Journal of Herbal Medicine最新文献

{"title":"Microfluidics assisted green synthesis of copper oxide nanoparticles from the aqueous leaf extract of Ipomoea quamoclit L. with its antimicrobial and antioxidant activity","authors":"D. Joanna Magdalene,&nbsp;D. Muthuselvam","doi":"10.1016/j.hermed.2024.100940","DOIUrl":"10.1016/j.hermed.2024.100940","url":null,"abstract":"<div><h3>Introduction</h3><div>Green nanosynthesis of medicinal plants are useful for the development of antibiotic agents. In this work, we have explored the antimicrobial and antioxidant activity of green synthesised copper oxide (CuO) nanoparticles (NPs) from tropical medicinal plant <em>Ipomoea quamoclit</em> L.</div></div><div><h3>Methods</h3><div>With the aid of microfluidic technology, a low-cost, polydimethylsiloxane (PDMS) lab-on-chip micromixer for green nanosynthesis of CuO nanoparticle using <em>Ipomoea quamoclit</em> is presented. The UV–Vis characteristics, Fourier Transform Infra-red (FTIR) spectrum, antimicrobial and antioxidant response using DPPH and hydrogen peroxide (H₂O₂) were reported. The antimicrobial efficacy of the synthesised CuO-NPs is tested against two-gram positive bacteria <em>Staphylococcus aureus, Micrococcus luteus,</em> two gram negative bacteria, <em>Enterobacter cloacae</em>, <em>Klebsiella pneumoniae</em> and two fungi species <em>Candida albicans</em>, <em>Aspergillus niger.</em></div></div><div><h3>Results</h3><div>UV–Vis spectrum for the synthesised CuO-NPs showed the absorbance at 670 nm, scanning electron microscope (SEM) image analysis and dynamic light scattering (DLS) analysis confirmed the presence of spherical shaped nanoparticle sized between 65 and 94.5 nm. The presence of bioactive functional groups of N-H, C-H and C=0 stretching was identified using Fourier Transform Infrared spectroscopy (FTIR). The maximum mean zone of inhibition obtained was 10.45<!--> <!-->±<!--> <!-->0.25 mm for fungi <em>A. niger</em>. The antioxidant activity using DPPH scavenging assay and hydrogen peroxide scavenging assay showed the IC₅₀ value 33.94 μg/ml and 42.54 μg/ml respectively.</div></div><div><h3>Conclusions</h3><div>The obtained results reveal the potential of CuO-NPs synthesised from <em>I. quamoclit</em> L. as a remarkable medicinal entity for wound healing, respiratory infection, fungal infection and urinary tract infection along with the improved antimicrobial and antioxidant activity.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100940"},"PeriodicalIF":2.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shenmai injection in treating chemotherapy-related cardiotoxicity of breast cancer: a systematic review and meta-analysis","authors":"Ming Feng ,&nbsp;Hong Huang ,&nbsp;Chang Yao","doi":"10.1016/j.hermed.2024.100936","DOIUrl":"10.1016/j.hermed.2024.100936","url":null,"abstract":"<div><h3>Objective</h3><div>Shenmai injection (SMI) is an established treatment for cardiac diseases, and we performed to evaluate the efficacy of SMI combined with chemotherapy drugs for the treatment of chemotherapy-induced cardiotoxicity.</div></div><div><h3>Methods</h3><div>The primary outcome was abnormal electrocardiogram (ECG), left ventricular ejection fraction (LVEF) and E/A. The secondary outcomes included myocardial injury biomarkers (creatine kinase [CK], creatine kinase MB [CK-MB], and cardiac troponin I [cTnI]) and lipid peroxide markers (superoxide dismutase [SOD], glutathione [GSH], and malondialdehyde [MAD]).</div></div><div><h3>Results</h3><div>Studies indicated that SMI combined with chemotherapy drugs has advantages over chemotherapy drugs alone in reducing the incidence of abnormal ECG (ST-T: RR = 0.613, 95% CI [0.437, 0.862], <em>P</em> = 0.005; extrasystole: RR = 0.527, 95% CI [0.349, 0.798], <em>P</em> = 0.002). Myocardial injury biomarkers in the experimental group were lower than those in the control group (CK: SMD = –2.614, 95% CI [–3.156, –2.071], <em>P</em> = 0.000; CK-MB: SMD = –6.882, 95% CI [–8.982, –4.782], <em>P</em> = 0.000; cTnI: SMD = –3.610, 95% CI [–4.949, –2.271], <em>P</em> = 0.000). Ultrasonic cardiogram analysis showed that the experimental group had a higher LVEF and E/A than the control group (LVEF: SMD = 1.572, 95% CI [1.176, 1.969], <em>P</em> = 0.000; E/A: SMD = 0.280, 95% CI [0.153, 0.407], <em>P</em> = 0.000). Lipid peroxide meta-analysis showed that the experimental group had higher SOD and GSH levels (SOD: weighted mean difference (WMD) = 39.783, 95% CI (32.524, 47.042), <em>P</em> = 0.000; GSH: WMD = 32.960, 95% CI [26.055, 39.865], <em>P</em> = 0.000), and lower malondialdehyde (MDA) (WMD = –4.962, 95% CI [–6.041, –3.883], <em>P</em> = 0.000).</div></div><div><h3>Conclusion</h3><div>SMI is effective in reducing cardiac injury and the incidence of cardiotoxicity.