Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology最新文献_第7页

Evaluation of bacterial uptake, antibacterial efficacy against Escherichia coli, and cytotoxic effects of moxifloxacin-loaded solid lipid nanoparticles. 评估负载莫西沙星的固体脂质纳米颗粒的细菌吸收、对大肠杆菌的抗菌效果和细胞毒性作用。

IF 2.1 4区医学

Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2022-12-30 eCollection Date: 2022-12-01 DOI: 10.2478/aiht-2022-73-3667

Merve Eylul Kiymaci, Gizem Ruya Topal, Ozgur Esim, Merve Bacanli, Cansel Kose Ozkan, Onur Erdem, Ayhan Savaser, Yalcin Ozkan

{"title":"Evaluation of bacterial uptake, antibacterial efficacy against Escherichia coli, and cytotoxic effects of moxifloxacin-loaded solid lipid nanoparticles.","authors":"Merve Eylul Kiymaci, Gizem Ruya Topal, Ozgur Esim, Merve Bacanli, Cansel Kose Ozkan, Onur Erdem, Ayhan Savaser, Yalcin Ozkan","doi":"10.2478/aiht-2022-73-3667","DOIUrl":"10.2478/aiht-2022-73-3667","url":null,"abstract":"Moxifloxacin (MOX) is an important antibiotic commonly used in the treatment of recurrent Escherichia coli (E. coli) infections. The aim of this study was to investigate its antibacterial efficiency when used with solid lipid nanoparticles (SNLs) and nanostructured lipid carriers (NLCs) as delivery vehicles. For this purpose we designed two SLNs (SLN1 and SLN2) and two NLCs (NLC1 and NLC2) of different characteristics (particle size, size distribution, zeta potential, and encapsulation efficiency) and loaded them with MOX to determine its release, antibacterial activity against E. coli, and their cytotoxicity to the RAW 264.7 monocyte/macrophage-like cell line in vitro. With bacterial uptake of 57.29 %, SLN1 turned out to be significantly more effective than MOX given as standard solution, whereas SLN2, NLC1, and NLC2 formulations with respective bacterial uptakes of 50.74 %, 39.26 %, and 32.79 %, showed similar activity to standard MOX. Cytotoxicity testing did not reveal significant toxicity of nanoparticles, whether MOX-free or MOX-loaded, against RAW 264.7 cells. Our findings may show the way for a development of effective lipid carriers that reduce side effects and increase antibacterial treatment efficacy in view of the growing antibiotic resistance.","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 4","pages":"260-269"},"PeriodicalIF":2.1,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/7d/aiht-73-260.PMC9985348.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine adverse effects of mono(2-ethylhexyl) phthalate and monobutyl phthalate in male pubertal rats. 邻苯二甲酸单（2-乙基己酯）和邻苯二甲酸单丁酯对雄性青春期大鼠内分泌的不良影响。

IF 2.1 4区医学

Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2022-12-30 eCollection Date: 2022-12-01 DOI: 10.2478/aiht-2022-73-3617

Gözde Karabulut, Nurhayat Barlas

{"title":"Endocrine adverse effects of mono(2-ethylhexyl) phthalate and monobutyl phthalate in male pubertal rats.","authors":"Gözde Karabulut, Nurhayat Barlas","doi":"10.2478/aiht-2022-73-3617","DOIUrl":"10.2478/aiht-2022-73-3617","url":null,"abstract":"Considering that research of adverse effects of mono(2-ethylhexyl) phthalate (MEHP) and monobutyl phthalate (MBP), two key metabolites of the most common phthalates used as plasticisers in various daily-life products, has been scattered and limited, the aim of our study was to provide a more comprehensive analysis by focusing on major organ systems, including blood, liver, kidney, and pancreas in 66 male pubertal rats randomised into eleven groups of six. The animals were receiving either metabolite at doses of 25, 50, 100, 200, or 400 mg/kg bw a day by gavage for 28 days. The control group was receiving corn oil. At the end of the experiment, blood samples were collected for biochemical, haematological, and immunological analyses. Samples of kidney, liver, and pancreas were dissected for histopathological analyses. Exposure to either compound resulted in increased liver and decreased pancreas weight, especially at the highest doses. Exposed rats had increased ALT, AST, glucose, and triglyceride levels and decreased total protein and albumin levels. Both compounds increased MCV and decreased haemoglobin levels compared to control. Although they also lowered the insulin level, exposed rats had negative islet cell and insulin antibodies, same as control. Treatment-related histopathological changes included sinusoidal degeneration in the liver, glomerular degeneration in the kidney, and degeneration of pancreatic islets. Our findings document toxic outcomes of MEHP and MBP on endocrine organs in male pubertal rats but also suggest the need for additional studies to better understand the mechanisms behind adverse effects in chronic exposure.","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 4","pages":"285-296"},"PeriodicalIF":2.1,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8a/e7/aiht-73-285.PMC9985344.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.1 4区医学

Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2022-12-30 eCollection Date: 2022-12-01 DOI: 10.2478/aiht-2022-73-3688

Antonio Zandona, Tamara Zorbaz, Katarina Miš, Sergej Pirkmajer, Maja Katalinić

{"title":"Cytotoxicity-related effects of imidazolium and chlorinated bispyridinium oximes in SH-SY5Y cells.","authors":"Antonio Zandona, Tamara Zorbaz, Katarina Miš, Sergej Pirkmajer, Maja Katalinić","doi":"10.2478/aiht-2022-73-3688","DOIUrl":"10.2478/aiht-2022-73-3688","url":null,"abstract":"Current research has shown that several imidazolium and chlorinated bispyridinium oximes are cytotoxic and activate different mechanisms or types of cell death. To investigate this further, we analysed interactions between these oximes and acetylcholine receptors (AChRs) and how they affect several signalling pathways to find a relation between the observed toxicities and their effects on these specific targets. Chlorinated bispyridinium oximes caused time-dependent cytotoxicity by inhibiting the phosphorylation of STAT3 and AMPK without decreasing ATP and activated ERK1/2 and p38 MAPK signal cascades. Imidazolium oximes induced a time-independent and significant decrease in ATP and inhibition of the ERK1/2 signalling pathway along with phosphorylation of p38 MAPK, AMPK, and ACC. These pathways are usually triggered by a change in cellular energy status or by external signals, which suggests that oximes interact with some membrane receptors. Interestingly, in silico analysis also indicated that the highest probability of interaction for all of our oximes is with the family of G-coupled membrane receptors (GPCR). Furthermore, our experimental results showed that the tested oximes acted as acetylcholine antagonists for membrane AChRs. Even though oxime interactions with membrane receptors need further research and clarification, our findings suggest that these oximes make promising candidates for the development of specific therapies not only in the field of cholinesterase research but in other fields too, such as anticancer therapy via altering the Ca2+ flux involved in cancer progression.","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 4","pages":"277-284"},"PeriodicalIF":2.1,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/e7/aiht-73-277.PMC9985343.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ozone disinfection efficiency against airborne microorganisms in hospital environment: a case study. 臭氧对医院环境中空气传播微生物的消毒效率：案例研究。

IF 2.1 4区医学

Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2022-12-30 eCollection Date: 2022-12-01 DOI: 10.2478/aiht-2022-73-3651

Kaća Piletić, Dijana Tomić Linšak, Bruno Kovač, Silvestar Mežnarić, Marin Repustić, Martina Radmanović-Skrbić, Ivana Gobin

{"title":"Ozone disinfection efficiency against airborne microorganisms in hospital environment: a case study.","authors":"Kaća Piletić, Dijana Tomić Linšak, Bruno Kovač, Silvestar Mežnarić, Marin Repustić, Martina Radmanović-Skrbić, Ivana Gobin","doi":"10.2478/aiht-2022-73-3651","DOIUrl":"10.2478/aiht-2022-73-3651","url":null,"abstract":"Even though ozone has shown its potential for air disinfection in hospital environment, its more frequent use has earned attention only with the COVID-19 pandemic due to its proven antimicrobial effect and low cost of production. The aim of this study was to determine its antimicrobial efficiency against the most common bacterial species in a real-life setting, that is, in the air of one postoperative room of the General Hospital Dr Ivo Pedišić (Sisak, Croatia). Air was sampled for aiborne bacteria before and after treatment with the ozone concentration of 15.71 mg/m3 for one hour. The most dominant Gram-positive bacteria of the genera Micrococcus, Staphylococcus, and Bacillus were reduced by 33 %, 58 %, and 61 %, respectively. The genus Micrococcus proved to be the most resistant. Considering our findings, we recommend longer air treatment with higher ozone concentrations in combination with mechanical cleaning and frequent ventilation.","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 4","pages":"270-276"},"PeriodicalIF":2.1,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/5d/aiht-73-270.PMC9985346.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in the recognition of sadness, anger, and fear in facial expressions: the role of the observer and model gender. 对面部表情中悲伤、愤怒和恐惧的识别差异：观察者和模特性别的作用。

