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Journal of Gastric Cancer最新文献

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Efficacy of Hyperthermic Pressurized Intraperitoneal Aerosol Chemotherapy in an In Vitro Model Using a Human Gastric Cancer AGS Cell Line and an Abdominal Cavity Model. 利用人体胃癌 AGS 细胞系和腹腔模型在体外模型中进行高热加压腹腔内气溶胶化疗的疗效。
IF 3.2 4区 医学
Journal of Gastric Cancer Pub Date : 2024-07-01 DOI: 10.5230/jgc.2024.24.e24
Sa-Hong Min, Jieun Lee, Mira Yoo, Duyeong Hwang, Eunju Lee, So Hyun Kang, Kanghaeng Lee, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung-Ho Kim
{"title":"Efficacy of Hyperthermic Pressurized Intraperitoneal Aerosol Chemotherapy in an In Vitro Model Using a Human Gastric Cancer AGS Cell Line and an Abdominal Cavity Model.","authors":"Sa-Hong Min, Jieun Lee, Mira Yoo, Duyeong Hwang, Eunju Lee, So Hyun Kang, Kanghaeng Lee, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung-Ho Kim","doi":"10.5230/jgc.2024.24.e24","DOIUrl":"10.5230/jgc.2024.24.e24","url":null,"abstract":"<p><strong>Purpose: </strong>Peritoneal carcinomatosis (PC) presents a major challenge in the treatment of late-stage, solid tumors, with traditional therapies limited by poor drug penetration. We evaluated a novel hyperthermic pressurized intraperitoneal aerosol chemotherapy (HPIPAC) system using a human abdominal cavity model for its efficacy against AGS gastric cancer cells.</p><p><strong>Materials and methods: </strong>A model simulating the human abdominal cavity and AGS gastric cancer cell line cultured dishes were used to assess the efficacy of the HPIPAC system. Cell viability was measured to evaluate the impact of HPIPAC under 6 different conditions: heat alone, PIPAC with paclitaxel (PTX), PTX alone, normal saline (NS) alone, heat with NS, and HPIPAC with PTX.</p><p><strong>Results: </strong>Results showed a significant reduction in cell viability with HPIPAC combined with PTX, indicating enhanced cytotoxic effects. Immediately after treatment, the average cell viability was 66.6%, which decreased to 49.2% after 48 hours and to a further 19.6% after 120 hours of incubation, demonstrating the sustained efficacy of the treatment. In contrast, control groups exhibited a recovery in cell viability; heat alone showed cell viability increasing from 90.8% to 94.4%, PIPAC with PTX from 82.7% to 89.7%, PTX only from 73.3% to 74.8%, NS only from 90.9% to 98.3%, and heat with NS from 74.4% to 84.7%.</p><p><strong>Conclusions: </strong>The HPIPAC system with PTX exhibits a promising approach in the treatment of PC in gastric cancer, significantly reducing cell viability. Despite certain limitations, this study highlights the system's potential to enhance treatment outcomes. Future efforts should focus on refining HPIPAC and validating its effectiveness in clinical settings.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"24 3","pages":"246-256"},"PeriodicalIF":3.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lifestyle Behaviors in Patients With Gastric Cancer: Continuous Need for Alcohol Abstinence and Muscle Strength Training Education. 胃癌患者的生活方式：戒酒和肌力训练教育的持续需求。
IF 3.2 4区 医学
Journal of Gastric Cancer Pub Date : 2024-07-01 DOI: 10.5230/jgc.2024.24.e27
Ji Won Seo, Kyu Na Lee, Kyung Do Han, Ki Bum Park
