American Journal of Geriatric Psychiatry最新文献

{"title":"41. THE RELATIONSHIP OF LONELINESS WITH INFLAMMATION AND HEALTH OUTCOMES ACROSS THE ADULT LIFESPAN AMONG PEOPLE LIVING WITH SCHIZOPHRENIA","authors":"Jaclyn Calkins ,&nbsp;Stephanie Ibrahim ,&nbsp;Jerry McDonald ,&nbsp;Lisa Eyler ,&nbsp;Ellen Lee","doi":"10.1016/j.jagp.2025.04.043","DOIUrl":"10.1016/j.jagp.2025.04.043","url":null,"abstract":"<div><h3>Introduction</h3><div>Loneliness is distress that arises from a perceived gap between desired and actual social connections. Loneliness has negative health effects, which are particularly impactful among older adults. People living with schizophrenia (PwS) report higher rates of loneliness than non-psychiatric controls (NCs). Loneliness is associated with more severe depressive, positive, and negative symptoms, as well as worse social functioning and physical health. Furthermore, in NCs, loneliness has been linked to elevated levels of inflammatory plasma biomarkers such as IL-6, TNF-α, and CRP; however, the relationship between loneliness and inflammation in PwS remains under-explored. This study examined the association between loneliness and inflammation in PwS and NCs, as well as between loneliness and health outcomes in PwS, including symptom severity (depressive, positive, and negative), well-being, and sleep quality. The aim was to enhance our understanding of how loneliness relates to both mental and physical health in this population. Our hypotheses were: 1) PwS would have higher loneliness, inflammation, and worse health outcomes compared to NCs; 2) higher loneliness would correlate with higher inflammation in PwS and NCs; and 3) in PwS, higher loneliness would be linked to worse health outcomes.</div></div><div><h3>Methods</h3><div>Subsamples were utilized in this study from an overall participant pool of 111 individuals with a diagnosis with schizophrenia or schizoaffective disorder, and a non-psychiatric comparison group of 108 people with no history of serious psychiatric illness. Loneliness among participants was assessed using the UCLA Loneliness Scale, depression with the Calgary Depression Scale (CDS), positive and negative symptoms of schizophrenia with the Scales for Assessment of Positive and Negative Symptoms (SAPS and SANS), physical and mental well-being with the 36-Item Short Form Health Survey (SF-36) composite scores, and sleep quality with the Pittsburgh Sleep Quality Index (PSQI). Biomarkers (IL-6, TNF-α, hs-CRP) were assayed from fasting blood samples to assess inflammation, and biomarker data was log-transformed for normalization. Statistical analyses included T-tests, Chi-Square tests, and general linear models, with age, sex, race, and education as covariates.</div></div><div><h3>Results</h3><div>The final study sample for hypotheses 1 and 2 included 89 PwS and 68 NCs, of which 49% were women, and the age range was 27-76 years old. PwS had higher overall loneliness (p &lt; 0.001, d = 0.89) and greater assayed levels of IL-6 (p = 0.002, d = 0.509), TNF-α (p = 0.005, d = 0.47), and hs-CRP (p = 0.044, d = 0.33). PwS were also more depressed and had worse physical well-being and mental well-being compared to NCs (p’s &lt; 0.001). PwS had similar sleep quality to NCs. No relationship was found between loneliness and levels of inflammatory biomarkers for PwS or NCs.</div><div>The study sample for hypothesis 3 w","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 10","pages":"Pages S29-S30"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"74. MENOPAUSE IN THE PSYCHIATRIC CLINIC: EXPLORING PATIENT’S PROFILE","authors":"Tanya Peguero Estevez ,&nbsp;Lea Marin ,&nbsp;Rachel Fremont","doi":"10.1016/j.jagp.2025.04.076","DOIUrl":"10.1016/j.jagp.2025.04.076","url":null,"abstract":"<div><h3>Introduction</h3><div>Introduction: Depressive illnesses result in substantial morbidity and mortality throughout the world, with women exhibiting more depressive diseases than men 1,2. There is strong evidence that reproductive transition phases in women, and menopause in particular, are associated with increased susceptibility to mental illness3,4. Studies also suggest that postmenopausal women with depression are at elevated risk for mild cognitive impairment and dementia 5. This may suggest that depression during or after menopause may represent a unique risk factor for subsequent cognitive decline and dementia in women. Despite this, there is no clear guidance on screening or treating menopausal patients in psychiatry. Evidence supports the preferential use of specific SSRI/SNRI, and certain drugs have received FDA approval for symptomatic menopause 6,7,8. Other studies suggest that Menopausal Hormone Therapy (MHT) may be beneficial for post-menopausal psychiatric symptoms in women, but findings are inconsistent8. No specific guidelines exist for the specific treatment of depression in post-menopausal women.