Pharmaceutical Sciences and Research最新文献_第4页

The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial 虾青素改善疼痛性糖尿病神经病变患者疼痛缓解的益处:一项开放标签、随机对照试验

Pharmaceutical Sciences and Research Pub Date : 2021-12-01 DOI: 10.7454/psr.v8i3.1217

R. Pinzon, Mary Rose Angelina Budi Harsana

{"title":"The Benefits of Astaxanthin to Improve Pain Relief in Patients with Painful Diabetic Neuropathy: An Open-Label, Randomized Controlled Trial","authors":"R. Pinzon, Mary Rose Angelina Budi Harsana","doi":"10.7454/psr.v8i3.1217","DOIUrl":"https://doi.org/10.7454/psr.v8i3.1217","url":null,"abstract":"Treatment of diabetic neuropathy is still carried out by providing symptomatic therapy, which only improves ± 50% of the total symptoms felt by patients, but does not tackle the underlying causes of the disease. Astaxanthin is a potent antioxidant, anti-inflammatory, and anti-diabetic carotenoid that could be an additional treatment option. We aimed to measure the effectiveness of administering astaxanthin as an additional therapy to improve the impact of pain and discomfort experienced daily by diabetes mellitus patients with painful diabetic neuropathy. We conducted a randomized experimental study with an open label design of 36 patients who had been diagnosed with painful diabetic neuropathy. The control group was treated with standard treatment for painful diabetic neuropathy, and the experimental group was given both standard and additional therapy of astaxanthin at a dose of 6 mg once per day. The impact of pain was assessed using the Brief Pain Inventory (BPI) before administering astaxanthin and on the 4th and 8th weeks after administering astaxanthin. The administration of therapy showed a significant improvement in the impact of pain experienced daily by patients on both treatment groups (p<0.05). However, the mean BPI score of the control and the experimental groups did not differ significantly each week (p>0.05). There is a significant improvement in the BPI of patients with painful diabetic neuropathy who were given additional treatment (add on) of astaxanthin compared to patients who were only given standard treatment for painful diabetic neuropathy.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46845065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation Method for Simultaneous Analysis of Betamethasone Dipropionate and Retinoic Acid in Cream Formulation by Ultra High-Performance Liquid Chromatography 超高效液相色谱法同时分析乳膏制剂中倍他米松和维甲酸的验证方法

Pharmaceutical Sciences and Research Pub Date : 2021-08-01 DOI: 10.7454/psr.v8i2.1063

引用次数: 1

Insights into Molecular Interaction of Flavonoid Compounds in Citrus Peel Bound to Collagenase and Elastase Enzymes: A Computational Study 柑橘皮中黄酮类化合物与胶原酶和弹性酶结合的分子相互作用:一项计算研究

Pharmaceutical Sciences and Research Pub Date : 2021-08-01 DOI: 10.7454/psr.v8i2.1202

T. M. Fakih

{"title":"Insights into Molecular Interaction of Flavonoid Compounds in Citrus Peel Bound to Collagenase and Elastase Enzymes: A Computational Study","authors":"T. M. Fakih","doi":"10.7454/psr.v8i2.1202","DOIUrl":"https://doi.org/10.7454/psr.v8i2.1202","url":null,"abstract":"Citrus peels contain various phytochemical active compounds such as flavonoids that are useful for antiaging cosmetic products. This study was conducted to identify the anti-collagenase and anti-elastase activities of flavonoid compounds in citrus peel and to determine the molecular interaction mechanism using the molecular docking method. The study was carried out through several stages, including preparation of enzyme macromolecules, preparation of flavonoid compound molecules, validation of molecular docking, identification of binding-free energy, visualization of interaction conformations, and predictions of molecular skin toxicity. The result showed that the flavonoid compounds in citrus peel (hesperidin, naringin, nobiletin, and tangeretin) could bind to collagenase and elastase enzymes. Naringin has the highest affinity for the collagenase enzyme with the binding-free energy of −9.52 kcal/ mol, while nobiletin has the highest affinity for the elastase enzyme with the binding-free energy of −6.44 kcal/mol. Compared to EGCG (epigallocatechin gallate), the flavonoid compounds have a lower affinity for the collagenase enzyme but a higher affinity for elastase enzymes. Hydrogen bonds and the hydrophobic interactions dominate the interaction between citrus peel’s flavonoids against the enzymes. When applied to the skin, flavonoid compounds are predicted to have no risk of skin toxicity. The flavonoid compounds of citrus peels are expected to have anti-collagenase and anti-elastase activities.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43165896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Chemical Properties, Biological Activities and Poisoning Treatment of Novichok: A Review 诺维乔克的化学性质、生物活性及中毒治疗研究进展

