Autonomic Neuroscience-Basic & Clinical最新文献

{"title":"Spontaneous baroreflex sensitivity is attenuated in male UCD-type 2 diabetes mellitus rats: A link between metabolic and autonomic dysfunction","authors":"Milena Samora ,&nbsp;Yu Huo ,&nbsp;Richard K. McCuller ,&nbsp;Suchit Chidurala ,&nbsp;Kimber L. Stanhope ,&nbsp;Peter J. Havel ,&nbsp;Audrey J. Stone ,&nbsp;Michelle L. Harrison","doi":"10.1016/j.autneu.2023.103117","DOIUrl":"10.1016/j.autneu.2023.103117","url":null,"abstract":"<div><p><span>Patients with type 2 diabetes mellitus (T2DM) have impaired arterial baroreflex function, which may be linked to the co-existence of obesity. However, the role of obesity and its related metabolic impairments on baroreflex dysfunction in T2DM is unknown. This study aimed to investigate the role of </span>visceral fat<span><span><span> and adiponectin, the most abundant cytokine produced by </span>adipocytes, on baroreflex dysfunction in T2DM rats. Experiments were performed in adult male UCD-T2DM rats assigned to the following experimental groups (n = 6 in each): prediabetic (Pre), diabetes-onset (T0), 4 weeks after onset (T4), and 12 weeks after onset (T12). Age-matched healthy Sprague-Dawley rats were used as controls. Rats were anesthetized and blood pressure was directly measured on a beat-to-beat basis to assess spontaneous baroreflex sensitivity (BRS) using the sequence technique. Dual-energy X-ray absorptiometry (DEXA) was used to assess body composition. Data are presented as mean ± SD. BRS was significantly lower in T2DM rats compared with controls at T0 (T2D: 3.7 ± 3.2 ms/mmHg vs Healthy: 16.1 ± 8.4 ms/mmHg; P = 0.01), but not at T12 (T2D: 13.4 ± 8.1 ms/mmHg vs Healthy: 9.2 ± 6.0 ms/mmHg; P = 0.16). T2DM rats had higher visceral fat mass, adiponectin, and insulin concentrations compared with control rats (all P &lt; 0.01). Changes in adiponectin and insulin concentrations over the measured time-points mirrored one another and were opposite those of the BRS in T2DM rats. These findings demonstrate that obesity-related metabolic impairments may contribute to an attenuated spontaneous BRS in T2DM, suggesting a link between metabolic and </span>autonomic dysfunction.</span></p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"249 ","pages":"Article 103117"},"PeriodicalIF":2.7,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10135722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of covid-19 on sleep quality and autonomic function in elderly diabetic women","authors":"Leonardo Hesley Ferraz Durans,&nbsp;Ellian Robert Vale Santos,&nbsp;Thamyres da Cruz Miranda,&nbsp;Helen Nara da Silva e Silva,&nbsp;Nivaldo de Jesus Silva Soares Júnior,&nbsp;Sarah Raquel Dutra Macedo,&nbsp;Cristiano Teixeira Mostarda","doi":"10.1016/j.autneu.2023.103118","DOIUrl":"10.1016/j.autneu.2023.103118","url":null,"abstract":"<div><h3>Aim</h3><p>to analyze the quality of sleep and cardiac autonomic modulation of elderly diabetic women in the post-covid-19 syndrome.</p></div><div><h3>Methodology</h3><p><span>41 elderly women, aged 60–75 years, with a diagnosis of Type 2 Diabetes Mellitus and who had covid-19 were included, divided into three groups: 14 in the Diabetes without covid-19 group (DG), 15 in the Diabetes with covid-19 group (CG), 12 in the Diabetes with covid-19 group who had Pulmonary Compromise (IG). Sleep quality was assessed using the Pittsburgh questionnaire, anamnesis<span>, capillary blood<span><span> glucose, blood pressure collection, anthropometry, resting electrocardiogram for 10 min for </span>heart rate variability (HRV) analysis. Data were analyzed by 1-way ANOVA followed by Tukey-Kramer Multiple Comparisons Test, significance for </span></span></span><em>p</em> ≤ 0.05.</p></div><div><h3>Results</h3><p><span>there was no significant difference in age, blood glucose, blood pressure, and body composition between the groups. In the analysis of sleep quality, there was significance in the following indices: sleep duration, sleep efficiency, sleep disturbances, and daytime sleepiness. Further, there was a reduction in autonomic indices between CG vs. DG: VarRR (ms</span>²), SDNN (ms), SD1 (ms), TINN (ms), HF-log (ms²), LF-log (ms²); and between IG vs. DG: VarRR (ms²), SDNN (ms), RMSSD (ms), SD1 (ms), SD2 (ms), and HF-log (ms²).</p></div><div><h3>Conclusion</h3><p>it is suggestive that diabetic elderly women who had covid-19, with and without pulmonary impairment, have impaired sleep quality and interference on HRV with decreased parasympathetic autonomic modulation.