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100936"},"PeriodicalIF":2.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological applications of Urtica dioica: a comprehensive review of its traditional use and modern scientific evidence","authors":"Md Alimoddin ,&nbsp;S. Jayakumari ,&nbsp;Butool Fatima ,&nbsp;Nadeem Hasan ,&nbsp;Sadat Ali ,&nbsp;Farheen Sami ,&nbsp;Md Sajid Ali ,&nbsp;Rajesh Sreedharan Nair ,&nbsp;Mohammed Tahir Ansari","doi":"10.1016/j.hermed.2024.100935","DOIUrl":"10.1016/j.hermed.2024.100935","url":null,"abstract":"<div><h3>Introduction</h3><div>This review article provides a comprehensive overview of the phytochemical constituents, traditional uses, and pharmacological applications of <em>Urtica dioica</em> (UD), commonly known as stinging nettle.</div></div><div><h3>Methodology</h3><div>An extensive literature search was conducted to identify 278 relevant articles. After eliminating 38 duplicates, we thoroughly analysed the remaining 240 articles by examining their titles and abstracts. Finally, 126 articles were selected for inclusion in this comprehensive study on UD.</div></div><div><h3>Discussion</h3><div>This review explores the plant identifiable characteristics, geographical distribution and taxonomic classification. The phytochemicals found in plants include sterols, fatty acids, alkaloids, terpenoids, flavonoids, lignans, and essential oils, all of which contribute to their medicinal and therapeutic properties. It exhibits a broad range of pharmacological activities including anti-inflammatory, hypoglycaemic, antiurolithiatic, neuroprotective, antioxidant, antimicrobial, antiproliferative, and anticancer effects. UD leaves contain high levels of antioxidants, which may be useful for the treatment of breast cancer by inducing apoptosis. UD extracts <em>exert</em> a protective function by regulating blood glucose levels and β-cell activity, exhibiting insulin-like effects. It also inhibits pro-inflammatory pathways and demonstrates hepatoprotective properties following hepatectomy. UD extract inhibits the proliferation and migration of cancer cells and displays antiviral activity against rotavirus and feline immunodeficiency virus. Furthermore, UD is effective in treating chronic conditions, such as prostatitis, dandruff, and osteoarthritis, thereby reducing the need for conventional medications.</div></div><div><h3>Conclusion</h3><div>The diverse uses and biological properties of UD make it a subject of interest for future research.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100935"},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained use of antimutagenic bioactives having affinity with DNA minor groove could prevent in vitro neoplastic induction","authors":"Jyoti Tripathi ,&nbsp;Surbhi Wadhawan ,&nbsp;Sumit Gupta ,&nbsp;Satyendra Gautam","doi":"10.1016/j.hermed.2024.100939","DOIUrl":"10.1016/j.hermed.2024.100939","url":null,"abstract":"<div><h3>Introduction</h3><div>Studies on the antimutagenic and anti-neoplastic effect of dietary ingredients can be useful in developing nutraceuticals for preventing neoplastic induction. In the current study the query whether food rich in antimutagenic potential equally suppress the neoplastic induction, was addressed, with potential mechanism of action.</div></div><div><h3>Methods</h3><div>The antimutagenic activity was evaluated using the TK6 gene mutation assay, assessing the reduction in ethyl methanesulfonate (EMS)-induced mutation in presence of vegetable extracts. The anti-⁠neoplastic activity was assessed using the C3H/⁠10T1/⁠2 cell transformation assay, quantifying the inhibition of anchorage-independent growth and type III foci formation. The prominent compounds in the vegetable extract were characterised using gas chromatography-⁠mass spectrometry (GC-⁠MS), and their interactions with DNA were predicted using molecular docking.</div></div><div><h3>Results</h3><div>Among the vegetable extracts, garlic exhibited the most potent antimutagenic and anti-neoplastic effects, followed by spinach and beans. Garlic extract exhibited significantly high antimutagenic potential (59<!--> <!-->±<!--> <!-->3%), and anti-neoplastic activity in the terms of inhibition of anchorage independence (65<!--> <!-->±<!--> <!-->3%) and inhibition of type III foci formation (90<!--> <!-->±<!--> <!-->5%). GC-MS analysis of garlic extract identified abundant organosulphur compounds, terpenes, and terpenoids. Molecular docking studies suggested that these compounds bind to the DNA minor groove with binding energies ranging from −⁠4.3 to −⁠7.21 kcal mol^-⁠1.</div></div><div><h3>Discussion</h3><div>The antimutagenic and antineoplastic activities showed a positive correlation (<em>r</em> <!