P. Dhikale, S. Chavhan, B. Adsul, Chinmay N. Gokhale, Aniket R. Ingale, K. Kinge
{"title":"Risk factors for cessation of viral RNA shedding in COVID-19 patients","authors":"P. Dhikale, S. Chavhan, B. Adsul, Chinmay N. Gokhale, Aniket R. Ingale, K. Kinge","doi":"10.4103/jss.jss_87_21","DOIUrl":"https://doi.org/10.4103/jss.jss_87_21","url":null,"abstract":"Objectives: Our study aimed to evaluate the risk factors for the cessation of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) RNA detection in a cohort of inpatients of laboratory-confirmed coronavirus disease 2019 (COVID-19) cases. Materials and Methods: This was a hospital-based, cross-sectional study. All COVID-19 patients positive on the reverse transcription polymerase chain reaction (RTPCR) test of nasopharyngeal samples who were admitted in this Dedicated COVID Hospital (DCH) from April to June 2020 were included in this study. The deceased patients were excluded.Cessation of Viral RNA Shedding (CVS) was considered to have been achieved on the date of the first negative SARS-CoV-2 RTPCR result out of the two consecutive negative SARS-CoV-2 PCR results on nasopharyngeal swabs taken 24 h apart. Results: Of the 4632 COVID-19 patients, 3307 (71.4%) patients achieved CVS. Patients had a median (IQR) time from positive to negative PCR of 16 (11–23) days. In multivariate cox regression analysis, age group 41 − 60 years (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.63–0.91), age >60 years (HR [CI] = 0.63 [0.53–0.78]), female sex (HR [CI] = 1.08 [1.01-1.16]), cancer (HR [CI] = 1.87 [1.03–3.41]) were the independent risk factors for cessation of viral shedding. Conclusion: Patients older than 40 years, male patients were shedding viral RNA for more duration and can be considered for the isolation for a longer duration.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"49 1","pages":"294 - 297"},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42224066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum lactate levels in critically Ill patients: An early marker to be targeted","authors":"Ruchi Kabra, S. Acharya, S. Sushanth Kumar","doi":"10.4103/jss.jss_113_22","DOIUrl":"https://doi.org/10.4103/jss.jss_113_22","url":null,"abstract":"Hyperlactatemia (excess blood lactate) is common in severely unwell individuals. Although lactate levels are routinely used to indicate insufficient tissue oxygenation, they can also be elevated by mechanisms unrelated to tissue oxygenation. Increased glycolysis may be a major cause of hyperlactatemia, especially in critically sick individuals. Despite this, elevated lactate levels have serious consequences for the morbidity and mortality of hyperlactatemia individuals. Despite the widespread use of the phrase lactic acidosis, a substantial link between lactate and pH appears only at higher lactate levels. As a result, the phrase lactate-related acidosis is more suitable. In early resuscitation, two recent studies have emphasized the necessity of monitoring lactate levels and adjusting treatment to changes in lactate levels. Structured lactate measures should be included in resuscitation protocols since lactate levels may be assessed quickly at the bedside from a variety of sources.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"49 1","pages":"246 - 250"},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47234763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jyothirmai Mallela, Tanmaya Metgud, M. Kamate, Deepti M. Kadeangadi
{"title":"Iron and zinc deficiency in children with febrile convulsions aged 6‒60 months ‒ A 1-year hospital-based case‒control study","authors":"Jyothirmai Mallela, Tanmaya Metgud, M. Kamate, Deepti M. Kadeangadi","doi":"10.4103/jss.jss_83_21","DOIUrl":"https://doi.org/10.4103/jss.jss_83_21","url":null,"abstract":"Context: Febrile seizures are one of the most common seizures in childhood. Febrile seizures occur in 2%–5% of children who are younger than 5 years of age. Studies have shown that iron, zinc, selenium, copper, and magnesium play a significant role in febrile seizures. This study was intended to study the relationship between iron and zinc deficiency with febrile seizures. Aim: To find the association of febrile convulsions with iron and zinc deficiency. Methodology: This hospital-based case‒control study was done in a tertiary care center in North Karnataka from January 2017 to December 2017. A total of 52 children fulfilling the inclusion criteria were included in case group. Control group contained 52 children who had fever without convulsions and matched for age, sex, and background disease with respective cases. Results: Both the groups were matched for age and gender. Majority of the children (76.92%) had a simple seizure. Cases had lower serum (Sr.) ferritin levels compared to controls with high odds ratio (OR) (25% vs. 1.92%; P < 0.001; OR = 17.00; P = 0.0075). Furthermore, cases had zinc deficiency compared to controls (84.62% vs. 25%; OR = 12.269; P < 0.001). The mean Sr. zinc levels (37.16 ± 22.07 vs. 75.75 ± 15.25 μg/dL; P < 0.001) were significantly low in cases. Conclusion and Interpretation: There was a significant association between febrile seizures with iron and zinc deficiency.