{"title":"Lifestyle Behaviors in Patients With Gastric Cancer: Continuous Need for Alcohol Abstinence and Muscle Strength Training Education.","authors":"Ji Won Seo, Kyu Na Lee, Kyung Do Han, Ki Bum Park","doi":"10.5230/jgc.2024.24.e27","DOIUrl":"10.5230/jgc.2024.24.e27","url":null,"abstract":"<p><strong>Purpose: </strong>This study was performed to assess the lifestyle-related behaviors of patients with gastric cancer (GC) and to investigate the associations between the time since GC diagnosis and these behaviors.</p><p><strong>Materials and methods: </strong>This study included 29,478 adults (including 338 patients with GC) aged ≥ 40 years who participated in the Korea National Health and Nutrition Examination Survey 2014-2021. Multiple logistic regression analysis explored the associations between the time since GC diagnosis (patients diagnosed with GC less than 5 years ago [<5 years group] and those diagnosed with GC 5 or more than years ago [≥5 years group]) and lifestyle factors. Subgroup analyses were conducted based on age and sex.</p><p><strong>Results: </strong>The current smoking rate was not lower in the GC group than in the healthy group, regardless of time since diagnosis. Compared to the healthy controls, monthly alcohol intake was lower in the <5 years group (odds ratio [OR], 0.450; 95% confidence interval [CI], 0.275-0.736). The ≥5 years group showed a lower rate of strength training (OR, 0.548; CI, 0.359-0.838), compared with the healthy control group. Subgroup analysis focusing on the ≥5 years group revealed a significantly lower rate of strength training, particularly in patients aged ≥65 years and male patients (OR, 0.519 and 0.553; CI, 0.302-0.890 and 0.340-0.901, respectively).</p><p><strong>Conclusions: </strong>Clinicians should continue educating patients on lifestyle behavior modifications, particularly alcohol abstinence, even beyond 5 years after GC diagnosis. Education on strength training is especially important for patients ≥65 years or male patients.</p>","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"24 3","pages":"316-326"},"PeriodicalIF":3.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term Outcomes of Patients With Early Gastric Cancer Who Had Lateral Resection Margin-Positive Tumors Based on Pathology Following Endoscopic Submucosal Dissection. 根据内镜黏膜下切除术后病理结果显示侧切边缘阳性肿瘤的早期胃癌患者的长期预后
IF 2.5 4区 医学
Journal of Gastric Cancer Pub Date : 2024-04-05 DOI: 10.5230/jgc.2024.24.e15
Jun Hee Lee, Sang Gyun Kim, Soo-Jeong Cho
{"title":"Long-term Outcomes of Patients With Early Gastric Cancer Who Had Lateral Resection Margin-Positive Tumors Based on Pathology Following Endoscopic Submucosal Dissection.","authors":"Jun Hee Lee, Sang Gyun Kim, Soo-Jeong Cho","doi":"10.5230/jgc.2024.24.e15","DOIUrl":"https://doi.org/10.5230/jgc.2024.24.e15","url":null,"abstract":"Long-term outcomes of patients with positive lateral margins (pLMs) after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). This study aimed to evaluate the remnant cancer and survival rates of patients with pLMs compared with those who underwent curative resection.","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"2 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Impact of Polyglycolic Acid Mesh to Reduce Pancreas-Related Complications After Minimally Invasive Surgery for Gastric Cancer: A Propensity Score Matching Analysis. 聚乙二醇网片对减少胃癌微创手术后胰腺相关并发症的临床影响：倾向得分匹配分析
IF 2.5 4区 医学
Journal of Gastric Cancer Pub Date : 2024-04-05 DOI: 10.5230/jgc.2024.24.e17
Motonari Ri, Manabu Ohashi, Rie Makuuchi, Masaru Hayami, Takeshi Sano, Souya Nunobe
