American Journal of Geriatric Psychiatry最新文献

{"title":"Sleep Capital: Linking Brain Health to Wellbeing and Economic Productivity Across the Lifespan","authors":"Diego A. Golombek Ph.D. ,&nbsp;Harris Eyre MD, Ph.D. ,&nbsp;Ignacio Spiousas Ph.D. ,&nbsp;Leandro P. Casiraghi Ph.D. ,&nbsp;Kaisa M. Hartikainen M.D., Ph.D. ,&nbsp;Timo Partonen M.D., Ph.D. ,&nbsp;Mika Pyykkö M.Sc. ,&nbsp;Charles F. Reynolds 3rd M.D. ,&nbsp;William M. Hynes Ph.D. ,&nbsp;Claudio L.A. Bassetti M.D., Ph.D. ,&nbsp;Michael Berk M.D., Ph.D. ,&nbsp;Kun Hu Ph.D. ,&nbsp;Agustín Ibañez Ph.D.","doi":"10.1016/j.jagp.2024.07.011","DOIUrl":"10.1016/j.jagp.2024.07.011","url":null,"abstract":"<div><h3>Introduction and framework</h3><div>Sleep capital contributes to individual and societal wellbeing, productivity, and economic outcomes and involves a novel aspect of brain capital. It encompasses the quality and quantity of sleep as integral components that influence cognitive abilities, mental and brain health, and physical health, affecting workplace productivity, learning, decision-making, and overall economic performance. Here, we bring a framework to understand the complex relationship between sleep quality, health, wellbeing, and economic productivity. Then we outline the multilevel impact of sleep on cognitive abilities, mental/brain health, and economic indicators, providing evidence for the substantial returns on investment in sleep health initiatives. Moreover, sleep capital is a key factor when considering brain health across the lifespan, especially for the aging population.</div></div><div><h3>Discussion</h3><div>We propose specific elements and main variables to develop specific indexes of sleep capital to address its impacts on health, wellbeing and productivity.</div></div><div><h3>Conclusion</h3><div>Finally, we suggest policy recommendations, workplace interventions, and individual strategies to promote sleep health and brain capital. Investing in sleep capital is essential for fostering a healthier, happier, fairer and more productive society.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 1","pages":"Pages 92-106"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141838614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition","authors":"Nancy R. Davison","doi":"10.1016/j.jagp.2024.10.003","DOIUrl":"10.1016/j.jagp.2024.10.003","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 1","pages":"Page 120"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic Stimulation to Improve Slow-Wave Sleep in Alzheimer's Disease: A Multiple Night At-Home Intervention","authors":"Laura Van den Bulcke M.D. ,&nbsp;Hannah Davidoff M.Sc. ,&nbsp;Elisabeth Heremans M.Sc. ,&nbsp;Yasmin Potts B.A. (Hons) ,&nbsp;Kristof Vansteelandt Ph.D. ,&nbsp;Maarten De Vos Ph.D. ,&nbsp;Daan Christiaens Ph.D. ,&nbsp;Louise Emsell Ph.D. ,&nbsp;Laura H. Jacobson Ph.D. ,&nbsp;Daniël Hoyer Ph.D., D.Sc. ,&nbsp;Bertien Buyse M.D., Ph.D. ,&nbsp;Mathieu Vandenbulcke M.D., Ph.D. ,&nbsp;Dries Testelmans M.D., Ph.D. ,&nbsp;Maarten Van Den Bossche M.D., Ph.D.","doi":"10.1016/j.jagp.2024.07.002","DOIUrl":"10.1016/j.jagp.2024.07.002","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the efficacy of closed-loop acoustic stimulation (CLAS) during slow-wave sleep (SWS) to enhance slow-wave activity (SWA) and SWS in patients with Alzheimer's disease (AD) across multiple nights and to explore associations between stimulation, participant characteristics, and individuals’ SWS response.</div></div><div><h3>Design</h3><div>A 2-week, open-label at-home intervention study utilizing the DREEM2 headband to record sleep data and administer CLAS during SWS.</div></div><div><h3>Setting and participants</h3><div>Fifteen older patients with AD (6 women, mean age: 76.27 [SD = 6.06], mean MOCA-score: 16.07 [SD = 6.94]), living at home with their partner, completed the trial.</div></div><div><h3>Intervention</h3><div>Patients first wore the device for two baseline nights, followed by 14 nights during which the device was programmed to randomly either deliver acoustic stimulations of 50 ms pink noise (± 40 dB) targeted to the slow-wave up-phase during SWS or only mark the wave (sham).</div></div><div><h3>Results</h3><div>On a group level, stimulation significantly enhanced SWA and SWS with consistent SWS enhancement throughout the intervention. However, substantial variability existed in individual responses to stimulation. Individuals received more stimulations on nights with increased SWS compared to baseline than on nights with no change or a decrease. In individuals, having lower baseline SWS correlated with receiving fewer stimulations on average during the intervention.