Audiology and Neuro-Otology最新文献

{"title":"THE ROLE OF IMAGING MODALITIES IN DIAGNOSIS AND OUTCOME OF OTITIS MEDIA WITH EFFUSION IN COCHLEAR IMPLANT CANDIDATES.","authors":"Ela Araz Server, Cigdem Kalaycik Ertugay, Ahmet Ahmet Volkan, Ozgur Yigit, Muhammed Ture, Eda Sunnetci","doi":"10.1159/000542590","DOIUrl":"https://doi.org/10.1159/000542590","url":null,"abstract":"<p><strong>Objective: </strong>We investigated the accuracy of imaging modalities in diagnosis and outcome of otitis media with effusion by correlating the imaging findings with the preoperative otomicroscopic examinations, tympanometric results, and intra-operative findings in patients who undergone cochlear implant surgery.</p><p><strong>Methods: </strong>The results of the preoperative physical examination, and intra-operative findings of patients younger than 18 years who underwent cochlear implant surgery at a single tertiary instution were recorded from their medical charts. Tympanometries, which were performed in maximum 1 week prior to imaging modalities, were analyzed. The high resolution computed tomography of temporal bone and magnetic resonance imaging of internal acoustic meati findings were reviewed. The mastoid cavity and middle ears were evaluated separately.</p><p><strong>Results: </strong>The data comprising of 280 ears were evaluated. The correlation between imaging findings and both physical examination and tympanometries were statistically significant (p=0.000). The intra-operative findings supported this correlation.</p><p><strong>Conclusions: </strong>Our study showed that imaging modalities might detect the middle ear and mastoid cavity effusions. The severity of these changes may differ according to the severity of disease.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-13"},"PeriodicalIF":1.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esteem® Active Middle Ear Implant versus Conventional Hearing Aids: Long-Term Performance.","authors":"Maurizio Barbara, Chiara Filippi, Silvia Tarentini, Giorgio Bandiera, Simonetta Monini, Edoardo Covelli","doi":"10.1159/000542158","DOIUrl":"10.1159/000542158","url":null,"abstract":"<p><strong>Introduction: </strong>The totally implantable active middle ear implant Esteem® may be considered an effective alternative to conventional hearing aids (cHAs) to manage moderate-to-severe forms of sensorineural hearing loss. This study aimed to provide long-term comparative data of Esteem performances with those achieved by cHA.</p><p><strong>Methods: </strong>From a total of 46 subjects who received unilateral application of Esteem®, and were followed up over the years, ten underwent an audiological assessment that compared the outcomes with those achieved in the contralateral ear by a cHA, considering the initially symmetric auditory thresholds in both ears. Other than pure tone audiometry and speech audiometry in quiet, the assessment was performed by using the adaptive speech in noise, i.e., Matrix test.</p><p><strong>Results: </strong>The mean speech intelligibility in quiet shows in the unaided situation a recognition of 50.7% at 71 dBHL, 71% at 69 dBHL with only contralateral cHA, 92% at 66 dBHL with only Esteem device and 94% at 61 dBHL with Esteem® device and contralateral cHA. The mean speech intelligibility in noise shows in the unaided situation a recognition of 36% at 71 dBHL, 56% at 69 dBHL with only contralateral cHA, 79% at 66 dBHL with only Esteem® device and 84% at 61 dBHL with Esteem® device and contralateral cHA. At Matrix test in the unaided condition, 4 patients reached 50% of intelligibility and the 50% threshold was obtained with a mean sound/noise ratio of +10 dBHL. In the contralaterally aided condition, 10 patients reached a 50% threshold in a condition of mean S/N ratio of +10.6 dBHL. In the Esteem® only and Esteem® plus cHA condition, all patients reached the 50% threshold with a mean S/N ratio of +3.4 dBHL with the Esteem® device and +0.92 dBHL with Esteem® plus a contralateral cHA, with a statistically nonsignificant difference. The mean deviation from the reference value (7.1 dB in the normal hearing population) was 17.1 dBHL, in unaided situation; this condition did not change with only the contralateral cHA (17.6 dBHL), whilst a significant improvement could be identified with only Esteem® device, where the mean deviation was 10.5 dBHL, and mostly with Esteem® device associated with the contralateral cHA, with a value of 8.02 dBHL.</p><p><strong>Conclusions: </strong>The adaptive speech audiometry in noise (Matrix Test) showed that binaural stimulation provides greater benefits in the speech recognition in noise test in comparison to monaural stimulation, especially when this is carried out only by the cHA. However, the Esteem® device allowed to obtain audiological benefits that are significantly superior to those offered by cHAs, especially in cases where the hearing loss is severe and, in some cases, profound, achieving performances almost comparable to those of a cochlear implant.