</div></div><div><h3>Objective</h3><div>To understand the current practices in a tertiary care psychiatric clinic regarding patients who may have menopause-related psychiatric disorders. We hypothesize that psychiatric providers may not readily identify the impact of menopause on psychiatric conditions and may not identify menopausal women as a subpopulation with specific needs.</div></div><div><h3>Methods</h3><div>In this retrospective chart review study, we obtained data from the Electronic Medical Record (EMR) at The Mount Sinai Behavioral Health Center in New York City outpatient department from 7/1/2023 to 6/27/2024 of female patients, ages 45 to 60 years. We identified patients with a comorbid diagnosis of symptomatic menopause and determined screening status by looking at keywords descriptive of menopause in the psychiatric note: “vasomotor”, “hot flashes”, “menopause\", \"flushing”, “vertigo\", \"dizziness”, “sweating”, “vagina” and “menstruation”. Variables such as race, ethnicity, psychiatric diagnosis, presence of MHT prescription, and psychiatric treatment currently used were also obtained for secondary analysis.</div></div><div><h3>Results</h3><div>Preliminary results: A total sample of 120 patients receiving outpatient psychiatric services with a co morbid menopause diagnosis were identified. Only eight patients (6.66%) had clear evidence of menopause discussion during their psychiatric encounter. Twenty-seven patients (22.5%) were on MHT, of which only 11.6% were a systemic formulation (oral/patch). The majority of identified patients were diagnosed with depressive disorders, followed by anxiety disorder as the most frequent psychiatric diagnosis. The antidepressants most prescribed were escitalopram and fluoxetine.</div></div><div><h3>Conclusions</h3><div>Conclusion: All individuals with female reproductive organs ove","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 10","pages":"Pages S54-S55"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"95. SECONDARY ANALYSIS LINKS COMMUNICATION IMPAIRMENT IN ADULTS WITH ALZHEIMER'S DISEASE AND RELATED DEMENTIAS TO ELEVATED CAREGIVER BURDEN AND SENSORY PROCESSING ABNORMALITIES","authors":"Nancy Wolff ,&nbsp;Clarissa Benzarti ,&nbsp;Laura Henley ,&nbsp;April Stauffer ,&nbsp;Brian Carter ,&nbsp;Elizabeth Rhodus","doi":"10.1016/j.jagp.2025.04.097","DOIUrl":"10.1016/j.jagp.2025.04.097","url":null,"abstract":"<div><h3>Introduction</h3><div>Declining communication is one of the hallmark symptoms of Alzheimer's disease and related dementias (ADRD). Communication deficits contribute to distress in the person with ADRD, relational challenges, and can impact the ability to accomplish necessary care tasks. While hearing loss has been established to be strongly related to communication capacity, a lesser explored area related to communication is that of cortical-level sensory processing in ADRD. We hypothesized communication impairment would be positively correlated with caregiver burden and sensory processing abnormalities in older adults with ADRD.</div></div><div><h3>Methods</h3><div>Using data collected from a non-pharmacological randomized controlled trial aimed at behavior modification in ADRD (participants with ADRD confirmed by Clinical Dementia Rating Scale [CDR] score of 1+ and primary caregiver report), this study conducted secondary data analysis using Pearson correlation to assess relationships among communication impairment as indicated on the CDR, caregiver burden (as measured by the Zarit Burden Inventory), and sensory processing abnormalities (as measured by the Adult Sensory Profile). Demographic data were assessed using summary statistical assessment.