Pharmaceutical Sciences and Research最新文献_第5页

The Potential Roles of Jamu for COVID-19: A Learn from the Traditional Chinese Medicine 贾木对COVID-19的潜在作用:从中医的学习

Pharmaceutical Sciences and Research Pub Date : 2020-08-05 DOI: 10.7454/psr.v7i4.1083

D. Hartanti, B. A. Dhiani, Shintia Lintang Charisma, R. Wahyuningrum

{"title":"The Potential Roles of Jamu for COVID-19: A Learn from the Traditional Chinese Medicine","authors":"D. Hartanti, B. A. Dhiani, Shintia Lintang Charisma, R. Wahyuningrum","doi":"10.7454/psr.v7i4.1083","DOIUrl":"https://doi.org/10.7454/psr.v7i4.1083","url":null,"abstract":"As the pandemic of the coronavirus disease 2019 (COVID-19) continues while there is no drug and vaccine available, every effort to discover one should be considered. This review aimed to discuss the potential use of jamu , the Indonesian traditional herbal medicine, to deal with COVID-19 by following those of more-established traditional Chinese medicine (TCM). The online literature search using the PubMed database, as well as the circulars from the Indonesian Ministry of Health, were carried out to collect data up to June 07, 2020. The use of TCM for the treatment and prevention of COVID-19 has been officiated in the Chinese National Clinical Guideline on COVID-19 Associated Pneumonia, with shen-fu-tang + su-he-xiang pill and xiang-sha-liu-junzi-tang as the most frequently suggested formulae to treat severe and recovery stages of COVID-19, respectively. In Indonesia, the highly promoted product for the prevention of this disease is likely the adaptation of a TCM formula, while the use of some other formulae, which mainly containing Zingiberaceae, is suggested by the Government for the said purpose. The rationalization of the use of medicinal plants and suggested polyherbal formulae, based on their available pharmacological activity and the bioactive compounds, is also discussed in this review. The use of jamu for COVID-19, however, needs to be carefully considered for the limited scientific data available to support it.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42170055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

SARS-CoV-2: Virology and Drug Repurposing Approaches 严重急性呼吸系统综合征冠状病毒2型：病毒学和药物再利用方法

Pharmaceutical Sciences and Research Pub Date : 2020-08-05 DOI: 10.7454/psr.v7i4.1073

R. Rahmasari, H. Setiawan, Rezi Riadhi Syahdi, Ayun Erwina Arifianti, M. I. Irianti, R. Sauriasari, J. Makau, Muhareva Raekiansyah

{"title":"SARS-CoV-2: Virology and Drug Repurposing Approaches","authors":"R. Rahmasari, H. Setiawan, Rezi Riadhi Syahdi, Ayun Erwina Arifianti, M. I. Irianti, R. Sauriasari, J. Makau, Muhareva Raekiansyah","doi":"10.7454/psr.v7i4.1073","DOIUrl":"https://doi.org/10.7454/psr.v7i4.1073","url":null,"abstract":"An emerging coronavirus, SARS-CoV-2, is the causative agent for the ongoing pandemic of coronavirus disease 2019 (COVID-19), which has caused a worldwide social and economic disruption. Currently, no antiviral drugs with proven clinical efficacy, or vaccines for its prevention. Therefore, to combat the pandemic of this novel coronavirus, new effective treatments are urgently needed. In the process of traditional drug development, developing new drugs from scratch is a time-consuming process, requires high-investment, and is a high-risk process, which is impractical to face the immediate global challenge of the SARS-CoV-2 pandemic. Drug repurposing strategy is one of the effective ways to quickly find a therapeutic agent for COVID-19 Existing medicines, which already have been tested and proven safe in humans might work for COVID-19 offering a potentially faster approach for the disease management. Here, we review h the latest research progress in epidemiology, viral genome, and life cycles of SARS-CoV-2. Further, we describe and discuss some promising drugs repurposed to target SARS-CoV-2 that are being evaluated in clinical trials.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48940683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dermaseptin-Based Antiviral Peptides to Prevent COVID-19 through In Silico Molecular Docking Studies against SARS-CoV-2 Spike Protein 基于Dermaseptin的抗病毒肽通过对SARS-CoV-2刺突蛋白的硅内分子对接研究预防新冠肺炎

