{"title":"Mast Cell Degranulation as a Histopathologic Marker in Fatal Anaphylaxis: An Illustrated Case of Vespidae Envenomation.","authors":"Nuha Mahmood, Rachel Martindale, Jared Brooks","doi":"10.1097/PAF.0000000000001064","DOIUrl":"https://doi.org/10.1097/PAF.0000000000001064","url":null,"abstract":"","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luke N Rodda, Kylie E Candela, Amy P Hart, Ellen G Moffatt, Sue Pearring, Karen S Scott
{"title":"Bladder Wash as an Alternative Postmortem Toxicology Specimen: Forensic Pathologists' Perspectives.","authors":"Luke N Rodda, Kylie E Candela, Amy P Hart, Ellen G Moffatt, Sue Pearring, Karen S Scott","doi":"10.1097/PAF.0000000000001034","DOIUrl":"10.1097/PAF.0000000000001034","url":null,"abstract":"<p><strong>Abstract: </strong>In postmortem forensic investigations, where the bladder is voided or dehydrated prior to autopsy, it is possible to wash the bladder with saline to collect the resulting \"bladder wash\" and any residual urine for toxicological analysis. Although this method is not yet commonplace or standard, a recent study has demonstrated that bladder wash is an effective alternative specimen in postmortem forensic toxicology. The current study aimed to assess forensic pathologists' opinions on the use of bladder wash samples both before and after reviewing bladder wash toxicological data. An online survey was distributed to forensic pathologists from NAME, and responses were analyzed to identify any shifts in perceptions after data presentation. The findings revealed that most forensic pathologists recognized the benefits of bladder wash collection and analysis as well as its usefulness in determining the cause and manner of death, with noticeable changes in perspective following exposure to supporting data. This study highlights the potential value of standardizing the easy and accessible collection of bladder wash for postmortem toxicological analysis, thereby providing forensic pathologists with invaluable information when other biological specimens are unavailable.</p>","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fatal Right Ventricular Perforation Caused by Guidewire During Adult Central Venous Catheter Placement.","authors":"Caterina Pesaresi, Beatrice Benedetti, Francesca M D'Ascenzo, Giulia D'Amati, Fabio De-Giorgio","doi":"10.1097/PAF.0000000000001063","DOIUrl":"https://doi.org/10.1097/PAF.0000000000001063","url":null,"abstract":"","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sim X DefenseCore Ammunition: Structural Composition, Radiologic Features, Ballistics, and Autopsy Findings.","authors":"Lorenzo Gitto, Meredith A Reynolds","doi":"10.1097/PAF.0000000000001062","DOIUrl":"https://doi.org/10.1097/PAF.0000000000001062","url":null,"abstract":"","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trends in Publication Outcomes of Platform Presentations at National Association of Medical Examiners (NAME) Annual Meetings From 2013 to 2022.","authors":"Elizabeth Lee, Daniel Atherton","doi":"10.1097/PAF.0000000000001061","DOIUrl":"https://doi.org/10.1097/PAF.0000000000001061","url":null,"abstract":"<p><p>The NAME annual meeting focuses on platform presentations as a means of sharing research, ideas, and education; however, little is known about the rate at which these presentations are subsequently published. This study analyzed trends related to publication outcomes of 651 presentations given from 2013 to 2022. Using Python scripts that queried the PubMed database, we found that 175 presentations (27%) went on to be published in the peer-reviewed literature [we also accounted for presentations published in Academic Forensic Pathology (AFP) in the years when AFP was not indexed in PubMed]. The journals AFP and the AJFMP accounted for most of the publications, but over 30 other journals were identified. Publications in AFP declined in the latter years of our study range, while publications in AJFMP increased. First authors from NMS, the CDC, and Ottawa-based institutions were among the most likely to publish their presentations. To assess the performance of our automated scripts, we also performed a manual Internet/PubMed search of presentation titles and authors; our automated scripts detected 97% of all matched presentations with PubMed. Information gleaned from studying bibliometric trends can help inform strategies for improving future educational programs.</p>","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ra Ivana Andric, Živana Slovic, Ivan Aleksic, Katarina Vitoševic
{"title":"Handmade Firearm and Ammunition Death: A Case Study.","authors":"Ra Ivana Andric, Živana Slovic, Ivan Aleksic, Katarina Vitoševic","doi":"10.1097/PAF.0000000000001059","DOIUrl":"https://doi.org/10.1097/PAF.0000000000001059","url":null,"abstract":"<p><p>We present a case of a 47-year-old man found in the isolated boiler room of his house, lying on the floor in a pool of blood. Next to the body, a handmade firearm was discovered. The weapon consists of 2 metal plumbing pipes of different circumferences and a percussion detonator at the base. The shotgun shell is made of plastic, and the cartridge contains 4 handmade metal pellets, each 10 mm in diameter. Upon external examination of the body, a gunshot wound was identified in the middle of the chest, fired through the deceased's clothing, which is a rather unusual characteristic when it comes to suicide. No defensive wounds were observed on the body. Although the deceased had no history of depression, prior suicide attempts, known motives, or identifiable personality traits associated with suicidal behavior, the sudden emergence of unusual circumstances, such as fear of consequences and financial hardship, led him to an affective suicide. This is the only case where both the shotgun and the ammunition are handmade.</p>","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra Mease, Franklin Boyd, Blake Patel, Carolina McEnnan
