclusion</h3><div>This systematic review demonstrated that RCTs comparing ACLR with or without ALC procedures have low FI and RFI values that tended to exceed loss to follow-up, demonstrating relative statistical fragility of existing literature. However, CFI values were high amongst RCTs, suggesting robustness in findings for quantitative outcomes. While fragility indices are important metrics of robustness to consider, their application in research and clinical practice should be further investigated.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 132-149"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-05-27DOI: 10.1016/j.knee.2025.05.012
Pablo Agustín Ramos Guarderas , Gonzalo Fernando Arteaga Guerrero , Medardo Javier Vargas Morante , Pablo David Ramos Murillo , Carlos Patricio Peñaherrera Carrillo , Francisco Endara Urresta , Daniel Alejandro Ramos Murillo , Alejandro Xavier Barros Castro
{"title":"Binomial theory applied to the creation of a treatment algorithm for patellofemoral pathology","authors":"Pablo Agustín Ramos Guarderas , Gonzalo Fernando Arteaga Guerrero , Medardo Javier Vargas Morante , Pablo David Ramos Murillo , Carlos Patricio Peñaherrera Carrillo , Francisco Endara Urresta , Daniel Alejandro Ramos Murillo , Alejandro Xavier Barros Castro","doi":"10.1016/j.knee.2025.05.012","DOIUrl":"10.1016/j.knee.2025.05.012","url":null,"abstract":"<div><div>The annual prevalence of patellofemoral pathology in the general population is 22.7%, and in adolescents, it is 28.9%. Diagnosing this pathology is complex and requires a proper clinical examination and complementary imaging studies for adequate treatment. This study aims to clarify, simplify, and present a diagnostic and treatment algorithm based on casuistry using binomial theory.</div></div><div><h3>Materials and methods</h3><div>A retrospective study included 100 patients, 70% female, with an average age of 31, diagnosed with patellofemoral pathology, treated with different therapeutic options described in the literature, and followed up for 12 months, evaluated using the Lysholm scale.</div></div><div><h3>Results</h3><div>Among the surgically treated patients, 75% scored between 65 and 83 points on the Lysholm scale after one month; at six months, 72% scored between 84 and 100 points; after one year, 92% scored between 84 and 100 points; and the remaining 8% showed no improvement or required additional surgical procedures. The <em>Q</em> angle, TT-TG, and Fulkerson classification were correlated, obtaining <em>P</em> values of 0.65, 0.72, and 0.55 respectively, suggesting a positive correlation between these variables. Finally, the three variables were correlated for surgical decision-making, obtaining a <em>P</em> value of 0.85, with a positive and statistically significant correlation.</div></div><div><h3>Conclusion</h3><div>The algorithm proposed in this study shows good results at the one-year follow-up and should be considered as a management option for patients with patellofemoral pathology.</div><div><strong>Level of Evidence:</strong> IV. Observational retrospective case series study.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 122-131"},"PeriodicalIF":1.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KneePub Date : 2025-05-27DOI: 10.1016/j.knee.2025.05.008
S. Ali Ghasemi , Ahmad Naja , Benjamin C. Murray , Arthur Bartolozzi , Gene Shaffer , James Raphael
{"title":"A novel arthroscopic-assisted fibular-based dual reconstruction with popliteus repair technique for posterolateral corner injury: a cadaveric and functional anatomic study","authors":"S. Ali Ghasemi , Ahmad Naja , Benjamin C. Murray , Arthur Bartolozzi , Gene Shaffer , James Raphael","doi":"10.1016/j.knee.2025.05.008","DOIUrl":"10.1016/j.knee.2025.05.008","url":null,"abstract":"<div><div>The structures of the posterolateral corner (PLC) work together as a single unit to provide both static and dynamic functions to the knee. Multiple techniques have been described for PLC reconstruction, however most of these techniques re-establish the static function of the PLC without addressing dynamic components. The popliteus muscle serves an important role in providing dynamic stability to the PLC, but this function is often not restored in reconstruction techniques. We describe a novel technique for PLC reconstruction that includes popliteus repair, and review the functional anatomy and biomechanics of the PLC. We also confirm the dynamic stabilizing role of the popliteus muscle through a biomechanical analysis of four cadavers.</div></div>","PeriodicalId":56110,"journal":{"name":"Knee","volume":"56 ","pages":"Pages 103-121"},"PeriodicalIF":1.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}