Audiology and Neuro-Otology最新文献

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The Mediating Role of Mindfulness and Self-Compassion in the Link between Tinnitus Distress and Anxiety. 正念和自我同情在耳鸣痛苦与焦虑之间的中介作用。
IF 1.4 4区 医学
Audiology and Neuro-Otology Pub Date : 2026-01-01 Epub Date: 2026-03-12 DOI: 10.1159/000550912
Weronika Caban, Paweł Holas, Mikołaj Kuncewicz, Kazimierz Niemczyk
{"title":"The Mediating Role of Mindfulness and Self-Compassion in the Link between Tinnitus Distress and Anxiety.","authors":"Weronika Caban, Paweł Holas, Mikołaj Kuncewicz, Kazimierz Niemczyk","doi":"10.1159/000550912","DOIUrl":"10.1159/000550912","url":null,"abstract":"<p><strong>Introduction: </strong>Tinnitus is the perception of sound in the absence of external stimuli, often experienced as ringing or buzzing. While many individuals habituate to tinnitus, others develop chronic tinnitus (CT), which can severely affect emotional well-being. Psychological mechanisms such as anxiety and maladaptive coping are known contributors to tinnitus distress, yet the protective role of mindfulness and self-compassion remains underexplored. This study examined the associations between tinnitus distress, anxiety, depression, mindfulness, and self-compassion in a clinical sample. It further investigated whether mindfulness and self-compassion mediate the relationship between tinnitus distress and anxiety.</p><p><strong>Methods: </strong>Ninety-two adults (mean age = 42.6 years; 64.1% female) with tinnitus lasting at least 2 months completed an online survey. Measures included the Tinnitus Functional Index, Hospital Anxiety and Depression Scale, Cognitive and Affective Mindfulness Scale-Revised, and Self-Compassion Scale-Short-Form. Correlational and mediation analyses were conducted using PROCESS.</p><p><strong>Results: </strong>Tinnitus distress was strongly correlated with anxiety (r = 0.484, p < 0.001) and moderately with depression (r = 0.304, p < 0.01). Both mindfulness and self-compassion were negatively associated with tinnitus distress and anxiety. Mediation analyses showed that self-compassion (β = 0.145, 95% CI [0.053, 0.252]) and mindfulness (β = 0.167, 95% CI [0.071, 0.272]) partially mediated the relationship between tinnitus distress and anxiety.</p><p><strong>Discussion: </strong>These findings support the role of mindfulness and self-compassion as protective factors in tinnitus-related anxiety. Interventions targeting these traits may help reduce emotional suffering in individuals with CT but require further evaluation. Longitudinal studies are recommended to confirm causal pathways.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"256-263"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tinnitus and Sensory Dysfunctions: A Cohort Study from Health Checkups before and during COVID-19 Endemic. 耳鸣和感觉功能障碍:来自COVID-19流行前和期间健康检查的队列研究
IF 1.4 4区 医学
Audiology and Neuro-Otology Pub Date : 2026-01-01 Epub Date: 2025-07-21 DOI: 10.1159/000547317
Tsutomu Nakashima, Tadao Yoshida, Masumi Kobayashi, Naomi Katayama, Naoki Saji, Hirokazu Suzuki, Mariko Shimono, Yasue Uchida, Saiko Sugiura, Michihiko Sone, Nobuyuki Hamajima
{"title":"Tinnitus and Sensory Dysfunctions: A Cohort Study from Health Checkups before and during COVID-19 Endemic.","authors":"Tsutomu Nakashima, Tadao Yoshida, Masumi Kobayashi, Naomi Katayama, Naoki Saji, Hirokazu Suzuki, Mariko Shimono, Yasue Uchida, Saiko Sugiura, Michihiko Sone, Nobuyuki Hamajima","doi":"10.1159/000547317","DOIUrl":"10.1159/000547317","url":null,"abstract":"<p><strong>Introduction: </strong>Tinnitus and smell dysfunction have been reported to be associated. The long-term course of tinnitus and sensory dysfunctions, including olfactory and gustatory dysfunctions, following COVID-19 infection requires further study.</p><p><strong>Materials and methods: </strong>A cohort study of tinnitus and sensory dysfunctions before and during the COVID-19 pandemic was conducted through health checkups in a rural area in Japan. Five hundred ten participants attended health checkups in August 2019, 434 in 2023, and 437 in 2024. Two hundred twenty-five participants attended the 2019 and 2023 health checkups, and one hundred seventy-one participants attended all three. The subjects included people 40 years of age or older. The questionnaire included information on tinnitus, hearing, vertigo, headache, smell, taste, and lifestyle habits. In 2023, the questionnaire included questions about COVID-19.