-->=<!--> <!-->0.92–0.93), where garlic extract showed the highest potential. The DNA binding properties of the prominent compounds in garlic extract suggests a potential mechanism of action involving interference with carcinogen activity and subsequent prevention of gene dysregulation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100939"},"PeriodicalIF":2.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combating paediatric pneumonia: the dynamic duo of cinnamon-clove steam and physiotherapy","authors":"Arslan Iftikhar,&nbsp;Mehlaqa Waseem,&nbsp;Haseeb Anwar","doi":"10.1016/j.hermed.2024.100938","DOIUrl":"10.1016/j.hermed.2024.100938","url":null,"abstract":"<div><h3>Introduction</h3><div>Paediatric community-acquired pneumonia (CAP) is a prevailing respiratory infection that impacts children in non-medical settings, giving rise to substantial morbidity and mortality, especially in less developed areas. The current study was aimed at finding a holistic approach for improving the management and treatment of paediatric CAP. For that purpose, a comparative interventional study was conducted to investigate the effectiveness of chest physiotherapy (CPT) combining with <em>Cinnamon varum</em> and <em>Syzygium aromaticum</em> steam therapy in paediatric CAP.</div></div><div><h3>Methods</h3><div>A total of 60 paediatric patient hospitalised with CAP were assessed. The study included both male and female participants aged between three and 14 years. The study was conducted at Children Hospital and Institute of Child Health in Faisalabad, Pakistan. The subjects were divided into three equal groups: group 1 received CPT, group 2 underwent CPT accompanied with nebulization, and group 3 received CPT along with steam therapy using <em>C. varum</em> and <em>S. aromaticum</em>. Each participant received the assigned therapy twice a day for seven consecutive days. The study was approved and registered by Ethics Review Committee, Government College University, Faisalabad, Pakistan (Reference number GCUF/ERC/214).</div></div><div><h3>Results</h3><div>Among the three groups studied, those who received the combined therapy exhibited improved outcome by improving the complete blood count (CBC), spirometer index, arterial blood gases (ABGs) and Systolic blood pressure, Multilobar infiltrates, Albumin, Respiratory rate, Tachycardia, Confusion, Oxygen and pH severity score for pneumonia.</div></div><div><h3>Conclusions</h3><div>The antimicrobial, anti-inflammatory and mucolytic properties of cinnamon and clove, along with the positive effects of CPT, resulted in reduced lung inflammation, enhanced respiratory performance, and improved vital signs.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100938"},"PeriodicalIF":2.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Human Papilloma Virus-Related Cervical and Gynaecological Pathogenesis Using Herbal Medicine, Meta Analysis","authors":"L. Qiao ,&nbsp;X. Fan ,&nbsp;Y. Xiao ,&nbsp;J. Liang","doi":"10.1016/j.hermed.2024.100933","DOIUrl":"10.1016/j.hermed.2024.100933","url":null,"abstract":"<div><h3>Introduction</h3><p>Human papillomavirus (<strong>HPV</strong>) is a major cause of cervical cancer, particularly types 16 and 18, which are responsible for 70% of cases. The current study’s main aim is to evaluate the impact of using herbal medicine extract for the management of HPV-related cervical and gynaecological pathogenesis.</p></div><div><h3>Methods</h3><p>A systematic literature was accomplished and 2007 patients with HPV-related diseases were recruited to the current studies; 1 089 of them were treated with herbal extracted products, and 918 were control groups. The inclusion criteria of the current study recruited only randomised clinical trials with a comparison-based design.</p></div><div><h3>Results</h3><p>Using herbal extracts for the treatment of HPV-related pathogenesis showed a significant improvement in short- and long-term using several plant-based preparations. Improved parameters were the rate of HPV clearance (<em>P</em> &lt; 0.001), rate of cervical intraepithelial neoplasia (<em>P</em> &lt; 0.001), and adverse events (<em>P</em> &gt; 0.05). In contrast to the significant difference between the intervention group and control regarding efficacy-related parameters, there were no significant differences regarding adverse events occurrence rate<strong>.</strong> The heterogeneity of different model levels was assessed by I² and ranged from 0% to 86.6%.</p></div><div><h3>Conclusions</h3><p>Using herbal medicine for the management of HPV-related cervical pathogenesis showed a beneficial impact regarding the clearance rate of high-risk HPV and a higher rate of cervical intraepithelial neoplasia regression. In addition, herbal medicines showed high safety rates compared to control.