Archives of Iranian Medicine最新文献

{"title":"Unveiling Macrosomia Risks of Non-Diabetic Women: Insights from Second Trimester Maternal Lipid Profiles.","authors":"Ahkam Göksel Kanmaz, Yasemin Alan, Murat Alan, Emrah Töz","doi":"10.34172/aim.31914","DOIUrl":"10.34172/aim.31914","url":null,"abstract":"<p><strong>Background: </strong>Macrosomia, characterized by excessive fetal growth, is common in infants born to women with pre-gestational diabetes and gestational diabetes mellitus (GDM). However, macrosomia, which leads to birth-related maternal and fetal complications and metabolic complications in the adolescence of the affected fetuses, also occurs in the pregnancies of non-diabetic women. This study aims to identify the association between second-trimester lipid profiles and macrosomia in non-diabetic pregnant women to aid in early diagnosis.</p><p><strong>Methods: </strong>This retrospective cohort study included 8,956 patients who delivered at a tertiary care center between 2017 and 2019. Exclusion criteria encompassed pre-existing diabetes, GDM, preeclampsia (PE), intrahepatic cholestasis of pregnancy, obesity, fetal chromosomal or genetic abnormalities, tobacco, alcohol, or drug use affecting lipid metabolism. Participants were divided into two groups: 621 with macrosomia and 873 controls. Second trimester maternal lipid profiles and demographic variables such as age, pregnancy week, and gender were assessed.</p><p><strong>Results: </strong>In the study cohort, maternal age (<i>P</i>=0.002), gestational week (<i>P</i>=0.003), and cesarean section rate (<i>P</i><0.001) were higher in the macrosomic group. High-density lipoprotein-cholesterol (HDL-C) was significantly lower, while total cholesterol (TC), triglycerides (TG), and low-density lipoprotein-cholesterol (LDL-C) were significantly higher in the macrosomic group (<i>P</i><0.001). Univariate analysis revealed positive associations between second-trimester TG (OR 1.023, 95% CI: 1.020‒1.033, <i>P</i><0.001), TC (OR 1.023, 95% CI: 1.016‒1.030, <i>P</i><0.001) and LDL-C (OR 1.036, 95% CI: 1.018-1.054, <i>P</i><0.001) with macrosomia and a negative association with HDL-C (OR 0.954, 95% CI: 0.923‒0.976, <i>P</i><0.001). However, after adjusted multivariable logistic analysis, only TG remained statistically significantly associated with macrosomia (OR 1.054, 95% CI: 1.033‒1.076, <i>P</i><0.001).</p><p><strong>Conclusion: </strong>Our study emphasizes the importance of early recognition and prevention of macrosomia. Structured prospective studies are needed to enhance macrosomia prediction and implement preventive measures, such as dietary modifications. These strategies will be crucial in preventing birth-related complications and long-term health risks, including diabetes, obesity, and cardiovascular diseases, associated with macrosomia.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 11","pages":"624-628"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Correlates of Probable Nonalcoholic Steatohepatitis (NASH) in Pars Cohort Study.","authors":"Amin Nakhostin-Ansari, Iman Menbari Oskouie, Reyhaneh Aghajani, Mohammad Mehdi Khadembashiri, Mohammad Ahmadi, Abdollah Gandomkar, Fatemeh Malekzadeh, Hossein Poustchi, Mohammad Reza Fattahi, Amir Anushiravani, Reza Malekzadeh","doi":"10.34172/aim.30020","DOIUrl":"10.34172/aim.30020","url":null,"abstract":"<p><strong>Background: </strong>Studies on the prevalence of nonalcoholic steatohepatitis (NASH) and the factors associated with its high prevalence among Iranian people are limited. This study evaluated the prevalence of NASH and its associated factors among Iranian adults using Pars Cohort Study (PCS) data.</p><p><strong>Methods: </strong>This cross-sectional study was conducted based on PCS, which includes 40-75-year-old adults from the Valashahr area. NASH was defined as alanine aminotransferase (ALT) higher than 40 U/L without evidence of hepatitis B or C infections. The prevalence of NASH and its associations with basic and demographic characteristics, socioeconomic characteristics, medical history, gastrointestinal symptoms, and laboratory tests were evaluated.