IF 2.1 4区医学

Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2022-12-30 eCollection Date: 2022-12-01 DOI: 10.2478/aiht-2022-73-3662

Antonela Kapitanović, Andrea Tokić, Nataša Šimić

{"title":"Differences in the recognition of sadness, anger, and fear in facial expressions: the role of the observer and model gender.","authors":"Antonela Kapitanović, Andrea Tokić, Nataša Šimić","doi":"10.2478/aiht-2022-73-3662","DOIUrl":"10.2478/aiht-2022-73-3662","url":null,"abstract":"This study investigated gender differences in the accuracy and speed of recognition of facial expressions of sadness, anger, and fear in male and female models showing these emotions. According to the fitness threat hypothesis, females should be faster and more accurate in recognising emotional facial expressions of fear and sadness, whereas males should be faster and more accurate in recognising anger. According to the evolutionary opponent's emotion recognition, male observers should be more efficient in recognising emotions presented by male models, and female observers in recognising emotions presented by female models. The facial expression recognition task included 210 colour images from the Karolinska Directed Emotional Faces (KDEF) database. The sample consisted of university students (29 male and 29 female). Testing was conducted individually, and efficiency measured with accuracy and speed of recognition (reaction time). The results showed that females were faster than males in recognizing all three facial expressions. They were also more accurate in recognizing fear, whereas there were no gender differences in accurate recognition of sadness and anger. No significant interactions were found between model and observer gender on either measure (accuracy and speed of recognition). However, all three emotional expressions were recognised more accurately, but not faster, when the model was female. The gender-specific pattern in facial expression recognition found in this study does not completely corroborate the fitness threat hypothesis.","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 4","pages":"308-313"},"PeriodicalIF":2.1,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/32/f3/aiht-73-308.PMC9985350.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational exposure to silica dust in Slovenia is grossly underestimated. 斯洛文尼亚的矽尘职业接触率被严重低估。

IF 2.1 4区医学

Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2022-12-30 eCollection Date: 2022-12-01 DOI: 10.2478/aiht-2022-73-3668

Andrea Margan, Dominika Verlak, Gregor Roj, Metoda Dodič Fikfak

{"title":"Occupational exposure to silica dust in Slovenia is grossly underestimated.","authors":"Andrea Margan, Dominika Verlak, Gregor Roj, Metoda Dodič Fikfak","doi":"10.2478/aiht-2022-73-3668","DOIUrl":"10.2478/aiht-2022-73-3668","url":null,"abstract":"As a by-product or material used in various industries crystalline silica contaminates the air many occupational settings. If its fine particles are inhaled, they are deposited in the lungs and may cause the development of silicosis, chronic obstructive pulmonary disease, and lung cancer. The goal of this study was to estimate occupational exposure to respirable crystalline silica (RCS) in Slovenia and the associated health risks. To do that, we ran two cross-sectional studies, one to determine the number of workers at risk of occupational exposure to RCS in Slovene industries and the other to determine and classify changes in the lung radiographs of glass factory workers exposed to RCS, as a means to infer health risks for other RCS exposed workers in Slovenia. However, the first study shows that official public data on occupational exposure to silica in Slovenia are unreliable and incomplete and that company representatives strongly underestimate occupational exposure to silica. Measurements of total and silica dust are made by 8.3 % and 1.8 % of companies working with silica, respectively. The second study shows that about a third of the exposed workers had lung changes associated with silicosis. We have failed to achieve the goal of our study, as the obtained data are grossly underestimated and unreliable, but it has opened our eyes as to what needs to be improved. All companies need to systematically be informed about occupational health risks, field inspections need to be consistent, regular, and intensified, and health surveillance of all exposed workers implemented regularly.","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 4","pages":"297-302"},"PeriodicalIF":2.1,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/71/30/aiht-73-297.PMC9985347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UGT2B7 c.-161C>T polymorphism frequency in Croatian population. 克罗地亚人群中 UGT2B7 c.-161C>T 多态性频率。

IF 2.1 4区医学

Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2022-12-30 eCollection Date: 2022-12-01 DOI: 10.2478/aiht-2022-73-3663

Tamara Božina, Ena Karačić, Lana Ganoci, Silvija Čuković-Čavka, Jozefina Palić, Nada Božina, Livija Šimičević

