Journal of Herbal Medicine最新文献

{"title":"Aloe vera Alters Periostin Expression, Abolishes EMT Phenotype, and Sensitises Cells to Radiation in Conjunction With Atorvastatin in Cervical Cancer","authors":"P. Thomas ,&nbsp;S. Sahoo ,&nbsp;S. Mahajan ,&nbsp;D.L. Hiremath ,&nbsp;A.H. Udayashankara ,&nbsp;S. Srivastava","doi":"10.1016/j.hermed.2024.100873","DOIUrl":"https://doi.org/10.1016/j.hermed.2024.100873","url":null,"abstract":"<div><h3>Introduction</h3><p>Resistance to chemoradiation therapy results in poor prognosis and relapse in a sizeable percentage of cervical cancer patients. Toxicities and long-term side effects associated with radiation also warrant the need for molecules that could sensitise cells to radiation therapy. Naturally-derived compounds are a reservoir of non-toxic, potentially effective radiosensitizers of therapy-resistant tumours. This study evaluates the antitumorigenic properties of Aloe vera extracts.</p></div><div><h3>Methods</h3><p>Phenotypic assays and biochemical experiments like flow cytometry, real-time quantitative PCR, immunofluorescent imaging, western blotting, migration, and wound-healing assays were used to determine the effect of Aloe vera on cervical cancer cell lines.</p></div><div><h3>Results</h3><p>While Aloe vera treatment caused no significant changes to proliferation, survival, and cell cycling profiles, the expression of periostin, a molecule known for its association with stem-like cancer cells, decreased significantly. Phenotypically, Aloe vera treatment led to diminished clonogenicity and migratory abilities. Finally, combinatorial treatment of cells with Aloe vera and atorvastatin (a pan-Rho GTPase inhibitor) before radiation therapy resulted in a marked decrease in cell survival.</p></div><div><h3>Conclusions</h3><p>Our findings prove that Aloe vera treatment leads to reduced expression of periostin and adversely affects self-renewal and migration. Importantly, this work provides evidence that Aloe vera, in combination with atorvastatin, could serve as potential radiosensitizers of cancer cells.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100873"},"PeriodicalIF":2.3,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140951673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of common household spices and herbs in combating the COVID-19: a review based on experimental and virtual screening","authors":"Aisha Saddiqa ,&nbsp;Usman Shazad ,&nbsp;Sundas Arshad","doi":"10.1016/j.hermed.2024.100887","DOIUrl":"https://doi.org/10.1016/j.hermed.2024.100887","url":null,"abstract":"<div><h3>Introduction</h3><p>As of December 2019, the seventh coronavirus strain (SARS-COV-2), also known as COVID-19, had erupted in Wuhan, China, causing a global pandemic. This virus, which has also caused over 6.9 million deaths, has infected over 700 million people globally. Alternative preventive and therapeutic strategies, such as medicinal botanicals, are being sought in response to the COVID-19 pandemic.</p></div><div><h3>Methods</h3><p>The combination of common herbal components with antiviral action, confirmed experimentally and computationally, is the subject of this review paper. We compiled a list of one hundred antiviral phytochemicals from Aloe vera, honey, cinnamon, garlic, ginger, clove, and black cumin seeds from the literature. These compounds targeted three important steps in the replication cycle of SARS-CoV-2: the spike protein, RdRp, ACE2, NSP-16, and main protease (MPro). The phytochemical’s anti-viral potential is determined by their binding energy levels.</p></div><div><h3>Results</h3><p>Many herbs and spices contain bioactive phytochemicals that have shown strong binding energies to inhibit various targets of the SARS-CoV-2 protein. The development of antiviral medications to treat SARS-CoV-2 could be aided by further clinical trials on these molecules.</p></div><div><h3>Conclusions</h3><p>According to the findings of the literature study, it was concluded that the phytochemicals that are found in common household herbs and spices have the potential to play a significant role in the prevention and treatment of coronavirus transmission.