Comparative Outcomes of Cochlear Implantation in Children with Auditory Neuropathy Spectrum Disorder and Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis.

IF 1.6 4区医学 Q2 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Audiology and Neuro-Otology Pub Date : 2025-07-07 DOI:10.1159/000546962

Qusai Tawakkul, Shahad Alsanosi, Asma Alahmadi, Sarah Alarifi, Murad Al-Momani, Ahmad Aldhafeeri, Salman Alhabib

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引用次数: 0

Abstract

Background: Cochlear implantation (CI) has emerged as a promising intervention for children with auditory neuropathy spectrum disorder (ANSD). Several studies have investigated the efficacy of cochlear implants in children with ANSD, demonstrating improvements in auditory performance and language skills following implantation. Whether the benefits and outcomes of CIs in children with ANSD are comparable to children with sensorineural hearing loss (SNHL) is still debatable. The present updated systematic review and meta-analysis evaluated the outcomes of CI for children with ANSD compared to children with SNHL.

Methods: A meta-analysis was conducted on studies that included pediatric patients and the outcomes of CI in patients with ANSD versus SNHL were compared. A comprehensive search was performed using the following electronic databases: PubMed, Scopus, Web of Science, EBSCOhost, and Cochrane Central Register of Controlled Trials (CENTRAL).

Results: . Fourteen studies (no. of patients =722 patients) were included. The total number of patients in the ANSD and SNHL groups in the present systematic review was 212 and 520, respectively. The most utilized assessment tests were the Speech Intelligibility Rating (SIR) and Categories of Auditory Performance (CAP) scores. The pooled estimate showed that patients with ANSD had comparable CAP scores compared to patients with SNHL (MD -0.52, 95% CI [-1.34, 0.29], P =0.21,). Likewise, three studies reported the SIR after CI and showed comparable findings between ANSD and SNHL patients. The pooled estimate showed that patients with ANSD had comparable SIR scores compared to patients with SNHL (MD -0.26, 95% CI [-0.65, 0.13], P =0.19).

Conclusion: While the results show mixed findings across various outcome measures, the overall impact of CI on speech recognition and language development appears to be positive and comparable between ANSD and SNHL.

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听力神经病变谱系障碍和感觉神经性听力损失儿童人工耳蜗植入术的比较结果：系统回顾和荟萃分析。

背景：人工耳蜗植入术（CI）已成为治疗儿童听神经病变谱系障碍（ANSD）的一种很有前景的干预手段。几项研究已经调查了人工耳蜗对患有ANSD的儿童的疗效，证明了植入后听觉表现和语言技能的改善。在患有ANSD的儿童中，CIs的益处和结果是否与患有感音神经性听力损失（SNHL）的儿童相当仍有争议。目前更新的系统综述和荟萃分析评估了与SNHL儿童相比，ANSD儿童CI的结果。方法：对包括儿科患者的研究进行荟萃分析，比较ANSD患者和SNHL患者CI的结果。使用以下电子数据库进行全面检索：PubMed、Scopus、Web of Science、EBSCOhost和Cochrane Central Register of Controlled Trials （Central）。结果:。14项研究(no。纳入722例患者。在本系统综述中，ANSD组和SNHL组的患者总数分别为212例和520例。最常用的评估测试是语音清晰度评级（SIR）和听觉表现类别（CAP）分数。合并估计结果显示，ANSD患者的CAP评分与SNHL患者相当（MD为-0.52,95% CI [-1.34, 0.29], P =0.21,）。同样，三项研究报告了CI后的SIR，并在ANSD和SNHL患者之间显示了相似的结果。汇总估计显示，与SNHL患者相比，ANSD患者的SIR评分相当（MD为-0.26,95% CI [-0.65, 0.13], P =0.19）。结论：虽然结果显示不同结果测量的结果不同，但CI对语音识别和语言发展的总体影响似乎是积极的，并且在ANSD和SNHL之间具有可比性。

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来源期刊

Audiology and Neuro-Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： ''Audiology and Neurotology'' provides a forum for the publication of the most-advanced and rigorous scientific research related to the basic science and clinical aspects of the auditory and vestibular system and diseases of the ear. This journal seeks submission of cutting edge research opening up new and innovative fields of study that may improve our understanding and treatment of patients with disorders of the auditory and vestibular systems, their central connections and their perception in the central nervous system. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines.