Audiology and Neuro-Otology最新文献

{"title":"Impact of Robotic-Assisted Electrode Array Insertion on Neural Health and Hearing Outcomes in Cochlear Implant Recipients.","authors":"Guillaume Gersdorff, Peter Nopp, Severine Camby, Philippe Lefebvre","doi":"10.1159/000552800","DOIUrl":"https://doi.org/10.1159/000552800","url":null,"abstract":"<p><p>Introduction Cochlear implants (CIs) have revolutionized the treatment of severe to profound sensorineural hearing loss, offering significant auditory benefits to individuals who do not benefit adequately from conventional hearing aids. The efficacy of CIs largely depends on the interface between the electrode array and auditory nerve fibers, with neural health playing a crucial role in postoperative outcomes. This study investigates the impact of robotic-assisted electrode array insertion on the preservation of neural health and auditory performance, evaluated through electrically evoked compound action potential (ECAP) measurements and audiometric outcomes. Material and methods A retrospective single-center study was conducted with 20 patients, divided into two groups: manual insertion (n=12) and robotic-assisted insertion (n=8). All patients received Med-El CIs with either FLEX 24 or FLEX 28 electrode arrays. The robotic-assisted insertions were performed using the RobOtol® system. ECAP measurements were taken to assess neural health. Audiometric evaluation using pure-tone audiometry (PTA) was performed preoperatively to confirm group equivalence, while speech intelligibility was assessed both pre- and postoperatively using the auditory capacity index (ACI). Results Robotic-assisted insertion significantly improved neural health preservation, as evidenced by a higher mean ECAP slope difference (2.99 ± 0.69) compared to manual insertion (1.42 ± 0.68), with a significant correlation between ECAP slope difference and speech intelligibility (R2 = 0.23, p=0.032). Additionally, patients in the robotic-assisted group demonstrated superior speech intelligibility scores (ACI: 84.5 ± 11.04%) compared to the manual group (ACI: 69.5 ± 14.29%). Discussion These findings suggest that robotic-assisted cochlear implant surgeries offer substantial benefits in terms of preserving neural health and enhancing auditory outcomes.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-13"},"PeriodicalIF":1.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared light protects residual hearing by preserving spiral ganglion neurons in an animal Model of CI Surgery.","authors":"Max Meuser, Sivan Faraj, Susanne Schwitzer, Arne Ernst, Rainer Seidl, Patrick Boyle, Dietmar Basta, Moritz Gröschel","doi":"10.1159/000551198","DOIUrl":"https://doi.org/10.1159/000551198","url":null,"abstract":"<p><strong>Introduction: </strong>Given that today's cochlear implant (CI) candidates frequently present with substantial residual low-frequency hearing, the preservation of residual hearing is becoming an increasingly crucial but as yet inadequately resolved aspect of CI surgery. A recent study has shown that a 15-minute treatment with light in the red to near-infrared range (NIR) before the insertion of a CI array resulted in a significant reduction of hearing loss, especially in the frequency range of residual hearing, accompanied by significant conservation of outer hair cells. Given that the total number of rescued hair cells was insufficient to account for the substantial reduction in hearing loss observed, the present study aims to investigate the potential protective effect of NIR on spiral ganglion neurons and ribbon synapses in the context of CI surgery.</p><p><strong>Methods: </strong>Guinea pigs underwent initial auditory brainstem response (ABR) recordings separately for each ear. Subsequently, unilateral NIR irradiation of the cochlea was performed, followed by bilateral insertion of guinea pig-sized electrode arrays. After 4 weeks, the ABR measurement was repeated and the cochleae were collected for histological analysis of spiral ganglion neurons and ribbon synapses.</p><p><strong>Results: </strong>A significant reduction of hearing loss was found on the NIR treated side across the entire frequency range tested. The number of ribbon synapses was not affected by the insertion of an electrode array, and could therefore, not be influenced by NIR treatment. Spiral ganglion neurons were significantly reduced 4 weeks after implantation. This effect was rescued by NIR treatment, specifically in the basal portion of the cochlea.</p><p><strong>Conclusion: </strong>These findings show a neuroprotective effect of NIR on SGNs, which may be crucial not only for the protection of residual hearing but also for the electrical stimulation of SGNs via a CI.