</p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"249 ","pages":"Article 103118"},"PeriodicalIF":2.7,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10128632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability as a marker and predictor of inflammation, nosocomial infection, and sepsis – A systematic review","authors":"Josephine Adam ,&nbsp;Sven Rupprecht ,&nbsp;Erika C.S. Künstler ,&nbsp;Dirk Hoyer","doi":"10.1016/j.autneu.2023.103116","DOIUrl":"10.1016/j.autneu.2023.103116","url":null,"abstract":"<div><h3>Purpose</h3><p>The autonomic nervous system interacts with the immune system via the inflammatory response. Heart rate variability (HRV), a marker of autonomic activity, is associated with inflammation, and nosocomial infections/sepsis, and has clinical implications for the monitoring of at-risk patients. Due to the vagal tone's influence on anti-inflammatory immune response, this association may predominately be reflected by vagally-mediated HRV indices. However, HRV's predictive significance on inflammation/infection remains unclear.</p></div><div><h3>Methods</h3><p>843 studies examining the associations/prognostic value of HRV indices on inflammation, and nosocomial infection/sepsis were screened in this systematic review. According to inclusion and exclusion criteria, 68 associative studies and 14 prediction studies were included.</p></div><div><h3>Results</h3><p>HRV and pro-inflammatory state were consistently associated in healthy subjects and patient groups. Pro-inflammatory state was related to reduced total power HRV including vagally- and non-vagally-mediated HRV indices. Similar, compared to controls, HRV reductions were observed during nosocomial infections/sepsis.</p><p>Only limited evidence supports the predictive value of HRV in the development of nosocomial infections/sepsis. Reduced very low frequency power HRV showed the highest predictive value in adults, even with different clinical conditions. In neonates, an increased heart rate characteristic score, combining reduced total power HRV, decreased complexity, and vagally-dominated asymmetry, predicted sepsis.</p></div><div><h3>Conclusions</h3><p>Pro-inflammatory state is related to an overall reduction in HRV rather than a singular reduction in vagally-mediated HRV indices, reflecting the complex autonomic-regulatory changes occurring during inflammation.</p><p>The potential benefit of using continuous HRV monitoring for detecting nosocomial infection-related states, and the implications for clinical outcome, need further clarification.</p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"249 ","pages":"Article 103116"},"PeriodicalIF":2.7,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10184709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons","authors":"Katherine R. Langen,&nbsp;Heather A. Dantzler,&nbsp;Procopio Gama de Barcellos-Filho,&nbsp;David D. Kline","doi":"10.1016/j.autneu.2023.103095","DOIUrl":"10.1016/j.autneu.2023.103095","url":null,"abstract":"<div><p><span>Transient receptor potential<span><span> melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained </span>hypoxia<span><span> (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased </span>neuronal activity<span> in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O</span></span></span></span>₂ (SH), or CIH (episodic 6 % O₂ for 10d). A subset of neurons from normoxic rats were exposed to in vitro incubation for 24-h in 21 % or 1 % O₂. Intracellular Ca²⁺ of dissociated neurons was monitored via Fura-2 imaging. Ca²⁺<span><span> levels increased upon TRPM3 activation via Pregnenolone sulfate (Preg) or CIM0216. </span>Preg responses were eliminated by the TRPM3 antagonist ononetin, confirming agonist specificity. Removal of extracellular Ca</span>²⁺ also eliminated Preg response, further suggesting Ca²⁺ influx via membrane-bound channels. In neurons isolated from SH-exposed rats, the TRPM3 elevation of Ca²⁺<span> was greater than in normoxic-exposed rats. The SH increase was reversed following a subsequent normoxic exposure. RNAScope demonstrated TRPM3 mRNA was greater after SH than in Norm ganglia. Incubating dissociated cultures from normoxic rats in 1 % O</span>₂ (24-h) did not alter the Preg Ca²⁺ responses compared to their normoxic controls. In contrast to in vivo SH, 10d CIH did not alter TRPM3 elevation of Ca²⁺<span>. Altogether, these results demonstrate a hypoxia-specific increase in TRPM3-mediated calcium influx.</span></p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"247 ","pages":"Article 103095"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9822290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exaggerated blood pressure elevation in response to orthostatic challenge, a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization","authors":"J. Antonio González-Hermosillo G ,&nbsp;Esteban Jorge Galarza ,&nbsp;Onasis Vicente Fermín ,&nbsp;José Manuel Núñez González ,&nbsp;Lucia Mariel Félix Álvarez Tostado ,&nbsp;Marco Antonio Estrada Lozano ,&nbsp;Claudia Ruíz Rabasa ,&nbsp;María del Rocio Martínez Alvarado","doi":"10.1016/j.autneu.2023.103094","DOIUrl":"10.1016/j.autneu.2023.103094","url":null,"abstract":"<div><h3>Objective</h3><p>Post-acute sequelae of SARS-COV-2 (PASC) are emerging as a major health challenge. Orthostatic intolerance secondary to autonomic failure has been found in PASC patients. This study investigated the effect of COVID-19 after recovery on blood pressure (BP) during the orthostatic challenge.