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100933"},"PeriodicalIF":2.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mechanism of Wenhua Decoction in the Treatment of Non–Small Cell Lung Cancer by Network Pharmacology and Molecular Dynamics Simulation","authors":"D. Wei","doi":"10.1016/j.hermed.2024.100934","DOIUrl":"10.1016/j.hermed.2024.100934","url":null,"abstract":"<div><h3>Introduction</h3><div>Network pharmacology approaches were applied to reveal the mechanism of Wenhua Decoction in non–small cell lung cancer (<strong>NSCLC</strong>) treatment.</div></div><div><h3>Methods</h3><div>Effective chemical constituents and targets of Wenhua Decoction were collected by database, and differentially expressed genes of NSCLC were screened. Restart random walk analysis for protein-protein interaction network was conducted using the intersected genes of differentially expressed genes and target genes in NSCLC as seeds. The top 50 genes in affinity coefficient were used to construct the drug-active constituent-gene interaction network. Molecular docking and molecular dynamic analyses were conducted for core targets and corresponding active constituents in the network. Quercetin content was determined by HPLC. Quantitative real time polymerase chain reaction (qRT-PCR) was performed to assess CDK1 expression in A549 cells. The effects of Wenhua Decoction on the cell cycle were evaluated in sh-CDK1 cells. Cellular thermal shift assay was utilised to examine the binding status between CDK1 and its target quercetin.</div></div><div><h3>Results</h3><div>The drug-active constituent-gene interaction network demonstrated that CDK1 was at the core of the network. Quercetin could bind to CDK1 stably while causing no significant changes in protein conformation. Wenhua Decoction treatment significantly reduced CDK1 expression and blocked transition of cancer cells from the G1 to the S phase. The quercetin content was 16.0 μg/g. Furthermore, cellular thermal shift assay experiment showed a high binding affinity between CDK1 and quercetin present in the Wenhua Decoction.</div></div><div><h3>Conclusions</h3><div>This study revealed potential targets, active constituents, and mechanism of Wenhua Decoction in treating NSCLC, providing a reference for clinical treatment of NSCLC with Wenhua Decoction.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100934"},"PeriodicalIF":2.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the immunomodulatory effects of polysaccharides in the management of inflammatory bowel disease: a review","authors":"Madhu Bala Durairajan,&nbsp;Parimelazhagan Thangaraj","doi":"10.1016/j.hermed.2024.100932","DOIUrl":"10.1016/j.hermed.2024.100932","url":null,"abstract":"<div><h3>Introduction</h3><p>This study highlights the diverse roles of polysaccharides in health, focusing on their potential applications in inflammatory bowel disease. Polysaccharides are complex biopolymers consisting of bonded monosaccharides that possess branching or linear forms.</p></div><div><h3>Objective</h3><p>As potential natural antioxidants and diabetes ameliorators, the study aimed on exploring the therapeutic applications of polysaccharides, particularly focusing its role in the treatment of inflammatory bowel disease.</p></div><div><h3>Sources of evidence</h3><p>Electronic bibliographic databases like PUBMED and Google Scholar were used to find relevant peer-reviewed studies in English from 2008 to 2024. Finally, 51 studies were included in the analysis.</p></div><div><h3>Results</h3><p>In inflammatory bowel disease, which is marked by mucosal inflammation and gut microbial dysbiosis, the interaction of genetics, environment, and gut microbiota highlights the significance of comprehending and treating dysbiosis for mucosal immunological health. Through their modulation of intestinal flora, the immune system, and inflammatory cytokines, polysaccharides significantly impact ulcerative colitis and Crohn’s disease. The intricate involvement of Toll-like receptors and downstream signalling pathways, including MAPK, GPCR, JAK-STAT and NF-κB, presents therapeutic opportunities for mitigating IBD complexities and restoring immune homoeostasis.</p></div><div><h3>Conclusion</h3><p>Polysaccharides demonstrate multifaceted benefits including anti-inflammatory, antioxidative, and immunomodulatory effects. By regulating cytokine signalling and supporting gut health, polysaccharides present promising avenues for developing therapeutics targeting inflammatory conditions, particularly inflammatory bowel diseases.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100932"},"PeriodicalIF":2.