{"title":"UGT2B7 c.-161C>T polymorphism frequency in Croatian population.","authors":"Tamara Božina, Ena Karačić, Lana Ganoci, Silvija Čuković-Čavka, Jozefina Palić, Nada Božina, Livija Šimičević","doi":"10.2478/aiht-2022-73-3663","DOIUrl":"10.2478/aiht-2022-73-3663","url":null,"abstract":"Uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7), enzyme responsible for the elimination of a number of xenobiotics through glucuronidation, is expressed in the gut, kidneys, intestines, and brain. However, data on the frequency of UGT2B7 polymorphisms in the Croatian population are limited. The aim of this study was to assess the frequency of the UGT2B7 c.-161C>T (rs7668258) polymorphism in the Croatian population and to compare it with reported frequencies in other populations. This polymorphism is in complete linkage disequilibrium with the UGT2B7 c.802C>T (UGT2B7*2, rs7439366) variant, which is important in clinical medicine. The study reports data of 501 participants from University Hospital Centre Zagreb. All data were collected and analysed retrospectively. Genotyping was performed by real-time polymerase chain reaction (PCR) using the TaqMan® Drug Metabolism Genotyping Assay for UGT2B7 c.-161C>T (rs7668258). We found that 120 (23.95 %) participants were carriers of the UGT2B7 c.-161CC genotype and 255 (50.9 %) were heterozygous carriers (UGT2B7 c.-161CT), while 126 (25.15 %) were homozygous carriers of the variant allele (UGT2B7 c.-161TT). The frequency of the variant UGT2B7 c.-161C>T allele in this study was T=0.506. The frequency of the UGT2B7 c.-161C>T allelic variants and genotypes in the Croatian population is similar to other European populations.","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 4","pages":"303-307"},"PeriodicalIF":2.1,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/3b/aiht-73-303.PMC9985345.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic and genetic derangement: a review of mechanisms involved in arsenic and lead toxicity and genotoxicity. 代谢和基因失调：砷和铅毒性及基因毒性相关机制综述。

IF 1.7 4区医学

Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2022-12-30 eCollection Date: 2022-12-01 DOI: 10.2478/aiht-2022-73-3669

Olubusayo Olujimi Sadiku, Andrés Rodríguez-Seijo

引用次数: 0

Resveratrol as antioxidant in cardiac surgery: is there potential for clinical application? 白藜芦醇作为心脏手术中的抗氧化剂：是否有临床应用潜力？

IF 2.1 4区医学

Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2022-12-30 eCollection Date: 2022-12-01 DOI: 10.2478/aiht-2022-73-3643

Mislav Planinc, Ivana Novak Jovanović, Dubravka Rašić, Maja Peraica, Željko Sutlić

引用次数: 0

Occupational burnout among teachers: is it seasonal? 教师职业倦怠:是季节性的吗?

IF 2.1 4区医学

Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2022-09-01 DOI: 10.2478/aiht-2022-73-3582

Nada Marić, Stefan Mandić-Rajčević, Nataša Maksimović, Petar Bulat

{"title":"Occupational burnout among teachers: is it seasonal?","authors":"Nada Marić, Stefan Mandić-Rajčević, Nataša Maksimović, Petar Bulat","doi":"10.2478/aiht-2022-73-3582","DOIUrl":"https://doi.org/10.2478/aiht-2022-73-3582","url":null,"abstract":"The aim of this cross-sectional study was to compare occupational burnout in two groups of teachers from the district of Bijeljina (Bosnia and Herzegovina) measured with the Serbian version of the Maslach Burnout Inventory survey for workers in human services (MBI-HSS) at the beginning (group 1) and the end of the school year 2018/2019 (group 2) to see if there are seasonal differences. The questionnaire also included standard sociodemographic data and job description (primary and/or secondary school position, length of service, and overtime work). The prevalence of emotional exhaustion and depersonalisation was low in both groups. However, emotional exhaustion and depersonalisation scores significantly shifted to higher values between the beginning and the end of the school year. We also found a statistically significant association between emotional exhaustion and overtime and between depersonalisation and work in a secondary school (p<0.05). These findings invite further research of occupational burnout seasonality in schoolteachers, preferably by following up cohorts which would be controlled for sociodemographic and work-related variables.","PeriodicalId":55462,"journal":{"name":"Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology","volume":"73 3","pages":"233-240"},"PeriodicalIF":2.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/56/aiht-73-233.PMC9837530.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10571127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0