</p><p><strong>Results: </strong>Overall, 8734 patients, including 3917 men (44.8%), were enrolled in this study. The mean age of participants was 52.62 years (SD=9.68), and 605 individuals had NASH (6.9%). In the regression analysis, in contrast to female gender (OR=0.31, 95% CI=0.249‒0.386, <i>P</i><0.001) and age (OR=0.951, 95% CI=0.941‒0.962, <i>P</i><0.001), history of heart disease (OR=1.499, 95% CI=1.146‒1.962, <i>P</i>=0.003), history of diabetes (OR=1.523, 95% CI=1.162‒1.995, <i>P</i>=0.002), hypertension (OR=1.241, 95% CI=1.023‒1.506, <i>P</i>=0.029), being overweight or obese (OR=2.192, 95% CI=1.755‒2.737, <i>P</i><0.001), being in the richest or second richest wealth index quantiles (OR=1.315, 95% CI=1.107‒1.156, <i>P</i>=0.002), and increased waist circumference (OR=1.409, 95% CI=1.107‒1.793, <i>P</i><0.005) were independently associated with a higher risk of having NASH.</p><p><strong>Conclusion: </strong>In this study, we determined the prevalence of NASH and found male gender, younger age, history of heart disease, history of diabetes, hypertension, socioeconomic status, and obesity as possible factors associated with a higher risk of NASH among Iranians.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 11","pages":"598-605"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal Value of Perfusion Index in Healthy Neonates Born in Iran.","authors":"Maryam Saeedi, Razieh Sangsari, Kayvan Mirnia, Monireh Ghanbari","doi":"10.34172/aim.31293","DOIUrl":"10.34172/aim.31293","url":null,"abstract":"<p><strong>Background: </strong>Perfusion index is a dependable indicator for assessing the perfusion status of newborns. A low perfusion index indicates compromised hemodynamic function. The study aims to investigate perfusion index in asymptomatic newborns aged 35 to 41 weeks who did not require medical support.</p><p><strong>Methods: </strong>Healthy neonates born in four major maternity hospitals of Tehran University from 2019 to 2021 were selected. To ensure consistency and reliability in data collection, a detailed manual was developed and distributed, along with comprehensive training sessions for all personnel involved.</p><p><strong>Results: </strong>A total of 994 newborns entered the study. Among them, echocardiography was adversely affected in 218 neonates due to abnormal screening pulse oximetry. Of these 218 neonates, 53 were found to have abnormal echocardiography results. The median perfusion index value in healthy neonates was 1.6%, and the median oxygen saturation was 97%. A percentile perfusion index curve was developed for healthy neonates to establish a normal reference range.</p><p><strong>Conclusion: </strong>Developing a percentile perfusion index curve specific to healthy neonates provides a useful reference range for healthcare providers to assess perfusion status in this population, but further research is needed to confirm its accuracy.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 11","pages":"606-610"},"PeriodicalIF":1.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gap Between the Actual Cost and Tariffs of Global Surgical Procedures: A Retrospective Cross-sectional Study in Qazvin Province, Iran.","authors":"Ehsan Zarei, Maedehsadat Hashemi, Pouria Farrokhi","doi":"10.34172/aim.31106","DOIUrl":"10.34172/aim.31106","url":null,"abstract":"<p><strong>Background: </strong>Iran's healthcare system has a significant discrepancy between the national tariff and the cost of global surgical procedures (GSPs). This study aimed to compare the actual costs of GSPs with national tariffs in Iran's public hospitals.</p><p><strong>Methods: </strong>This retrospective cross-sectional study was conducted in 2017. Using the census method, 6126 GSPs performed in three public hospitals were investigated in this study. Additionally, national tariffs from the Supreme Council of Health Insurance were obtained. The tariff-cost gap was the discrepancy between a GSP's actual costs and tariff. Multiple linear regression analysis determined factors affecting the tariff-cost gap.</p><p><strong>Results: </strong>The average actual cost of GSPs was 637 USD, while the average tariff was 495 USD. The reimbursement covered only 78% of the costs. The gap was higher in older (B=1.05, 95% CI: 0.76-1.35, <i>P</i><0.001), females (B=26.7, 95% CI: 15.5-37.9, <i>P</i><0.001), patients with a longer stay (B=81.2, 95% CI: 77.5-84.8, <i>P</i><0.001), and procedures performed by full-time surgeons (B=67.3, 95% CI: 56.9-77.5, <i>P</i><0.001). Furthermore, neurosurgery had the highest effect on forecasting the gap between actual costs and tariffs among surgical specialties (B=346.9, 95% CI: 214.3-479.5, <i>P</i><0.001).