Pharmaceutical Sciences and Research Pub Date : 2020-08-05 DOI: 10.7454/psr.v7i4.1079

T. M. Fakih

{"title":"Dermaseptin-Based Antiviral Peptides to Prevent COVID-19 through In Silico Molecular Docking Studies against SARS-CoV-2 Spike Protein","authors":"T. M. Fakih","doi":"10.7454/psr.v7i4.1079","DOIUrl":"https://doi.org/10.7454/psr.v7i4.1079","url":null,"abstract":"A pandemic coronavirus disease of 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now been declared a global pandemic by the World Health Organization. The search for new drugs, especially by utilizing antiviral peptides is a very potential area. Through this study, protein-peptide docking and protein-protein docking simulations were conducted using in silico methods to identify, evaluate, and explore the molecular affinity and interaction of dermaseptin peptide molecules produced by frogs of the genus Phyllomedusa against the SARS-CoV-2 spike protein macromolecule, and its effect on attachment to the surface of the ACE-2 (Angiotensin Converting Enzyme-2) receptor. Protein-peptide docking simulation results show that dermaseptin-S9 peptide molecule has the best affinity to the active site of SARS-CoV-2 spike protein macromolecule binding site, with a binding free energy value of − 792.93 kJ/mol. Then the results of protein-protein docking simulations proved that dermaseptin-S9 peptide molecule was able to prevent the attachment of SARS-CoV-2 spike protein to the surface of the ACE-2 receptor, with a total energy value of 517.85 kJ/mol. Therefore, it is hoped that dermaseptin-S9 peptide molecule can be further studied in the development of novel antiviral peptide candidates for the control of COVID-19 infectious disease.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45553801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Cytokine Storm in COVID-19: An Overview, Mechanism, Treatment Strategies, and Stem Cell Therapy Perspective 新冠肺炎中的细胞因子风暴：概述、机制、治疗策略和干细胞治疗前景

Pharmaceutical Sciences and Research Pub Date : 2020-08-05 DOI: 10.7454/psr.v7i4.1092

N. Azmi, M. U. Puteri, D. Lukmanto

引用次数: 10

Formulasi Gel Ekstrak Daun Kelor (Moringa oleifera Lamk) Sebagai Sediaan Antiinflamasi 海带叶提取物凝胶抗炎制剂的研制

Pharmaceutical Sciences and Research Pub Date : 2020-04-30 DOI: 10.7454/psr.v7i1.1065

N. Sugihartini, Syauqul Jannah, Tedjo Yuwono

引用次数: 4

Evaluation of Potential Drug Interaction of Analgesic in Cancer Patient Receiving Palliative Care in Dharmais Cancer Hospital 癌症患者在癌症医院接受姑息治疗时镇痛药的潜在药物相互作用评价

Pharmaceutical Sciences and Research Pub Date : 2020-04-30 DOI: 10.7454/psr.v7i1.1064

Eme Stepani Sitepu, Atika Wahyu Puspitasari, N. Azmi, L. Sari

{"title":"Evaluation of Potential Drug Interaction of Analgesic in Cancer Patient Receiving Palliative Care in Dharmais Cancer Hospital","authors":"Eme Stepani Sitepu, Atika Wahyu Puspitasari, N. Azmi, L. Sari","doi":"10.7454/psr.v7i1.1064","DOIUrl":"https://doi.org/10.7454/psr.v7i1.1064","url":null,"abstract":"Analgesics are mostly used in cancer patients receiving palliative care to improve the quality of life of patients. Besides analgesics, cancer patients receiving palliative care were also given other drugs in combination to overcome other symptoms of cancer, and this combination could potentially cause drug interactions. This study was aimed to analyze the potential of drug interactions with analgesics in cancer patients. The study design was cross-sectional with a retrospective method and descriptive study. The sample of this study was cancer palliative care patient’s prescription at Dharmais Cancer Hospital in the period of January – December 2017. The sample analyzed in this study consisted of 273 prescriptions. This study found that there were 191 prescriptions (69.9%) of analgesics which potentially interacted with 316 interaction cases. Fentanyl and morphine with 61 cases (19.3%), morphine and gabapentin with 60 cases (18.9%) and morphine and amitriptyline with 33 cases (10.4%) were observed as the three most analgesics-other drugs interaction. Based on severity levels, there were 73.5% of major interaction, 26.3% of moderate interaction, and 0.2% of minor interaction. This study concluded that high occurrence of drug interactions was observed in analgesic drugs, therefore close monitoring is needed in cancer patient receiving palliative care.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44376360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Ethanolic Extract of Pinang Masak Jambi (Areca Catechu L.) as A Modulator of Doxorubicin Cytotoxic Effect in Breast Cancer Therapy 槟榔槟榔醇提物在乳腺癌治疗中阿霉素细胞毒作用的研究