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Different Adaptation Formulas on Mid-Latency Auditory Evoked Potentials in Adults with Hearing Aids.","authors":"Nedim Ugur Kaya, Emine Aydin, F Ceyda Akin Ocal, Bulent Satar","doi":"10.1159/000541023","DOIUrl":"https://doi.org/10.1159/000541023","url":null,"abstract":"<p><strong>Introduction: </strong>We were conducting this study to evaluate the effects of different hearing aid adaptation formulas on middle latency responses (MLR) in adult hearing aid users.</p><p><strong>Methods: </strong>The study included 72 participants: those with moderate hearing loss using hearing aids with two different formulas for the last year, those with moderate hearing loss not using hearing aids, and those without hearing loss. Sixteen participants using NAL-NL1 and NAL-RP formulas were Group 1; twenty using NAL-NL2 and DSL formulas were Group 2; fifteen with hearing loss not using devices were Group 3; and twenty-one without hearing loss were Group 4. We obtained and compared MLR responses, including Na latency, Pa latency, and Na-Pa amplitude.</p><p><strong>Results: </strong>Group 1 mean Na-Pa amplitude value was found to be higher than Group 2 (p = 0.001). No significant difference was observed between Group 1 and Group 2 in terms of Na latency and Pa latency values (p = 0.001; p = 0.035). It was observed that the mean Na-Pa amplitude values in Group 1 and Group 2 were higher than Group 3 (p = 0.001), but this elevation reached the level of statistical significance only in Group 1. No difference was observed between Group 1, Group 2, and Group 3 in terms of Na latency and Pa latency values (p = 0.001; p = 0.035). Compared with those without hearing loss (Group 4), participants with hearing loss (Group 1, Group 2, and Group 3) had longer Na latency and Pa latency values (p = 0.001; p = 0.035), and Na-Pa amplitudes were lower (p = 0.001). The effect of current (tested) hearing aid usage time on Na latency, Pa latency, and Na-Pa amplitude values of Group 1 and Group 2 was not observed. In all groups, there was a positive correlation between audiometric airway/bone conduction pure tone averages and speech acquisition threshold values, Na latency and Pa latency values, and a negative correlation between Na-Pa amplitude values. In all groups, there was a negative correlation between speech discrimination scores and Na and Pa latency values, as well as a positive correlation between Na and Pa amplitude values. There was a positive correlation between age and Pa latency values in all groups, as well as a negative correlation between Na and Pa amplitude values.</p><p><strong>Conclusion: </strong>Middle latency responses are affected by the presence of hearing loss, the use of hearing aids, and different hearing aid adaptation formulas. MLR measurements with a hearing aid can be used as an objective test to evaluate the benefit of hearing aid use.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-16"},"PeriodicalIF":1.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Memantine on Cisplatin-induced Ototoxicity.","authors":"Selis Gülseven Güven, Hilal Erdoğan, Murat Arslan, Onur Ersoy, Erdoğan Bulut, Özlem Tuğçe Çilingir Kaya, Serap Sırvancı, Cem Uzun","doi":"10.1159/000542496","DOIUrl":"https://doi.org/10.1159/000542496","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to investigate electrophysiologically and histopathologically, the protective effects of intratympanic memantine, an N-methyl-D-aspartate receptor antagonist, on ototoxicity caused by cisplatin, an anti-neoplastic agent used in many types of cancer.</p><p><strong>Methods: </strong>Thirty-seven guinea pigs with a normal auditory function were randomly allocated to group 1 (Cisplatin; n=8), group 2 (Memantine; n=8), group 3 (Cisplatin+Memantine; n=8), group 4 (Cisplatin+Physiological Serum [PS]; n=8), and group 5 (Control; n=5). Auditory assessments were conducted using distortion product otoacoustic emissions (DPOAE) within a frequency range of 1-32 kHz, and auditory brainstem responses (ABR) within 8-32 kHz. A single dose of cisplatin (12 mg/kg) was administered intraperitoneally, followed by intratympanic administration of 0.2 mL of either memantine or PS to both ears at least half an hour before cisplatin administration. Subsequent auditory evaluations were conducted 72 h after cisplatin administration. Histopathological analyses were performed using light microscopy of the right ear and scanning electron microscopy (SEM) of the left ear.