Audiology and Neuro-Otology最新文献

{"title":"Response to oral steroids for sudden sensorineural hearing loss: considerations of age, time to treatment, and degree of hearing loss.","authors":"Erin Harvey, Grace Callan, Neil Osafo, David Friedland, Michael Harris, Jazzmyne Adams, Kristen Osinski, Ling Tong, Jake Luo","doi":"10.1159/000545672","DOIUrl":"https://doi.org/10.1159/000545672","url":null,"abstract":"<p><strong>Introduction: </strong>Compare outcomes of oral steroids (OS) to intratympanic (IT) steroids for treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) in a retrospective cohort study at a tertiary academic center.</p><p><strong>Methods: </strong>Patients diagnosed with ISSNHL receiving at least one course of OS between January 2009 and February 2022 were reviewed. OS patients were compared to a previously reported cohort of 74 patients who underwent IT treatment.</p><p><strong>Interventions: </strong>OS or IT steroid therapy for ISSNHL. Full, partial or no recovery rates of hearing thresholds stratified by modality of treatment, age, degree of hearing loss, and time to initiation of treatment were measured.</p><p><strong>Results: </strong>There were 96 patients treated with OS and 74 patients treated with IT steroid. Full recovery was more frequent in patients who underwent oral steroid therapy (43.8%) compared to IT therapy (25.68%, p=0.017). For patients under 40 years old, full recovery rates were similar between OS (60.0%) and IT (61.5%). In patients over 40 years old, however, full recovery was seen in 40.7% of patients on OS and 18% for IT. Further, while those over 65 years had the worst rates of full recovery to IT steroid (<20%), this age group had a 50% full recovery rate with oral steroids. Additional factors correlating with response to both OS and IT treatment included degree of hearing loss and time to starting steroids.</p><p><strong>Conclusion: </strong>Oral steroid therapy was associated with greater likelihood of full recovery in all patient age groups compared to those treated with IT steroid alone, in combination with oral steroid, or for salvage. A significant difference in response was seen in those over 65 years raising consideration of age stratification in decision making for steroid modality in treatment of ISSNHL.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-19"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Comorbidities on Cochlear Implantation Outcomes in Adults Under 60.","authors":"Jamie A Schlacter, Christine Schremp, Allen Khudaverdyan, Emily R Spitzer, Susan B Waltzman","doi":"10.1159/000546569","DOIUrl":"https://doi.org/10.1159/000546569","url":null,"abstract":"<p><strong>Introduction: </strong>Prior studies have demonstrated that comorbid conditions can negatively impact cochlear implantation (CI) outcomes in elderly patients, but few have examined how comorbidities affect younger adult CI recipients. This study examines the relationship between comorbidities and CI outcomes in adults under 60 years old.</p><p><strong>Methods: </strong>We reviewed all CI recipients between 20 to 60 years old from 2015-2019 at a tertiary academic medical center. Patient data were collected including comorbidities, demographics, etiology, and length of deafness (LOD). Patients' Charlson Comorbidity Index (CCI) was calculated. The primary outcome was speech perception scores at 1-year on the consonant-nucleus-consonant (CNC) word test.</p><p><strong>Results: </strong>There were 118 patients who underwent CI (15% 20-29 years, 22% 30-39, 21% 40-49, 42% 50-60), averaging 1.8 comorbidities. Mean LOD was 19.7 years, and most etiologies were unknown (53.4%). 34% had no comorbidities, and the most frequent comorbidities were hypertension (14%), asthma (10%), anxiety (8%), acoustic neuroma (8%), and arthritis (7%). Comorbidity frequency was similar across ages, but cardiovascular comorbidities varied by patient decade (50-60 yrs: 41% vs. 20-49 yrs: 12-22%, p = 0.004). Compared to studies on elderly CI outcomes, our cohort had fewer comorbidities with reduced cardiac events and neurological conditions. We did not find differences in 1-year CNC scores or complications based on the number of comorbidities or any single comorbidity. However, there was a difference in individual improvement in CNC word scores by age group (p = 0.024). Patients' CCI did not correlate to post-op scores.</p><p><strong>Conclusion: </strong>Subjects showed improved speech understanding post-CI. The number and type of comorbidities were not meaningful predictors of 1-year speech perception scores, suggesting adult CI users under 60 years with comorbidities can expect comparable outcomes to those without comorbidities.