</p><p><strong>Results: </strong>Tinnitus, hearing impairment, and smell dysfunction were associated. Fear and anxiety about COVID-19 infection were significantly associated with tinnitus after adjusting for age and sex. Irregular sleep time and fewer sports and exercise habits were significantly associated with tinnitus, not smell or taste dysfunction. In an investigation of identical persons, deterioration of tinnitus was conspicuous in 2023 compared to 2019 in persons with strong fear and anxiety about COVID-19.</p><p><strong>Conclusions: </strong>Tinnitus is related to lifestyle habits compared to other sensory disorders. Fear and anxiety about COVID-19, rather than COVID-19 infection itself, significantly influenced tinnitus during the COVID-19 pandemic in rural areas.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"12-18"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Audiological Benefits of the CROS System for Cochlear Implant Users. CROS系统对人工耳蜗使用者的听力学益处。
IF 1.4 4区 医学
Audiology and Neuro-Otology Pub Date : 2026-01-01 Epub Date: 2026-02-20 DOI: 10.1159/000550626
Anna Ratuszniak, Anita Obrycka, Artur Lorens, Justyna Witkowska, Henryk Skarzynski
{"title":"The Audiological Benefits of the CROS System for Cochlear Implant Users.","authors":"Anna Ratuszniak, Anita Obrycka, Artur Lorens, Justyna Witkowska, Henryk Skarzynski","doi":"10.1159/000550626","DOIUrl":"10.1159/000550626","url":null,"abstract":"<p><strong>Introduction: </strong>When a unilateral cochlear implant (CI) is implanted in a bilaterally deaf person they may still experience, along with significant benefits, certain limitations. The use of a contralateral routing of signal (CROS) system, which transmits the signal from the deaf side to the side with the speech processor, creates an opportunity to reduce these limitations and improve hearing performance in difficult acoustic conditions. In this study, a wireless CROS solution from Advanced Bionics specifically designed for CI speech processors is investigated.</p><p><strong>Methods: </strong>Speech-in-noise tests based on monosyllabic word tests were given to 15 CI users with CROS switched on and off. Three spatially different listening setups were used to probe three binaural effects (binaural redundancy, head shadow, and squelch), together with spatial release from masking. The mean age of users was 66.2 years (standard deviation = 10.6), and all participants had ≥9 months of experience with their CI.</p><p><strong>Results: </strong>The speech-in-noise tests revealed improved speech intelligibility in some test conditions when using the CROS device compared to listening with just a unilateral CI. No spatial release from masking was observed.</p><p><strong>Conclusion: </strong>The investigated CROS system is a valuable addition to unilateral CI systems in cases where bilateral implantation is not an option.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"237-244"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inner Ear Test Battery Aligned with Hydrops Magnetic Resonance Imaging to Differentiate Acute-Onset Sensorineural Hearing Loss. 内耳测试电池对齐Hydrops MRI鉴别急性发作感音神经性听力损失。
IF 1.4 4区 医学
Audiology and Neuro-Otology Pub Date : 2026-01-01 Epub Date: 2026-04-27 DOI: 10.1159/000552081
Jui-En Lee, Yu-Fen Wang, Yi-Ho Young
{"title":"Inner Ear Test Battery Aligned with Hydrops Magnetic Resonance Imaging to Differentiate Acute-Onset Sensorineural Hearing Loss.","authors":"Jui-En Lee, Yu-Fen Wang, Yi-Ho Young","doi":"10.1159/000552081","DOIUrl":"10.1159/000552081","url":null,"abstract":"<p><strong>Introduction: </strong>This study differentiates cases of acute-onset sensorineural hearing loss (SNHL) that did not meet the diagnostic criteria for either sudden SNHL or Meniere's disease, leading to a diagnostic challenge.</p><p><strong>Methods: </strong>All 46 patients with acute-onset SNHL underwent an inner ear test battery followed by hydrops magnetic resonance imaging (MRI). Twenty-four patients (28 ears) who tested positive for endolymphatic hydrops (EH) on hydrops MRI were referred to the EH group. Another 22 patients (22 ears) who tested negative for EH were classified as the non-EH group.</p><p><strong>Results: </strong>Significant difference in the mean hearing levels between EH and non-EH groups was identified at frequencies of 125, 250, 500, and 1,000 Hz, but not at frequencies ranging from 2,000 Hz through 8,000 Hz. A declining sequence of abnormality rates - from audiometry (96%), cervical vestibular-evoked myogenic potential (cVEMP) test (75%), ocular VEMP test (57%) to the caloric test (43%) - was observed in the EH group but not in the non-EH group. This pattern closely paralleled the decreasing prevalence of EH on hydrops MRI, which moved from the cochlea (79%), saccule (61%), utricle (57%) to the semicircular canals (4%).</p><p><strong>Conclusion: </strong>A comprehensive inner ear test battery aligned with hydrops MRI may enhance understanding of disease mechanisms and aid differential diagnosis in selected ambiguous cases of acute-onset SNHL, whether it arises from EH.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"299-306"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Hearing Patterns to Functional Outcomes: Quantifying Audiometric Profiles for Precision Hearing Care. 从听力模式到功能结果:量化精确听力护理的听力测量资料。