</div></div><div><h3>Conclusion</h3><div>CLAS during SWS is a promising nonpharmacological method to enhance SWA and SWS in AD. However, patients with lower baseline SWS received fewer stimulations during the intervention, possibly resulting in less SWS enhancement. Individual variability in response to stimulation underscores the need to address personalized stimulation parameters in future research and therapy development.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 1","pages":"Pages 73-84"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keeping Clinically-Rooted Interventions at the Heart of Hospital Workplace Safety","authors":"Carmen Black M.D., M.H.S. ,&nbsp;Noah Sobel B.A. ,&nbsp;Jordyn Williams B.A.","doi":"10.1016/j.jagp.2024.07.015","DOIUrl":"10.1016/j.jagp.2024.07.015","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 1","pages":"Pages 15-17"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Memoirs of a Healthcare Worker During the Pandemic","authors":"Deanna C. Fernandes Pharm.D.","doi":"10.1016/j.jagp.2024.09.002","DOIUrl":"10.1016/j.jagp.2024.09.002","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 1","pages":"Page 122"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Gerotranscendence: Lived Experience of a Neurodegenerative Disorder and a Spiritual Awakening to Nondual Awareness","authors":"Helen Lavretsky M.D., M.S. ,&nbsp;Neil Schuitevoerder Ph.D.","doi":"10.1016/j.jagp.2024.09.006","DOIUrl":"10.1016/j.jagp.2024.09.006","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 1","pages":"Pages 107-111"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor: “Psychedelics in Older Adults: Difficulties of a Clear Therapeutic Evidence”","authors":"Hannes Kettner M.S. ,&nbsp;Leor Roseman Ph.D. ,&nbsp;Adam Gazzaley M.D., Ph.D. ,&nbsp;Robin L. Carhart-Harris Ph.D. ,&nbsp;Lorenzo Pasquini Ph.D.","doi":"10.1016/j.jagp.2024.09.009","DOIUrl":"10.1016/j.jagp.2024.09.009","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 1","pages":"Pages 118-119"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor Sleep is Common in Treatment-Resistant Late-life Depression and Associated With Poorer Antidepressant Response: Findings From the OPTIMUM Clinical Trial","authors":"Michael S.B. Mak M.D. ,&nbsp;Marie Anne Gebara M.D. ,&nbsp;Eric J. Lenze M.D. ,&nbsp;Daniel M. Blumberger M.D. ,&nbsp;Patrick J. Brown Ph.D. ,&nbsp;Pilar Cristancho M.D. ,&nbsp;Alastair J. Flint M.B ,&nbsp;Jordan F. Karp M.D. ,&nbsp;Helen Lavretsky M.D. ,&nbsp;J. Philip Miller A.B. ,&nbsp;Charles F. Reynolds III M.D. ,&nbsp;Steven P. Roose M.D. ,&nbsp;Benoit H. Mulsant M.D. ,&nbsp;Sarah T. Stahl Ph.D.","doi":"10.1016/j.jagp.2024.07.020","DOIUrl":"10.1016/j.jagp.2024.07.020","url":null,"abstract":"<div><h3>Background</h3><div>Adults with treatment-resistant late-life depression (TRLLD) have high rates of sleep problems; however, little is known about the occurrence and change in sleep during pharmacotherapy of TRLLD. This analysis examined: (1) the occurrence of insufficient sleep among adults with TRLLD; (2) how sleep changed during pharmacotherapy; and (3) whether treatment outcomes differed among participants with persistent insufficient sleep, worsened sleep, improved sleep, or persistent sufficient sleep.</div></div><div><h3>Methods</h3><div>Secondary analysis of data from 634 participants age 60+ years in the OPTIMUM clinical trial for TRLLD. Sleep was assessed using the sleep item from the Montgomery-Asberg Depression Rating Scale at the beginning (week-0) and end (week-10) of treatment. The analyses examined whether treatment outcomes differed among participants with persistent insufficient sleep, worsened sleep, improved sleep, or persistent sufficient sleep during depression treatment.</div></div><div><h3>Results</h3><div>About half (51%, n = 323) of participants reported insufficient sleep at baseline. Both persistent insufficient sleep (25%, n = 158) and worsened sleep (10%, n = 62) during treatment were associated with antidepressant nonresponse. Participants who maintained sufficient sleep (26%, n = 164) or who improved their sleep (n = 25%, n = 158) were three times more likely to experience a depression response than those with persistent insufficient sleep or worsened sleep.</div></div><div><h3>Conclusion</h3><div>Insufficient sleep is common in TRLLD and it is associated with poorer treatment response to antidepressants.