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-17"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balance performance in children who are deaf and hard of hearing.","authors":"Adam C King, Abby Frazier, Krystal L Werfel, Emily Lund","doi":"10.1159/000545482","DOIUrl":"https://doi.org/10.1159/000545482","url":null,"abstract":"<p><strong>Introduction: </strong>Hearing loss impacts children's ability to learn language and motor skills. This study examined the postural control differences between children who are deaf and hard of hearing (DHH) and typical hearing (TH), who differ in language and literacy performance, across diverse balance tasks.</p><p><strong>Methods: </strong>Thirty-three children between the ages of six and 13 performed a battery of balance tasks evaluating postural control and mobility. Twenty-six children were classified as DHH, while seven were TH children. Children participated in an extended battery of language and literacy measures, not unlike an intense academic day schedule. Assessments of postural control were conducted during a pre- and post-fatigue state.</p><p><strong>Results: </strong>Children who are DHH exhibited lower degrees of balance than TH children across the clinical, static, and dynamic balance evaluations.</p><p><strong>Conclusions: </strong>Our findings provide evidence of robust balance impairments for children who are DHH beyond standard clinical evaluations. Fatigue effects induced by testing had a greater impact on TH than DHH children, which may be related to chronic fatigue traits in DHH children. Overall, the results underscore the importance of characterizing balance impairments of children with hearing loss and determining the degree of impact on activities like academics.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-17"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adults Implanted as Children: Long-Term Educational, Occupational, and Speech Perception Outcomes.","authors":"Emily R Spitzer, Alexandria Juliet Lichtl, Susan B Waltzman","doi":"10.1159/000545788","DOIUrl":"10.1159/000545788","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates factors that relate to long-term educational and occupational outcomes of adults who received cochlear implants (CIs) during childhood.</p><p><strong>Methods: </strong>A retrospective chart review was conducted on 109 adults who received a CI before the age of 15 between 2000 and 2012 at a US tertiary medical center. Demographic variables, speech perception scores, and educational and vocational achievements were analyzed. Current US Census and Bureau of Labor Statistics data were used for comparison.</p><p><strong>Results: </strong>The median age at implantation was 2.81 years, and the median age at data collection was 27.30 years. Most subjects were unilaterally implanted (63.3%) and used an oral communication approach (89.0%). Educational outcomes showed that 17% completed a high school diploma or less, and 9% completed an associates or technical degree. Seventy-two percent of the subjects achieved a bachelor's degree or higher, significantly higher than the general US population (37.9%). Occupational outcomes indicated that subjects were employed across various job categories, with a higher proportion in jobs requiring considerable preparation (job zone 4) compared to the general population. There was a significant negative correlation between age at implantation and speech perception scores. Better word recognition scores were also associated with better educational and occupational outcomes.</p><p><strong>Conclusions: </strong>Adults who received CIs as children demonstrate excellent educational and occupational outcomes, surpassing those of the general US population. Early implantation and the absence of additional disabilities positively influence these outcomes. Continued investigation of nonspeech outcomes and the factors that influence them is essential to provide better support services for future cohorts.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of auditory temporal processing in individuals with subjective tinnitus using gap detection and forward masking tests.","authors":"Hatice Kübra Bozkurt, Emine Aydin, F Ceyda Akin Öcal, Songül Aksoy, Bülent Satar","doi":"10.1159/000546372","DOIUrl":"https://doi.org/10.1159/000546372","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate auditory temporal processing skills and word discrimination performance in noise among individuals with subjective tinnitus and normal hearing.</p><p><strong>Methods: </strong>Fifty-five individuals were included: 27 individuals with chronic subjective tinnitus in the study group and 28 healthy individuals in the control group. Interventions included the Word-in-Noise Discrimination Test (WIND), auditory temporal processing tests (Gap Detection Test (GDT) and Forward Masking Test (FMT)), the Standardized Mini Mental Test for cognitive assessment, and the Tinnitus Handicap Inventory to evaluate the impact of tinnitus.</p><p><strong>Results: </strong>In the GDT and FMT results, both right and left ear values were significantly higher in the study group (p<0.05). A significant difference was observed between the study and control groups in terms the WIND test results (p<0.05). However, when the study group was divided into two subgroups based on the presence or absence of WIND problems, no significant difference was found between the groups regarding the auditory temporal processing tests (p>0.05).