</div></div><div><h3>Results</h3><div>Data were analyzed from 19 participants with ADRD. Participants consisted of 11 females, 8 males, x̄ age of 78.21 (SD=10.15), and x̄ Standard Global CDR of 1.625. All participants had functioning sensory acuity with or without aids (i.e., hearing aids). Care partners consisted of 16 females, 3 males, x̄ age of 62.32 (SD=11.56), and spouses were the most frequent care partners. Analyses indicated a significant strong positive correlation between communication impairment and caregiver burden (r =0.59, p=0.007). Additionally, communication impairment was significantly positively correlated with sensory processing abnormalities within the domains of sensory sensitivity (r=0.64, p=0.004) and sensory avoiding (r=0.49, p=0.037). There was no significant correlation between sensory processing abnormalities and caregiver burden.</div></div><div><h3>Conclusions</h3><div>Both receptive (hearing) and expressive (speech) communication is vital to encourage cooperative completion of care tasks. Communication impairment in ADRD is linked to increased caregiver burden as well as cortical-level sensory processing abnormalities beyond standard hearing loss. Additional exploration is warranted to determine causal mechanisms between sensory processing abnormalities and communication impairment in ADRD, especially since findings may have implications on care strategies.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 10","pages":"Pages S70-S71"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"98. FIVE-FACTOR MODEL PERSONALITY TRAITS AS PREDICTOR OF POST CABG DEPRESSION: SUB-ANALYSIS OF NEUROPSYCHIATRIC OUTCOMES AFTER HEART SURGERY (NOAHS) STUDY","authors":"Rebecca Lee ,&nbsp;Joy Choi ,&nbsp;Patrick Walsh ,&nbsp;Mark Oldham","doi":"10.1016/j.jagp.2025.04.100","DOIUrl":"10.1016/j.jagp.2025.04.100","url":null,"abstract":"<div><h3>Introduction</h3><div>Coronary artery bypass graft surgery (CABG) is the most common cardiac surgery with an estimated 200,000 procedures annually in the United States. Depression after CABG surgery occurs in 30–40% of patients and is associated with higher morbidity and mortality. Identifying risk factors could lead to new prevention and treatment strategies for post-CABG depression. Psychological factors including personality traits have identified as a risk factor for coronary heart disease; however, few studies have examined the relationship between personality and post-CABG depression. We examined each of the five factors in the Five-Factor Model (FFM) of personality in association with post-CABG depression based on a subsample of the Neuropsychiatric Outcomes After Heart Surgery (NOAHS) study.</div></div><div><h3>Methods</h3><div>This is a secondary analysis of the Neuropsychiatric Outcomes After Heart Surgery (NOAHS) Study, which was a prospective, single-site study at a tertiary care academic center. Patients undergoing elective CABG surgery were recruited prior to surgery to complete the NEO Five-Factor Inventory (NEO-FFI) inventory, which is a 60-item assessment for personality traits. Before and one year after CABG, participants were evaluated for depression with the Diagnostic Interview Structured Hamilton (DISH). Depression was defined as either minor or major depression per DSM-IV. Subjects also completed patient Health Questionnaire (PHQ-9), Geriatric Depression Scale (GDS), 7-item Generalized Anxiety Disorder scale (GAD-7), and sociodemographic, medical, and neuropsychological assessment. We used independent samples t-tests to compare personality factors in those with vs without post-CABG depression. Next, we calculated unadjusted and adjusted odds ratios (ORs) with 95% CI, using logistic regression with the NEO-FFI factor t-scores as the main predictor variables and post-CABG depression as the outcome of interest while adjusting for potential confounding.</div></div><div><h3>Results</h3><div>We assessed 55 subjects (mean age: 65.1 ± 9.7 years; female: 26%; non-White: 85%). Four out of 55 subjects (7.3%) had pre-CABG depression, and 11 out of 54 subjects (20.4%; 1 missing) developed post-CABG depression. Subjects who developed post-CABG depression had higher t-scores on neuroticism (47.27 ± 12.95 vs 39.67 ± 6.59, p = .006) and lower t-scores on conscientiousness (47.29 ± 9.25 vs 54.80 ± 8.79, p = .015) than those without. Logistic regression models revealed a significant association between neuroticism t-score and post-CABG depression after adjusting for age, gender, and presence of pre-CABG depression (OR = 1.101, 95% CI [1.010, 1.101], p = .029). There was a statistically insignificant association between post-CABG depression and lower extraversion (OR = 0.932, 95% CI [0.858, 1.013], p =.097). Openness, agreeableness, and conscientiousness were not associated with post-CABG depression on logistic regression.