Neurogenetics最新文献_第10页

A novel nonsense variant in EXOC8 underlies a neurodevelopmental disorder EXOC8的一种新的无义变体是神经发育障碍的基础

IF 2.2 4区医学

Neurogenetics Pub Date : 2022-04-23 DOI: 10.1007/s10048-022-00692-7

A. Ullah, J. Krishin, N. Haider, Brekhna Aurangzeb, Abdullah, Sufyan Suleman, W. Ahmad, T. Hansen, S. Basit

引用次数: 3

Clinical, genetic profile and disease progression of sarcoglycanopathies in a large cohort from India: high prevalence of SGCB c.544A > C 印度一个大型队列中肌聚糖病的临床、遗传特征和疾病进展：SGCB c.544A的高患病率 > C

IF 2.2 4区医学

Neurogenetics Pub Date : 2022-04-13 DOI: 10.1007/s10048-022-00690-9

M. Bardhan, R. Anjanappa, K. Polavarapu, V. Preethish-Kumar, S. Vengalil, S. Nashi, S. Sanga, Hansashree Padmanabh, Ravi Kiran Valasani, V. Nishadham, M. Keerthipriya, T. Geetha, V. Ramprasad, G. Arunachal, Priya Treesa Thomas, Moulinath Acharya, A. Nalini

引用次数: 4

Inherited metabolic diseases mimicking hereditary spastic paraplegia (HSP): a chance for treatment 类似遗传性痉挛性截瘫(HSP)的遗传性代谢疾病:治疗的机会

IF 2.2 4区医学

Neurogenetics Pub Date : 2022-04-09 DOI: 10.1007/s10048-022-00688-3

H. Teive, C. Camargo, E. Pereira, L. Coutinho, R. Munhoz

引用次数: 2

Identification of a 5 bp duplicate in the AP1S2 gene of an individual with X-linked intellectual disability x连锁智力残疾患者AP1S2基因5bp重复序列的鉴定

IF 2.2 4区医学

Neurogenetics Pub Date : 2022-04-07 DOI: 10.1007/s10048-022-00691-8

Dengna Zhu, Mingmei Wang, Yiran Xu, Jiamei Zhang, Fan Yang, Zuozhen Yang

引用次数: 0

A novel homozygous variant in RNF170 causes hereditary spastic paraplegia: a case report and review of the literature. 一种新的RNF170纯合子变异导致遗传性痉挛性截瘫:一个病例报告和文献回顾。

IF 2.2 4区医学

Neurogenetics Pub Date : 2022-04-01 Epub Date: 2022-01-18 DOI: 10.1007/s10048-022-00685-6

Eliane Chouery, Cybel Mehawej, Andre Megarbane

{"title":"A novel homozygous variant in RNF170 causes hereditary spastic paraplegia: a case report and review of the literature.","authors":"Eliane Chouery, Cybel Mehawej, Andre Megarbane","doi":"10.1007/s10048-022-00685-6","DOIUrl":"https://doi.org/10.1007/s10048-022-00685-6","url":null,"abstract":"Hereditary spastic paraplegia (HSP) refers to a group of genetic disorders characterized by progressive weakness and stiffness in the muscles of the legs. To date, more than 83 types of HSP exist, differing in their etiology, their degree of severity, and the nature of symptoms associated with each of these conditions. Owing to their genetic and clinical heterogeneity, the establishment of an accurate diagnosis can be very challenging, especially with the clinical overlap observed between those conditions and other neurogenetic diseases. A 7-year-old girl, born to a consanguineous Iraqi family, was referred to us for clinical and genetic evaluation. The patient presents with progressive difficulty in walking that started when she was 3 years old, lower limb predominant spastic paraparesis, and mild upper limbs involvement with slight tremor in the hands, all occurring in the absence of neurodevelopmental or growth delays. Whole exome sequencing revealed a novel homozygous missense variation in the RNF170 gene (NM_030954.3; p.Cys107Trp), thus establishing the diagnosis of HSP. Here, we report the second missense biallelic variation in RNF170 and we discuss thoroughly all previously reported cases with RNF170-linked HSP.","PeriodicalId":56106,"journal":{"name":"Neurogenetics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39919377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Detection of copy number variants and genes by chromosomal microarray in an Emirati neurodevelopmental disorders cohort. 通过染色体微阵列检测阿联酋神经发育障碍队列中的拷贝数变异和基因。

IF 2.2 4区医学

Neurogenetics Pub Date : 2022-04-01 Epub Date: 2022-03-24 DOI: 10.1007/s10048-022-00689-2

Nasna Nassir, Isra Sati, Shaiban Al Shaibani, Awab Ahmed, Omar Almidani, Hosneara Akter, Marc Woodbury-Smith, Ahmad Abou Tayoun, Mohammed Uddin, Ammar Albanna