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"49 1","pages":"288 - 293"},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47277921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of insulin resistance and beta-cell dysfunctions in newly diagnosed polycystic ovarian syndrome patients","authors":"Vikrant Ghatnatti, S. Patil, H. Kour","doi":"10.4103/jss.jss_4_21","DOIUrl":"https://doi.org/10.4103/jss.jss_4_21","url":null,"abstract":"Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing glucose intolerance and diabetes attributed to increased insulin resistance (IR). However, it is not clear whether β-cell dysfunction has a central role in pathogenesis. The distinction has important implications for the prevention of type 2 diabetes in PCOS with interventions that ameliorate IR. This study aimed to find if IR differs among the various phenotypes of PCOS and perform a quantitative estimation of β-cell dysfunction versus IR in patients of PCOS participants. Materials and Methods: This case–control study was conducted for 1 year in the Endocrinology and Gynaecology outpatient departments at Gauhati Medical College. Fifty women newly diagnosed with PCOS, as per the Rotterdam criteria, were considered cases. Fifty, age- and body mass index-matched healthy females were taken as controls. Fasting and postprandial blood glucose, serum insulin, testosterone, and oral glucose tolerance test values were taken. Impaired fasting glucose, impaired glucose tolerance (IGT), and type 2 diabetes mellitus T2DM were diagnosed according to ADA 2011 criteria. IR and β-cell function were determined by “homeostasis model assessment (HOMA)”. Results: We observed an altered relationship between IR and insulin secretion, consistent with an intrinsic β-cell defect, wherein IR led to a decreased amount of compensatory insulin secretion in PCOS compared with normal women. The correlation coefficients relating HOMA%B to HOMA-IR were lower in PCOS, indicating less compensatory insulin secretion for a given increment in IR. Conclusion: PCOS patients are at increased risk of developing glucose intolerance and diabetes.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"49 1","pages":"260 - 264"},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48300959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nagarjuna Sivaraj, K. Rachel., T. Suvvari, Shilaja Prasad, Sriharsha Boppana, Vineetha Naidu, P. Vegi, Youssef Aboufandi, L. S. Simhachalam Kutikuppala
{"title":"Association of SNP rs163550 in IL5RA Gene with Risk of Preeclampsia","authors":"Nagarjuna Sivaraj, K. Rachel., T. Suvvari, Shilaja Prasad, Sriharsha Boppana, Vineetha Naidu, P. Vegi, Youssef Aboufandi, L. S. Simhachalam Kutikuppala","doi":"10.4103/jss.jss_70_22","DOIUrl":"https://doi.org/10.4103/jss.jss_70_22","url":null,"abstract":"Background: Several research have looked at the significance of SNPs in inflammatory mediator genes and their link to preeclamptic pregnancies, but the results have not been conclusive enough to explain why SNPs in inflammatory mediator genes may increase the risk of preeclampsia. The goal of this study is to analyze the IL5RA SNPs in order to learn more about the possible link between preeclampsia and inflammatory genes. Materials and Methods: A total of 304 pregnant participants were a part of this prospective observational case-control study, out of which 152 had preeclampsia, and the other 152 participants had normotensive pregnancies. The “polymerase chain reaction-restriction fragment length polymorphism” method was used to genotype SNP rs163550. Results: The commonness of the IL5RA rs163550G allele has been linked to an increased risk for preeclampsia with P value: 0.0230 and odds ratio: 0.6818 (95% confidence interval: 0.489–0.9505). Conclusion: A prominent association among the IL5RA rs163550 SNP and preeclampsia in comparison to nonpreeclampsia has been observed in the study. The study stands first to report IL5RA Polymorphism association with the pathogenesis of preeclampsia's among the Indian population.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"49 1","pages":"272 - 276"},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42608879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strengthening the process of implementation of coaching in medical education settings","authors":"S. Shrivastava, P. Shrivastava","doi":"10.4103/jss.jss_55_21","DOIUrl":"https://doi.org/10.4103/jss.jss_55_21","url":null,"abstract":"The branch of medicine is quite complex and it requires a wide range of teaching–learning innovations, student support activities, and faculty motivation to ensure that the goals of medical education are accomplished. The purpose of the current review is to explore the role of coaching in improving the learning and skill acquisition in the field of medical education. An extensive search of all materials related to the topic was carried out in the PubMed search engine and a total of 22 articles were selected based on the suitability with the current review objectives. The ultimate aim of coaching in medical education is to unearth the real potential of the students to optimize their performance by helping them to learn instead of teaching them. Coaching is a strategy to help medical students to become competent and reflective practitioner. In addition, coaching plays an important role in the refinement of technical skills (like surgical skills) and nontechnical skills. To conclude, coaching in medical education has significant scope to improve the learning outcomes among students and even make them lifelong learners. The need of the hour is to implement a coaching system in each of the medical colleges after considering the local logistics and with the active support of faculty members.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"49 1","pages":"229 - 232"},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49612209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Divya Gohil, Merin Shaji, Gaurang D. Baxi, T. Palekar