IF 1.4 4区 医学
Audiology and Neuro-Otology Pub Date : 2026-01-01 Epub Date: 2026-03-19 DOI: 10.1159/000551057
Perrine Morvan, Marta Campi, Guillaume Staerman, Pauline Roger, Fabien Auberger, Catherine Boiteux, Alexandre Osty, Paul Avan, Bernard Fraysse, Hung Thai-Van
{"title":"From Hearing Patterns to Functional Outcomes: Quantifying Audiometric Profiles for Precision Hearing Care.","authors":"Perrine Morvan, Marta Campi, Guillaume Staerman, Pauline Roger, Fabien Auberger, Catherine Boiteux, Alexandre Osty, Paul Avan, Bernard Fraysse, Hung Thai-Van","doi":"10.1159/000551057","DOIUrl":"10.1159/000551057","url":null,"abstract":"<p><strong>Introduction: </strong>Hearing aid (HA) outcomes vary substantially despite similar hearing loss severity. We tested whether audiometric configuration improves outcome prediction beyond traditional measures.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 22,694 adults (aged 50-90 years) fitted with HAs across 780 French audiology centers (2018-2021). Eight audiometric profiles were defined a priori based on pathophysiological classifications. Machine learning models identified predictors of speech reception threshold improvement in quiet (SRT<sub>Q</sub>, ≥6 dB) and noise (SRT<sub>N</sub>, ≥2 dB).</p><p><strong>Results: </strong>Overall, 93% of participants showed demonstrated meaningful improvement in SRT<sub>Q</sub> and/or SRT<sub>N</sub>. Adding profile membership variable increased prediction accuracy by 6% for SRT<sub>N</sub> and 5% for SRT<sub>Q</sub>. Profile-stratified analysis revealed distinct optimization pathways: Profile A (moderate presbycusis) benefited from 4 kHz amplification and follow-up appointments; Profile C (ski slope) required premium technology and high compliance; Profile D (advanced presbycusis) responded exclusively to frequency-specific precision, resisting behavioral interventions. Mid-to-high frequencies (2-6 kHz) drove noise outcomes; low frequencies (250-1,000 Hz) and clinical support predicted quiet performance. Globally, the amplification of both low and high frequencies are beneficial for both SRT<sub>Q</sub> and SRT<sub>N</sub>, and high frequencies especially for SRT<sub>N</sub>.</p><p><strong>Conclusion: </strong>Audiometric profiling adds significant predictive value beyond traditional severity measures, identifying profile-specific intervention levers (amplification strategy, technology; choice, compliance, follow-up appointments) for personalized optimization. This configuration-aware approach supports precision audiology, where treatment is guided by an audiometric profile and expected outcomes.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"264-281"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship between Static and Dynamic Balance and Fatigue in Adults Aged 60 and above. 60岁及以上老年人静、动平衡与疲劳的关系
IF 1.4 4区 医学
Audiology and Neuro-Otology Pub Date : 2026-01-01 Epub Date: 2025-12-18 DOI: 10.1159/000550083
Gamze Nas Özütemiz, Gizem Güner, Gizem Kır, Deniz Uyar
{"title":"The Relationship between Static and Dynamic Balance and Fatigue in Adults Aged 60 and above.","authors":"Gamze Nas Özütemiz, Gizem Güner, Gizem Kır, Deniz Uyar","doi":"10.1159/000550083","DOIUrl":"10.1159/000550083","url":null,"abstract":"<p><strong>Background: </strong>The aging process is accompanied by sensory, motor, and cognitive declines that increase the risk of balance disorders. Fatigue is a prevalent yet often overlooked symptom among older adults.</p><p><strong>Objective: </strong>This study examines the relationship between fatigue and balance in individuals 60 years and older to provide evidence for preventive and rehabilitative strategies.</p><p><strong>Methods: </strong>Fatigue was assessed using the Fatigue Assessment Scale (FAS) and the Fatigue Impact Scale (FIS), while balance was evaluated with the Timed Up and Go (TUG) test, the Tinetti Balance and Gait Test (TBT-TGT), and the Single-Leg Stance Test (SLST).