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"46 ","pages":"Article 100887"},"PeriodicalIF":2.3,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141090561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of chewing gum containing Zingiber officinale on dry mouth condition in haemodialysis patients compared to chewing gum without Zingiber officinale","authors":"Sara Pourshahidi ,&nbsp;Soheila Manifar ,&nbsp;Fatemeh Dadashi ,&nbsp;Ahmad R. Shamshiri ,&nbsp;Mahboob L. Pezeshki ,&nbsp;Faraz Mojab","doi":"10.1016/j.hermed.2024.100872","DOIUrl":"https://doi.org/10.1016/j.hermed.2024.100872","url":null,"abstract":"<div><h3>Introduction</h3><p>Xerostomia is the most common presentation of salivary glands dysfunction affecting about 20% of the population. This study investigated the effect of ginger gum on xerostomia and quality of life in haemodialysis patients.</p></div><div><h3>Methods</h3><p>Thirty patients undergoing haemodialysis with dry mouth were randomly divided to ginger and placebo gum groups. At the beginning of the study, unstimulated and stimulated saliva samples were collected and Xerostomia Inventory (XI) and Oral Health Impact Profile (OHIP-Per14) questionnaires were administered. After 14 days, stimulated and unstimulated saliva samples were collected again and XI and OHIP-Per14 questionnaires were completed. Analysis of covariance was applied for statistical analysis.</p></div><div><h3>Results</h3><p>The rate of unstimulated salivary flow (<em>P</em> <!-->=<!--> <!-->0.03) and oral health related quality of life (<em>P</em> <!-->=<!--> <!-->0.03) were significantly higher in patients that received ginger chewing gum. The amount of stimulated saliva (<em>P</em> <!-->=<!--> <!-->0.10) and the mean severity of dry mouth (<em>P</em> <!-->=<!--> <!-->0.19) were higher in patients receiving ginger gum compared to the placebo group, but the difference was not statistically significant.</p></div><div><h3>Conclusion</h3><p>With regard to the effect of ginger gum on increasing unstimulated saliva and quality of life, it can be proposed as a safe, inexpensive, and available method to manage dry mouth.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"46 ","pages":"Article 100872"},"PeriodicalIF":2.2,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peltophorum (Caesalpinioideae, Fabaceae): a review on ethnobotanical, pharmacological and phytochemical profiles","authors":"Lucía S. Di Ciaccio ,&nbsp;Alejandra V. Catalano ,&nbsp;Paula G. López ,&nbsp;Renée H. Fortunato ,&nbsp;Adriana E. Salvat","doi":"10.1016/j.hermed.2024.100883","DOIUrl":"https://doi.org/10.1016/j.hermed.2024.100883","url":null,"abstract":"<div><h3>Introduction</h3><p>Seven species of three are recognised in the genus <em>Peltophorum</em>, distributed in the tropics and subtropics of America, South Africa, Asia, and Oceania. These species are used as ornamentals, restorers of degraded ecosystems, and forestry, providing commercially valuable wood. This review aims to analyse the different records of biological activity reported for the genus.</p></div><div><h3>Methods</h3><p>Bibliographic searches were conducted across various recognised databases, including Google Scholar, PubMed, Scopus, ScienceDirect, and Portal da Periódicos da CAPES. The searches encompassed articles, research theses, and books specifically addressing ethnobotany, isolated chemical constituents, and bioactivities within <em>Peltophorum</em> species. The exploration covered the years 1982–2023, and the connectors 'and' and 'or' were used.</p></div><div><h3>Results</h3><p>The total number of articles on the genus <em>Peltophorum</em> evaluated was 85, with seven excluded based on the editor's requirements and the nature of the research. This study comprehensively investigated the seven taxonomically recognised species, documenting the activities of synonyms and updating their nomenclatural binomials under the International Plant Names Index (IPNI). The review considered the diverse biological activities associated with these species, encompassing antiparasitic, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, antioxidant, antimutagenic, and traditional medicinal uses such as analgesic, hepatoprotective, and cardioprotective effects, among others. Analysis of phytochemical groups linked to different bioactivities revealed a predominance of phenolic compounds, coumarins, flavonoids, saponins, and tannins.