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Trends in Glycoscience and Glycotechnology最新文献

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DHB Matrix with Additives for Direct MALDI Mass Spectrometry of Carbohydrates and Glycoconjugates 含添加剂的DHB基质用于碳水化合物和糖缀合物的直接MALDI质谱分析
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-03-25 DOI: 10.4052/tigg.2214.1e
Hiroshi Hinou
{"title":"DHB Matrix with Additives for Direct MALDI Mass Spectrometry of Carbohydrates and Glycoconjugates","authors":"Hiroshi Hinou","doi":"10.4052/tigg.2214.1e","DOIUrl":"https://doi.org/10.4052/tigg.2214.1e","url":null,"abstract":"Matrix-assisted laser desorption/ionization (MALDI) is one of the soft ionization methods in mass spectrometry (MS). Its analyte compatibility with a matrix can improve analyte-selective ionization efficiency and control the fragmentation properties of the product ions. 2,5-dihydroxybenzoic acid (DHB) is a versatile matrix that can be used for various molecular species. Although DHB is commonly used as the matrix of first choice for MALDI MS of glycans, many attempts to optimize DHB for glycan analysis using additives have also been reported. This mini-review will present additives of the DHB-based matrix that promote direct analysis of carbohydrates and glycoconjugates by MALDI MS.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135997520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer-targeting Antibody-sialidase Conjugate Reverses Polarization of Tumor-associated Macrophage and Improves Immune Checkpoint Blockade Therapy 肿瘤靶向抗体-唾液酸酶偶联物逆转肿瘤相关巨噬细胞极化并改善免疫检查点阻断治疗
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-03-25 DOI: 10.4052/tigg.2302.6e
Tsukasa Shigehiro
{"title":"Cancer-targeting Antibody-sialidase Conjugate Reverses Polarization of Tumor-associated Macrophage and Improves Immune Checkpoint Blockade Therapy","authors":"Tsukasa Shigehiro","doi":"10.4052/tigg.2302.6e","DOIUrl":"https://doi.org/10.4052/tigg.2302.6e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135997208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functions of Protein <i>C</i>-Mannosylation in Physiology and Pathology 蛋白&lt;i&gt;C&lt;/i&gt;-甘露糖基化在生理和病理中的功能
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-03-25 DOI: 10.4052/tigg.2218.1e
Kazuchika Nishitsuji, Midori Ikezaki, Shino Manabe, Yoshito Ihara
{"title":"Functions of Protein &lt;i&gt;C&lt;/i&gt;-Mannosylation in Physiology and Pathology","authors":"Kazuchika Nishitsuji, Midori Ikezaki, Shino Manabe, Yoshito Ihara","doi":"10.4052/tigg.2218.1e","DOIUrl":"https://doi.org/10.4052/tigg.2218.1e","url":null,"abstract":"Protein C-mannosylation is a unique type of protein glycosylation in which a single α-mannose is attached to the indole C2 of tryptophan (Trp) through a C–C bond. The Trp-x-x-Trp (WxxW) sequences, whose first Trp residue may be C-mannosylated, constitute the consensus motifs of this rare glycosylation modification. Dpy-19 was recognized as a gene encoding C-mannosyltransferase in Caenorhabditis elegans. DPY19L1 and DPY19L3 were later confirmed as mammalian C-mannosyltransferases. The consensus motif can be found in the thrombospondin type 1 repeat and cytokine receptor type I families as well as in many other proteins, and recent studies suggest critical roles of C-mannosylation in the folding, sorting, and/or secretion of the substrate proteins. We successfully synthesized C-mannosylated Trp-containing Trp-Ser-Pro-Trp (WSPW) peptides. As a result of using these peptides in our investigations, we proposed that C-mannosylation may have biological functions in addition to contributing to the folding and stability of the substrate proteins. In this mini-review, we discuss the biological roles of C-mannosylation in physiology and pathology as based on our recent findings.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135997206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Glycan Editing Opens the Door to Understanding the Precise Structure–Function Relationships of Proteoglycans 化学聚糖编辑为理解蛋白聚糖的精确结构-功能关系打开了大门
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-03-25 DOI: 10.4052/tigg.2227.6j
Yoshiyuki Manabe
{"title":"Chemical Glycan Editing Opens the Door to Understanding the Precise Structure–Function Relationships of Proteoglycans","authors":"Yoshiyuki Manabe","doi":"10.4052/tigg.2227.6j","DOIUrl":"https://doi.org/10.4052/tigg.2227.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135997209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DHB Matrix with Additives for Direct MALDI Mass Spectrometry of Carbohydrates and Glycoconjugates 含添加剂的DHB基质用于碳水化合物和糖缀合物的直接MALDI质谱分析
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-03-25 DOI: 10.4052/tigg.2214.1j
H. Hinou
{"title":"DHB Matrix with Additives for Direct MALDI Mass Spectrometry of Carbohydrates and Glycoconjugates","authors":"H. Hinou","doi":"10.4052/tigg.2214.1j","DOIUrl":"https://doi.org/10.4052/tigg.2214.1j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43890425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXTL2-related Glycosaminoglycan Biosynthesis and Disease extl2相关的糖胺聚糖生物合成与疾病