</p><p><strong>Results: </strong>Auditory evaluations conducted before and after treatment revealed significant findings. Specifically, within groups 3 and 4, ABR thresholds were elevated at all frequencies (p=0.00), whereas the DPOAE signal-to-noise ratios were reduced at frequencies of 8, 12, 16, and 24 kHz (p=0.001, p=0.01, p=0.01, and p=0.00, respectively). Histopathologically, both light microscopy and SEM revealed that the cisplatin+memantine group exhibited fewer hair cells and nuclear degeneration in the spiral ganglion than the cisplatin and cisplatin+PS groups. Additionally, the stria vascularis thickness was greater in the cisplatin+memantine group than in cisplatin and cisplatin+PS groups.</p><p><strong>Conclusion: </strong>Despite the negative electrophysiological findings, the histopathological outcomes suggest that intratympanic memantine may have a potential protective effect against cisplatin-induced ototoxicity. However, further investigations are warranted to corroborate these findings and elucidate the underlying mechanisms of action of memantine.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-27"},"PeriodicalIF":1.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speech Perception Outcomes with the Anatomy-Based Fitting Map Among Experienced, Adult Cochlear Implant Users: A Longitudinal Study.","authors":"Pelden Wangchuk, Cila Umat, Foong Yen Chong, Faizah Mohd Zaki, Asma Abdullah","doi":"10.1159/000540965","DOIUrl":"https://doi.org/10.1159/000540965","url":null,"abstract":"<p><strong>Introduction: </strong>Anatomy-based fitting (ABF), a relatively new technique for cochlear implant programming, attempts to lessen the impact of the electrode insertion location-related frequency-to-place mismatch (FPM). This study aimed to compare vowels and consonant perception in quiet and in noise among experienced adult cochlear implant (CI) users using the ABF and the regular, conventional-based fitting (CBF) map (pre-ABF) over six months.</p><p><strong>Method: </strong>Nine ears from eight experienced adult CI users were included in the experimental and longitudinal research. Using surgical planning software called Otoplan, post-operative computed CT scans were used to determine the locations of intracochlear electrodes and their angle of insertion. The anatomy-based frequency bands were produced by Maestro 9.0 CI fitting software using the Otoplan data. Nonsense syllables with consonant-vowel-consonant (CVC) recognition scores in quiet and noise (+5dB SNR) were compared at baseline, three, and six months after ABF. The vowels involved were /a, i, u/, while the consonants were voiced /b, d, g/ and voiceless /p, t, k/ plosives. Speech pieces were presented at 30 dB SL in a sound-treated room through a loudspeaker positioned at 0° azimuth.</p><p><strong>Results: </strong>On average, the ABF maps shifted center frequency ranging from 0.46 semitones (0.04 octave) at (E12) to 23.94 semitones (1.99 octave) at (E1) as compared to the CBF maps. The mean vowel and consonant identification scores in quiet and in noise were significantly higher in ABF than in CBF (p<0.05) with a large effect size and the trend of improvement was seen with time. Voiced consonants had better scores than the voiceless consonants.</p><p><strong>Conclusion: </strong>The results demonstrated improved perception of vowels and consonants, particularly for sounds containing voicing cues after using the ABF maps. The results also suggested that ABF could be more effective for voice detection in noise. Overall, the findings indicate that correcting place mismatch with an ABF map may improve speech perception, at least among experienced adult cochlear implant users.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-30"},"PeriodicalIF":1.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Different Auditory Stimuli and Cognitive Tasks on Balance in Healthy Young Adults.","authors":"Özge Gedik Toker, Elif Durgut, Erdem Emre Yılmaz, Kubra Alpay, Hulya Nilgun Gurses","doi":"10.1159/000541841","DOIUrl":"https://doi.org/10.1159/000541841","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigated the effect of different auditory stimuli and cognitive tasks on balance in healthy young adults.</p><p><strong>Methods: </strong>Thirty-three participants, aged 23.33 ± 2.43 years, were included in the study. The hearing levels of the participants were determined. Static and dynamic postural stability and limits of stability (LOS) tests were performed in the absence of auditory stimuli, in the presence of spondee word lists at 70 dB(A) and in the presence of spondee+white noise (-6 dB signal-to-noise ratio [SNR]), while auditory stimuli were presented bilaterally with supra-aural headphones. Participants were asked to repeat the words they listened to while performing balance-related tasks.