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-23"},"PeriodicalIF":1.4,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing preservation and efficacy outcomes in CI632 recipients with sloping high-frequency hearing loss: Multicenter trial results.","authors":"Sarah Mowry, Robert Cullen, Sarah Sydlowski, Alejandro Rivas, Joseph Ursick, Erika Woodson, Viral D Tejani, Kristen Lewis, Paul Reinhart","doi":"10.1159/aud/abnag004","DOIUrl":"https://doi.org/10.1159/aud/abnag004","url":null,"abstract":"<p><strong>Introduction: </strong>Adults with substantial residual low‑frequency (LF) hearing are increasingly considered for cochlear implantation. This study evaluated hearing preservation and speech performance outcomes using a slim perimodiolar electrode (CI632) in adults under expanded indications.</p><p><strong>Methods: </strong>In a prospective, open label, single arm feasibility trial at three U.S. tertiary centers, ten adults with LF thresholds ≤50 dB HL at 500 Hz, sloping high frequency loss, and aided CNC scores ≤60% in the ear to be implanted received the CI632 device. Participants were followed for 12 months postactivation. Assessments included air and bone conduction audiometry, electrode impedances, unilateral and bilateral CNC in quiet and AzBio sentences in noise, patient reported outcomes, and postoperative CT imaging.</p><p><strong>Results: </strong>The LF pure tone average (125-500 Hz) showed a mean shift of 19.3 dB at activation and remained stable at 22.4 dB at 12 months. Impedances were stable across visits. Due to preserved acoustic hearing, all participants utilized electric-acoustic stimulation in the implant ear. Speech recognition improved significantly across all measures, with an average improvement at 12 months ranging from 22 to 54 percentage points, depending on the test. Patient reported outcomes also improved. CT imaging confirmed scala tympani placement for all electrodes, with a mean angular insertion depth of 406.6°.</p><p><strong>Conclusion: </strong>The slim perimodiolar electrode can preserve LF acoustic hearing in adults implanted under expanded indications, supporting meaningful objective and subjective benefit. Hearing preservation outcomes in this cohort exceeded those typically reported for perimodiolar arrays, and preserved LF hearing contributed strongly to improved speech understanding in noise.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1"},"PeriodicalIF":1.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution intraoperative guide for cochlear implant surgery using optical coherence tomography.","authors":"Guillaume Gersdorff, Phoebe Ramos, Sudanthi Wijewickrema, Stephen O Apos Leary, Philippe Lefèbvre, Jean-Marc Gerard","doi":"10.1159/000552581","DOIUrl":"https://doi.org/10.1159/000552581","url":null,"abstract":"<p><p>Introduction Despite advances in soft surgery, intra-cochlear trauma during CI electrode insertion still occurs, potentially damaging cochlear micro-structures and affecting hearing outcomes or future treatments. While the round window membrane (RWM) approach is generally less traumatic, the hook region's complex anatomy can still cause mechanical injury, often due to limited visual guidance. Preoperative imaging and intraoperative Optical Coherence Tomography (OCT) could reduce trauma by offering high-resolution, real-time visualization of cochlear micro-structures. Methods Eight fresh-frozen human temporal bones (TB1-TB8) were included. The first six specimens (TB1-TB6) underwent micro-CT scanning with manual segmentation to establish detailed anatomical baselines and served for OCT-micro-CT co-registration. Following a standard cochlear implantation approach, intra-cochlear structures behind the round window membrane (RWM) were visualized using a microscope-integrated OCT system, with additional imaging performed via an anteroinferior cochleostomy to compare access routes. Electrode insertions were performed under OCT guidance in selected specimens, while feasibility of intraoperative workflow and insertion dynamics was assessed in TB7-TB8 under fluoroscopic control. Results OCT images were successfully obtained for each TB, with proper RWM exposure being crucial. The OCT microscope enabled scanning of the RWM and scala tympani (ST) from various axes, depths, and angles at a surgical working distance, improving assessment of proximal ST anatomy. OCT appears reliable for evaluating micro-anatomy through the RWM, guiding CI electrode selection, approach, and proximal array course modification during insertion. By visualizing critical structures and inferring deeper ones, it supports preoperative imagery-based planning and may reduce the risk of intracochlear damage. Conclusion Intra-operative OCT imaging enhances the precision of cochlear opening site and electrode insertion axis. By integrating OCT, CI surgery could shift from a largely blind procedure to one with significant visual guidance, reducing surgical trauma and improving postoperative hearing preservation.