</p><p><strong>Conclusion: </strong>Public hospitals suffer from large financial losses due to the national tariff for many GSPs not covering their actual costs. It is suggested that tariffs be increased for certain customer segments that can bear higher costs and global tariffs be adjusted to match actual service delivery costs.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 10","pages":"580-587"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Research Trends on Colorectal Cancer (2014-2023): A Scientometric and Visualized Study.","authors":"Iman Menbari Oskouie, Hediyeh Alemi, Naghmeh Khavandgar, Heydar Ali Mardani-Fard, Azadeh AleTaha, Amir-Hossein Mousavian, Ali Rahimi, Mohammad Abdollahi, Akbar Soltani, Amir Kasaeian, Majid Sorouri","doi":"10.34172/aim.31944","DOIUrl":"10.34172/aim.31944","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) ranks as the third most common cancer worldwide, significantly contributing to cancer-related deaths and increasingly affecting younger populations. Although its impact on patients' quality of life is profound, scientometric studies on CRC remain underexplored. The objective of this study was to evaluate the scientific literature on CRC from 2014 to 2023, employing a range of scientometric and statistical approaches.</p><p><strong>Methods: </strong>This study obtained CRC-related publications from the Scopus database. The analyses of the collaboration and co-occurrence among countries/regions, institutions, journals, references, authors, and keywords were conducted utilizing VOSviewer, facilitating the identification of key research trends and emergent subjects.</p><p><strong>Results: </strong>A review of Scopus entries yielded 200,385 papers on CRC in the last decade, noting a yearly increase in publications from 2014 to 2023. China emerged as the most prolific contributor with 46,674 documents. A positive correlation was identified between a country's CRC research output and gross domestic product (GDP; <i>r</i>=0.961, <i>P</i><0.001). The journal \"Cancers\" led to 3006 articles, and H. Brenner stood out as the foremost author with 452 publications. However, the Ministry of Education of the People's Republic of China led institutional contributions to 3094 papers.</p><p><strong>Conclusion: </strong>With a leading count of 46674 articles, China dominated CRC research, particularly highlighted by the Ministry of Education of the People's Republic of China. The primarily obtained keywords were CRC, cancer, prognosis, rectal cancer, and colon cancer. Despite the presence of global collaborations, there is a pressing need for increased research funding and support in the CRC, especially within developing nations. This study is a navigational tool for medical professionals, researchers, and surgical assistants to grasp the international progress and directions in CRC research.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 10","pages":"563-572"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Post-traumatic Stress Disorder in Iranian Population From 2019 to 2024: A Systematic Review and Meta-analysis.","authors":"Asad Imani, Shahram Molavynejad, Mojgan Khademi, Mohammad Adineh, Elham Shafiei, Mohsen Savaie","doi":"10.34172/aim.31230","DOIUrl":"10.34172/aim.31230","url":null,"abstract":"<p><strong>Background: </strong>Post-traumatic stress disorder (PTSD) is a disorder that arises from experiencing traumatic events such as traffic accidents, war, natural disorders, and job incidents. This study focused on determining the epidemiology of PTSD in the Iranian population from 2019 to 2024.</p><p><strong>Methods: </strong>In this systematic review and meta-analysis, we explored databases such as PubMed, Embase, Web of Knowledge, Scopus, and Magiran to achieve a maximum variety of screened articles. The quality of the included articles was evaluated using the STROBE checklist. For data analysis, due to the variation in reporting the PTSD prevalence across the reviewed articles, heterogeneity was assessed using the I² index, and a random effect model was applied to account for this variation.</p><p><strong>Results: </strong>Out of 800 articles found in the initial review, only 15 articles were entered in the final analysis based on inclusion and exclusion criteria, with a total of 9868 participants. The overall PTSD prevalence in the Iranian population was 31.87% (95% confidence interval [CI]=17.87- 45.87, I²=95.29%, <i>P</i><0.001). Additionally, PTSD prevalence in men (36.64%) was higher than in women (35.52%).