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential use of plant-based therapeutics for the management of SARS-COV2 infection in diabetes mellitus – a review","authors":"Neha Deora ,&nbsp;Krishnan Venkatraman","doi":"10.1016/j.hermed.2024.100923","DOIUrl":"10.1016/j.hermed.2024.100923","url":null,"abstract":"<div><h3>Introduction</h3><p>The COVID-19 pandemic observed during 2019–2021 challenged healthcare systems, making the infection a global public health emergency. Diabetes emerged rapidly as a major comorbidity for COVID-19 severity, increasing the risk of negative outcomes in diabetics if infected with COVID-19. The pandemic has prompted extensive research into potential therapies, including the investigation of natural products as repurposing drugs. They have unrivalled benefits, including a wealth of experience, diverse biological activity, and unique diversity.</p></div><div><h3>Objective</h3><p>This updated review aims to emphasise on some of the plants and their metabolites that are known to offer therapeutic benefits against diabetes mellitus towards increased inflammation, blood coagulation and vascular complications and can be used as potential adjuvant therapy in diabetics with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.</p></div><div><h3><strong>Methods</strong></h3><p>The reported literature was sourced from PubMed, Science Direct, Google Scholar, Web of Science, Scopus, Clinical Trials.gov, and Wiley online library with a focus on peer-reviewed English-language publications that exclusively addressed type 2 diabetes and COVID-19 interaction, clinical implications, and the anti-diabetic effects of natural products and traditional medicine.</p></div><div><h3>Conclusion</h3><p>The anti-inflammatory, immunomodulatory, anticoagulant and endothelial nitric oxide synthase (eNOS) modulating potential of several of these plants laid down a strong rationale for their use in developing therapies against SARS-CoV-2 infection, and may represent a beneficial contributory step in the management of COVID-19 in diabetics.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"47 ","pages":"Article 100923"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"South African medicinal plants used for health conditions affecting males: an ethnobotanical review","authors":"Mompati V. Chakale ,&nbsp;Makhotso Lekhooa ,&nbsp;Adeyemi O. Aremu","doi":"10.1016/j.hermed.2024.100931","DOIUrl":"10.1016/j.hermed.2024.100931","url":null,"abstract":"<div><h3>Introduction</h3><p>Health issues affecting males remain a public health challenge due to the limited treatments and male health-seeking behaviour. In South Africa, local communities have relied on plant-based therapies to address health issues including those affecting males. This review explored the ethnobotanical and indigenous knowledge of plants used for managing male urogenital and sexual-reproductive conditions in South Africa, to establish the existing status and identify gaps for further research.</p></div><div><h3>Methods</h3><p>Following a systematic search, 51 eligible studies were extracted from electronic databases.</p></div><div><h3>Results</h3><p>A total of 337 plants belonging to 83 families were collated across seven provinces in South Africa. Fabaceae (37) and Asteraceae (37) were the most represented plant families. <em>Hypoxis hemerocallidea</em> Fisch., C.A.Mey. &amp; Avé-Lall. (18 citations), and <em>Entada elephantina</em> (Burch.) S.A.O’Donnell &amp; G.P.Lewis (synonym: <em>Elephantorrhiza elephantina</em> (Burch.) Skeels) (12 citations) were the commonly used plants. Roots (33.4%) and leaves (17%) were the most commonly used plant parts. Decoction (44%) and oral-based (53%) were the dominant preparation and administration method, respectively. The two major health conditions had 18 sub-categories as derived from the eligible studies. Particularly, aphrodisiac and erectile dysfunction were the most encountered conditions and were managed with 133 plants. Provinces such as the Northern Cape and North West had limited studies on plants used for male healthcare needs.</p></div><div><h3>Conclusion</h3><p>We highlighted the importance of plants in meeting the primary healthcare needs of males. This suggests the need to promote additional research into the cultural, therapeutic, and dynamic trends in the use of plants for meeting the healthcare needs of males, especially in rural areas.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"47 ","pages":"Article 100931"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2210803324000885/pdfft?md5=821655e148a4e1cff4539cedf42777a1&pid=1-s2.0-S2210803324000885-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}