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-26"},"PeriodicalIF":1.4,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratympanic Steroid Regimen For Prevention Of Cisplatin-Induced Hearing Loss: A Systematic Review.","authors":"Musaed Alzahrani, Zohour Almalki, Shatha Yahya Alqahtani, Farah S Alnemari, Fahad S Alghamdi, Sarah O Aljuaid","doi":"10.1159/aud/abnag002","DOIUrl":"https://doi.org/10.1159/aud/abnag002","url":null,"abstract":"<p><strong>Background and objective: </strong>Cisplatin exhibits a steep dose-response relationship, wherein its therapeutic efficacy increases significantly with higher doses. This dose escalation, however, is limited by severe adverse effects, notably ototoxicity, which can lead to permanent and disabling hearing loss. The objective of this review was to evaluate the potential efficacy of intratympanic steroid administration (ITD) in preventing cisplatin-induced hearing loss (CiHL).</p><p><strong>Materials and methods: </strong>A systematic literature search was conducted using PubMed, Cochrane Library, and Scopus databases for evidence-based research articles published between January 2004 and July 2023. The search strategy focused on intratympanic steroids for cisplatin-related ototoxicity. Two independent reviewers performed the search, screening, and study selection according to predefined PICOS (Population, Intervention, Comparison, Outcome, Study design) criteria. Only randomized controlled trials (RCTs) involving patients receiving cisplatin and treated with an intratympanic steroid regimen were included. The review process adhered to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.</p><p><strong>Results: </strong>The initial database and manual searches identified 383 records. Following title and abstract screening, 42 articles underwent full-text review. After applying the eligibility criteria, 38 studies were excluded, resulting in four RCTs for qualitative synthesis. Risk of bias (RoB) assessment revealed a high-risk concerning allocation concealment in all four studies. Additionally, a substantial risk of detection bias was present in three RCTs. According to the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) framework, the overall quality of evidence was rated as high in one study, moderate in two, and low in one.</p><p><strong>Conclusion: </strong>This review did not confirm a consistent otoprotective benefit of intratympanic steroid administration against CiHL. None of the included studies demonstrated high-quality evidence for a significant protective effect. The available RCTs report inconsistent outcomes and collectively fail to establish a definitive therapeutic advantage for ITD in this context. These discrepancies may be attributable to methodological variations across studies, including differences in steroid dosage, concentration, timing of administration relative to cisplatin therapy, and patient populations. Further rigorously designed RCTs with standardized protocols are warranted to definitively assess the potential role of ITD in mitigating cisplatin ototoxicity.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1"},"PeriodicalIF":1.4,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedicine-Enabled Multidisciplinary Preoperative Workflow for Humanitarian Cochlear Implant Delivery.","authors":"Eman Hajr, Asma Alahmadi, Yassin Abdelsamad, Ziad A Memish, Fida Almuhawas, Farid Alzhrani, Abdulrahman Hagr","doi":"10.1159/aud/abnag003","DOIUrl":"https://doi.org/10.1159/aud/abnag003","url":null,"abstract":"<p><p>Telemedicine may facilitate multidisciplinary cochlear implant (CI) candidate evaluation in settings where access to specialized otologic and audiologic care is limited. This study evaluated an online, multidisciplinary preoperative workflow for CI candidate selection and surgical planning during a high-volume humanitarian campaign supported by the King Salman Humanitarian Aid and Relief Centre (KSrelief). In this descriptive study, 142 children with severe-to-profound hearing loss underwent online review by a committee of otologists, audiologists, and speech-language pathologists, based on audiologic data, caregiver-submitted speech and communication videos, and high-resolution CT/MRI imaging. The primary outcome was the adequacy of online assessment for preoperative planning and case preparedness. Online assessment provided sufficient information for surgical planning across all evaluated domains, with sufficiency rates of 100% for audiologic data, 97.2% for speech-language data, and 95.1% for imaging data. Cochlear implantation was completed over three consecutive operative days (30 cases on day 1, 66 on day 2, and 46 on day 3). Preoperative online imaging review enabled early recognition of anatomical complexity and supported efficient resource preparation (including electrode availability and surgical planning), facilitating successful implantation of all scheduled children. A small proportion of cases required intraoperative electrode plan adjustment. Postoperative radiography confirmed correct array placement in all but one case, and surgical complications were infrequent and manageable. A structured online multidisciplinary preoperative workflow was essential to enabling surgical planning and coordinated cochlear implant delivery at this scale and pace in a humanitarian setting.