Pharmaceutical Sciences and Research Pub Date : 2021-08-01 DOI: 10.7454/psr.v8i2.1205

T. Rahmania, B. W. Wardhani, Editha Renesteen, Y. Harahap

引用次数: 4

The Effect of Ethanol Extract of Punica granatum Linn. Leaves on Lipid Profiles of Dyslipidemic Rat 石榴醇提物的作用。血脂异常大鼠叶片脂质谱变化

Pharmaceutical Sciences and Research Pub Date : 2021-08-01 DOI: 10.7454/psr.v8i2.1106

Afrillia Nuryanti Garmana, Lia Nurul Sakinah

{"title":"The Effect of Ethanol Extract of Punica granatum Linn. Leaves on Lipid Profiles of Dyslipidemic Rat","authors":"Afrillia Nuryanti Garmana, Lia Nurul Sakinah","doi":"10.7454/psr.v8i2.1106","DOIUrl":"https://doi.org/10.7454/psr.v8i2.1106","url":null,"abstract":"It has been reported that peel of Punica granatum has antidyslipidemic activity. The aim of this research was to investigate the antidyslipidemic activity of Punica granatum leaf. The dried Punica granatum leaves were extracted with 96% ethanol. Rats were divided into several groups, which were normal, positive control, simvastatin at a dose of 10 mg/kg bw as reference group, and Punica granatum extract at a dose of 100 mg/kg. Before treatment, male Wistar rats were fed with high cholesterol chow for 3 months, and then plant extract was given for 4 weeks. Blood samples were collected at week 0, 12, 14, and 16 to measure the levels of total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, and triglyceride. Furthermore, at the last day of extract treatment, the aorta was isolated and haematoxylin-eosin stained. Administration of ethanol leaf extract of Punica granatum at a dose of 100 mg/kg for 2 weeks significantly reduced the total cholesterol and LDL-cholesterol levels up to 27.6% and 34.79%, respectively, compared to positive control group. After 4 weeks of extract treatment, the reduction of total cholesterol and LDL-cholesterol level were up to 59.9% and 75.05%, respectively. There was no effect of extract on HDL-cholesterol and triglyceride level. Furthermore, histological study showed that ethanol extract of P. granatum reduced aortic wall thickness significantly compared to untreated group. Punica granatum leaf is potential to be developed as an antidyslipidemic drug.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47215502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Artificial Intelligence toward Personalized Medicine 面向个性化医疗的人工智能

Pharmaceutical Sciences and Research Pub Date : 2021-08-01 DOI: 10.7454/psr.v8i2.1199

M. W. Gifari, Pugud Samodro, D. Kurniawan

{"title":"Artificial Intelligence toward Personalized Medicine","authors":"M. W. Gifari, Pugud Samodro, D. Kurniawan","doi":"10.7454/psr.v8i2.1199","DOIUrl":"https://doi.org/10.7454/psr.v8i2.1199","url":null,"abstract":"In current medical practice when a patient feels symptoms he/she would consult the doctor. The doctor then gives medication in a one-fits-all fashion. However, recent genetics studies had shown that different genetic makeup can results in different effects on medication, so the medication should be customed for every individual. The main idea of “personalized medicine” is to provide the right intervention including medication to the right patient at the right time and dose. With this approach, the medication paradigm would shift from curative to preventive. The rise of personalized medicine had been possible because the information from ever-increasing biomolecular (proteomics, genomics, and other omics) and health-related data are successfully “mined” by Artificial Intelligence (AI) tools. In this paper, we proposed that AI systems toward personalized medicine must have acceptable performance, be readily interpretable by the clinical community, and be validated in a large cohort. We examined a few landmark papers with the keyword “AI for personalized medicine application”; 1) automatic image-based patient classification, 2) automatic gene-based cancer classification, and 3) automatic health-record heart failure with preserved ejection fraction patient phenotyping. All the examples are evaluated by their performance, interpretability, and clinical validity. From the analysis, we concluded that AI for personalized medicine could benefit by five factors: (1) standardization and pooling of genetics and health data, nationally and internationally, (2) the use of multi-modalities data, (3) disease specialist to guide the development of AI model, (4) investigation of AI-finding by clinical community, and (5) follow-up of AI-finding by the large clinical trial.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45890753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antifungal Activity of Polyscias scutellaria Fosberg Leaves Against Candida albicans 黄芩叶对白色念珠菌的抗真菌活性研究