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 10","pages":"Pages S72-S73"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25. EXPLORING QUALITY OF LIFE IMPACT REPORTED BY CAREGIVERS IN THE FTD INSIGHTS SURVEY","authors":"Devon Chenette ,&nbsp;Stella McCaughey ,&nbsp;Robert Reinecker ,&nbsp;Carrie Milliard ,&nbsp;Penny Dacks ,&nbsp;Tiffany Chow","doi":"10.1016/j.jagp.2025.04.027","DOIUrl":"10.1016/j.jagp.2025.04.027","url":null,"abstract":"<div><h3>Introduction</h3><div>As the most common form of dementia affecting persons under age 60, frontotemporal degeneration (FTD) can cause financial, career, and household challenges for caregivers that are unique from late-onset dementia. Additionally, FTD causes loss of insight that can give patients a different impression of their burden of disease. To further understand FTD patient and caregiver experiences, a subset of data collected in the FTD Insights Survey was analyzed.</div></div><div><h3>Methods</h3><div>The FTD Insights Survey was developed and executed by the Association for Frontotemporal Degeneration (AFTD) and the FTD Disorders Registry. Reported impact to quality of life (QoL), especially with respect to FTD “symptoms affecting activities with others” were assessed in those who identified “I am or was a primary or secondary caregiver for someone with FTD” vs. responders who were diagnosed with FTD. Pearson’s chi-square test was used to assess association among variables. Cramer’s V was used to assess association strength, nominal p-values were reported.</div></div><div><h3>Results</h3><div>A greater percentage of caregivers reported “loss of financial security” and “loss of important family relationships” as impacted QoL indicators. The strongest effect size observed was loss of financial security (nominal p LESS THAN 0.001, V=0.358). A greater percentage of caregivers reported impact to all “symptoms affecting activities with others” indicators. The strongest effect size observed was impact to intimacy with a spouse or partner (nominal p LESS THAN 0.001, V=0.365).</div></div><div><h3>Conclusions</h3><div>Caregivers more frequently acknowledged certain QoL impact indicators, especially “difficulty doing activities with others”, compared to individuals diagnosed with FTD. These data are consistent with reported loss of insight and support the importance of assessing the burden of disease through caregiver reporting.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 10","pages":"Page S18"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"46. COMPARING THE EFFICACY OF BRAIN STIMULATION THERAPIES FOR LATE-LIFE DEPRESSION: A NETWORK META-ANALYSIS","authors":"Chemin Lin ,&nbsp;Chen-Hsin Yu ,&nbsp;Huang-Li Lin ,&nbsp;Ying-Chih Cheng","doi":"10.1016/j.jagp.2025.04.048","DOIUrl":"10.1016/j.jagp.2025.04.048","url":null,"abstract":"<div><h3>Introduction</h3><div>Late-life depression (LLD) is a common and debilitating condition. Brain stimulation therapies, including electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS), offer promising alternatives to traditional treatments. However, their relative efficacy in older adults remains unclear. This meta-analysis aims to provide evidence-based guidance for optimizing brain stimulation approaches in clinical practice.</div></div><div><h3>Methods</h3><div>A network meta-analysis (NMA) was conducted to compare brain stimulation therapies for LLD. A systematic literature search identified randomized controlled trials (RCTs) evaluating ECT, rTMS, tDCS, and other neuromodulation techniques. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were computed to assess treatment effects on depression severity. A Bayesian NMA estimated relative treatment rankings, and statistical models evaluated heterogeneity and consistency.</div></div><div><h3>Results</h3><div>This meta-analysis includes 17 studies with 1,056 participants, comparing nine brain stimulation treatments. Compared to sham, all interventions improved depression severity. Bilateral ECT (SMD = 1.14, 95% CI: 0.07–2.21) and mixed ECT (SMD = 1.12, 95% CI: -0.09–2.33) showed the highest efficacy. High-frequency rTMS (20Hz) had a notable effect (SMD = 1.47, 95% CI: 0.35–2.59), while lower-frequency rTMS and tDCS showed more modest improvements.