{"title":"Clinical Impact of Polyglycolic Acid Mesh to Reduce Pancreas-Related Complications After Minimally Invasive Surgery for Gastric Cancer: A Propensity Score Matching Analysis.","authors":"Motonari Ri, Manabu Ohashi, Rie Makuuchi, Masaru Hayami, Takeshi Sano, Souya Nunobe","doi":"10.5230/jgc.2024.24.e17","DOIUrl":"https://doi.org/10.5230/jgc.2024.24.e17","url":null,"abstract":"Prevention of pancreas-related complications after gastric cancer surgery is critical. Polyglycolic acid (PGA) mesh reduces postoperative pancreatic fistula formation following pancreatic resection. However, the clinical efficacy of PGA mesh in gastric cancer surgery has not been adequately investigated.","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"206 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Smoking and Alcohol Consumption on Early-Onset Gastric Cancer Development in Young Koreans: A Population-Based Study. 吸烟和饮酒对韩国年轻人早期胃癌发展的影响：一项基于人群的研究
IF 2.5 4区 医学
Journal of Gastric Cancer Pub Date : 2024-04-05 DOI: 10.5230/jgc.2024.24.e2
Seung Joo Kang, Cheol Min Shin, Kyungdo Han, Jin Hyung Jung, Eun Hyo Jin, Joo Hyun Lim, Yoon Jin Choi, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
{"title":"Impact of Smoking and Alcohol Consumption on Early-Onset Gastric Cancer Development in Young Koreans: A Population-Based Study.","authors":"Seung Joo Kang, Cheol Min Shin, Kyungdo Han, Jin Hyung Jung, Eun Hyo Jin, Joo Hyun Lim, Yoon Jin Choi, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee","doi":"10.5230/jgc.2024.24.e2","DOIUrl":"https://doi.org/10.5230/jgc.2024.24.e2","url":null,"abstract":"Although smoking and alcohol consumption are known risk factors for gastric cancer (GC), studies assessing their effects on early-onset GC are limited. In this nationwide, population-based, prospective cohort study, we assessed the effects of smoking and alcohol consumption on early-onset GC in patients aged &lt;50 years.","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"28 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Recurrence Pattern Multiplicity in Predicting Post-recurrence Survival in Patients Who Underwent Curative Gastrectomy for Gastric Cancer. 复发模式多重性在预测胃癌治愈性胃切除术患者复发后存活率中的作用
IF 2.5 4区 医学
Journal of Gastric Cancer Pub Date : 2024-04-05 DOI: 10.5230/jgc.2024.24.e18
Jun-Young Yang, Ji-Hyeon Park, Seung Joon Choi, Woon Kee Lee
{"title":"Role of Recurrence Pattern Multiplicity in Predicting Post-recurrence Survival in Patients Who Underwent Curative Gastrectomy for Gastric Cancer.","authors":"Jun-Young Yang, Ji-Hyeon Park, Seung Joon Choi, Woon Kee Lee","doi":"10.5230/jgc.2024.24.e18","DOIUrl":"https://doi.org/10.5230/jgc.2024.24.e18","url":null,"abstract":"This study aimed to investigate the recurrence patterns in patients who underwent curative surgery for gastric cancer (GC) and analyze their prognostic value for post-recurrence survival (PRS).","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"3 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peritoneal Washing Cytology Positivity in Gastric Cancer: Role of Lymph Node Metastasis as a Risk Factor. 胃癌腹膜清洗细胞学阳性：淋巴结转移作为风险因素的作用
IF 2.5 4区 医学
Journal of Gastric Cancer Pub Date : 2024-04-05 DOI: 10.5230/jgc.2024.24.e14
Sojung Kim, Han Hong Lee, Kyo Young Song, Ho Seok Seo
{"title":"Peritoneal Washing Cytology Positivity in Gastric Cancer: Role of Lymph Node Metastasis as a Risk Factor.","authors":"Sojung Kim, Han Hong Lee, Kyo Young Song, Ho Seok Seo","doi":"10.5230/jgc.2024.24.e14","DOIUrl":"https://doi.org/10.5230/jgc.2024.24.e14","url":null,"abstract":"Peritoneal washing cytology (PWC) is a widely used diagnostic tool for detecting peritoneal metastasis of advanced gastric cancer. However, the prognosis of patients with positive PWC remains poor even after gastrectomy, and treatments vary among institutions and eras. In this study, we identified the clinical factors that can help predict cytology-positive (CY(+)) gastric cancer.","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"123 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-world Nationwide Outcomes of Minimally Invasive Surgery for Advanced Gastric Cancer Based on Korean Gastric Cancer Association-Led Survey. 根据韩国胃癌协会主导的调查，全国范围内晚期胃癌微创手术的实际效果。