Pharmaceutical Sciences and Research Pub Date : 2020-12-31 DOI: 10.7454/psr.v7i3.1026

Nada Marcha Putri, Jasmine Regita Putri, B. Elya, R. Adawiyah

{"title":"Antifungal Activity of Polyscias scutellaria Fosberg Leaves Against Candida albicans","authors":"Nada Marcha Putri, Jasmine Regita Putri, B. Elya, R. Adawiyah","doi":"10.7454/psr.v7i3.1026","DOIUrl":"https://doi.org/10.7454/psr.v7i3.1026","url":null,"abstract":"Polyscias scutellaria Fosberg is one of the indigenous plants from Indonesia that widely used as folk medicines for several illnesses. The leaves of P. scutellaria were previously studied as an antimicrobial agent. Nonetheless, this theory of antifungal activity has never been scientifically verified. This study aimed to evaluate the antifungal activity of P. scutellaria against Candida albicans. The leaves of P. scutellaria were macerated using an ethanol solvent. Then, the extract was evaporated and dissolved by 1% DMSO into different concentrations (100 μg/mL, 200 μg/mL, 400 μg/mL, 800 μg/mL, 1600 μg/mL, 3200 μg/mL, and 6400 μg/mL). Fluconazole, as a common antifungal treatment, was used as the positive control. The antifungal activity of P. sculletaria against Candida albicans was tested using well dilution and diffusion disc methods. Ethanol extract of P. scutellaria leaves showed antifungal activities against Candida albicans. It showed the minimum inhibitory concentration of above 6400 μg/mL and formed the inhibitory zone against Candida albicans. As a conclusion, ethanol extract of P. scutellaria has the potential to be used as an antifungal agent against Candida albicans.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47085602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of Antipsychotic Activity of Ethanolic Bark Extract of Myrica esculenta in Rats 杨梅乙醇树皮提取物对大鼠抗精神病活性的评价

Pharmaceutical Sciences and Research Pub Date : 2020-12-31 DOI: 10.7454/psr.v7i3.1098

Biswash Sapkota, Ankit Acharya, Bishal Dangi, H. Annegowda

{"title":"Evaluation of Antipsychotic Activity of Ethanolic Bark Extract of Myrica esculenta in Rats","authors":"Biswash Sapkota, Ankit Acharya, Bishal Dangi, H. Annegowda","doi":"10.7454/psr.v7i3.1098","DOIUrl":"https://doi.org/10.7454/psr.v7i3.1098","url":null,"abstract":"The antipsychotic properties of Myrica esculenta stem bark were evaluated. The stem bark was collected, shade dried, and pulverized. Extraction was carried out with 70% ethanol by occasional shaking. Preliminary phytochemical screening of the extract was investigated in this study. Antipsychotic activity was evaluated against apomorphine-induced stereotypy using cook’s pole climbing apparatus and haloperidol-induced catalepsy models. Bioamine determination of noradrenaline and dopamine was also performed. The extract contains phytochemicals, including glycosides, flavonoids, volatile oils, proteins, saponins, phenolics, and tannins. The result showed decreased apomorphine-induced stereotyped behavior. This study reported significant dose-dependent potentiation of haloperidol-induced catalepsy in rats and a longer time needed by the rat to climb the pole in a dose-dependent manner. Also, it significantly decreased brain dopamine and noradrenaline level. The ethanolic extract of M. esculenta exhibited significant antipsychotic activity in rats. Further neurochemical investigation is needed to explore the plant drug’s mechanism of action regarding anti-dopaminergic functions and establish the plant as an antipsychotic agent.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49203765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Anti-proliferation Effect of an Isolated Butanol Fraction of Tampa Badak (Voacanga foetida (Bl.) K. Schum) Leaves on Leukemia, Lung, and Cervical Cancer 坦帕叶丁醇分离部位对白血病、肺癌和宫颈癌的抗增殖作用

Pharmaceutical Sciences and Research Pub Date : 2020-12-31 DOI: 10.7454/psr.v7i3.1196