</p><p><strong>Conclusion: </strong>Tinnitus poses a significant burden for patients; thus, assessing its impact on daily activities and quality of life is essential.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-20"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Analysis of Hearing Status and Hearing Healthcare Utilization of English-Speaking Expatriates in Thailand.","authors":"Shade Avery Kirjava, Amornphat Kitro, Ratana Sapbamrer, Pheerasak Assavanopakun, Rungnapa Malasao, Pimbucha Rusmevichientong, Michele M Wood","doi":"10.1159/000545789","DOIUrl":"https://doi.org/10.1159/000545789","url":null,"abstract":"<p><p>Objective This study seeks to assess the prevalence of hearing difficulties and hearing healthcare system utilization among English-speaking migrants living in Thailand. Design, Setting, and Participants A cross-sectional survey was digitally distributed to online forums and communities for English-speaking migrants living in Thailand. Ninety participants were included in the study. Results Seventy-seven percent of men and 75.8% of women reported at least some hearing difficulty. People who reported hearing loss were more likely to be white, and people who reported greater social disruption due to hearing difficulty were more likely to be younger or transgender. Though people with more hearing loss had received hearing testing more recently than peers with less hearing loss, very few participants treated their hearing loss with hearing aids and no participants received their hearing healthcare services in Thailand. Conclusion and Relevance This study shows that English speaking migrants living in Thailand may have hearing difficulty and low rates of hearing healthcare utilization. These results highlight the need for additional research to understand the hearing healthcare needs of this population.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-26"},"PeriodicalIF":1.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Migraine Abortive Drugs on Benign Paroxysmal Positional Vertigo Odds - A Database Analysis.","authors":"Marwin Li, Claire Ceriani, Hongyan Li","doi":"10.1159/000545977","DOIUrl":"https://doi.org/10.1159/000545977","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with migraine may be more susceptible to benign paroxysmal positional vertigo (BPPV) than the general population. Although the underlying pathophysiology remains uncertain, it has been postulated that recurrent vasospasms associated with migraine attacks may cause inner ear ischemia and changes in endolymph pressure. Currently, there are no specific recommendations for preventing BPPV in this vulnerable patient population. Among commonly used migraine abortive drugs, triptans, which are selective serotonin agonists, are known to be vasoconstrictive, whereas calcitonin gene-related peptide (CGRP) antagonists are not. This population-based study uses a federated electronic medical record (EMR) database to characterize the prevalence of BPPV among migraine patients and its relevance to their choice of abortive drug.</p><p><strong>Methods: </strong>In this case-control study, EMR data from the TriNetX US Collaborative Network was queried for subjects who were seen at a participating healthcare organization for a vestibular disorder (ICD10: H81) between 2019 and 2024. Subjects must also have a concomitant, pre-existing diagnosis of migraine (G43). These patients were stratified by age (18-44, 45-64, 65+ years) and sex. The resulting cohorts were then divided into those with and without a BPPV diagnosis (H81.1). Patients with prior documented head trauma (S02, S06, S09), middle or inner ear surgery, or vitamin D deficiency (E55) were excluded. The prevalence of pre-existing triptan and CGRP antagonist use of each BPPV cohort was compared against the non-BPPV cohort of the same age and sex using Chi-square analysis.</p><p><strong>Results: </strong>As expected, the female subject population had significantly higher prevalence of migraine (17.06% vs 7.26%, p<0.0001) than the males. Among migraine patients of all ages and sexes, triptan use was significantly more common among BPPV patients than non-BPPV patients (30.90% vs 25.35%, p<0.0001). Conversely, CGRP antagonists were more commonly used by non-BPPV patients than by BPPV patients (3.17% vs 2.45%, p=0.0005).</p><p><strong>Conclusion: </strong>This study shows that, among patients with vestibular disorders, migraine patients with BPPV are more often exposed to triptans, and less to CGRP antagonists, than those without BPPV. Triptans may increase the prevalence of BPPV by potentiating vasoconstriction during migraine attacks, which may result in inner ear ischemia and alterations of endolymphatic pressure, while CGRP antagonists do not. Therefore, CGRP antagonists may be preferrable over triptans for preventing BPPV in migraine patients.