</div></div><div><h3>Conclusions</h3><div>High-frequency rTMS and ECT, particularly bilateral ECT, appear most effective for LLD. All brain stimulation methods showed benefits, and clinicians should consider availability, tolerability, and patient preference when selecting the optimal treatment.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 10","pages":"Page S34"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"62. MANAGING VISUAL RELEASE HALLUCINATIONS: A SYSTEMATIC REVIEW","authors":"Vishnu Tiwari ,&nbsp;David Gomez ,&nbsp;Feras Alkharboush","doi":"10.1016/j.jagp.2025.04.064","DOIUrl":"10.1016/j.jagp.2025.04.064","url":null,"abstract":"<div><h3>Introduction</h3><div>Visual release hallucinations (described as Charles Bonnet Syndrome or CBS) are thought to result from disinhibition of visual cortical neurons following acquired blindness. While visual release hallucinations are often non-distressing and present with retained insight, a portion of patients with continuous or thematically upsetting visual hallucinations report distress and quality of life impairment. Few systematic investigations into management options for individuals with CBS have been conducted.</div></div><div><h3>Methods</h3><div>Pubmed, Embase, and Cochrane were searched from inception until 09/30/24 according to guidelines from PRISMA. The input “visual release hallucinations” OR “Charles Bonnet Syndrome” AND “treatment” OR “management” were used to generate search queries. Observational and experimental studies involving behavioral, environmental, or medication management options in humans were eligible for inclusion. Studies reporting resolution of acute-onset CBS following discontinuation of iatrogenic medication or other acute reversible causes were excluded from analysis.</div></div><div><h3>Results</h3><div>13 studies meeting pre-specified inclusion criteria were found. One double-blind RCT found significant improvement in visual hallucinations with minimal tolerability issues from the use of tDCS. An open-label investigation of a Japanese herbal preparation (Yi-gi san) found improvement in visual hallucinations after a 4 week period of treatment. The remainder of data described individual cases and case series, with individual reports describing successful treatment of CBS with agents including anti-epileptic medication, antipsychotics, and cholinesterase inhibitors. Case reports noting successful use of supportive treatments such as psychoeducation, eye-training exercises, and social support were also found.</div></div><div><h3>Conclusions</h3><div>Though classically described as non-distressing and with preserved insight, Charles Bonnet Syndrome can meet the threshold for treatment. Pharmacologic options appear to be effective in single case reports (and may be attractive based on theoretical etiological considerations) but may carry the potential for adverse effects. Results from a single RCT investigating tDCS argue in favor of the use of neuromodulation in some patients. Evidence to strongly support any treatment option for Charles Bonnet Syndrome is limited at this time, though psychosocial and environmental interventions appear attractive based on their lack of iatrogenic effects. Data from high quality prospective studies is needed to make further conclusions about management options in Charles Bonnet Syndrome.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 10","pages":"Page S46"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"40. NEGATIVE BELIEFS OF AGING AND BELIEFS OF MASCULINITY: THE IMPACT ON OLDER ADULT MEN'S WELL-BEING","authors":"Darby Mackenstadt ,&nbsp;Carolyn Adams-Price","doi":"10.1016/j.jagp.2025.04.042","DOIUrl":"10.1016/j.jagp.2025.04.042","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to evaluate the relationship between beliefs of masculinity and depression in older adult men, with the purpose to inform research about factors that contribute to older adult men’s suicide risk. Although research about older men's mental health is scarce, it has been suggested that hegemonic masculinity beliefs may be a risk factor of suicide in older adult men (Pattyn et al., 2015; Smith et al., 2007). The Health, Illness, Men, and Masculinity (HIMM) framework suggests