Adriani Susanty, Dachriyanus Dachriyanus, Y. Yanwirasti, F. Wahyuni, A. P. Sekar, N. Alimin, Magdazaleni Magdazaleni, Sri Esky Sofia, Citra Dewi

{"title":"The Anti-proliferation Effect of an Isolated Butanol Fraction of Tampa Badak (Voacanga foetida (Bl.) K. Schum) Leaves on Leukemia, Lung, and Cervical Cancer","authors":"Adriani Susanty, Dachriyanus Dachriyanus, Y. Yanwirasti, F. Wahyuni, A. P. Sekar, N. Alimin, Magdazaleni Magdazaleni, Sri Esky Sofia, Citra Dewi","doi":"10.7454/psr.v7i3.1196","DOIUrl":"https://doi.org/10.7454/psr.v7i3.1196","url":null,"abstract":"Voacanga foetida (Bl.) K.Schum leaves are known to have cytotoxic activity against blood cancer cells. This study was aimed to determine the potential of an isolated butanol fraction of Voacanga foetida (Bl.) K.Schum leaves (Tb3 compound) in inhibiting the proliferation of several cancer cells, including leukemia (K562), lung cancer (A549), and cervical cancer (HeLa) using the dye exclusion method. We found that the percentage of anti-proliferation of the Tb3 compound was increased in a dose-dependent manner, where it showed 83% (K562), 72.3% (He-La), and 70.7% (A549) inhibition at higher concentration. These values were relatively higher compared to doxorubicin as a positive control, 77.1%, 63.8%, and 62.7%, respectively. Moreover, the IC50 values of the Tb3 compound were still in the range of active cytotoxic compounds based on NCI classification, which is less than 4 μg/mL; 0.5 μg/mL, 2.4 μg/mL, and 3.6 μg/mL for K562, A549, and He-La, respectively. Therefore, this study indicated the potential anticancer effect of an isolated butanol fraction of the Tb3 compound to inhibit cancer cell proliferation, which provides an alternative for cancer therapy.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44614245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Potential Risk Factors for Mortality Due to Cardiovascular Disease Among Hemodialysed Patients in Indonesia 印度尼西亚血液透析患者心血管疾病死亡的潜在危险因素

Pharmaceutical Sciences and Research Pub Date : 2020-08-30 DOI: 10.7454/psr.v7i2.1096

Diana Laila Ramatillah, S. Sulaiman, K. Khan

{"title":"Potential Risk Factors for Mortality Due to Cardiovascular Disease Among Hemodialysed Patients in Indonesia","authors":"Diana Laila Ramatillah, S. Sulaiman, K. Khan","doi":"10.7454/psr.v7i2.1096","DOIUrl":"https://doi.org/10.7454/psr.v7i2.1096","url":null,"abstract":"Severe vascular calcifications, alterations in cardiovascular structure and function, immune dysfunction, and anemia are adverse effects of parathyroid hormone (PTH), which may contribute to increase risk factors of cardiovascular morbidity and mortality among renal failure patients. To evaluate the potential risk factors for mortality due to cardiovascular disease among hemodialysed patients in Indonesia, this cohort study was conducted. This study included 178 patients on hemodialysis who had been followed up two times a week for nine months (prospective cohort) and 185 patients who died in the last five years (retrospective cohort). Universal sampling technique were used to select the study subjects. Male was prevalence among hemodialysed patients in hemodialysis center, Jakarta, Indonesia and the third group of age (51-60 years) was predominant among these patients. Java ethnicity was found in almost 50% hemodialysed patients in this hemodialysis center. Most of those patients had hypertensive family history. Besides that, more than 70 percent of them were married and non-smoker. The study found that cardiovascular disease caused mortality among hemodialysed patients in Indonesia and the duration of cardiovascular disease influenced the probability of death/risk of mortality among these patients (HR 2.39, p = 0.006). Mortality among patients on hemodialysis in this study was caused by cardiovascular disease, and this cause of death was included in one of the biggest causes. During the study, several practice patterns revealed no PTH level check, no patients got calcimimetic agents such as rocalcitriol/calcitriol and calcium value check was conducted irregularly. As we know, there is a correlation between PTH, calcium and cardiovascular disease. Hence, mortality due to cardiovascular disease among hemodialysed patients significantly correlated with the duration of cardiovascular disease, and potentially with lack of PTH check, calcium check and rocalcitriol/ calcitriol supplement given to those patients.","PeriodicalId":55754,"journal":{"name":"Pharmaceutical Sciences and Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48808805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0