Pharmaceutical Sciences and Research Pub Date : 2020-04-30 DOI: 10.7454/psr.v7i1.1067

F. Fitrianingsih, Indri Maharini, Diah Tri Utami

{"title":"Development of Ethanolic Extract of Pinang Masak Jambi (Areca Catechu L.) as A Modulator of Doxorubicin Cytotoxic Effect in Breast Cancer Therapy","authors":"F. Fitrianingsih, Indri Maharini, Diah Tri Utami","doi":"10.7454/psr.v7i1.1067","DOIUrl":"https://doi.org/10.7454/psr.v7i1.1067","url":null,"abstract":"Doxorubicin is one of the chemotherapy agents that is often used in breast cancer therapy. Phenomenon of breast cancer cell resistance to chemotherapy agents has been traced to the molecular level. The development of compounds that can overcome drug resistance chemotherapy needs to be continuously developed, especially agents with specific molecular targets, namely P-glycoprotein (Pgp), NFkB, cyclin, and cyclin-dependent kinase (CDK). Another alternative is the combination of chemotherapy agents with chemopreventive agents (co-chemotherapy) to reduce side effects and increase sensitivity of cancer cells. Doxorubicin is often used in breast cancer therapy. This study was performed to determine the effect of ethanolic extract of Pinang Masak Jambi ( Areca catechu L.) (EEPMJ) and doxorubicin combination on MCF-7 breast cancer cells. Cytotoxic assay of EEPMJ and doxorubicin, alone, or in combination, was done using MTT test method to determine the IC 50 and CI (Combination Index) values. The results indicated that EEPMJ and doxorubicin had IC 50 values of 75.1 µg/ml and 22 µg/ml, respectively. Based on CI values, all combination concentration showed varying CI values. The concentration of 1/8 IC 50 of EEPMJ with 1/2, 1/4, and 1/8 IC50 of doxorubicin showed a strong synergistic effect (CI 0.1 - 0.3), with the inhibition of cell viability up to 67.39%. This synergistic effect occurs because EEPMJ potentially could increases the cytotoxicity of doxorubicin.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44507030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encapsulation of Temulawak Extract by Using Nanocrystalline Cassava and Sago Starches and Maltodextrin 纳米晶木薯、西米淀粉和麦芽糖糊精包封铁木犀草提取物

Pharmaceutical Sciences and Research Pub Date : 2020-04-30 DOI: 10.7454/psr.v7i1.1068