</p></div><div><h3>Research design and methods</h3><p>Thirty-one out of 45 patients hospitalized due to COVID-19-related pneumonia that developed PASC and did not have hypertension at discharge were studied. They underwent a head-up tilt test (HUTT) at 10.8 ± 1.9 months from discharge. All met the PASC clinical criteria, and an alternative diagnosis did not explain the symptoms. This population was compared with 32 historical asymptomatic healthy controls.</p></div><div><h3>Results</h3><p>Exaggerated orthostatic blood pressure response (EOPR)/orthostatic hypertension (OHT) was detected in 8 out of 23 (34.7 %) patients, representing a significantly increased prevalence (7.67-fold increase <em>p</em> = 0.009) compared to 2 out of 32 (6.4 %) asymptomatic healthy controls matched by age, who underwent HUTT and were not infected with SARS-CoV-2.</p></div><div><h3>Conclusions</h3><p>This prospective evaluation in patients with PASC revealed abnormal blood pressure rise during the orthostatic challenge, suggesting of autonomic dysfunction in a third of the studied subjects. Our findings support the hypothesis that EOPR/OHT may be a phenotype of neurogenic hypertension. Hypertension in PASC patients may adversely affect the cardiovascular burden in the world.</p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"247 ","pages":"Article 103094"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial of the special issue on autonomic nervous system and cerebral blood flow autoregulation","authors":"Alberto Porta ,&nbsp;Ronney B. Panerai","doi":"10.1016/j.autneu.2023.103092","DOIUrl":"10.1016/j.autneu.2023.103092","url":null,"abstract":"","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"247 ","pages":"Article 103092"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9666883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons","authors":"Krystal Karunungan ,&nbsp;Rachel H. Garza ,&nbsp;Ana Cristina Grodzki ,&nbsp;Megan Holt ,&nbsp;Pamela J. Lein ,&nbsp;Vidya Chandrasekaran","doi":"10.1016/j.autneu.2023.103085","DOIUrl":"10.1016/j.autneu.2023.103085","url":null,"abstract":"<div><p><span>Autonomic dysfunction<span> has been observed in Alzheimer's disease (AD); however, the effects of genes involved in AD on the </span></span>peripheral nervous system<span><span> are not well understood. Previous studies have shown that presenilin-1 (PSEN1), the catalytic subunit<span> of the gamma secretase<span> (γ-secretase) complex, mutations in which are associated with familial AD function, regulates dendritic growth in hippocampal neurons. In this study, we examined whether the γ-secretase pathway also influences dendritic growth in primary sympathetic neurons. Using </span></span></span>immunoblotting<span> and immunocytochemistry<span><span><span>, molecules of the γ-secretase complex, PSEN1, PSEN2<span>, PEN2, </span></span>nicastrin<span> and APH1a, were detected in sympathetic neurons dissociated from embryonic (E20/21) rat sympathetic ganglia. Addition of bone morphogenetic protein-7 (BMP-7), which induces dendrites in these neurons, did not alter expression or localization of γ-secretase </span></span>complex proteins<span>. BMP-7-induced dendritic growth was inhibited by siRNA<span> knockdown of PSEN1 and by three γ-secretase inhibitors, γ-secretase inhibitor IX (DAPT), LY-411575 and BMS-299897. These effects were specific to dendrites and concentration-dependent and did not alter early downstream pathways of BMP signaling. In summary, our results indicate that γ-secretase activity enhances BMP-7 induced dendritic growth in sympathetic neurons. These findings provide insight into the normal cellular role of the γ-secretase complex in sympathetic neurons.