{"title":"Detection of copy number variants and genes by chromosomal microarray in an Emirati neurodevelopmental disorders cohort.","authors":"Nasna Nassir, Isra Sati, Shaiban Al Shaibani, Awab Ahmed, Omar Almidani, Hosneara Akter, Marc Woodbury-Smith, Ahmad Abou Tayoun, Mohammed Uddin, Ammar Albanna","doi":"10.1007/s10048-022-00689-2","DOIUrl":"https://doi.org/10.1007/s10048-022-00689-2","url":null,"abstract":"Copy number variations (CNVs) are highly implicated in the etiology of neurodevelopmental disorders (NDDs), and chromosomal microarray analysis (CMA) has been recommended as a first-tier test for many NDDs. We undertook a study to identify clinically relevant CNVs and genes in an ethnically homogenous population of the United Arab Emirates. We genotyped 98 patients with NDDs using genome-wide chromosomal microarray analysis, and observed 47.1% deletion and 52.9% duplication CNVs, of which 11.8% are pathogenic, 23.5% are likely pathogenic, and 64.7% VOUS. The average size of copy number losses (3.9 Mb) was generally higher than of gains (738.4 kb). Analysis of VOUS CNVs for constrained genes (enrichment for brain critical exons and high pLI genes) yielded 7 unique genes. Among these 7 constrained genes, we propose FNTA and PXK as potential candidate genes for neurodevelopmental disorders, which warrants further investigation. Thirty-two overlapping CNVs (Decipher and ClinVar) containing the FNTA gene were previously identified in NDD patients and 6 overlapping CNVs (Decipher and ClinVar) containing the PXK gene were previously identified in NDD patients. Our study supports the utility of CMA for CNV profiling which aids in precise genetic diagnosis and its integration into therapeutics and management of NDD patients.","PeriodicalId":56106,"journal":{"name":"Neurogenetics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40319322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Altered pituitary morphology as a sign of benign hereditary chorea caused by TITF1/NKX2.1 mutations. 垂体形态改变是由TITF1/NKX2.1突变引起的良性遗传性舞蹈病的标志。

IF 2.2 4区医学

Neurogenetics Pub Date : 2022-04-01 Epub Date: 2022-01-25 DOI: 10.1007/s10048-021-00680-3

Steffi Thust, Liana Veneziano, Michael H Parkinson, Kailash P Bhatia, Elide Mantuano, Cristina Gonzalez-Robles, Indran Davagnanam, Paola Giunti

{"title":"Altered pituitary morphology as a sign of benign hereditary chorea caused by TITF1/NKX2.1 mutations.","authors":"Steffi Thust, Liana Veneziano, Michael H Parkinson, Kailash P Bhatia, Elide Mantuano, Cristina Gonzalez-Robles, Indran Davagnanam, Paola Giunti","doi":"10.1007/s10048-021-00680-3","DOIUrl":"https://doi.org/10.1007/s10048-021-00680-3","url":null,"abstract":"Benign hereditary chorea (BHC) is a rare genetically heterogeneous movement disorder, in which conventional neuroimaging has been reported as normal in most cases. Cystic pituitary abnormalities and features of empty sella have been described in only 7 patients with BHC to date. We present 4 patients from 2 families with a BHC phenotype, 3 of whom underwent targeted pituitary MR imaging and genetic testing. All four patients in the two families displayed a classic BHC phenotype. The targeted pituitary MR imaging demonstrated abnormal pituitary sella morphology. Genetic testing was performed in three patients, and showed mutations causing BHC in three of the patients, as well as identifying a novel nonsense mutation of the TITF1/NKX2-1 gene in one of the patients. The presence of the abnormal pituitary sella in two affected members of the same family supports the hypothesis that this sign is a distinct feature of the BHC phenotype spectrum due to mutations in the TITF1 gene. Interestingly, these abnormalities seem to develop in adult life and are progressive. They occur in at least 26% of patients affected with Brain-lung-thyroid syndrome. As a part of the management of these patients we recommend to perform follow-up MRI brain with dedicated pituitary imaging also in adult life as the abnormality can occur years after the onset of chorea.","PeriodicalId":56106,"journal":{"name":"Neurogenetics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39860137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Experiences in the molecular genetic and histopathological evaluation of calpainopathies. 痛觉病变的分子遗传学和组织病理学评价经验。

IF 2.2 4区医学

Neurogenetics Pub Date : 2022-04-01 Epub Date: 2022-02-14 DOI: 10.1007/s10048-022-00687-4

Berk Ozyilmaz, Ozgur Kirbiyik, Taha R Ozdemir, Ozge Kaya Ozer, Yasar B Kutbay, Kadri M Erdogan, Merve Saka Guvenc, Şener Arıkan, Tuba Sozen Turk, Murat Yıldırım Kale, Irem Fatma Uludag, Figen Baydan, Filiz Sertpoyraz, Pinar Gencpinar, Gulden Diniz