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-01-25 DOI: 10.4052/tigg.2201.1j
Satomi Nadanaka, Hiroshi Kitagawa
{"title":"EXTL2-related Glycosaminoglycan Biosynthesis and Disease","authors":"Satomi Nadanaka, Hiroshi Kitagawa","doi":"10.4052/tigg.2201.1j","DOIUrl":"https://doi.org/10.4052/tigg.2201.1j","url":null,"abstract":"がん抑制遺伝子Exostosinファミリーメンバーに属するEXT1あるいはEXT2は、遺伝性多発性外骨腫の原因遺伝子であり、これらの遺伝子産物はヘパラン硫酸の合成に関わるポリメラーゼとしてはたらく。EXTL2はがん抑制遺伝子ファミリーメンバーに相同性を示す3つのEXT様（EXT-like）遺伝子の一つであり、N-アセチルヘキソサミン転移酵素をコードする。しかしながら、EXTL2がグリコサミノグリカン（GAG）の生合成に果たす役割についてもEXTL2の生物学的重要性についても長い間不明であった。著者らはEXTL2がGAG生合成を調節し、その制御の破綻が病態形成過程に関与することを明らかにした。本ミニレヴューでは、EXTL2によるGAGの生合成制御が機能的に重要である点について述べ、EXTL2の発現低下が様々な疾患の進展に関わる可能性を示したい。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136043389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glass Science of Glycolipids 糖脂玻璃科学
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-01-25 DOI: 10.4052/tigg.2121.1e
Shigesaburo Ogawa
{"title":"Glass Science of Glycolipids","authors":"Shigesaburo Ogawa","doi":"10.4052/tigg.2121.1e","DOIUrl":"https://doi.org/10.4052/tigg.2121.1e","url":null,"abstract":"Glass transition is a phenomenon in which an amorphous phase undergoes an abrupt change in its thermodynamic properties at a certain temperature referred to as that material’s glass transition temperature (Tg). Recently, studies have been conducted on the glass transition of glycolipids, including carbohydrate-based surfactants, which have covalently linked sugar and hydrocarbon moieties. These are reported to form various phases such as the glassy lamellar gel (Lβ) phases, glassy thermotropic liquid crystal (LC) phases like the fluid lamellar (Lα), hexagonal columnar (Colh) and cubic LC phases, and glassy lyotropic LC phases such as Lα and cubic LC phases. In addition, the relationships between the structure of glycolipids, their LC phases, and Tg have been reported. Furthermore, the phase transition between Lα and Lβ phases in the glassy state and the relaxation behavior of structural and thermodynamic parameters at glass transition have been investigated. These results reveal the universality of the glass transition phenomenon, as well as some properties specific to the glass transition of glycolipids. Several promising applications have been proposed for pharmaceutical fields. Future research is expected to shed light on the glass transition of glycolipids and glycans in biomembranes and their contribution to the expression of functions.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135998468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sialoglycomic Analysis Using Sialic Acid Recognition Molecules as Probes 以唾液酸识别分子为探针的唾液糖合成分析
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-01-25 DOI: 10.4052/tigg.2225.6e
Masaya Hane
{"title":"Sialoglycomic Analysis Using Sialic Acid Recognition Molecules as Probes","authors":"Masaya Hane","doi":"10.4052/tigg.2225.6e","DOIUrl":"https://doi.org/10.4052/tigg.2225.6e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136043383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXTL2-related Glycosaminoglycan Biosynthesis and Disease extl2相关的糖胺聚糖生物合成与疾病
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-01-25 DOI: 10.4052/tigg.2201.1e
S. Nadanaka, H. Kitagawa
{"title":"EXTL2-related Glycosaminoglycan Biosynthesis and Disease","authors":"S. Nadanaka, H. Kitagawa","doi":"10.4052/tigg.2201.1e","DOIUrl":"https://doi.org/10.4052/tigg.2201.1e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46346734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Progress in the Development and Application of Lectin Mimics 凝集素模拟物的开发与应用进展
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-01-25 DOI: 10.4052/tigg.2207.1e
Yu Nakagawa
{"title":"Recent Progress in the Development and Application of Lectin Mimics","authors":"Yu Nakagawa","doi":"10.4052/tigg.2207.1e","DOIUrl":"https://doi.org/10.4052/tigg.2207.1e","url":null,"abstract":"Emerging significance of carbohydrates in various biological processes has accelerated the development and application of carbohydrate-binding small molecules (lectin mimics). In the past three decades, tremendous progress has been seen in designing lectin mimics that can capture carbohydrates in aqueous media. The efforts to use carbohydrate-binding natural products in carbohydrate research have been also initiated in recent years. By focusing on the lectin mimics of synthetic and natural origins, this minireview outlines their molecular basis of carbohydrate recognition, and discusses their potential for application in carbohydrate research.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136043381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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