</p><p><strong>Results: </strong>No significant differences between the three conditions were observed in the postural stability and LOS results. Increase in total repetition error was observed as the listening task became more difficult.</p><p><strong>Conclusion: </strong>The presence of auditory stimuli and the cognitive tasks did not cause any changes in the participants' balance.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series Suggests Peaking Transimpedance as a Possible Marker for Scalar Dislocations in Cochlear Implantation.","authors":"Anna C Kopsch, Luise Wagner, Stefan K Plontke, Sabrina Kösling","doi":"10.1159/000541954","DOIUrl":"10.1159/000541954","url":null,"abstract":"<p><strong>Introduction: </strong>During postoperative implant control, we observed extraordinary peaks in transimpedance measurements. While searching for a possible reason, it appeared that they might correlate with scalar dislocations.</p><p><strong>Methods: </strong>In this retrospective case series, six adult CI patients who underwent transimpedance measurements and postoperative imaging were analyzed. Intra- and postoperative transimpedance measurements were visual inspected. The intracochlear position of electrodes was radiologically identified.</p><p><strong>Results: </strong>From 6 patients with transimpedance matrices showing an extraordinary peak in the off-diagonal area, five electrode arrays showed no correct scalar localization in the scala tympani, and one had a correct scalar localization in the scala tympani.</p><p><strong>Conclusions: </strong>A peaking transimpedance might be a marker for scalar dislocation in CIs.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nationwide, Population-Based Study of Intelligence and Hearing Loss among 3,104,670 Adolescents.","authors":"Nir Tsur, Yonatan Reuven, Mor Rittblat, Shlomi Abuhasira, Andrei Lubarski, Ohad Hilly, Zivan Beer","doi":"10.1159/000542157","DOIUrl":"10.1159/000542157","url":null,"abstract":"<p><strong>Purpose: </strong>Epidemiological studies have demonstrated a relationship between general intelligence (GI) in youth and hearing loss (HL). However, no large-scale study assessed the relations of GI in late adolescence with conductive HL (CHL) and sensorineural HL (SNHL), stratified by severity. This study examined the connection between HL and GI in late adolescence.</p><p><strong>Methods: </strong>Cross-sectional study on mandatory premilitary recruitment data recorded during 1967-2019 of patients aged 17-19. We compared GI between SNHL, CHL, and those with normal hearing. In addition, we used logistic regression to measure the associations between HL and GI after adjuring for age, sex, education, and socioeconomic status.</p><p><strong>Results: </strong>Among 3,104,851 adolescents assessed, 20,075 (0.6%) exhibited HL. We categorized GI into three levels for analysis: low (lowest category), medium, and high (reference category). Adjusted odds ratios (ORs) revealed that SNHL was associated with lower GI levels, with ORs ranging from 1.3 (95% confidence interval [CI] 1.4-1.2) for the lowest GI category to 1.1 (95% CI 1.15-0.04) for the medium category. CHL (CHL) also demonstrated significant associations, with ORs from 1.8 (95% CI 1.9-1.6) for the lowest GI level to 1.1 (95% CI 1.2-0.9) for medium. Further analysis revealed a statistically significant, severity-dependent relationship between SNHL and the odds of being in the lowest GI quartile (Q1). Specifically, the ORs for SNHL ranged from 1.2 (95% CI 1.1-1.3) to 1.3 (95% CI 1.1-1.5) as severity increased, indicating a strong link between greater SNHL severity and reduced cognitive performance. In contrast, CHL did not show a consistent correlation between its severity and GI outcomes, with an OR of 1.6 (95% CI 1.2-2.3) across severity levels.</p><p><strong>Conclusion: </strong>We report a strong relationship between HL and GI in late adolescence. SNHL, but not CHL, demonstrated a severity-based decline in GI. The results highlight the value of early, specifically targeted therapies for HL that consider its etiology and degree.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensorineural Hearing Loss Negatively Impacts Cognition in Older Subjects with Normal Lateral Semi-Circular Canal Function.","authors":"Hanne Gommeren, Tinne Vandenbroeke, Joyce Bosmans, Griet Mertens, Patrick Cras, Sebastiaan Engelborghs, Angelique Van Ombergen, Annick Gilles, Marc Lammers, Vincent Van Rompaey","doi":"10.1159/000541436","DOIUrl":"https://doi.org/10.1159/000541436","url":null,"abstract":"<p><strong>Introduction: </strong>Worldwide around 400 million people suffer from hearing loss. There is increasing evidence that hearing loss is a modifiable risk factor for cognitive decline. However, several risk factors for cognition are common in hearing-impaired individuals, including vestibular dysfunction, anxiety, and depression. This study aimed to explore the effect of hearing loss on cognitive functioning in older adults, considering the effects of vestibular function, anxiety, and depression on cognitive performance.