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1"},"PeriodicalIF":1.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reading Abilities and Visual Evoked Potentials in Hearing-Impaired Children: A Comparative Study of Cochlear Implant and Hearing Aid Users.","authors":"Erdem Emre Yilmaz, Selma Yılar, Işık Baltacı, Nurten Uzun Adatepe, Ahmet Atas","doi":"10.1159/aud/abnag001","DOIUrl":"10.1159/aud/abnag001","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate reading comprehension skills, visual evoked potentials (VEP), and saccadic eye movements in hearing aid (HA) users, cochlear implant (CI) users, and individuals with normal hearing (NH), to investigate the relationship between sensory processing and reading ability.</p><p><strong>Methods: </strong>The study included 45 participants, 15 HA users, 15 CI users and 15 NH. VEP, a saccadic test, and a reading comprehension test were performed. VEP recordings were conducted with and without the hearing device for HA and CI users.</p><p><strong>Results: </strong>Reading comprehension scores in the CI group were significantly lower than those in the NH and HA groups (p < .001). Rightward saccade velocity was consistently lower than leftward velocity across all groups. Notably, VEP amplitudes in HA users (N1-P1: p = .048) and CI users (N1-P1: p = .005, .019, .001; P1-N2: p = .010, .008, .022) were significantly larger in the unaided condition (without device) compared to the aided condition. Correlation analyses did not reveal a consistent pattern of association between reading comprehension scores and VEP parameters.</p><p><strong>Conclusion: </strong>While reading skills were found to be weaker in the CI group, the absence of a direct correlation between VEP/saccadic parameters and reading scores suggests that lower-level sensory processing and higher-order reading comprehension may operate through distinct mechanisms. The increased VEP amplitudes observed without hearing devices suggest a cross-modal neuroplastic compensation in the visual cortex during auditory deprivation.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1"},"PeriodicalIF":1.4,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Use of Cochlear Implants in the Older Adult Population.","authors":"Maya Hatley, Emily R Spitzer, Susan B Waltzman","doi":"10.1159/000553546","DOIUrl":"10.1159/000553546","url":null,"abstract":"<p><strong>Objective: </strong>Hearing loss affects 60-70% of elderly people, with ∼10% of these potentially eligible for cochlear implantation (CI). While outcomes in older adults have been positive, concerns remain regarding long-term auditory performance due to higher incidence of comorbidities, reduced cortical plasticity, and cognitive decline. This study evaluates 10-year speech perception outcomes and potential mediating factors in adults ≥60 years old at implantation.</p><p><strong>Methods: </strong>A retrospective chart review identified 98 patients implanted between 2006 and 2014 who were ≥60 years old at surgery with ≥10 years of follow-up. The primary outcome was unilateral (CI-only) Consonant-Nucleus-Consonant (CNC) word scores in quiet at 10 years, also measured preoperatively and at one and 5 years postoperatively.</p><p><strong>Results: </strong>Mean age at implantation was 70.2 years (standard deviation [SD]: 6.4, range: 60.1-85.3), and mean CI experience was 12.6 years (SD: 2.5, range: 10.0-20.1). CNC scores improved significantly from preoperative levels at one (d: 54.2%, q = 31.70, p < 0.001), five (d: 56.5%, q = 31.8, p < 0.001), and 10 years (d: 60.0%, q = 34.67, p < 0.001), without significant differences among postoperative time points. CNC scores did not differ significantly between patients implanted ≥70 versus <70 years old (F(1, 96) = 1.1, p = 0.306). Greater average daily CI use at most recent appointment correlated with higher CNC scores at all postoperative intervals (r = 0.435-0.595, p < 0.001). Inability to live independently was associated with significantly lower scores at 5 years (d = 15.2, p = 0.003).