that one's beliefs of masculinity may factor into the health and wellness of adult men (Evans et al., 2011). Negative perception of aging has also been seen to lead to negative physical and mental health outcomes older adult men or women (Levy, 2009; Levy et al, 2023). Stereotype content theory suggests that as men age, they are likely to experience a shift from others seeing him through a lens of jealousy and envy to then through a lens of pity and sympathy (Fiske, 2018). It is then hypothesized that older adult men who have a negative perception of aging and a high adherence to masculine beliefs would have the most negative outcomes, physically and mentally.</div></div><div><h3>Methods</h3><div>Participants were men aged 60 years and older who lived in southern states. They were primarily White (87%), had some college credit (28%), married (61%), and retired (71%). Participants who fully completed the survey were provided compensation with gift cards or other items of value (i.e., airplane miles, gas points) that equal a value of $5 to $10.</div><div>536 participants indicated informed consent. Participants were excluded from analyses if they were under the age of 60 years old (n = 108), completed less than 50% of the survey (n = 35), or did not respond to any items on the Masculine Behaviors Scale (n = 30).</div><div>The survey participants completed was about 100 items long. Of the scales included, the Masculine Behavior Scale (MBS) is a 20-item scale that asks how many stereotypical masculine behaviors one participates in. The scale has four subscales: restrictive emotionality, inhibited affection, success dedication, and exaggerated self-reliance (Snell, 1989). Participants were also asked to complete Attitudes Toward Aging Questionnaire, a 24-item scale that evaluates thoughts about aging in three factors: psychological growth, psychosocial loss, and physical change (Laidlaw et. al., 2007). The psychosocial loss subscale focuses on psychological and social losses in aging, and higher scores would assume an individual views aging as negative. Lastly, the Short Form Health Survey – 12 (SF-12) was used to evaluate participants' perception of their overall health and their abilities within the last month through its two factors: physical component summary (PCS-12) and mental component summary (MCS-12). A cutoff score of 50 or less on the PCS-12 factor indicates a physical health condition, and a score of 42 or less on the MCS-12 ","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 10","pages":"Page S29"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"19. A RANDOMIZED PROSPECTIVE SURVEY TO UNDERSTAND DEMENTIA RESEARCH READINESS ACROSS DIVERSE COMMUNITIES","authors":"Martha Sajatovic ,&nbsp;Lynn Herrmann ,&nbsp;Clara Knebusch ,&nbsp;Joy Yala ,&nbsp;David Silva ,&nbsp;Nicole Fiorelli ,&nbsp;Edna Fuentes-Casiano ,&nbsp;Christopher Burant","doi":"10.1016/j.jagp.2025.04.022","DOIUrl":"10.1016/j.jagp.2025.04.022","url":null,"abstract":"<div><h3>Introduction</h3><div>Even with recruitment efforts for racial and ethnic minorities in dementia research, there is still underrepresentation in these communities. Targeting barriers and facilitators to research participation, we developed and tested a culturally tailored communication approach tailored for Hispanics.</div></div><div><h3>Methods</h3><div>An iterative process informed by input from the minority advisory board of an Alzheimer’s Disease Research Center, developed 2 brief health communication videos, featuring Hispanic actors/Spanish language sub-titles. The experimental video (POWER) focused on barriers, facilitators, and readiness to participate in dementia research. The control video focused on education only. A randomized prospective survey compared POWER vs. control. While race or ethnicity were not inclusion criteria for enrollment, we oversampled Hispanic and non-white communities. We examined change pre vs. post-video on dementia knowledge, cumulative barriers, and facilitators to research participation, as well as change in research readiness measured by Transtheoretical behavior change model.</div></div><div><h3>Results</h3><div>The analyzable sample (N= 184) had a mean age of 40.0 (Standard deviation/SD 13.2) years, 57.4% (n=105) female, 47.2% (n=85) non-white, 21.2% (n=39) Hispanic, with 88 individuals randomized to POWER and 96 to control. Unadjusted evaluation of change from pre vs. post-video showed significant improvements in dementia knowledge, research facilitators and research barriers (p LESS THAN .001 all) but no significant difference between POWER vs. controls. Adjusted for age, gender, race, ethnicity and education, only change in dementia knowledge remained significantly improved for the group as a whole, with no significant difference between POWER vs. controls. In the entire sample, Hispanics exposed to any communication had significantly less improvement in research readiness (r= -.217, p=.003). Exploratory analysis of positive change predictors in those randomized to POWER and to control suggests Hispanics in POWER may have an advantage with respect to dementia knowledge (r=.248, p=.02) and research facilitators (r=.342, p=.001).</div></div><div><h3>Conclusions</h3><div>Health communications can improve dementia knowledge across diverse communities.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 10","pages":"Pages S14-S15"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10. BRAIN PARENCHYMA AND VASCULATURE AMYLOID: CLINICAL IMPLICATIONS OF A QUADRUPLE HIT?","authors":"Julia Golden ,&nbsp;Jessica Principe ,&nbsp;David Adamowicz ,&nbsp;Ricardo Salazar","doi":"10.1016/j.jagp.2025.04.013","DOIUrl":"10.1016/j.jagp.2025.04.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Cerebral amyloid angiopathy (CAA) is a disease of small and medium-sized vessels that affects the arteries in the cerebral cortex and the overlying leptomeninges. Over the disease course, amyloid progressively deposits in the vessel walls, producing fragile vessels that are susceptible to hemorrhage, ischemia, and inflammation. Patients typically present with intra-cerebral hemorrhages and transient focal neurological episodes. We discuss a patient with cerebrovascular imaging markers of CAA plus confirmed Alzheimer's disease (AD), neuropsychiatric symptoms (NPS) of dementia, and combat post-traumatic stress disorder (PTSD) who has remained cognitively and functionally stable for three years despite worsening disease burden on imaging.</div></div><div><h3>Methods</h3><div>A 73-year-old male war veteran with combat PTSD, CAA, AD, hypertension, hyperlipidemia, paroxysmal atrial fibrillation, and superior mesenteric artery dissection presented to our academic center geropsychiatry clinic in 2021 with six months of paranoia and verbal outbursts. His symptoms of cognitive decline date back to 2015, and neuropsychiatric testing in 2017 linked these initial frontal system weaknesses to active PTSD. In 2020, he was diagnosed with mild AD dementia confirmed by cerebrospinal fluid AD biomarkers with elevated total tau (t-tau) at 249 pg/ml; elevated phosphorylated tau (p-tau)/Abeta42 ratio at 0.054; decreased amyloid beta1-42 (Abeta42) at 505 pg/ml; and elevated p-tau = 27.1 pg/ml. A brain MRI showed multiple microhemorrhages and superficial siderosis on the right temporal lobe, indicating probable CAA. The patient's wife reported increased agitation over trivial matters, jealousy, and inferences of infidelity. The patient started memantine 10 mg daily and received NPS of dementia psychoeducation. After three years, his cognitive and functional statuses were stable. A repeat MRI in 2023 showed increasing punctate foci and mildly increased generalized volume loss of the bilateral temporal and occipital lobes. Despite NPS improvement and stabilization, the patient's disease progressed.</div></div><div><h3>Results</h3><div>CAA is a common co-pathology of AD, occurring in 20–100% of AD cases. Traditionally, cognitive decline in CAA has been thought to result from intra-cerebral hemorrhage and/or AD pathology. More recent research suggests CAA-specific pathways of neurodegeneration. As the current case alludes, there may also be co-occurring neuroprotective pathways at work. Through a biopsychosocial lens, we investigate potential genetic factors, medication positive effects, and lifestyle choices that may have contributed to the patient's relative cognitive stability.</div></div><div><h3>Conclusions</h3><div>This case provides insights into the clinical course of CAA, the pathophysiology of neurodegeneration in CAA, and potential mediators of disease burden.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"33 10","pages":"Pages S7-S8"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}