</p><p><strong>Conclusion: </strong>The prevalence of PTSD in young Iranian men is relatively high, and there was no statistically significant decrease in PTSD prevalence between 2019 and 2024.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 10","pages":"588-594"},"PeriodicalIF":16.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine-Learning Application for Predicting Metabolic Dysfunction-Associated Steatotic Liver Disease Using Laboratory and Body Composition Indicators.","authors":"Fatemeh Masaebi, Mehdi Azizmohammad Looha, Morteza Mohammadzadeh, Vida Pahlevani, Mojtaba Farjam, Farid Zayeri, Reza Homayounfar","doi":"10.34172/aim.31269","DOIUrl":"10.34172/aim.31269","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a significant global health burden without established curative therapies. Early detection and preventive strategies are crucial for effective MASLD management. This study aimed to develop and validate machine-learning (ML) algorithms for accurate MASLD screening in a geographically diverse, large-scale population.</p><p><strong>Methods: </strong>Data from the prospective Fasa Cohort Study, initiated in rural Fars province, Iran (March 2014), were employed for this purpose. The required data were collected using blood tests, questionnaires, liver ultrasonography, and physical examinations. A two-step approach identified key predictors from over 100 variables: (1) statistical selection using mean decrease Gini in random forest and (2) incorporation of clinical expertise for alignment with known MASLD risk factors. The hold-out validation approach (with a 70/30 train/validation split) was utilized, along with 5-fold cross-validation on the validation set. Logistic regression, Naïve Bayes, support vector machine, and light gradient-boosting machine (LightGBM) algorithms were compared for model construction with the same input variables based on area under the receiver operating characteristic curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy.</p><p><strong>Results: </strong>A total of 6,180 adults (52.7% female) were included in the study, categorized into 4816 non-MASLD and 1364 MASLD cases with a mean age (±standard deviation [SD]) of 48.12 (±9.61) and 49.47 (±9.15) years, respectively. Logistic regression outperformed other ML algorithms, achieving an accuracy of 0.88 (95% confidence interval [CI]: 0.86-0.89) and an AUC of 0.92 (95% CI: 0.90-0.93). Among more than 100 variables, the key predictors included waist circumference, body mass index (BMI), hip circumference, wrist circumference, alanine aminotransferase levels, cholesterol, glucose, high-density lipoprotein, and blood pressure.</p><p><strong>Conclusion: </strong>Integration of ML in MASLD management holds significant promise, particularly in resource-limited rural settings. Additionally, the relative importance assigned to each predictor, particularly prominent contributors such as waist circumference and BMI, offers valuable insights into MASLD prevention, diagnosis, and treatment strategies.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 10","pages":"551-562"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive Effects of a CVD Polypill on Developing Diabetes Among Patients With Metabolic Syndrome: Results of the PolyIran-Liver Trial.","authors":"Elham Jafari, Hossein Poustchi, Abbas Mohagheghi, Maryam Sharafkhah, Masoud Khoshnia, Alireza Nateghi, Shahin Merat, Reza Malekzadeh","doi":"10.34172/aim.31839","DOIUrl":"10.34172/aim.31839","url":null,"abstract":"<p><strong>Background: </strong>While cardiovascular disease (CVD) polypills have demonstrated significant benefits in preventing CVD events by managing CVD risk factors and improving patient adherence, their effects on blood glucose levels, an important risk factor for CVD, remain unknown.</p><p><strong>Methods: </strong>We analyzed data from the PolyIran-Liver trial, which involved 1,508 participants aged 50 and above. Of these, 787 were randomly assigned to receive a polypill (consisting of aspirin, atorvastatin, hydrochlorothiazide, and valsartan), while 721 received usual care as the control group over a five-year period. The aim was to determine whether there were any significant differences in fasting blood sugar (FBS) levels between the two groups at baseline, middle, and end of the study. The data analysis focused on three subgroups: participants with diabetes, those with metabolic syndrome (MetS) but without diabetes, and participants without diabetes or MetS.