{"title":"Experiences in the molecular genetic and histopathological evaluation of calpainopathies.","authors":"Berk Ozyilmaz, Ozgur Kirbiyik, Taha R Ozdemir, Ozge Kaya Ozer, Yasar B Kutbay, Kadri M Erdogan, Merve Saka Guvenc, Şener Arıkan, Tuba Sozen Turk, Murat Yıldırım Kale, Irem Fatma Uludag, Figen Baydan, Filiz Sertpoyraz, Pinar Gencpinar, Gulden Diniz","doi":"10.1007/s10048-022-00687-4","DOIUrl":"https://doi.org/10.1007/s10048-022-00687-4","url":null,"abstract":"Calpainopathy is mainly characterized by symmetric and progressive weakness of proximal muscles. Several reports showed that the most common LGMD subtype is LGMDR1 or calpainopathy, which had previously been defined as LGMD2A. Until now, more than 500 likely pathogenic/pathogenic variants in the CAPN3 gene have been reported. However, a clear genotype-phenotype association had not yet been established and this causes major difficulties in predicting the prognosis in asymptomatic patients and in providing genetic counseling for prenatal diagnosis. In this report, we aimed to add new data to the literature by evaluating 37 patients with likely pathogenic/pathogenic variants for the detected variants' nature, patients' phenotypes, and histopathological features. As a result, the general clinical presentation of the 23 different variants was presented, the high frequency of NM_000070.3:c.550delA mutation in Exon 4 was discussed, and some novel genotype-phenotype associations were suggested. We have underlined that calpainopathy can be misdiagnosed with inflammatory myopathies histopathologically. We have also emphasized that, in young or adult patients with mild to moderate proximal muscle weakness and elevated CK levels, calpainopathy should be the first suspected diagnosis.","PeriodicalId":56106,"journal":{"name":"Neurogenetics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39917284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Novel biallelic variants in NRROS associated with a lethal microgliopathy, brain calcifications, and neurodegeneration. 与致死性小胶质病变、脑钙化和神经变性相关的新型NRROS双等位基因变异。

IF 2.2 4区医学

Neurogenetics Pub Date : 2022-04-01 DOI: 10.1007/s10048-022-00683-8

Julia Macintosh, Alexa Derksen, Chantal Poulin, Nancy Braverman, Adeline Vanderver, Isabelle Thiffault, Steffen Albrecht, Geneviève Bernard

引用次数: 2

An intronic GNAO1 variant leading to in-frame insertion cause movement disorder controlled by deep brain stimulation. 内含子GNAO1变异导致帧内插入引起运动障碍，由深部脑刺激控制。

IF 2.2 4区医学

Neurogenetics Pub Date : 2022-04-01 Epub Date: 2022-02-11 DOI: 10.1007/s10048-022-00686-5

Sachiko Miyamoto, Mitsuko Nakashima, Shinobu Fukumura, Satoko Kumada, Hirotomo Saitsu

{"title":"An intronic GNAO1 variant leading to in-frame insertion cause movement disorder controlled by deep brain stimulation.","authors":"Sachiko Miyamoto, Mitsuko Nakashima, Shinobu Fukumura, Satoko Kumada, Hirotomo Saitsu","doi":"10.1007/s10048-022-00686-5","DOIUrl":"https://doi.org/10.1007/s10048-022-00686-5","url":null,"abstract":"GNAO1 variants are associated with a wide range of neurodevelopmental disorders including epileptic encephalopathies and movement disorders. It has been reported that some GNAO1 variants are associated with movement disorders, and the 207-246 amino acid region was proposed as a mutational hotspot. Here, we report an intronic variant (NM_020988.3:c.724-8G>A) in GNAO1 in a Japanese girl who showed mild developmental delay and movement disorders including dystonia and myoclonus. Her movement disorders were improved by deep brain stimulation treatment as previously reported. This variant has been recurrently reported in four patients and was transmitted from her mother who possessed the variant as low-prevalent mosaicism. Using RNA extracted from lymphoblastoid cells derived from the patient, we demonstrated that the variant caused abnormal splicing of in-frame 6-bp intronic retention, leading to 2 amino acid insertion (p.Thr241_Asn242insProGln). Immunoblotting and immunostaining using WT and mutant GNAO1 vectors showed no significant differences in protein expression levels, but the cellular localization pattern of this mutant was partially shifted to the cytoplasm whereas WT was exclusively localized in the cellular membrane. Our report first clarified abnormal splicing and resulting mutant protein caused by the c.724-8G>A variant.","PeriodicalId":56106,"journal":{"name":"Neurogenetics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39910201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7