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Polysialic Acid/Polysialyltransferases and Psychiatric Disorders 聚唾液酸/聚唾液基转移酶与精神疾病
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-05-25 DOI: 10.4052/tigg.2313.2e
Masaya Hane
{"title":"Polysialic Acid/Polysialyltransferases and Psychiatric Disorders","authors":"Masaya Hane","doi":"10.4052/tigg.2313.2e","DOIUrl":"https://doi.org/10.4052/tigg.2313.2e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45320146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polysialic Acid/Polysialyltransferases and Psychiatric Disorders 多唾液酸/多唾液基转移酶与精神疾病
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-05-25 DOI: 10.4052/tigg.2313.2j
Masaya Hane
{"title":"Polysialic Acid/Polysialyltransferases and Psychiatric Disorders","authors":"Masaya Hane","doi":"10.4052/tigg.2313.2j","DOIUrl":"https://doi.org/10.4052/tigg.2313.2j","url":null,"abstract":"ポリシアル酸はシアル酸の直鎖状のホモポリマーであり、胎児脳では広く発現しているが、成体脳では神経可塑性の高い限られた領域にしか発現していない。従来、ポリシアル酸はその物理化学的性質から反接着分子と考えられていた。しかし、近年、脳の発達や高次脳機能にかかわる生理活性物質を細胞表面付近で直接結合させ、その作用を包括的に制御していることが明らかになった。また、死後脳の解析や大規模比較ゲノム解析により、ポリシアル酸やその生合成酵素であるST8SIA2と精神疾患との関連性が明らかにされてきている。本稿では、ST8SIA2に見出された様々な一塩基多型（SNPs）のポリシアル酸の生合成及び機能に与える影響について、培養細胞やマウスを用いた生化学的解析の結果を中心に紹介する。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134996414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycoengineering for the Production of Lysosomal Enzymes 生产溶酶体酶的糖工程
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-05-25 DOI: 10.4052/tigg.2204.1j
Yu-He Tang, Ganglong Yang, Morihisa Fujita
{"title":"Glycoengineering for the Production of Lysosomal Enzymes","authors":"Yu-He Tang, Ganglong Yang, Morihisa Fujita","doi":"10.4052/tigg.2204.1j","DOIUrl":"https://doi.org/10.4052/tigg.2204.1j","url":null,"abstract":"リソソームは細胞内外で不要となった核酸、タンパク質、脂質、糖質などの生体高分子の分解を行う細胞内小器官である。内部は酸性に保たれており、約60種類の多種多様な加水分解酵素が存在している。これらのリソソーム酵素をコードする遺伝子や酵素の細胞内輸送に関わるタンパク質をコードする遺伝子に欠損が生じると、基質である代謝物が細胞内に蓄積し、リソソーム蓄積症を発症する。現在、いくつかのリソソーム蓄積症の治療として、最も用いられているのが酵素補充療法である。これは、体外で生産された組換えリソソーム酵素を静脈内投与する方法である。リソソーム酵素の細胞内への取り込みには、マンノース-6-リン酸受容体やマンノース受容体が関与しており、組換えリソソーム酵素のN結合型糖鎖構造が取り込み効率に寄与している。本総説では、リソソーム蓄積症と酵素補充療法について概説し、組換えリソソーム酵素の糖鎖改変の現状について解説をする。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134996416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Aspects of Cancer-associated Glycans in Gliomas 胶质瘤中癌症相关聚糖的分子研究
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-05-25 DOI: 10.4052/tigg.2306.2e
Y. Ohkawa
{"title":"Molecular Aspects of Cancer-associated Glycans in Gliomas","authors":"Y. Ohkawa","doi":"10.4052/tigg.2306.2e","DOIUrl":"https://doi.org/10.4052/tigg.2306.2e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46406352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a Synthetic Strategy for Gangliosides Using the Unique Chemical Structure of Sialic Acid 利用唾液酸独特的化学结构合成神经节苷类化合物的研究进展
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-05-25 DOI: 10.4052/tigg.2312.2e
Hide-Nori Tanaka