</p><p><strong>Results: </strong>While fatigue had a negative impact on both static and dynamic balance, no statistically significant differences were detected between the fatigued and severely fatigued groups. Analyses revealed weak to moderate negative correlations between fatigue scales and measures of both static and dynamic balance, with mental fatigue demonstrating a comparatively stronger relationship with static balance. In the regression analysis, the model including age and mental fatigue overall explained 27.9% of the variance in single-leg stance duration.</p><p><strong>Conclusions: </strong>The results of our study indicate that fatigue markedly impairs both static and dynamic balance performance among older adults.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"177-187"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative Intracochlear Electrocochleography and Hearing Preservation Early after Cochlear Implantation: A Meta-Analysis. 人工耳蜗植入术中耳蜗内ECochG与早期听力保护的meta分析。
IF 1.4 4区 医学
Audiology and Neuro-Otology Pub Date : 2026-01-01 Epub Date: 2025-11-29 DOI: 10.1159/000549281
Orit Samuel, Fatima Moumen Denanto, Adrian Dalbert, Aaron Collins, William Shute, Christofer Bester, Stephen O Apos Leary
{"title":"Intraoperative Intracochlear Electrocochleography and Hearing Preservation Early after Cochlear Implantation: A Meta-Analysis.","authors":"Orit Samuel, Fatima Moumen Denanto, Adrian Dalbert, Aaron Collins, William Shute, Christofer Bester, Stephen O Apos Leary","doi":"10.1159/000549281","DOIUrl":"10.1159/000549281","url":null,"abstract":"<p><strong>Aim: </strong>There are a range of approaches to intraoperative electrocochleography (ECochG) monitoring across different implant systems, and these show inconsistent results. Here, we synthesize by meta-analysis the evidence for real-time intracochlear ECochG recorded during cochlear implantation predicting residual hearing.</p><p><strong>Methods: </strong>Inclusion criteria included original studies in which real-time ECochG was undertaken on a commercial cochlear implant (CI) and residual hearing outcomes at least 4 weeks after implantation were reported. Thirteen studies comprising 313 individual patient data sets met inclusion criteria. Full data sets were sought from the authors. Studies were rated for quality and bias. Details about study design (observational or interventional) and electrode characteristics (lateral wall or perimodiolar) were extracted. Relative hearing loss across the low frequencies (250-1,000 Hz) was the main outcome, with decibel loss and functional hearing as secondary outcomes. Effects were explored by forest plot, and then linear mixed modelling on the full data sets. Sensitivity analyses included recalculation of hearing preservation using thresholds across different frequencies.</p><p><strong>Results: </strong>Thirteen studies, including 313 full patient data sets, were included, and meta-analysis was performed on lateral wall electrodes. A drop of ECochG amplitude of >30%, even if transient, predicted residual hearing across all metrics (decibel, relative, and functional), and data-synthesis methods (forest plots and linear modelling) for all systems where real-time measurements were available. A drop of amplitude of at least 60% across insertion predicted relative but not decibel hearing loss in linear mixed modelling. The \"pattern\" of ECochG drop, as described by Harris in 2017, did not predict residual hearing by any method.</p><p><strong>Discussion: </strong>The only truly \"real-time\" measurement that predicted residual hearing was an instantaneous drop in ECochG amplitude, with or without recovery. Large drops over the insertion did too, but these can only be calculated after insertion, and after the cochlear trauma has been done. All CI systems now offer real-time monitoring - these results provide guidance on how best to use it to optimize clinical outcomes.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"150-166"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What People with Tinnitus Want: A Survey of Desired Tinnitus Digital Therapy Features. 耳鸣患者想要什么:耳鸣数字治疗功能的调查。
IF 1.4 4区 医学
Audiology and Neuro-Otology Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI: 10.1159/000548828
Eilaf Narejo, Rosie Dobson, Grant Donald Searchfield