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 1","pages":"Pages 63-72"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Aging in US Veterans with Mental Disorders: Results From the National Health and Resilience in Veterans Study","authors":"Jeonghyun Shin M.D. ,&nbsp;Ian C. Fischer Ph.D. ,&nbsp;Peter J. Na M.D., M.P.H. ,&nbsp;Dilip V. Jeste M.D. ,&nbsp;Robert H. Pietrzak Ph.D., M.P.H.","doi":"10.1016/j.jagp.2024.07.018","DOIUrl":"10.1016/j.jagp.2024.07.018","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine the prevalence and correlates of successful aging in US veterans who screened positive for current major depressive disorder (MDD), generalized anxiety disorder (GAD), and/or posttraumatic stress disorder (PTSD).</div></div><div><h3>Methods</h3><div>In a nationally representative sample of 475 US military veterans (mean age=58.3, SD=14.7; range 24–92) who screened positive for MDD, GAD, and/or PTSD, multivariable logistic regression and relative importance analyses were conducted to identify independent correlates of successful aging.</div></div><div><h3>Results</h3><div>One-in-five (20.6%) veterans rated themselves as aging successfully. Resilience and gratitude were the strongest positive correlates of successful aging, accounting for 38.1% and 32.4% of the explained variance, respectively. Greater somatic symptoms were the strongest negative correlate, accounting for 11.2% of the explained variance. Higher gratitude moderated the negative association between somatic symptoms and successful aging.</div></div><div><h3>Conclusions</h3><div>Positive psychiatry interventions targeting psychosocial factors such as resilience and gratitude may help promote successful aging among US veterans with mental disorders.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 1","pages":"Pages 85-91"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial, Ethnic, and Age-Related Disparities in Sedation and Restraint Use for Older Adults in the Emergency Department","authors":"Patelle Jivalagian M.P.H. ,&nbsp;Cameron J. Gettel M.D., M.H.S. ,&nbsp;Colin M. Smith M.D., M.Sc.G.H. ,&nbsp;Leah Robinson M.P.H. ,&nbsp;Morgan Brinker B.A. ,&nbsp;Dhruvil Shah B.S. ,&nbsp;Anusha Kumar M.S. ,&nbsp;Isaac V. Faustino M.S. ,&nbsp;Bidisha Nath M.B.B.S., M.P.H. ,&nbsp;Erika Chang-Sing M.D. ,&nbsp;R. Andrew Taylor M.D., M.H.S. ,&nbsp;Maura Kennedy M.D., M.P.H. ,&nbsp;Ula Hwang M.D., M.P.H. ,&nbsp;Ambrose H. Wong M.D., M.S.Ed., M.H.S.","doi":"10.1016/j.jagp.2024.07.004","DOIUrl":"10.1016/j.jagp.2024.07.004","url":null,"abstract":"<div><h3>Objectives</h3><div>Older adults may present to the emergency department (ED) with agitation, a symptom often resulting in chemical sedation and physical restraint use which carry significant risks and side effects for the geriatric population. To date, limited literature describes the patterns of differential restraint use in this population.</div></div><div><h3>Design, setting, participants, and measurements</h3><div>This retrospective cross-sectional study used electronic health records data from ED visits by older adults (age ≥65 years) ranging 2015–2022 across nine hospital sites in a regional hospital network. Logistic regression models were estimated to determine the association between patient-level characteristics and the primary outcomes of chemical sedation and physical restraint.</div></div><div><h3>Results</h3><div>Among 872,587 ED visits during the study period, 11,875 (1.4%) and 32,658 (3.7%) encounters involved the use of chemical sedation and physical restraints respectively. The populations aged 75-84, 85-94, 95+ years had increasingly higher odds of chemical sedation [adjusted odds ratios (AORs) 1.35 (95% CI 1.29–1.42); 1.82 (1.73–1.91); 2.35 (2.15–2.57) respectively] as well as physical restraint compared to the 65-74 group [AOR 1.31 (1.27–1.34); 1.55 (1.50–1.60); 1.69 (1.59–1.79)]. Compared to the White Non-Hispanic group, the Black Non-Hispanic and Hispanic/Latinx groups had significantly higher odds of chemical sedation [AOR 1.26 (1.18–1.35); AOR 1.22 (1.15–1.29)] and physical restraint [AOR 1.12 (95% CI 1.07–1.16); 1.22 (1.18–1.26)].</div></div><div><h3>Conclusion</h3><div>Approximately one in 20 ED visits among older adults resulted in chemical sedation or physical restraint use. Minoritized group status was associated with increasing use of chemical sedation and physical restraint, particularly among the oldest old. These results may indicate the need for further research in agitation management for historically marginalized populations in older adults.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 1","pages":"Pages 1-14"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}