{"title":"Development of a Synthetic Strategy for Gangliosides Using the Unique Chemical Structure of Sialic Acid","authors":"Hide-Nori Tanaka","doi":"10.4052/tigg.2312.2e","DOIUrl":"https://doi.org/10.4052/tigg.2312.2e","url":null,"abstract":"Gangliosides are the components of lipid rafts involved in several biological events such as signal transduction. The synthesis of structurally well-defined gangliosides is necessary in order to elucidate the formation mechanisms and functions of lipid rafts at the molecular level. However, previous methods to achieve stereocontrol in glycosidic bond formation of sialic acid have shown that it is substrate-dependent. Therefore, the chemical synthesis of gangliosides and their glycans remains a challenging task in carbohydrate chemistry. This review presents the development of a 1,5-lactam synthetic strategy for gangliosides.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134996415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Target-Specific O-linked N-acetylglucosamine Modification with a Dual-Specificity Aptamer Reveals Functions of O-GlcNAcylation in β-catenin 双特异性适配体修饰o -连接n -乙酰氨基葡萄糖揭示o - glcn酰化在β-catenin中的作用
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-05-25 DOI: 10.4052/tigg.2309.6j
Haruki Odaka
{"title":"Target-Specific O-linked N-acetylglucosamine Modification with a Dual-Specificity Aptamer Reveals Functions of O-GlcNAcylation in β-catenin","authors":"Haruki Odaka","doi":"10.4052/tigg.2309.6j","DOIUrl":"https://doi.org/10.4052/tigg.2309.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43631481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ステープルオリゴ糖の設計・合成・機能評価 斯台普低聚糖的设计、合成、功能评价
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-05-25 DOI: 10.4052/tigg.2311.6j
Shinnosuke Wakamori
{"title":"ステープルオリゴ糖の設計・合成・機能評価","authors":"Shinnosuke Wakamori","doi":"10.4052/tigg.2311.6j","DOIUrl":"https://doi.org/10.4052/tigg.2311.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47742301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Glycan Editing Opens the Door to Understanding the Precise Structure–Function Relationships of Proteoglycans 化学甘氨酸编辑打开了理解蛋白质聚糖精确结构-功能关系的大门
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-03-25 DOI: 10.4052/tigg.2227.6e
Y. Manabe
{"title":"Chemical Glycan Editing Opens the Door to Understanding the Precise Structure–Function Relationships of Proteoglycans","authors":"Y. Manabe","doi":"10.4052/tigg.2227.6e","DOIUrl":"https://doi.org/10.4052/tigg.2227.6e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42927847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functions of Protein C-Mannosylation in Physiology and Pathology 蛋白c -甘露糖基化在生理和病理中的作用
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-03-25 DOI: 10.4052/tigg.2218.1j
Kazuchika Nishitsuji, Midori Ikezaki, S. Manabe, Y. Ihara
{"title":"Functions of Protein C-Mannosylation in Physiology and Pathology","authors":"Kazuchika Nishitsuji, Midori Ikezaki, S. Manabe, Y. Ihara","doi":"10.4052/tigg.2218.1j","DOIUrl":"https://doi.org/10.4052/tigg.2218.1j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47034861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer-targeting Antibody-sialidase Conjugate Reverses Polarization of Tumor-associated Macrophage and Improves Immune Checkpoint Blockade Therapy 肿瘤靶向抗体-唾液酸酶偶联物逆转肿瘤相关巨噬细胞极化并改善免疫检查点阻断治疗
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-03-25 DOI: 10.4052/tigg.2302.6j
Tsukasa Shigehiro
{"title":"Cancer-targeting Antibody-sialidase Conjugate Reverses Polarization of Tumor-associated Macrophage and Improves Immune Checkpoint Blockade Therapy","authors":"Tsukasa Shigehiro","doi":"10.4052/tigg.2302.6j","DOIUrl":"https://doi.org/10.4052/tigg.2302.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42117443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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