{"title":"What People with Tinnitus Want: A Survey of Desired Tinnitus Digital Therapy Features.","authors":"Eilaf Narejo, Rosie Dobson, Grant Donald Searchfield","doi":"10.1159/000548828","DOIUrl":"10.1159/000548828","url":null,"abstract":"<p><strong>Introduction: </strong>Tinnitus is the perception of sound when no sound is present. Due to its heterogenous nature, tinnitus can impact people differently. Tinnitus disorder occurs when the perception of tinnitus affects quality of life. Personalized digital mHealth therapy approaches to tinnitus treatment have been proposed to address the heterogeneity of tinnitus. To build self-efficacy in tinnitus management, there should be alignment between therapeutic objectives and the needs of end users. This survey was undertaken to learn the desirable features a digital therapy should have from the perspective of people with tinnitus.</p><p><strong>Methods: </strong>A cross-sectional online survey of 986 people on a tinnitus research list was undertaken asking questions about their experience of tinnitus and desirable features in a digital tinnitus therapy.</p><p><strong>Results: </strong>The highest rated problems with tinnitus were \"loss of peace and quiet\" and \"sound intrusiveness\" (median [Mdn] 4/5). The most common problems that participants wanted help with were learning about treatments and management, hearing, tinnitus elimination, sleep, and reduction in tinnitus. Participants rated sound-based brain-training games (training to focus away from tinnitus) as the top feature they wanted in digital therapy (Mdn 5/5, extremely important). Mann-Whitney U tests identified differences in problems and solutions when variables were grouped according to gender (female/male), self-reported hearing loss (yes/no), country of residence (New Zealand [NZ], non-NZ), and app use (yes/no). Females and males rated tinnitus problems differently, and females tended to rate solutions as more valuable than males.</p><p><strong>Conclusions: </strong>A survey of many people with tinnitus identified common problems and preferred solutions. Although a high percentage of responders wanted tinnitus eliminated, a large number recognized the desirability of management through sound-based and psychological approaches. This information can assist clinicians and researchers developing therapies.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"103-114"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining the Access Routes to Intracochlear Drug Delivery Based on Temporal Bone Histology 3-Dimensional Models. 基于颞骨组织学三维模型确定耳蜗内给药通路。
IF 1.4 4区 医学
Audiology and Neuro-Otology Pub Date : 2026-01-01 Epub Date: 2025-12-10 DOI: 10.1159/000548540
Zohar Hovev, Daniel Moverman, Alicia M Quesnel, Ophir Handzel
{"title":"Defining the Access Routes to Intracochlear Drug Delivery Based on Temporal Bone Histology 3-Dimensional Models.","authors":"Zohar Hovev, Daniel Moverman, Alicia M Quesnel, Ophir Handzel","doi":"10.1159/000548540","DOIUrl":"10.1159/000548540","url":null,"abstract":"<p><p><p>Introduction: Optimizing inner ear access is necessary for the genetic and regenerative treatment of sensorineural hearing loss. This is a descriptive histological study, with three-dimensional modeling of the microanatomy of minimally invasive transcanal access routes to the scala tympani through the round window, and suggested form and dimensions of injection needles for inner ear drug delivery.</p><p><strong>Methods: </strong>Three-dimensional models of eight human temporal bone histological sections were created to measure key anatomical relationships and optimal needle trajectories.</p><p><strong>Results: </strong>To spare the inner ear structures and reach the greatest depth in the scala tympani, the optimal trajectory via the round window is achieved with a needle leaned on and bent at the superiormost point of the round window niche operculum. The length of the needle's medial part is between 1.375 mm (1.2-1.6 mm) and 3.49 mm (2.8-4.3 mm), with a bend angle of 147° (123-167°). The penetration point of the round window membrane is its vertical axis center, reducing the risk of damage to the inner ear structure and avoiding the crista fenestra. The crista may shift the penetration point inferiorly when visible and not found behind the round window membrane. In all eight temporal bones, the crista never reached the center of the round window membrane, with the horizontal distance between the crista edge and the center being 0.55 mm (0.4-0.75 mm).</p><p><strong>Conclusion: </strong>The data reveal the form and size factors for optimal transcanal access to the inner ear for structure- and function-preserving drug delivery. </p>.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"167-176"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12788827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Two Precurved Cochlear Implant Electrode Arrays from the Same Manufacturer: Electrophysiological Differences with Possible Implications for Fitting and Battery Life. 来自同一制造商的两种预弯曲人工耳蜗电极阵列的比较:电生理差异与可能的安装和电池寿命的影响。
IF 1.4 4区 医学
Audiology and Neuro-Otology Pub Date : 2026-01-01 Epub Date: 2025-10-09 DOI: 10.1159/000548485
Khalil Rafiqi, Kristoffer Foldager Jørgensen, Anders Britze
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