治疗湿疹的中药浴：39 项随机对照试验的系统回顾和元分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine Pub Date : 2024-10-23 DOI:10.1016/j.hermed.2024.100959

Yiran Chen , Xiaoxuan Ma , Xiaoya Fei , Ying Luo , Yue Luo , Xin Ma , Le Kuai , Bin Li , Bin Fan , Xiaojie Ding

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引用次数: 0

摘要

导言中药浴（CHB）在治疗湿疹方面具有良好的前景，但目前尚缺乏高质量的临床证据。方法检索PubMed、Embase、Cochrane图书馆、中国知网、VIP中文期刊服务平台和万方数据库中比较中药浴与非中药浴干预治疗湿疹的随机对照试验。结果我们的荟萃分析纳入了39项随机对照试验的数据，结果显示CHB的疗效优于常规疗法（RR，1.15；95% CI，1.11-1.20；P <；0.00001），与常规疗法联合使用时，疗效也有所改善（RR，1.14；95% CI，1.09-1.19；P <；0.00001）。湿疹面积严重性指数评分（平均差 [MD]，-1.04；95% CI，-1.50 至 -0.59；P <；0.00001）、视觉模拟量表评分（MD，-0.61；95% CI，-0.64 至 -0.58；P <；0.00001）和皮肤科生活质量指数评分（MD，-1.15；95% CI，-1.68 至 -0.61；P <；0.00001），同时复发率较低（RR，0.24；95% CI，0.14 至 0.41；P <；0.00001），而不良事件风险未增加。结论中药浴是治疗湿疹的一种安全有效的替代疗法，能显著改善临床症状，并具有潜在的免疫学益处。未来的研究应侧重于更大规模、高质量的随机对照试验和中药浴配方的详细生化分析，以进一步验证这些发现并探索其作用机制。

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Chinese Herbal Bath for Eczema: A Systematic Review and Meta-analysis of 39 Randomised Controlled Trials

Introduction

Chinese herbal bath (CHB) shows promise in treating eczema, but high-grade clinical evidence is lacking. This review aims to systematically evaluate the efficacy and safety of CHB in the treatment of eczema.

Methods

PubMed, Embase, Cochrane Library, China Network Knowledge Infrastructure, VIP Chinese Journal Service Platform, and Wan Fang Database were searched for Randomised controlled trials comparing CHB with non-CHB interventions for eczema. RevMan5.4 software was used to calculate the 95% confidence interval (CI) risk ratio (RR) and perform meta-analysis.

Results

Our meta-analysis incorporated data from 39 randomised controlled trials, demonstrating CHB's enhanced efficacy over conventional therapy (RR, 1.15; 95% CI, 1.11–1.20; P < 0.00001) and improved outcomes when used in conjunction with conventional therapy (RR, 1.14; 95% CI, 1.09–1.19; P < 0.00001). Significant improvements were observed in Eczema Area Severity Index scores (mean difference [MD], −1.04; 95% CI, −1.50 to −0.59; P < 0.00001), visual analogue scale scores (MD, −0.61; 95% CI, −0.64 to −0.58; P < 0.00001), and Dermatology Life Quality Index scores (MD, −1.15; 95% CI, −1.68 to −0.61; P < 0.00001), alongside a lower recurrence rate (RR, 0.24; 95% CI, 0.14–0.41; P < 0.00001) without an increased risk of adverse events. Additionally, immunological marker analysis revealed significant modulatory effects on the immune response.

Conclusions

Chinese herbal bath represents a safe and effective alternative for eczema treatment, offering significant clinical improvements and potential immunological benefits. Future research should focus on larger, high-quality randomised controlled trials and detailed biochemical analyses of CHB formulations to further validate these findings and explore the mechanisms of action.

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来源期刊

Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.