</p></div><div><h3>Conclusions</h3><p>A detailed review of the <em>Peltophorum</em> genus was presented, inclusive of the phytochemical background, as well as various pharmacological and ethnobotanical activities. This contribution provides valuable information for future research.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100883"},"PeriodicalIF":2.3,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140914303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Mentha spicata Essential Oil (Supermint Oral Drops) on Gastric Residual Volume in Mechanically Ventilated Intensive Care Unit Patients: A Parallel-Group, Triple-Blinded, Randomised, Placebo-Controlled Trial","authors":"F. Mohammadzadeh ,&nbsp;S.S. Bilondi ,&nbsp;M. Sahebanmaleki ,&nbsp;J. Asari–Sani-Mend ,&nbsp;M. Tavakolizadeh ,&nbsp;H. Aalami ,&nbsp;A. Delshad Noghabi","doi":"10.1016/j.hermed.2024.100886","DOIUrl":"10.1016/j.hermed.2024.100886","url":null,"abstract":"<div><h3>Introduction</h3><p>Delayed gastric emptying is a prevalent problem in intensive care unit (<strong>ICU</strong>) patients on mechanical ventilation receiving enteral nutrition. This study aimed to assess the effect of <em>Mentha spicata</em> essential oil (Supermint oral drops) on gastric residual volume (<strong>GRV</strong>) in this patient population.</p></div><div><h3>Methods</h3><p>In this clinical trial study, from May 1, 2020 to January 30, 2021, 60 mechanically ventilated ICU patients were randomly assigned to intervention and control groups. From the first day of their feeding, patients in the intervention and control groups, respectively, received 20 drops of the Supermint and placebo dissolved in 40 ml of water, three times daily for 4 days. The GRV was measured at the baseline and during four days of intervention. Data were analysed using a generalised estimation equation regression model.</p></div><div><h3>Results</h3><p>Of the patients, 58.1% were female. The mean age of patients was 71.5 (SD = 14.2), and 65.5% were hospitalised for coronavirus disease 2019. The results indicated no significant difference between the two groups in terms of the baseline GRV (<em>P</em> = 0.181). There was a significant interaction between time and the treatment group (<em>P</em> &lt; 0.001), which suggested that GRV changes over time were different between the two groups. In the control group, the average GRV increased by 0.07 for each unit increase in time, while in the Supermint group, it decreased significantly by 1.09.</p></div><div><h3>Conclusions</h3><p>The current study’s finding suggested that <em>M spicata</em> essential oil may have the potential to reduce GRV in ICU patients undergoing mechanical ventilation. Further studies are needed to confirm this finding.</p></div><div><h3>IRCT code</h3><p>No: IRCT20191223045868N1. Date: March 28, 2020. Available at: <span>http://irct.ir/trial/46580</span><svg><path></path></svg>.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100886"},"PeriodicalIF":2.3,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140772741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of sesame oil on postpartum after-pain in multiparous women: a randomised, triple-blind, placebo-controlled clinical trial","authors":"Mahdis Mehrabi Bardar ,&nbsp;Fatemeh Zahra Karimi ,&nbsp;Seyed Reza Mazloum ,&nbsp;Roshanak Salari","doi":"10.1016/j.hermed.2024.100885","DOIUrl":"10.1016/j.hermed.2024.100885","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to evaluate the impact of sesame oil soft gels on postpartum pain in multiparous women.</p></div><div><h3>Methods</h3><p>A total of 86 multiparous women participated in a randomised, triple-blind, placebo-controlled trial. The women received a 1.1-g capsule of sesame oil or placebo after vaginal delivery every 6 hours for 24 hours. After-pain was assessed using a pain-o-meter 1 hour after each dose of medication or placebo.</p></div><div><h3>Results</h3><p>After the intervention, the mean scores of pain intensity (<em>P</em> <!-->&lt;<!--> <!-->0.001), emotional pain (<em>P</em> <!-->&lt;<!--> <!-->0.001), physical pain (<em>P</em> <!-->&lt;<!--> <!-->0.001) and total pain (<em>P</em> <!-->&lt;<!--> <!-->0.001) in the group that received sesame oil soft gels were significantly lower than those in the placebo group.</p></div><div><h3>Conclusion</h3><p>Sesame oil soft gels are affordable, easily available and they have been shown to decrease the severity of after-pains in multiparous women that would reduce the necessity of chemical drugs usage which have various side effects.