IF 2.5 4区 医学
Journal of Gastric Cancer Pub Date : 2024-04-05 DOI: 10.5230/jgc.2024.24.e16
Sin Hye Park, Mira Han, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Bang Wool Eom
{"title":"Real-world Nationwide Outcomes of Minimally Invasive Surgery for Advanced Gastric Cancer Based on Korean Gastric Cancer Association-Led Survey.","authors":"Sin Hye Park, Mira Han, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Bang Wool Eom","doi":"10.5230/jgc.2024.24.e16","DOIUrl":"https://doi.org/10.5230/jgc.2024.24.e16","url":null,"abstract":"The study aimed to investigate real-world surgical outcomes of minimally invasive surgery (MIS) for advanced gastric cancer using Korean Gastric Cancer Association (KGCA)-led nationwide data.","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"117 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Prognosis of Upper-Third Gastric Cancer With That of Middle and Lower-Third Gastric Cancer. 上段胃癌与中段和下段胃癌的预后比较
IF 2.5 4区 医学
Journal of Gastric Cancer Pub Date : 2024-04-05 DOI: 10.5230/jgc.2024.24.e3
Ji Yeon Park, Eun Ji Kim, Jae Yeong Yang, Ki Bum Park, Oh Kyoung Kwon
{"title":"Comparison of the Prognosis of Upper-Third Gastric Cancer With That of Middle and Lower-Third Gastric Cancer.","authors":"Ji Yeon Park, Eun Ji Kim, Jae Yeong Yang, Ki Bum Park, Oh Kyoung Kwon","doi":"10.5230/jgc.2024.24.e3","DOIUrl":"https://doi.org/10.5230/jgc.2024.24.e3","url":null,"abstract":"Gastric cancer is one of the most common cancers in Korea, and the proportion of upper-third gastric cancers has been steadily increasing over the last two decades. This study aimed to evaluate the effect of tumor location on gastric cancer prognosis.","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"33 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Modified eCura System to Stratify the Risk of Lymph Node Metastasis in Undifferentiated-Type Early Gastric Cancer After Endoscopic Resection. 内镜切除术后未分化型早期胃癌淋巴结转移风险分层的改良eCura系统
IF 2.5 4区 医学
Journal of Gastric Cancer Pub Date : 2024-04-05 DOI: 10.5230/jgc.2024.24.e13
Hyo-Joon Yang, Hyuk Lee, Tae Jun Kim, Da Hyun Jung, Kee Don Choi, Ji Yong Ahn, Wan Sik Lee, Seong Woo Jeon, Jie-Hyun Kim, Gwang Ha Kim, Jae Myung Park, Sang Gyun Kim, Woon Geon Shin, Young-Il Kim, Il Ju Choi
{"title":"A Modified eCura System to Stratify the Risk of Lymph Node Metastasis in Undifferentiated-Type Early Gastric Cancer After Endoscopic Resection.","authors":"Hyo-Joon Yang, Hyuk Lee, Tae Jun Kim, Da Hyun Jung, Kee Don Choi, Ji Yong Ahn, Wan Sik Lee, Seong Woo Jeon, Jie-Hyun Kim, Gwang Ha Kim, Jae Myung Park, Sang Gyun Kim, Woon Geon Shin, Young-Il Kim, Il Ju Choi","doi":"10.5230/jgc.2024.24.e13","DOIUrl":"https://doi.org/10.5230/jgc.2024.24.e13","url":null,"abstract":"The original eCura system was designed to stratify the risk of lymph node metastasis (LNM) after endoscopic resection (ER) in patients with early gastric cancer (EGC). We assessed the effectiveness of a modified eCura system for reflecting the characteristics of undifferentiated-type (UD)-EGC.","PeriodicalId":56072,"journal":{"name":"Journal of Gastric Cancer","volume":"92 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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