Serum oxidative stress is associated with the progression of knee osteoarthritis: A 5-year longitudinal cohort in the Yakumo study

IF 1.6 4区医学 Q3 ORTHOPEDICS

Knee Pub Date : 2025-06-21 DOI:10.1016/j.knee.2025.05.023

Hiroaki Ido , Taisuke Seki , Yasuhiko Takegami , Yusuke Osawa , Hiroki Iida , Hiroaki Nakashima , Shinya Ishizuka , Yukiharu Hasegawa , Shiro Imagama

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引用次数: 0

Abstract

Introduction

Knee osteoarthritis (KOA) is a chronic degenerative disease characterized by a reduction in joint cartilage in the in-knee joint. However, few reports have investigated the relationship between serum reactive oxygen species (ROS) and KOA. We aimed to investigate whether oxidative stress, assessed using d-ROM and biological antioxidant potential (BAP), is associated with the severity and progression of KOA in community-dwelling individuals.

Method

We enrolled 95 participants (190 knees) who participated in the Yakumo Study. We used a computer-aided diagnosis system for KOA to obtain the average joint space width (aJSW), minimal joint space width (mJSW), joint space area (JSA), and femorotibial angle; calculated the difference between JSW and JSA at 5 years and at baseline; and divided the study population into two groups based on median d-ROM and BAP values. Statistical analyses were conducted between the groups, including propensity score matching based on age, sex, body mass index, and medial mJSW at baseline between high d-ROMs (HD) and low d-ROMs (LD) groups.

Results

The median values for the lateral and medial mJSW, aJSW, and JSA were significantly narrower in the HD group than in the LD group. The medial mJSW, aJSW and JSA at the 5-year follow-up were significantly narrower in the HD group than those in the LD group.

Conclusions

Oxidative stress level was found to be associated with joint space narrowing and progression of joint space narrowing over the course of five years in clinical settings.

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血清氧化应激与膝骨关节炎的进展相关：Yakumo研究的5年纵向队列研究

膝骨关节炎（KOA）是一种慢性退行性疾病，其特征是膝关节内关节软骨减少。然而，很少有研究血清活性氧（ROS）与KOA之间关系的报道。我们的目的是研究氧化应激是否与社区居民KOA的严重程度和进展有关，用rom和生物抗氧化潜能（BAP）来评估。方法我们招募了参加Yakumo研究的95名受试者（190个膝关节）。我们使用计算机辅助诊断系统获得KOA的平均关节间隙宽度（aJSW）、最小关节间隙宽度（mJSW）、关节间隙面积（JSA）和股胫角；计算5年及基线时JSW与JSA的差异；并根据中位数- rom和BAP值将研究人群分为两组。组间进行统计分析，包括基于年龄、性别、体重指数和高d- rom （HD）组和低d- rom （LD）组基线时的内侧mJSW的倾向评分匹配。结果HD组侧、内侧mJSW、aJSW、JSA的中位值明显窄于LD组。5年随访时，HD组内侧mJSW、aJSW和JSA明显窄于LD组。结论氧化应激水平与关节间隙变窄及关节间隙变窄的进展有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Knee 医学-外科

CiteScore

3.80

自引率

5.30%

发文量

171

审稿时长

6 months

期刊介绍： The Knee is an international journal publishing studies on the clinical treatment and fundamental biomechanical characteristics of this joint. The aim of the journal is to provide a vehicle relevant to surgeons, biomedical engineers, imaging specialists, materials scientists, rehabilitation personnel and all those with an interest in the knee. The topics covered include, but are not limited to: • Anatomy, physiology, morphology and biochemistry; • Biomechanical studies; • Advances in the development of prosthetic, orthotic and augmentation devices; • Imaging and diagnostic techniques; • Pathology; • Trauma; • Surgery; • Rehabilitation.