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100885"},"PeriodicalIF":2.3,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140795808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Insight Into Anti-inflammatory Potential of Hibiscus rosa-sinensis Flower Extract as a Herbal Remedy: A Systematic Review","authors":"J.R. Geeganage ,&nbsp;M.D.T.L. Gunathilaka","doi":"10.1016/j.hermed.2024.100884","DOIUrl":"10.1016/j.hermed.2024.100884","url":null,"abstract":"<div><h3>Introduction</h3><p>Inflammation is a biological response of the immune system to noxious stimuli. Typically, non-steroidal anti-inflammatory drugs are used to treat inflammatory diseases but have several adverse effects. Therefore, it is important to search for natural plant-based remedies to treat inflammatory conditions. <em>Hibiscus rosa-sinensis</em> is a flowering plant belonging to the genus <em>Hibiscus</em>, which is widely used as a home remedy in Sri Lanka.</p></div><div><h3>Methods</h3><p>The information was collected via major scientific databases including PubMed, ScienceDirect, Google Scholar, and Springer related to the <em>H rosa-sinensis</em> species, polyphenols, chemical composition, and how the flower extract shows anti-inflammatory potential. Collected data were then analysed and interpreted.</p></div><div><h3>Results</h3><p>The flower <em>H rosa-sinensis</em> is a rich source of polyphenolic compounds including flavonoids and non-flavonoids, tannins, alkaloids, glycosides, saponins, terpenoids, vitamins, and other organic acids, which are reported to exhibit antioxidant and anti-inflammatory potential. The anti-inflammatory activity of <em>H rosa-sinensis</em> flower is expressed via several mechanisms including the reduction of oxidative stress, inhibition of nuclear factor kappa-B and mitogen-activated protein kinase pathways, and the alterations of the arachidonic acid pathway. In addition, the inhibition of inducible nitric oxide synthase enzyme and caspase activity and reduction of polymorphonuclear leucocyte infiltration can be given as other mechanisms.</p></div><div><h3>Conclusions</h3><p><em>H rosa-sinensis</em> flower is a rich source of bioactive compounds that exhibit potent antioxidant and anti-inflammatory activities.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100884"},"PeriodicalIF":2.3,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140788724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capsaicin Ameliorates Chemotherapy Response via Cancer Hallmarks Modulation: An Overview of its Synergic Potential","authors":"R.F. Costa ,&nbsp;F.C. Cadoná","doi":"10.1016/j.hermed.2024.100882","DOIUrl":"10.1016/j.hermed.2024.100882","url":null,"abstract":"<div><h3>Introduction</h3><p>Cancer is a disease caused by genetic changes and disordered cell growth with high incidences over the years. Conventional treatments such as chemotherapy act on cells that are in constant cell division; however, frequently, they are not selective to cancer cells and can damage healthy cells. For this reason, side effects such as nausea, dizziness, hair loss, weight loss, and fatigue are reported by patients. Moreover, some cancers present resistance to chemotherapy treatment. Therefore, studies focusing on functional and natural products, especially those rich in bioactive compounds, such as capsaicin, could be used as chemotherapy adjuvant to improve treatment response and decrease side effects.</p></div><div><h3>Methods</h3><p>In this scenario, we conducted a review of 75 articles regarding the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation.</p></div><div><h3>Results</h3><p>In this scenario, we reviewed the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation. This natural bioactive molecule ameliorates the chemotherapy response by several cancer pathway regulations.</p></div><div><h3>Conclusions</h3><p>This review was able to show that capsaicin has a remarkable effect as an adjuvant to improve chemotherapy and reduce side effects.