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-16"},"PeriodicalIF":1.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000544897","DOIUrl":"https://doi.org/10.1159/000544897","url":null,"abstract":"","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of the Electrode-Neural Interface in supporting long term outcomes in cochlear implantation. Expert opinion.","authors":"Ángel Ramos-Macias, Robert Briggs, Byung Yoon Choi, David Friedmann, Akira Ishiyama, Thomas Lenarz, Emmanuel Mylanus, Stephen O'Leary, J Thomas Roland, Andrzej Zarowski","doi":"10.1159/000546003","DOIUrl":"https://doi.org/10.1159/000546003","url":null,"abstract":"<p><p>Background Since first introduced in the mid 1980's, cochlear implant (CI) technology has significantly evolved to reach the current state of the art. Commencing with straight, lateral wall electrode arrays, advances in the last decade led to the development of slim perimodiolar arrays that lie closer to the electrically targeted spiral ganglion. Over the years, as a consequence of improving hearing benefits, CI indications have been steadily expanded. Today, individuals with moderately severe to profound sensorineural hearing loss, many with residual hearing in the low-frequency range, may receive a cochlear implant in one or both ears. Summary Before implantation, individual recipient characteristics, such as years of auditory deprivation, hearing thresholds and speech understanding ability with conventional amplification can have an effect on CI hearing outcomes. Surgical procedures such as careful, soft surgery techniques are imperative to reduce cochlear trauma and optimize outcomes and can be supported by surgical guidance tools and drug therapies to help preserve the delicate intra-cochlear structures. Histopathological investigations provide evidence that support the design concept of slim perimodiolar electrode arrays. Modiolar proximity and scalar tympani location permit energy efficient, focused electrical stimulation of the targeted neural interface, while minimizing injury to the fine structures of the intracochlear lateral wall and its blood supply. Key Messages Modiolar electrode arrays may provide highly consistent scala tympani placement and modiolar proximity which may improve functional hearing outcomes, compared to lateral wall electrode arrays results. Modiolar proximity can result in narrower spread of excitation, reduced channel interaction, lower electrical stimulation thresholds and may improve speech understanding. Preservation of functional residual low-frequency hearing is possible with both straight and perimodiolar electrode arrays.  .</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-18"},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional Responses to Music Are Diminished in Bilateral Cochlear Implant Users.","authors":"Isaac L Alter, Alexander Chern, Megan E Kuhlmey, Meghan A Despotidis, Scott Kelly, Michael W Denham, Alexis S Leiderman, Anil K Lalwani","doi":"10.1159/000543299","DOIUrl":"10.1159/000543299","url":null,"abstract":"<p><strong>Introduction: </strong>Emotional response to music, though a central facet of music listening, remains poorly understood. In this study, we investigate the emotional responses to music among bilateral cochlear implantees.</p><p><strong>Methods: </strong>Bilateral CI users and normal-hearing (NH) controls were recruited from a tertiary academic center and community hearing loss groups. Participants listened (via an online survey) to ten previously validated 15-s musical clips representing multiple genres and wide range of valence (happiness vs. sadness) and arousal (excitement vs. calm) and rated the musical clips on validated nine-point visual analog scales of valence and arousal.</p><p><strong>Results: </strong>In total, 25 bilateral CI users and 18 NH controls completed the study. Compared to NH controls, CI users demonstrated significantly increased error in valence identification (mean [SD] 1.75 [0.61] vs. 1.16 [0.29], p < 0.001) but equivalent arousal error. There were significant differences for 8 of 20 total ratings between NH and CI groups. Additionally, CI users demonstrated a significantly constricted range of arousal (4.69 [1.39] vs. 6.04 [1.33], p = 0.0025) but a preserved range of valence (4.99 [1.57] vs. 5.62 [1.13], p = 0.13). Implantees reported significantly lower music enjoyment (5.78 [3.57] vs. 8.57 [1.17], p = 0.0016) than NH controls, and enjoyment was significantly associated with both valence and arousal range.</p><p><strong>Conclusions: </strong>Bilateral CI users' emotional response to music is significantly constricted compared to NH controls. Blunted appreciation of emotional content likely contributes to reduced music enjoyment among cochlear implantees and is a critical target for improvement.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-11"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}