</span></span></span></span></span></p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"247 ","pages":"Article 103085"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9769033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress and the autonomic nervous system","authors":"David S. Goldstein","doi":"10.1016/j.autneu.2023.103096","DOIUrl":"10.1016/j.autneu.2023.103096","url":null,"abstract":"","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"247 ","pages":"Article 103096"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9659325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of sex and menstrual cycle phase on sympathetic action potential recruitment patterns during hypercapnic-hypoxic apnea","authors":"Yasmine Coovadia ,&nbsp;J. Kevin Shoemaker ,&nbsp;Charlotte W. Usselman","doi":"10.1016/j.autneu.2023.103093","DOIUrl":"10.1016/j.autneu.2023.103093","url":null,"abstract":"<div><p><span>Previously, we demonstrated that integrated muscle sympathetic nerve activity<span><span> (MSNA) responses to acute chemoreflex stress were augmented during the early follicular (EF) phase of the </span>menstrual cycle<span> relative to both the midluteal (ML) phase and males. These differences were most pronounced in the amplitude component of MSNA, suggesting EF-driven increases in action potential (AP) recruitment in females. Therefore, we tested the hypothesis that neural recruitment, quantified as MSNA AP discharge patterns during acute chemoreflex stress, is potentiated during EF. We retrospectively analyzed MSNA data from 9 young males and 7 young females tested during the EF and ML phases at rest and during a voluntary end-inspiratory hypercapnic-hypoxic apnea. Sympathetic AP discharge patterns were analyzed using wavelet-based methodology. Apnea-driven increases in AP frequency and AP content per integrated burst were greater in EF relative to ML (APs/min: </span></span></span><em>P</em> = 0.02; APs/burst: <em>P</em> = 0.03) and to males (APs/min: <em>P</em> = 0.04; APs/burst: P = 0.02). The recruitment of new larger AP clusters was greater in EF than ML (<em>P</em> &lt; 0.01) but not different from males (<em>P</em> = 0.50). Interestingly, we observed a positive association between the magnitude of change in the estrogen/progesterone ratio from EF to ML and the change in AP cluster recruitment, as both decreased from EF to ML (R² = 0.82; <em>P</em><span> &lt; 0.01). This suggests that the enhanced progesterone dominance over estrogen during ML may blunt the recruitment of new larger APs. Overall, these data indicate that both sex and the menstrual cycle impact AP recruitment patterns in a manner which may be mediated, at least in part, by gonadal hormones.</span></p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"247 ","pages":"Article 103093"},"PeriodicalIF":2.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal TRPV1 channel desensitization enhances stress-induced hyperthermia during social stress in rats","authors":"T.O. Reis,&nbsp;S.I.S.R. Noronha,&nbsp;P.M.A. Lima,&nbsp;A.R.R. De Abreu,&nbsp;L.B.T. Mesquita,&nbsp;F.I. Ferreira,&nbsp;F.C. Silva,&nbsp;D.A. Chianca-Jr,&nbsp;R.C. De Menezes","doi":"10.1016/j.autneu.2023.103073","DOIUrl":"10.1016/j.autneu.2023.103073","url":null,"abstract":"<div><h3>Aims</h3><p><span><span><span>In rats, stress-induced hyperthermia caused by social interaction depends on </span>brown adipose tissue<span> (BAT) thermogenesis and peripheral </span></span>vasoconstriction<span>. However, the peripheral mechanisms responsible for regulating the level of hyperthermia during social stress are still unknown. The transient receptor potential vanilloid 1 (TRPV1) subfamily, expressed in sensory and visceral neurons, can serve as a </span></span>thermoreceptor. Here, we tested the hypothesis that the abdominal TRPV1 is essential in regulating stress-induced hyperthermia during social stress.</p></div><div><h3>Main methods</h3><p><span>Male Wistar rats received an intraperitoneal injection of </span>Resiniferatoxin<span> (RTX) - an ultra-potent capsaicin analog, (i.e., to desensitize the TRPV1 channels) or vehicle. Seven days later, we evaluated the effects of abdominal TRPV1 channels desensitization on core body temperature (CBT), brown adipose tissue (BAT) temperature, tail skin temperature, and heart rate (HR) of rats subjected to a social stress protocol.</span></p></div><div><h3>Key findings</h3><p>We found abdominal TRPV1 desensitization increased CBT and BAT temperature but did not change tail skin temperature and HR during rest. However, under social stress, we found that abdominal TRPV1 desensitization heightened the increase in CBT and BAT caused by stress. Also, it abolished the increase in tail skin temperature that occurs during and after social stress. TRPV1 desensitization also delayed the HR recovery after the exposure to the social stress.</p></div><div><h3>Significance</h3><p>These results show that abdominal TRPV1 channels desensitization heightens stress-induced hyperthermia, causing heat dissipation during and after social stress, enabling optimal thermal control during social encounters.</p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":"246 ","pages":"Article 103073"},"PeriodicalIF":2.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9346696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}