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100882"},"PeriodicalIF":2.3,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragalus Mongholicus: A Review of its Pharmacological Mechanisms Against Gastric Cancer","authors":"J.J. Tibenda ,&nbsp;Y. Du ,&nbsp;Y. Nan ,&nbsp;S. Huang ,&nbsp;G. Chen ,&nbsp;N. Ning ,&nbsp;X. Li ,&nbsp;Y. Yang ,&nbsp;L. Yuan","doi":"10.1016/j.hermed.2024.100881","DOIUrl":"10.1016/j.hermed.2024.100881","url":null,"abstract":"<div><h3>Introduction</h3><p>Astragalus membranaceus (<strong>AM</strong>) is an outstanding traditional medicinal herb that has been highly utilised for many decades in China, mainly as an adaptogen. Several medicinal functions have been associated with the components of astragalus, such as antitumour, anti-inflammatory, immune-enhancing, antioxidative, neuroprotective, and cardioprotective functions. In addition to providing future ideas on the pharmacological effects of AM in the treatment of gastric cancer (<strong>GC</strong>), this review aims to elucidate the active components of AM and its antitumour effects in GC, as well as highlight the existing experimental studies on the mechanism of AM in GC.</p></div><div><h3>Methods</h3><p>Literature publications relevant to the aim of the study were screened from Science Direct, PubMed, Web of Science, and Google Scholar. ‘Astragalus mongholicus,’ ‘Astragalus mongholicus, Gastric Cancer,’ ‘Astragalus Polysaccharides, Gastric Cancer,’ ‘Astragalus Saponins, Gastric Cancer,’ and ‘Flavonoids of Astragalus’ were the key terms used.</p></div><div><h3>Results</h3><p>Studies showed that the mechanism of action of AM in GC mainly includes suppression of cellular migration, proliferation, and invasion of GC cells. Furthermore, AM promotes cell cycle arrest and apoptosis by regulating several intracellular signalling pathways involved mainly in the immune system and inflammation.</p></div><div><h3>Conclusions</h3><p>The main active ingredients of AM, such as Astragalus polysaccharide, Astragaloside IV, and flavonoids like calycosin, play a major role in attenuating GC. The compounds were found to possess potent antitumour effects against GC and have to be further evaluated. Astragalus membranaceus is also a potential adjuvant chemotherapy agent.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100881"},"PeriodicalIF":2.3,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic study on herbal cream for various clinical and therapeutic application: current status and future prospects","authors":"Arushi,&nbsp;Ashok Behera,&nbsp;Neeraj K. Sethiya,&nbsp;Satish Shilpi","doi":"10.1016/j.hermed.2024.100880","DOIUrl":"10.1016/j.hermed.2024.100880","url":null,"abstract":"<div><h3>Introduction</h3><p>Recent trends and current market analysis suggest demand for herbal formulations, including herbal creams, is increasing over synthetic creams due to their lower toxicity and fewer side effects, followed by more skin nourishment capability, according to several published studies. Moreover, published literature lacks any updated, compiled explanatory review on herbal creams. Therefore, we designed the present communication to accomplish the current requirement.</p></div><div><h3>Objective</h3><p>The major objective of the present communication is to provide the clinical data-based evidence and state of the art adopted for the formulation and development of herbal cream, including its composition and manufacturing processes, to establish therapeutic effectiveness.</p></div><div><h3>Method</h3><p>Both online and offline literature searches were performed and screened. The publications accounted for <em>in vitro</em> and clinical studies, followed by various preparation methods, classification and manufacturing process were included. There were a total of 150 papers finally selected and reviewed in the present communications addressing concerns related to herbal cream from 1995 to July 2023.</p></div><div><h3>Result</h3><p>It was established that herbal creams can be produced using a variety of techniques and methods. Majorly anti-inflammatory, dermatitis, anti-trauma, anti-aging, anti-acne, and vulvovaginal herbal creams were enlisted in terms of different clinical and therapeutic application.</p></div><div><h3>Conclusion</h3><p>The evidence from the present systematic review suggests that more human clinical trials with larger sample sizes are needed in order to achieve higher accuracy in terms of the safety and efficacy of herbal creams.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100880"},"PeriodicalIF":2.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}