</p><p><strong>Method: </strong>A cross-sectional study was performed on 42 subjects with moderate-to-severe sensorineural hearing loss (SNHL) and 42 matched normal-hearing controls. Matching was based on the following factors; sex, age, education level, level of anxiety and depression, and vestibular function. The test battery consisted of a cognitive assessment (Repeatable Battery for the Assessment of Neuropsychological Status adjusted for the Hearing Impaired [RBANS-H]), hearing assessment (Pure Tone Average and speech-in-noise testing), and vestibular assessment (video Head Impulse Test [vHIT]). Depression and anxiety were evaluated using the Hospital Anxiety and Depression Scale (HADS) and Beck Depression Inventory (BDI) questionnaires.</p><p><strong>Results: </strong>A significantly lower total cognitive (RBANS-H) score was observed in the group with SNHL compared to controls (100.93 [12.94] vs. 108.88 [10.47], p = 0.003). The difference among both groups was most pronounced in the subdomains Visuospatial/Constructional (92.90 [16.32] vs. 103.12 [12.83], p = 0.002) and Attention (96.62 [12.52] vs. 104.02 [11.81], p = 0.007). The other subdomains Immediate Memory, Language, and Delayed Memory did not differ significantly between the groups with SNHL and the normal-hearing controls.</p><p><strong>Conclusion: </strong>The results of this study indicate that hearing loss negatively affects cognitive functioning, even in older adults with normal vestibular function.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of a Food Supplement in the Treatment of Tinnitus with Comorbid Headache: A Statistical and Machine Learning Analysis with a Literature Review.","authors":"Zacharias Kalentakis, Georgios Feretzakis, Georgia Baxevani, Georgios Dritsas, Effrosyni Papatheodorou","doi":"10.1159/000541842","DOIUrl":"10.1159/000541842","url":null,"abstract":"<p><strong>Introduction: </strong>Tinnitus, the perception of sound without an external auditory stimulus, affects approximately 10-15% of the population and is often associated with significant comorbidities such as headaches. These conditions can severely impact the quality of life. The aim of this study was to evaluate the efficacy of a food supplement in reducing the symptoms of both tinnitus and headache in patients experiencing these conditions concurrently.</p><p><strong>Methods: </strong>This prospective study included 32 patients (21 males and 11 females) aged between 23 and 68 years (mean age 49.38 years) who were experiencing both tinnitus and headache. The study assessed the impact of a food supplement on tinnitus and headache over a 90-day treatment period using three main instruments: the Tinnitus Handicap Inventory (THI), the Headache Impact Test (HIT-6), and a Visual Analog Scale (VAS) for discomfort. Statistical analyses, including paired t tests, were conducted to compare pre- and posttreatment scores. In the same dataset, Ridge Regression, a linear regression model with L2 regularization, was used to predict posttreatment scores (THI90, HIT90, VAS90).</p><p><strong>Results: </strong>The results indicated a statistically significant reduction in all three measures after 90 days of treatment. The mean THI score decreased from 29.81 to 27.06 (p = 0.011), the mean HIT-6 score decreased from 50.41 to 48.75 (p = 0.019), and the mean VAS score for discomfort decreased from 7.63 to 7.13 (p = 0.033). The optimal Ridge Regression model was found with an \"alpha\" value of approximately 3.73. The performance metrics on the test set were as follows: Mean Squared Error (MSE) of 13.91 and an R-squared score of 0.61, indicating that the model explains approximately 61% of the variance in the posttreatment scores. These results indicate that pretreatment scores are significant predictors of posttreatment outcomes, and gender plays a notable role in predicting HIT and VAS scores posttreatment.</p><p><strong>Conclusion: </strong>This study demonstrates that a food supplement is effective in reducing the symptoms of tinnitus and headache in patients suffering from both conditions. The significant improvements in THI, HIT-6, and VAS scores indicate a positive impact on patient quality of life. Further research with larger sample sizes and more detailed subgroup analyses is recommended to fully understand the differential impacts of treatment across various demographics.</p>","PeriodicalId":55432,"journal":{"name":"Audiology and Neuro-Otology","volume":" ","pages":"1-12"},"PeriodicalIF":1.6,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}