</p><p><strong>Conclusion: </strong>Speech perception outcomes were stable in most elderly CI users 10 years post-implantation. Performance was not associated with age at implantation but was positively related to consistent device use and independent living. Limitations include some missing data, especially 10 years postoperatively, and inability to assess the impact of cognitive function on outcomes.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13485281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial and Coronal Cochlear Aperture Measurements and their relationship with Internal Auditory Canal and Cochlear Nerve.","authors":"Levent Sennaroglu","doi":"10.1159/000551620","DOIUrl":"https://doi.org/10.1159/000551620","url":null,"abstract":"<p><strong>Background: </strong>the relationship of the cochlear aperture, internal auditory canal and the cochlear nerve, has not been finalized as there is a wide range for normative values for cochlear aperture between 1.2 mm and 1.9 mm. Materials and Methods This study was performed between 2020-2024 on 1241 ears with Incomplete partitions (types I, II and III), cochlear hypoplasia and normal cochlea with cochlear aperture abnormalities. There were 158 ears with normal anatomy as the control group. Cochlear aperture is measured on axial midmodiolar section and coronal sections. Internal acoustic canal midpoint measurement is made perpendicular to the canal at the midpoint. Cochlear nerve was graded under 4 categories: 1-Normal 2-Mild hypoplasia 3-Hardly visible 4-Aplastic Results: Cochlear nerve hypoplasia and aplasia are most frequently encountered in cochlear hypoplasia and cochlear aperture abnormality groups. There is statistically significant, positive and strong relationship between axial and coronal measurements of cochlear aperture. However, both axial and coronal measurements show significant differences among groups: values for normal group are significantly higher than cochlear hypoplasia and cochlear aperture abnormality groups, and lower than Incomplete partition groups (types I, II and III). There is a strong relationship between cochlear aperture and the status of the cochlear nerve. Conclusion There is a relationship between cochlear aperture measurements and cochlear nerve status. If the axial measurement is less than 1.26 mm and coronal measurement less than 1.30 mm there is a high chance of CN aplasia.</p><p><strong>Key words: </strong>inner ear malformations, cochlear aperture, internal auditory canal, cochlear nerve deficiency, cochlear nerve aplasia.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-22"},"PeriodicalIF":1.4,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden Traumatic Noise Exposure Induces an Altered Wave I in the Auditory Brainstem Response in Human.","authors":"Elenor Lundgren, Eleonor Koro, Åsa Kjellgren, Sten Hellström, Fredrik Öhberg, Mimmi Werner","doi":"10.1159/000553367","DOIUrl":"10.1159/000553367","url":null,"abstract":"<p><strong>Introduction: </strong>Noise trauma may induce auditory symptoms and temporary or permanent shifts in hearing thresholds, assessed with a tone audiogram. Until recently it has been assumed that primary changes after noise trauma exclusively represent damage to the sensory hair cells. Contrary, animal studies have now shown early alterations in auditory brainstem response (ABR) characteristic of auditory neuropathy (AN), as reduction or absence of wave I, following noise trauma. AN involves a variety of disease mechanisms in the cochlea and auditory nerve, affecting the synaptic encoding and/or neural transmission of auditory information. The aim of this study was to evaluate whether patients exposed to noise trauma exhibit click ABR alterations characteristic of AN.</p><p><strong>Method: </strong>Thirty-one adult patients who attended an ear-nose and throat clinic, after a noise trauma, were included and an age- and gender-matched control group of 31 adults was constructed. To evaluate audiologic hearing impairment pure tone audiometry, speech intelligibility, click ABR and transient evoked otoacoustic emissions (TEOAE)/cochlear microphonics (CM) were performed. A full linear mixed model including the interaction between sex and group was tested.</p><p><strong>Results: </strong>Our study showed that individuals exposed to sudden and distinct traumatic noise exhibit a statistically significant reduction (81.1 nV, p < 0.001) in the amplitude of wave I in ABR.</p><p><strong>Conclusion: </strong>We suggest that the hearing investigation after sudden traumatic noise exposure should therefore be expanded with ABR to confirm or exclude AN.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-14"},"PeriodicalIF":1.4,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13485285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}