</p><p><strong>Results: </strong>Of the total studied population, with a mean age of 59±6.7 years, 328(22%) were identified with diabetes, 371 (25%) with MetS but without diabetes, and 809 (54%) without diabetes or MetS. We observed a trend of rising FBS levels until month 30, followed by a subsequent decline at month 60. Participants in the polypill group exhibited lower FBS levels than the control group at both time points, with statistically significant differences in all three subgroups at month 30 and in the MetS-without diabetes at month 60 (mean difference: -9.3 mg/dl, 95% CI: 13.9 to -4.6).</p><p><strong>Conclusion: </strong>The polypill used in this study may have the potential to delay the onset of diabetes in patients with MetS more effectively than in the general population. However, its beneficial effects on the blood sugar levels of diabetic individuals require further investigation.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 10","pages":"538-544"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of <i>Ornithodoros tholozani</i>, the Main Vector of Iranian Tick-born Relapsing Fever.","authors":"Ali Emadzadeh, Shirin Taraz Jamshidi","doi":"10.34172/aim.31196","DOIUrl":"10.34172/aim.31196","url":null,"abstract":"<p><p>Doctor Joseph Désiré Tholozan was a French physician who became the special physician of Nassereddin Shah, King of Persia (Iran) in the 19^th century. He studied lots of topics in the field of epidemiology of infectious diseases. His efforts led to the discovery of the main vector of Iranian tick-born relapsing fever, <i>Ornithodoros tholozani</i>. He was also one of the pioneers of the Iranian Sanitary Council, whose efforts led to the foundation of the Ministry of Health of Iran a few decades later. This paper is a brief review of his biography and his roles in promoting health in Iran in the 19^th century.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 10","pages":"595-597"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Congenital Anomalies in Iran.","authors":"Ahmad Khaleghnejad-Tabari, Saeed Dastgiri, Hamid Soori, Alireza Ansari-Moghaddam, Haleh Ghaem, Mahmoud Latifi, Mohammad Reza Maracy, Saeed Aslanabadi, Fathollah Roshanzamir, Hamid Reza Forootan, Mehran Peivaste, Mehrdad Hoseinpour, Nasibeh Khaleghnejad-Tabari, Arameh Abbasian, Arghavan Haj-Sheykholeslami","doi":"10.34172/aim.31287","DOIUrl":"10.34172/aim.31287","url":null,"abstract":"<p><strong>Background: </strong>Annually, 3-8 million infants are born with congenital anomalies worldwide, ranging from 3% to 7% of births in different countries. This study aimed to investigate the nationwide epidemiological features of birth defects in Iran.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in six major regions across Iran. The data sources were the maternity facilities affiliated with regional universities of medical sciences. All children were examined by obstetricians, pediatricians, or midwives at birth, and newborns were followed until discharge from the facility for health status, maturity, and congenital defects.</p><p><strong>Results: </strong>A total of 138,643 births were registered in the maternity facilities across the study regions. Among these newborns, 3,458 cases were diagnosed with congenital anomalies, representing an overall prevalence rate of 249.4 per 10000 births (95% CI: 241.2-257.8). Genital organ anomalies exhibited the highest rates of defects in the country with 92.7 per 10000 births (95% CI: 86.4-98.9), followed by limb anomalies at 83.3 per 10000 births (95% CI: 77.4-89.3). The prevalence of respiratory system, chromosomal, and urinary tract anomalies was less than 10 per 10000 births.</p><p><strong>Conclusion: </strong>Until a national registry for congenital anomalies is established, this study provides essential data on the magnitude of the health problems caused by congenital anomalies in Iran. The findings would be vital for planning and evaluating antenatal screening for birth defects, particularly for high-risk groups and regions in the country.</p>","PeriodicalId":55469,"journal":{"name":"Archives of Iranian Medicine","volume":"27 10","pages":"545-550"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}