{"title":"Role of proprioceptive neuromuscular facilitation exercises in post-COVID individuals: A randomized-control trial","authors":"Divya Gohil, Merin Shaji, Gaurang D. Baxi, T. Palekar","doi":"10.4103/jss.jss_73_22","DOIUrl":"https://doi.org/10.4103/jss.jss_73_22","url":null,"abstract":"Background: Pulmonary function, fatigue, and chest mobility are three important parameters which are impaired after COVID-19. Manual stretching procedures have the potential to improve pulmonary function, reduce fatigue, and improve chest mobility. However, evidence regarding their effectiveness in post-COVID-19 population remains unknown. This study explores the effectiveness of two different types of stretching techniques on pulmonary function, fatigue, and chest expansion in post-COVID-19 population. Materials and Methodology: Forty post-COVID-19 patients with mild and moderate impairment were divided into two groups (20 each). Group A received hold relax proprioceptive neuromuscular facilitation (PNF) pectoral stretching while Group B received chest mobility exercises for 20 min each for 7 sessions. The outcomes measures were pulmonary function test, fatigue, and chest expansion. Results: Significant within-group differences for all outcome measures were seen at the end of intervention. Between-group analysis showed a significant statistical difference in few parameters of pulmonary function testing and chest expansion in Group A than Group B. However, no statistical significance on Fatigue after the 7 sessions of intervention. Conclusions: In COVID-19 survivors with mild and moderate impairment, hold relax PNF stretching than chest mobility exercises has a significant effect on improving pulmonary function, reducing fatigue, and improving chest expansion.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"49 1","pages":"277 - 283"},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42961968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health science exhibition as a tool for health awareness among schoolchildren and the general public","authors":"Vishwanath M. Pattanshetti","doi":"10.4103/jss.jss_285_22","DOIUrl":"https://doi.org/10.4103/jss.jss_285_22","url":null,"abstract":"","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"49 1","pages":"219 - 220"},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48227250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advocating active and meaningful involvement of patients in the delivery of medical education","authors":"S. Shrivastava, P. Shrivastava","doi":"10.4103/jss.jss_80_21","DOIUrl":"https://doi.org/10.4103/jss.jss_80_21","url":null,"abstract":"The onus of knowledge acquisition and learning has demonstrated a paradigm shift in the field of medical education. The present review has been carried out to explore and understand the role of patient involvement in the training of medical students. An extensive search of all materials related to the topic was carried out in the PubMed search engine, and a total of 26 articles were selected based on the suitability with the current review objectives. The involvement of patients in medical education has been linked with a wide range of proven benefits and learning progression. The patients can discharge multiple roles, namely a teacher, developing curriculum, assessor, and someone who can select students for the course. The role of actively involving patients in the teaching process is bound to have some challenges and barriers considering the different aspects in heterogeneous settings. The ideal approach to involve patients in medical education has to start with sensitizing the faculty members and the medical students about the benefits that can be derived out of such clinical interactions. The successful implementation will essentially require adequate resource support and faculty involvement. To conclude, the patient involvement in medical training is not a new practice, but the ground reality is that we are falling short to optimize the benefits of the overall practice. The need of the hour is to adopt a systematic approach and structure the overall program, so that we can derive tangible benefits out of the same and prepare the future generation of doctors in the delivery of patient-centered care.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"49 1","pages":"251 - 255"},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41439738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}