T. Sunarti, Fatimah J. Pasaribu, C. Winarti

{"title":"Encapsulation of Temulawak Extract by Using Nanocrystalline Cassava and Sago Starches and Maltodextrin","authors":"T. Sunarti, Fatimah J. Pasaribu, C. Winarti","doi":"10.7454/psr.v7i1.1068","DOIUrl":"https://doi.org/10.7454/psr.v7i1.1068","url":null,"abstract":"This study was conducted to evaluate the performance of Curcuma zanthorrhiza crude extract after encapsulated in nanocrystalline starch, and to investigate the effect of the ratio of nanocrystalline starches and maltodextrin; and the effect of concentration of temulawak extract on nanocapsule characteristics, as well as encapsulation effect on the stability of antioxidant activity. Preparation of nanocrystalline starch was conducted by using lintnerization and ethanol precipitation of cassava and sago starches. Nanocrystalline starch and maltodextrin were used as matrices with the ratio varied from 25:75, 50:50, and 75:25. The mixture of temulawak extract and matrices were homogenized and spray dried. Nanocapsules characteristics included the efficiency of encapsulation and drug loading, and antioxidant activity test were investigated. Nanocrystalline cassava and sago starches we re potentially modified starch that can be used as the matrix for its low solubility and digestibility. It showed that the ratio of nanocrystalline starch, maltodextrin, and concentration of temulawak extract significantly influenced the nanocapsule characteristics. The best encapsulation condition obtained for nanocrystalline matrix from cassava starch with the ratio of nanocrystalline starch: maltodextrin 25:75 (%w/w) and 10% concentration of the temulawak extract, while for sago are 75:25 (%w/w) and 10% concentration of temulawak extract. Nanocrystalline matrix from cassava starch revealed higher encapsulation efficiency and antioxidant activity. The use of high temperature s during spray drying affected by the slight decline of antioxidant activity of encapsulated temulawak extract. Encapsulation of temulawak extract by using nanocrystalline starch and maltodextrin c ould retain and protect its antioxidant activity.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45053572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

ACE Inhibitory Activity and Functional Group Analysis of Solvent- Partitioned Fractions of Eleusine indica Eleusine indica溶剂分配部分ACE抑制活性及官能团分析

Pharmaceutical Sciences and Research Pub Date : 2020-04-30 DOI: 10.7454/psr.v7i1.1054

Jade Celon Cometa, Liahona Faith Roldan Mancol, Anthony Nalzaro Yen, Joanne Katherine Talens Manlusoc

{"title":"ACE Inhibitory Activity and Functional Group Analysis of Solvent- Partitioned Fractions of Eleusine indica","authors":"Jade Celon Cometa, Liahona Faith Roldan Mancol, Anthony Nalzaro Yen, Joanne Katherine Talens Manlusoc","doi":"10.7454/psr.v7i1.1054","DOIUrl":"https://doi.org/10.7454/psr.v7i1.1054","url":null,"abstract":"Eleusine indica Linn. Gaerth or Indian goose grass has been widely used as an alternative natural anti-hypertensive agent. However, the rationale behind this mechanism is still unknown. The purpose of this study is to confirm the presence of functional groups that may be responsible for its ACE inhibitory activity and its possible synergism. Each solvent-portioned fraction was analyzed by FTIR, individual ACE inhibitory activity, and combination of fractions. FTIR results of solvent-partitioned fractions revealed that O-H and C-H stretches were present in all fractions. In addition to this, C-O and C=O groups were also present in all fractions except in ethyl acetate. S=O groups were also present in chloroform, ethyl acetate, and n-butanol fractions. Other function groups such as N-O and C=C groups were present in ethyl acetate and n-butanol fractions, respectively. The highest % inhibition obtained among the individual fraction is n-butanol at 96.031 % ± 0.004 at 500 ug/ml. The lowest % inhibition obtained among the individual fraction is chloroform at 32.544 % ± 0.011 at 500 ug/ml. The highest % inhibition among the combined fractions is ethyl acetate:butanol at 95.727% ± 20.847, while the lowest % inhibition in combination is hexane:chloroform at 89.626 % ± 19.577. The fraction with the lowest IC 50 is hexane at 15.357, while the highest IC 50 is chloroform at 168.207 ug/ml. Functional group present may be associated with the antihypertensive activity of the E. indica extracts. The more polar solvent-partitioned fractions of E. indica has a higher ACE inhibitory activity compared to its less polar solvent-partitioned fractions. The higher ACE inhibitory activity may be associated with the secondary metabolites present in the more polar fractions. There is also possible synergism present in the combined solvent-partitioned fractions as their % inhibition is higher than their individual effects.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46648191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efek Xilooligosakarida (XOS) dalam Mencegah Diabetes Mellitus Tipe 2 二型梅利托斯糖尿病(XOS)预防糖尿病的作用

Pharmaceutical Sciences and Research Pub Date : 2019-12-31 DOI: 10.7454/psr.v6i3.4467

Lusi Putri Dwita, H. Rahmi

引用次数: 0