{"title":"Acute Necrotizing Eosinophilic Myocarditis in a 27-year-old Woman: A Case Report.","authors":"Alexandra Mease, Franklin Boyd, Blake Patel, Carolina McEnnan","doi":"10.1097/PAF.0000000000001060","DOIUrl":"https://doi.org/10.1097/PAF.0000000000001060","url":null,"abstract":"<p><p>Acute necrotizing eosinophilic myocarditis is an uncommon type of myocarditis commonly presenting as fulminant congestive heart failure and histologically characterized by dense eosinophilic infiltrates in a background of necrotic cardiomyocytes. We present the case of a 27-year-old woman who died suddenly due to severe shock and multiorgan failure and was found to have acute necrotizing eosinophilic myocarditis at autopsy. We discuss the possible precipitating factors underlying our case and the considerations this case and others in the literature provide to pathologists investigating the unexpected death of young adults.</p>","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melissa A Pasquale-Styles, Suzanne Doyon, John Agboola, Ryan J Cole, William Schroeder, Michael Hays
{"title":"Fatal Potassium Thiocyanate Poisoning Presenting With Falsely Elevated Chloride Concentration.","authors":"Melissa A Pasquale-Styles, Suzanne Doyon, John Agboola, Ryan J Cole, William Schroeder, Michael Hays","doi":"10.1097/PAF.0000000000001057","DOIUrl":"https://doi.org/10.1097/PAF.0000000000001057","url":null,"abstract":"<p><p>Potassium thiocyanate is a long-discontinued weak antihypertensive and an uncommonly encountered toxic agent. We report a 52-year-old man who presented to the emergency department with a sudden onset of altered mental status, vomiting, and seizures after a suspected toxic ingestion. Clinical laboratory tests showed a falsely elevated serum chloride (>200 mmol/L) with other normal electrolytes, resulting in a significant negative anion gap. An endoscopy showed gastric mucosa edema and hyperemia. Repeated electroencephalograms showed moderate to severe encephalopathy. He remained symptomatic until his death 9 days later. An autopsy found hypoxic-ischemic changes in the brain. Toxicological analysis on antemortem blood collected 93 to 95 hours after apparent ingestion revealed a thiocyanate concentration of 260 μg/mL and cyanide concentration of 0.21 μg/mL. Toxicology on postmortem specimens revealed thiocyanate concentrations of 78 μg/mL in cardiac blood, 75 μg/mL in peripheral blood, 16 μg/g in brain, 49 μg/g in kidney, 37 μg/g in liver, and 21 μg/g in skeletal muscle. Further investigation found an internet order for potassium thiocyanate in the days before ingestion. This case report raises the awareness of thiocyanate as a potentially re-emerging toxin and pseudohalide that can interfere with clinical laboratory testing and present as falsely elevated serum chloride (pseudohyperchloremia).</p>","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"First Case Report of the Use of Postmortem Wide-Angle Fundus Photography in Abusive Head Trauma.","authors":"Toru Oshima, Hiroshi Yoshikawa, Hidehisa Sekijima, Hirokazu Kotani","doi":"10.1097/PAF.0000000000001055","DOIUrl":"10.1097/PAF.0000000000001055","url":null,"abstract":"<p><p>Retinal hemorrhages commonly cooccur with abusive head trauma (AHT). While wide-field fundus photography is crucial for documenting retinal hemorrhage in living children, in fatal cases, a pathologic examination is traditionally used. This report describes the case of a 4-year-old girl who died of head trauma suspected to have been caused by physical abuse. Before the autopsy, wide-field fundus photography using scanning laser ophthalmoscopy (SLO) was performed to document retinal hemorrhages. Imaging revealed that retinal hemorrhages were predominantly located at the posterior pole and in the peripheral retina of the right eye. The autopsy confirmed cranial injuries, including acute subdural hematoma. Pathologic examination of the eyes revealed hemorrhages beneath the internal limiting membrane and within the inner to outer nuclear layers of the retina. The cause of death was determined to be head trauma leading to an acute subdural hematoma. This case confirms that wide-field fundus photography using SLO can be performed postmortem, supplementing pathologic findings. Postmortem fundus photography, particularly using SLO, has the potential to reduce the risk of artifact introduction during the preparation of traditional specimens. Additional case studies are required to further refine the use of this technique and establish its potential forensic application in the diagnosis of AHT.</p>","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Autopsy Case of ANCA-Negative Small Vessel Vasculitis With Glomerular Crescents.","authors":"Thomas Auen, Erin Linde","doi":"10.1097/PAF.0000000000001058","DOIUrl":"10.1097/PAF.0000000000001058","url":null,"abstract":"","PeriodicalId":55535,"journal":{"name":"American Journal of Forensic Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}